ENSG00000136051

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311317 ENSG00000136051 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC4 protein_coding retained_intron 9.36769 1.182207 15.8018 0.06673502 0.4803212 3.729295 1.08886197 0.1077019 1.734621 0.0401751 0.25293949 3.889704 0.092975000 0.08896667 0.10963333 0.02066667 0.889616578 0.001206855 FALSE  
ENST00000332180 ENSG00000136051 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC4 protein_coding protein_coding 9.36769 1.182207 15.8018 0.06673502 0.4803212 3.729295 5.88160750 0.8968879 10.301480 0.1126455 0.57568252 3.507183 0.633608333 0.76720000 0.65283333 -0.11436667 0.602165765 0.001206855 FALSE  
ENST00000551290 ENSG00000136051 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC4 protein_coding processed_transcript 9.36769 1.182207 15.8018 0.06673502 0.4803212 3.729295 0.01131308 0.0905046 0.000000 0.0905046 0.00000000 -3.329190 0.008895833 0.07116667 0.00000000 -0.07116667 0.274435158 0.001206855    
ENST00000552203 ENSG00000136051 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC4 protein_coding protein_coding 9.36769 1.182207 15.8018 0.06673502 0.4803212 3.729295 0.79147500 0.0000000 1.322384 0.0000000 0.06429554 7.057867 0.095458333 0.00000000 0.08403333 0.08403333 0.001206855 0.001206855    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136051 E001 0.0000000       12 105107324 105107454 131 +      
ENSG00000136051 E002 0.0000000       12 105107714 105107714 1 +      
ENSG00000136051 E003 0.0000000       12 105107715 105107730 16 +      
ENSG00000136051 E004 12.0698590 0.0019109461 8.742039e-01 9.231159e-01 12 105107731 105107771 41 + 0.818 0.910 0.353
ENSG00000136051 E005 16.7814900 0.0010624719 8.489064e-01 9.062174e-01 12 105107772 105107785 14 + 0.941 1.093 0.560
ENSG00000136051 E006 31.4166513 0.0006146541 3.816437e-01 5.259497e-01 12 105107786 105107861 76 + 1.198 1.222 0.083
ENSG00000136051 E007 44.3339448 0.0004696381 2.359083e-02 5.896940e-02 12 105111125 105111264 140 + 1.349 1.222 -0.445
ENSG00000136051 E008 24.9617685 0.0007371593 3.138714e-02 7.465880e-02 12 105114216 105114269 54 + 1.118 0.910 -0.767
ENSG00000136051 E009 25.2869952 0.0007722853 2.872038e-02 6.944378e-02 12 105114362 105114427 66 + 1.123 0.910 -0.784
ENSG00000136051 E010 26.9147031 0.0015448516 4.648774e-02 1.029163e-01 12 105115184 105115229 46 + 1.146 0.980 -0.606
ENSG00000136051 E011 37.0156859 0.2309961400 6.805796e-02 1.401453e-01 12 105115661 105115728 68 + 1.280 0.984 -1.064
ENSG00000136051 E012 40.4782876 0.0045470267 3.856258e-02 8.838945e-02 12 105118446 105118528 83 + 1.310 1.183 -0.445
ENSG00000136051 E013 35.0564974 0.0131111655 1.572392e-01 2.714263e-01 12 105120555 105120597 43 + 1.247 1.184 -0.225
ENSG00000136051 E014 1.2104850 0.0109673605 5.389405e-01 6.702685e-01 12 105121089 105121100 12 + 0.182 0.385 1.453
ENSG00000136051 E015 44.4285647 0.0020812130 2.531870e-01 3.896815e-01 12 105121101 105121204 104 + 1.340 1.350 0.033
ENSG00000136051 E016 42.8764158 0.0007162233 3.709044e-02 8.564413e-02 12 105122118 105122238 121 + 1.331 1.222 -0.383
ENSG00000136051 E017 41.2895205 0.0005362452 2.571287e-02 6.334493e-02 12 105126004 105126127 124 + 1.318 1.183 -0.473
ENSG00000136051 E018 39.7327135 0.0007392319 3.758461e-02 8.655627e-02 12 105126235 105126362 128 + 1.302 1.183 -0.418
ENSG00000136051 E019 55.8435472 0.0042411487 3.997022e-03 1.313484e-02 12 105127129 105127289 161 + 1.447 1.258 -0.657
ENSG00000136051 E020 44.5804799 0.0015084335 2.423798e-02 6.030274e-02 12 105133770 105133896 127 + 1.350 1.222 -0.450
ENSG00000136051 E021 0.4418608 0.0251173268 1.000000e+00 1.000000e+00 12 105133897 105133899 3 + 0.087 0.000 -9.259
ENSG00000136051 E022 49.5077786 0.0010253635 9.943751e-02 1.896215e-01 12 105137886 105138011 126 + 1.388 1.350 -0.131
ENSG00000136051 E023 46.1036923 0.0088735704 6.037286e-01 7.244537e-01 12 105140294 105140401 108 + 1.350 1.427 0.266
ENSG00000136051 E024 53.2501005 0.0004679215 8.742185e-01 9.231262e-01 12 105140899 105141045 147 + 1.410 1.528 0.409
ENSG00000136051 E025 37.6000346 0.0060001223 7.456714e-02 1.508438e-01 12 105141167 105141246 80 + 1.280 1.183 -0.343
ENSG00000136051 E026 38.4902491 0.0036234833 1.724291e-01 2.913657e-01 12 105142453 105142558 106 + 1.287 1.257 -0.104
ENSG00000136051 E027 41.6753785 0.0005144796 4.672052e-02 1.033254e-01 12 105143127 105143243 117 + 1.321 1.222 -0.346
ENSG00000136051 E028 54.3785595 0.0004402660 1.681631e-03 6.224211e-03 12 105144287 105144448 162 + 1.435 1.222 -0.744
ENSG00000136051 E029 28.2424144 0.0046195177 4.263559e-03 1.388047e-02 12 105144449 105144455 7 + 1.169 0.826 -1.271
ENSG00000136051 E030 0.0000000       12 105144456 105144717 262 +      
ENSG00000136051 E031 54.7179196 0.0005461368 1.693700e-02 4.479248e-02 12 105144718 105144872 155 + 1.434 1.321 -0.392
ENSG00000136051 E032 38.1910294 0.0009836690 1.024673e-01 1.942689e-01 12 105146452 105146526 75 + 1.284 1.222 -0.217
ENSG00000136051 E033 44.9893013 0.0086941535 8.163727e-01 8.838104e-01 12 105147042 105147146 105 + 1.341 1.448 0.369
ENSG00000136051 E034 3.1774898 0.0048105113 7.173407e-01 8.127585e-01 12 105147147 105147543 397 + 0.396 0.385 -0.061
ENSG00000136051 E035 6.5186207 0.0034091077 9.190453e-05 4.839357e-04 12 105147610 105147905 296 + 0.519 1.222 2.765
ENSG00000136051 E036 0.9598804 0.0165316760 3.795369e-01 5.238084e-01 12 105149474 105149614 141 + 0.137 0.385 1.940
ENSG00000136051 E037 50.9772881 0.0007679435 3.969719e-01 5.407439e-01 12 105149615 105149749 135 + 1.397 1.448 0.177
ENSG00000136051 E038 29.1512258 0.0006967910 1.165178e-01 2.149759e-01 12 105152343 105152345 3 + 1.175 1.093 -0.294
ENSG00000136051 E039 47.1306171 0.0004906659 1.443068e-01 2.538700e-01 12 105152346 105152451 106 + 1.369 1.350 -0.067
ENSG00000136051 E040 6.6652981 0.0023883743 5.231600e-01 6.568955e-01 12 105155110 105155208 99 + 0.623 0.585 -0.167
ENSG00000136051 E041 0.4449813 0.0214792130 1.319961e-01 2.368916e-01 12 105156507 105156614 108 + 0.060 0.384 3.258
ENSG00000136051 E042 1.5102936 0.0089621367 1.666087e-01 2.837783e-01 12 105156615 105156725 111 + 0.203 0.585 2.260
ENSG00000136051 E043 33.7071502 0.0006537641 3.802033e-02 8.738947e-02 12 105156726 105156792 67 + 1.236 1.093 -0.508
ENSG00000136051 E044 36.1510614 0.0006144491 1.669761e-01 2.842661e-01 12 105157236 105157322 87 + 1.256 1.222 -0.119
ENSG00000136051 E045 43.3603758 0.1516489337 3.539780e-01 4.982582e-01 12 105160001 105160148 148 + 1.328 1.353 0.086
ENSG00000136051 E046 21.8619364 0.1012188726 5.829037e-01 7.071283e-01 12 105162749 105162790 42 + 1.027 1.309 1.007
ENSG00000136051 E047 23.9761537 0.1435515460 4.518215e-01 5.927429e-01 12 105162791 105162845 55 + 1.055 1.422 1.298
ENSG00000136051 E048 60.0478345 0.0383681874 8.381528e-01 8.987996e-01 12 105164111 105164307 197 + 1.458 1.585 0.435
ENSG00000136051 E049 0.2987644 0.0274610088 1.000000e+00   12 105164308 105164633 326 + 0.060 0.000 -8.675
ENSG00000136051 E050 31.3473858 0.0009714753 7.708094e-01 8.520430e-01 12 105164641 105164672 32 + 1.194 1.290 0.338
ENSG00000136051 E051 43.5518278 0.0111166376 7.796853e-01 8.583693e-01 12 105164673 105164740 68 + 1.326 1.427 0.350
ENSG00000136051 E052 311.2151498 0.0264155896 1.424162e-10 2.449195e-09 12 105166864 105169130 2267 + 2.108 2.668 1.868