ENSG00000135976

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000420699 ENSG00000135976 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD36 protein_coding protein_coding 2.088828 0.5968561 3.202836 0.02891425 0.09693468 2.404421 0.56671923 0.14807821 0.8760723 0.052820217 0.31154900 2.486786 0.27149583 0.2455667 0.2683000 0.02273333 0.9859961926 0.0001300394 FALSE TRUE
ENST00000421946 ENSG00000135976 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD36 protein_coding retained_intron 2.088828 0.5968561 3.202836 0.02891425 0.09693468 2.404421 0.29780504 0.10208726 0.3354037 0.026206969 0.05257284 1.623661 0.15615833 0.1710333 0.1048000 -0.06623333 0.5815789132 0.0001300394 FALSE TRUE
ENST00000452478 ENSG00000135976 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD36 protein_coding retained_intron 2.088828 0.5968561 3.202836 0.02891425 0.09693468 2.404421 0.50311897 0.32794061 0.8120894 0.067694364 0.15343614 1.282526 0.27489167 0.5506333 0.2533333 -0.29730000 0.0737232673 0.0001300394 FALSE TRUE
ENST00000461153 ENSG00000135976 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD36 protein_coding protein_coding 2.088828 0.5968561 3.202836 0.02891425 0.09693468 2.404421 0.05875571 0.01874998 0.3129663 0.009964298 0.31296633 3.489751 0.02712083 0.0328000 0.1036333 0.07083333 0.7882443393 0.0001300394 FALSE TRUE
ENST00000494336 ENSG00000135976 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD36 protein_coding retained_intron 2.088828 0.5968561 3.202836 0.02891425 0.09693468 2.404421 0.45691040 0.00000000 0.7433701 0.000000000 0.07353908 6.235287 0.19865417 0.0000000 0.2325333 0.23253333 0.0001300394 0.0001300394 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135976 E001 1.8519324 0.020600951 0.2726285650 0.411580693 2 97113153 97113217 65 + 0.344 0.527 0.971
ENSG00000135976 E002 2.8859098 0.072127578 0.3596728351 0.503993712 2 97113218 97113495 278 + 0.479 0.617 0.640
ENSG00000135976 E003 0.9200378 0.406893050 0.0716050666 0.146013197 2 97113496 97113551 56 + 0.147 0.518 2.515
ENSG00000135976 E004 5.5229882 0.112199361 0.5924711568 0.715016647 2 97113552 97113766 215 + 0.700 0.760 0.245
ENSG00000135976 E005 8.4822629 0.009499335 0.1478966132 0.258817707 2 97113767 97113936 170 + 0.830 0.987 0.594
ENSG00000135976 E006 6.8041360 0.002420043 0.3362985290 0.480125606 2 97118064 97118178 115 + 0.766 0.864 0.387
ENSG00000135976 E007 7.3474393 0.044484693 0.1802428565 0.301487449 2 97118344 97118517 174 + 0.786 0.946 0.618
ENSG00000135976 E008 0.5953508 0.107943831 0.0866496160 0.170038428 2 97118518 97118829 312 + 0.103 0.408 2.539
ENSG00000135976 E009 1.9283081 0.007626215 0.5424703849 0.673230218 2 97122887 97122993 107 + 0.417 0.253 -1.029
ENSG00000135976 E010 1.6243469 0.063514072 0.1826517143 0.304513824 2 97124460 97124597 138 + 0.394 0.000 -13.617
ENSG00000135976 E011 1.6575426 0.008348203 0.6332845487 0.748008666 2 97127067 97127134 68 + 0.344 0.411 0.387
ENSG00000135976 E012 2.5358519 0.026837565 0.5951975442 0.717324007 2 97142640 97142668 29 + 0.459 0.527 0.332
ENSG00000135976 E013 3.1206953 0.088409089 0.8400161558 0.900089595 2 97142763 97142835 73 + 0.533 0.525 -0.037
ENSG00000135976 E014 2.6465692 0.093939898 0.8497310327 0.906753355 2 97144518 97144546 29 + 0.497 0.409 -0.455
ENSG00000135976 E015 2.7948504 0.106238107 0.3381013851 0.481965817 2 97144640 97144712 73 + 0.533 0.252 -1.618
ENSG00000135976 E016 0.8899506 0.013487772 0.4516233830 0.592556878 2 97146486 97146516 31 + 0.256 0.000 -12.743
ENSG00000135976 E017 1.6432613 0.062951374 0.1823825411 0.304206949 2 97149295 97149361 67 + 0.394 0.000 -13.620
ENSG00000135976 E018 2.0935412 0.130470361 0.1394228836 0.247243282 2 97151879 97151939 61 + 0.460 0.000 -13.971
ENSG00000135976 E019 2.5236470 0.007371232 0.3341464042 0.477899411 2 97152504 97152534 31 + 0.498 0.253 -1.444
ENSG00000135976 E020 3.5868829 0.004342305 0.4639948419 0.603746219 2 97154675 97154741 67 + 0.597 0.411 -0.903
ENSG00000135976 E021 4.0976544 0.004059470 0.7920871443 0.867020008 2 97158107 97158167 61 + 0.611 0.619 0.033
ENSG00000135976 E022 3.4344371 0.004519648 0.1570622691 0.271187609 2 97158588 97158655 68 + 0.597 0.253 -1.902
ENSG00000135976 E023 2.5057647 0.005951324 0.0564941139 0.120584979 2 97162099 97162138 40 + 0.516 0.000 -14.245
ENSG00000135976 E024 2.2927360 0.006474673 0.9779968582 0.990365514 2 97164283 97164311 29 + 0.438 0.411 -0.143
ENSG00000135976 E025 2.1401884 0.007154344 0.3912537062 0.535180856 2 97164397 97164469 73 + 0.394 0.527 0.682
ENSG00000135976 E026 1.3381542 0.010226073 0.2378982774 0.371694844 2 97167577 97167605 29 + 0.344 0.000 -13.328
ENSG00000135976 E027 1.8583638 0.008113223 0.6099948726 0.729385804 2 97167695 97167767 73 + 0.394 0.253 -0.902
ENSG00000135976 E028 2.2928352 0.007051187 0.3942999152 0.538149633 2 97179738 97179766 29 + 0.394 0.528 0.685
ENSG00000135976 E029 3.1107797 0.005225939 0.6696507854 0.776383440 2 97179861 97179933 73 + 0.533 0.412 -0.612
ENSG00000135976 E030 2.8226243 0.014523096 0.7988064512 0.871625752 2 97181598 97181626 29 + 0.498 0.412 -0.441
ENSG00000135976 E031 4.5230163 0.004537725 0.6484545716 0.759961480 2 97181721 97181793 73 + 0.652 0.528 -0.557
ENSG00000135976 E032 2.8235573 0.005842653 0.0405326638 0.092001241 2 97183459 97183487 29 + 0.550 0.000 -14.406
ENSG00000135976 E033 3.6235032 0.004454129 0.1379818458 0.245268693 2 97183582 97183654 73 + 0.611 0.253 -1.966
ENSG00000135976 E034 3.9858547 0.004425380 0.3803902536 0.524684139 2 97185316 97185344 29 + 0.625 0.412 -1.027
ENSG00000135976 E035 5.6292298 0.002949130 0.1203703571 0.220501296 2 97185438 97185510 73 + 0.756 0.412 -1.572
ENSG00000135976 E036 4.0029203 0.004156849 0.3805412707 0.524816019 2 97187198 97187226 29 + 0.625 0.412 -1.027
ENSG00000135976 E037 5.1852927 0.003196983 0.1666585055 0.283842655 2 97187329 97187401 73 + 0.724 0.412 -1.442
ENSG00000135976 E038 2.0724367 0.006880066 0.0945797771 0.182252206 2 97189087 97189115 29 + 0.459 0.000 -13.965
ENSG00000135976 E039 3.1818699 0.024679907 0.2137261250 0.342914720 2 97189218 97189290 73 + 0.566 0.253 -1.762
ENSG00000135976 E040 3.0365835 0.005032094 0.2287381294 0.360937143 2 97190978 97191006 29 + 0.550 0.253 -1.690
ENSG00000135976 E041 3.7835515 0.004402891 0.1215867296 0.222197839 2 97191109 97191181 73 + 0.625 0.253 -2.028
ENSG00000135976 E042 2.6572801 0.005744537 0.0477667446 0.105205679 2 97192858 97192886 29 + 0.533 0.000 -14.327
ENSG00000135976 E043 3.0948745 0.005277063 0.0291183219 0.070232528 2 97192981 97193053 73 + 0.582 0.000 -14.550
ENSG00000135976 E044 1.7524540 0.371540564 0.2846356821 0.424891271 2 97194726 97194754 29 + 0.415 0.000 -13.731
ENSG00000135976 E045 2.8093472 0.511721388 0.5760357896 0.701536760 2 97194845 97194917 73 + 0.530 0.254 -1.591
ENSG00000135976 E046 2.0878638 0.090312509 0.5367309438 0.668450108 2 97196593 97196621 29 + 0.438 0.253 -1.138
ENSG00000135976 E047 2.9947663 0.005239077 0.2294399748 0.361761379 2 97196716 97196788 73 + 0.550 0.253 -1.691
ENSG00000135976 E048 2.5635146 0.008081194 0.3345699388 0.478306553 2 97198463 97198491 29 + 0.498 0.253 -1.443
ENSG00000135976 E049 2.9237898 0.005550251 0.7330182295 0.824348529 2 97198586 97198658 73 + 0.516 0.412 -0.530
ENSG00000135976 E050 2.2154193 0.006746259 0.0795114108 0.158763868 2 97200334 97200362 29 + 0.479 0.000 -14.064
ENSG00000135976 E051 3.7491066 0.005529926 0.9303508772 0.960181571 2 97200453 97200525 73 + 0.582 0.528 -0.249
ENSG00000135976 E052 3.5610701 0.017704239 0.2309961048 0.363669409 2 97202202 97202230 29 + 0.516 0.696 0.797
ENSG00000135976 E053 3.1796904 0.005706996 0.3913136367 0.535226543 2 97202321 97202393 73 + 0.498 0.619 0.558
ENSG00000135976 E054 3.1244206 0.061794664 0.1755757232 0.295436365 2 97204068 97204096 29 + 0.480 0.694 0.967
ENSG00000135976 E055 4.7873755 0.027570326 0.3413026617 0.485214825 2 97204191 97204263 73 + 0.639 0.759 0.496
ENSG00000135976 E056 2.3055483 0.128938437 0.9396374551 0.966086284 2 97205940 97205968 29 + 0.439 0.412 -0.144
ENSG00000135976 E057 2.6032555 0.007672217 0.3333460570 0.477060876 2 97206063 97206135 73 + 0.498 0.253 -1.443
ENSG00000135976 E058 2.0359155 0.007352420 0.8114471737 0.880362351 2 97207811 97207839 29 + 0.394 0.412 0.098
ENSG00000135976 E059 2.5582015 0.006130695 0.5265947436 0.659795864 2 97207934 97208006 73 + 0.438 0.528 0.443
ENSG00000135976 E060 2.5540488 0.007721673 0.5274794923 0.660546178 2 97209681 97209709 29 + 0.438 0.528 0.443
ENSG00000135976 E061 3.8062492 0.004169054 0.1169790851 0.215650628 2 97209800 97209872 73 + 0.533 0.759 0.973
ENSG00000135976 E062 5.1110053 0.003368704 0.4068528107 0.550488157 2 97211546 97211574 29 + 0.665 0.759 0.387
ENSG00000135976 E063 5.6541307 0.002993814 0.2846696116 0.424925178 2 97211669 97211741 73 + 0.689 0.815 0.507
ENSG00000135976 E064 0.4470576 0.023293645 0.3329369585 0.476615822 2 97212727 97213418 692 + 0.103 0.252 1.555
ENSG00000135976 E065 1.5772166 0.223138616 0.5351358271 0.667069425 2 97213419 97213447 29 + 0.316 0.416 0.586
ENSG00000135976 E066 3.2079062 0.168607638 0.7585391272 0.843109010 2 97213542 97213614 73 + 0.550 0.415 -0.670
ENSG00000135976 E067 2.8411746 0.005845610 0.2602409428 0.397723062 2 97215301 97215329 29 + 0.533 0.253 -1.613
ENSG00000135976 E068 2.9195234 0.005219567 0.7327287365 0.824145274 2 97215425 97215497 73 + 0.516 0.412 -0.530
ENSG00000135976 E069 1.8456783 0.007755155 0.6096576385 0.729114048 2 97217177 97217205 29 + 0.394 0.253 -0.902
ENSG00000135976 E070 1.2910239 0.010227897 0.3675189244 0.511902227 2 97217300 97217372 73 + 0.256 0.412 0.973
ENSG00000135976 E071 2.2457194 0.030213658 0.1398714870 0.247850883 2 97219050 97219078 29 + 0.369 0.620 1.240
ENSG00000135976 E072 3.7247799 0.004404854 0.6164382336 0.734502846 2 97219174 97219246 73 + 0.566 0.619 0.236
ENSG00000135976 E073 1.9982379 0.007236911 0.8112235682 0.880205646 2 97224806 97224808 3 + 0.394 0.411 0.098
ENSG00000135976 E074 3.2829191 0.004845959 0.4447149851 0.586274969 2 97224809 97224879 71 + 0.516 0.619 0.470
ENSG00000135976 E075 0.8836079 0.013624787 0.4515629842 0.592510460 2 97233730 97233871 142 + 0.256 0.000 -12.743
ENSG00000135976 E076 2.8283728 0.011467534 0.2945635366 0.435660416 2 97241266 97241479 214 + 0.459 0.619 0.752
ENSG00000135976 E077 3.7558873 0.019860564 0.6275796252 0.743369789 2 97243846 97244029 184 + 0.566 0.620 0.240
ENSG00000135976 E078 6.9238451 0.002616144 0.0009247954 0.003701819 2 97245157 97245599 443 + 0.689 1.081 1.507
ENSG00000135976 E079 1.1050531 0.011743879 0.9491317277 0.972114952 2 97245600 97246071 472 + 0.256 0.253 -0.027
ENSG00000135976 E080 0.0000000       2 97247476 97247628 153 +      
ENSG00000135976 E081 2.0283131 0.024953930 0.3360129262 0.479829954 2 97247629 97249050 1422 + 0.369 0.528 0.821
ENSG00000135976 E082 0.0000000       2 97249144 97249214 71 +      
ENSG00000135976 E083 0.0000000       2 97249215 97249551 337 +      
ENSG00000135976 E084 0.0000000       2 97249552 97249645 94 +      
ENSG00000135976 E085 0.0000000       2 97250144 97250173 30 +      
ENSG00000135976 E086 0.0000000       2 97250174 97250199 26 +      
ENSG00000135976 E087 0.0000000       2 97250774 97252120 1347 +      
ENSG00000135976 E088 0.0000000       2 97264329 97264521 193 +