ENSG00000136052

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258538 ENSG00000136052 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC41A2 protein_coding protein_coding 2.579321 0.6941287 4.171128 0.05828444 0.5633618 2.569981 0.9312223 0.60189071 1.3058770 0.03553931 0.08315589 1.104679 0.5013833 0.88606667 0.3193000 -0.5667667 0.01396049 0.01396049 FALSE TRUE
ENST00000424946 ENSG00000136052 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC41A2 protein_coding protein_coding 2.579321 0.6941287 4.171128 0.05828444 0.5633618 2.569981 0.1570082 0.00000000 0.7687713 0.00000000 0.43372772 6.283128 0.0497250 0.00000000 0.1801333 0.1801333 0.45246722 0.01396049   FALSE
ENST00000549713 ENSG00000136052 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC41A2 protein_coding processed_transcript 2.579321 0.6941287 4.171128 0.05828444 0.5633618 2.569981 0.4165082 0.00000000 0.4956347 0.00000000 0.25637222 5.660024 0.1232417 0.00000000 0.1061667 0.1061667 0.47411225 0.01396049   FALSE
MSTRG.7914.3 ENSG00000136052 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC41A2 protein_coding   2.579321 0.6941287 4.171128 0.05828444 0.5633618 2.569981 0.8389308 0.05632018 1.2155553 0.05632018 0.09723649 4.207844 0.2630292 0.06956667 0.3064333 0.2368667 0.11952999 0.01396049 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136052 E001 73.2720265 0.0004202964 2.349134e-07 2.221849e-06 12 104801801 104804974 3174 - 1.764 1.961 0.661
ENSG00000136052 E002 7.0471277 0.0028312025 2.968045e-02 7.133362e-02 12 104804975 104805033 59 - 0.946 0.636 -1.237
ENSG00000136052 E003 18.2142506 0.0642750536 9.887457e-01 9.969976e-01 12 104805034 104805337 304 - 1.245 1.270 0.087
ENSG00000136052 E004 0.5954526 0.0184362123 2.667942e-01 4.050500e-01 12 104834091 104834179 89 - 0.247 0.000 -9.666
ENSG00000136052 E005 13.6788797 0.0015184187 6.093363e-01 7.288520e-01 12 104844472 104844620 149 - 1.122 1.172 0.179
ENSG00000136052 E006 11.8194452 0.0015938727 5.192086e-01 6.533327e-01 12 104845843 104845974 132 - 1.054 1.120 0.240
ENSG00000136052 E007 10.7156387 0.0017342834 5.367310e-01 6.684501e-01 12 104861291 104861370 80 - 1.015 1.082 0.243
ENSG00000136052 E008 16.5556279 0.0012031437 9.110181e-01 9.474774e-01 12 104866432 104866579 148 - 1.212 1.203 -0.031
ENSG00000136052 E009 14.1661912 0.0276901807 3.974875e-01 5.412407e-01 12 104886293 104886439 147 - 1.109 1.205 0.343
ENSG00000136052 E010 11.0865004 0.0015442287 4.909712e-01 6.282923e-01 12 104889033 104889177 145 - 1.068 0.994 -0.271
ENSG00000136052 E011 8.5722916 0.0020429371 9.673039e-01 9.835275e-01 12 104895274 104895345 72 - 0.946 0.942 -0.014
ENSG00000136052 E012 12.4808402 0.0014706809 3.521371e-01 4.963899e-01 12 104909655 104909762 108 - 1.115 1.018 -0.353
ENSG00000136052 E013 12.9857510 0.0014406618 1.476292e-01 2.584690e-01 12 104927973 104928096 124 - 1.146 0.994 -0.551
ENSG00000136052 E014 10.7181063 0.0075519470 5.135166e-01 6.483378e-01 12 104928097 104928161 65 - 1.046 0.970 -0.282
ENSG00000136052 E015 11.6101333 0.0017181019 2.739423e-01 4.130457e-01 12 104928162 104928243 82 - 1.089 0.969 -0.439
ENSG00000136052 E016 10.3813482 0.0017254377 9.873320e-01 9.961500e-01 12 104928244 104928299 56 - 1.015 1.018 0.009
ENSG00000136052 E017 7.9546003 0.0023735115 3.175221e-01 4.604180e-01 12 104928300 104928310 11 - 0.875 0.994 0.449
ENSG00000136052 E018 11.9820974 0.0178731159 8.888905e-01 9.329354e-01 12 104928311 104928389 79 - 1.082 1.062 -0.072
ENSG00000136052 E019 14.0568154 0.0015109022 1.463745e-02 3.967864e-02 12 104928390 104928491 102 - 1.202 0.943 -0.942
ENSG00000136052 E020 16.8848520 0.0011429720 1.784702e-03 6.550419e-03 12 104928492 104928694 203 - 1.282 0.969 -1.126
ENSG00000136052 E021 0.7834997 0.1301515275 8.153092e-01 8.830505e-01 12 104931632 104931791 160 - 0.247 0.192 -0.465
ENSG00000136052 E022 0.0000000       12 104951491 104951528 38 -      
ENSG00000136052 E023 5.2757353 0.0048006412 2.054547e-03 7.394848e-03 12 104958088 104958189 102 - 0.864 0.324 -2.507
ENSG00000136052 E024 4.0245765 0.0040807189 7.509099e-02 1.516800e-01 12 104958190 104958319 130 - 0.732 0.425 -1.401
ENSG00000136052 E025 0.6696487 0.0252222960 1.000000e+00 1.000000e+00 12 104958601 104958621 21 - 0.197 0.192 -0.046
ENSG00000136052 E026 0.8232405 0.1337805403 8.187077e-01 8.854405e-01 12 104958622 104958744 123 - 0.247 0.193 -0.454