ENSG00000136021

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360820 ENSG00000136021 HEK293_OSMI2_2hA HEK293_TMG_2hB SCYL2 protein_coding protein_coding 11.17562 2.836373 18.60906 0.2449663 0.764413 2.709584 1.8466796 0.2474012 3.89704997 0.09361397 0.70626786 3.923989 0.1392625 0.08666667 0.206900000 0.12023333 1.204249e-01 7.944733e-13 FALSE TRUE
ENST00000547735 ENSG00000136021 HEK293_OSMI2_2hA HEK293_TMG_2hB SCYL2 protein_coding retained_intron 11.17562 2.836373 18.60906 0.2449663 0.764413 2.709584 0.3755434 1.1425804 0.03364112 0.32220335 0.03364112 -4.723036 0.1306792 0.38780000 0.001733333 -0.38606667 5.121108e-09 7.944733e-13 FALSE TRUE
ENST00000549687 ENSG00000136021 HEK293_OSMI2_2hA HEK293_TMG_2hB SCYL2 protein_coding protein_coding 11.17562 2.836373 18.60906 0.2449663 0.764413 2.709584 2.4447675 0.0000000 4.02218624 0.00000000 0.53073995 8.655418 0.1230167 0.00000000 0.214600000 0.21460000 7.944733e-13 7.944733e-13 FALSE TRUE
MSTRG.7866.1 ENSG00000136021 HEK293_OSMI2_2hA HEK293_TMG_2hB SCYL2 protein_coding   11.17562 2.836373 18.60906 0.2449663 0.764413 2.709584 5.9154197 1.0696292 10.02245353 0.33696593 0.69525227 3.216067 0.4851667 0.39516667 0.542533333 0.14736667 6.378082e-01 7.944733e-13 FALSE TRUE
MSTRG.7866.3 ENSG00000136021 HEK293_OSMI2_2hA HEK293_TMG_2hB SCYL2 protein_coding   11.17562 2.836373 18.60906 0.2449663 0.764413 2.709584 0.2308392 0.2614293 0.00000000 0.26142930 0.00000000 -4.762505 0.0588000 0.08566667 0.000000000 -0.08566667 4.471489e-01 7.944733e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136021 E001 1.0246279 0.1041540588 4.382763e-01 5.801678e-01 12 100267140 100267176 37 + 0.243 0.000 -15.097
ENSG00000136021 E002 9.7734177 0.0016976357 7.161623e-01 8.118795e-01 12 100267177 100267245 69 + 0.839 0.995 0.589
ENSG00000136021 E003 11.2642306 0.0015185375 5.242705e-01 6.578540e-01 12 100267246 100267248 3 + 0.884 1.074 0.706
ENSG00000136021 E004 31.0499461 0.0006762744 9.283003e-01 9.588765e-01 12 100267249 100267396 148 + 1.303 1.410 0.369
ENSG00000136021 E005 24.3051638 0.0127096100 2.688097e-01 4.072814e-01 12 100267397 100267792 396 + 1.222 1.199 -0.083
ENSG00000136021 E006 63.8456033 0.0003787747 9.398040e-04 3.753411e-03 12 100282943 100283131 189 + 1.633 1.513 -0.410
ENSG00000136021 E007 35.7163986 0.0005456886 1.528271e-03 5.728430e-03 12 100283132 100283147 16 + 1.397 1.199 -0.693
ENSG00000136021 E008 72.6842815 0.0003469858 1.341956e-06 1.084319e-05 12 100291503 100291660 158 + 1.699 1.471 -0.778
ENSG00000136021 E009 0.0000000       12 100291661 100291989 329 +      
ENSG00000136021 E010 0.4762024 0.3304181078 3.403507e-01 4.843194e-01 12 100296762 100296807 46 + 0.084 0.299 2.207
ENSG00000136021 E011 80.3794054 0.0003148593 8.745238e-07 7.352917e-06 12 100298031 100298175 145 + 1.740 1.526 -0.729
ENSG00000136021 E012 76.7686827 0.0005233193 3.347402e-04 1.519381e-03 12 100311044 100311193 150 + 1.714 1.596 -0.400
ENSG00000136021 E013 109.7598867 0.0003130278 5.671039e-07 4.965390e-06 12 100312432 100312653 222 + 1.872 1.710 -0.545
ENSG00000136021 E014 76.9572947 0.0003739116 4.629183e-05 2.629955e-04 12 100313422 100313538 117 + 1.717 1.563 -0.524
ENSG00000136021 E015 64.3081591 0.0018667844 4.636100e-02 1.026910e-01 12 100314489 100314614 126 + 1.629 1.607 -0.074
ENSG00000136021 E016 72.4840189 0.0003353586 4.021376e-02 9.142856e-02 12 100315558 100315734 177 + 1.678 1.666 -0.041
ENSG00000136021 E017 0.3030308 0.3764095282 1.000000e+00   12 100317681 100317692 12 + 0.085 0.000 -13.278
ENSG00000136021 E018 0.0000000       12 100317715 100317802 88 +      
ENSG00000136021 E019 59.7932273 0.0014622154 1.350586e-01 2.411723e-01 12 100317803 100317925 123 + 1.595 1.607 0.042
ENSG00000136021 E020 0.1515154 0.0433051379 7.873140e-01   12 100319224 100319286 63 + 0.044 0.000 -12.272
ENSG00000136021 E021 53.2291963 0.0004664282 8.438438e-03 2.488150e-02 12 100323525 100323597 73 + 1.556 1.471 -0.290
ENSG00000136021 E022 42.0291993 0.0005472475 5.669315e-06 3.985434e-05 12 100323598 100323638 41 + 1.475 1.141 -1.170
ENSG00000136021 E023 0.1472490 0.0449511221 7.882809e-01   12 100323639 100323836 198 + 0.044 0.000 -12.271
ENSG00000136021 E024 66.1242245 0.0003898473 6.638562e-04 2.766510e-03 12 100326622 100326754 133 + 1.649 1.526 -0.420
ENSG00000136021 E025 0.0000000       12 100327185 100327234 50 +      
ENSG00000136021 E026 65.4599888 0.0005591802 6.633521e-01 7.714364e-01 12 100329201 100329319 119 + 1.621 1.710 0.303
ENSG00000136021 E027 2.3314577 0.0063534770 4.182648e-01 5.615407e-01 12 100333647 100334165 519 + 0.359 0.598 1.201
ENSG00000136021 E028 72.7521960 0.0019513457 9.235545e-01 9.558402e-01 12 100334166 100334266 101 + 1.663 1.773 0.373
ENSG00000136021 E029 0.2987644 0.0277065750 1.000000e+00   12 100335591 100335624 34 + 0.084 0.000 -13.271
ENSG00000136021 E030 64.5055537 0.0004053278 6.331245e-01 7.478709e-01 12 100335625 100335691 67 + 1.615 1.702 0.294
ENSG00000136021 E031 0.1515154 0.0433051379 7.873140e-01   12 100335692 100335810 119 + 0.044 0.000 -12.272
ENSG00000136021 E032 73.0950919 0.0003752290 4.633172e-01 6.031202e-01 12 100335811 100335906 96 + 1.670 1.743 0.247
ENSG00000136021 E033 87.4152845 0.0003260499 6.202734e-01 7.375007e-01 12 100337387 100337506 120 + 1.743 1.833 0.305
ENSG00000136021 E034 667.5795358 0.0084416021 8.065631e-14 2.325384e-12 12 100338528 100341715 3188 + 2.574 2.926 1.172