ENSG00000135974

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258457 ENSG00000135974 HEK293_OSMI2_2hA HEK293_TMG_2hB C2orf49 protein_coding protein_coding 15.32738 8.942209 23.30073 0.7560036 0.8022172 1.380678 4.3274558 1.82907553 6.3685407 0.26570077 0.19509739 1.7942457 0.28867083 0.20253333 0.27340000 0.07086667 0.061680108 0.006804529 FALSE TRUE
ENST00000410049 ENSG00000135974 HEK293_OSMI2_2hA HEK293_TMG_2hB C2orf49 protein_coding protein_coding 15.32738 8.942209 23.30073 0.7560036 0.8022172 1.380678 1.4970334 0.07576452 3.6468915 0.07576452 0.08859139 5.4140931 0.06892083 0.01016667 0.15663333 0.14646667 0.006804529 0.006804529 FALSE TRUE
MSTRG.18976.1 ENSG00000135974 HEK293_OSMI2_2hA HEK293_TMG_2hB C2orf49 protein_coding   15.32738 8.942209 23.30073 0.7560036 0.8022172 1.380678 0.7881127 1.07843923 0.3277807 0.17590133 0.32778075 -1.6881018 0.06528333 0.11936667 0.01316667 -0.10620000 0.049615887 0.006804529 FALSE TRUE
MSTRG.18976.4 ENSG00000135974 HEK293_OSMI2_2hA HEK293_TMG_2hB C2orf49 protein_coding   15.32738 8.942209 23.30073 0.7560036 0.8022172 1.380678 7.1454677 4.28060431 10.6432108 0.33298938 0.34329613 1.3120355 0.43889583 0.48826667 0.45686667 -0.03140000 0.886053579 0.006804529 FALSE TRUE
MSTRG.18976.6 ENSG00000135974 HEK293_OSMI2_2hA HEK293_TMG_2hB C2orf49 protein_coding   15.32738 8.942209 23.30073 0.7560036 0.8022172 1.380678 0.5981568 0.61844577 0.9057900 0.19285350 0.39791823 0.5432286 0.05438333 0.06690000 0.03980000 -0.02710000 0.585741961 0.006804529 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135974 E001 0.4355181 0.5817119797 6.559066e-01 7.657068e-01 2 105337532 105337539 8 + 0.203 0.000 -9.537
ENSG00000135974 E002 0.9096442 0.2055772686 6.585921e-01 7.676771e-01 2 105337540 105337547 8 + 0.300 0.185 -0.905
ENSG00000135974 E003 1.2385976 0.3583560854 9.632342e-01 9.807785e-01 2 105337548 105337560 13 + 0.341 0.315 -0.159
ENSG00000135974 E004 67.3653408 0.0028686417 7.793810e-01 8.581190e-01 2 105337561 105337686 126 + 1.803 1.796 -0.022
ENSG00000135974 E005 1.6188183 0.0943125881 4.616681e-01 6.015781e-01 2 105338044 105338153 110 + 0.342 0.495 0.828
ENSG00000135974 E006 44.8140396 0.0055739795 6.840463e-01 7.871076e-01 2 105339583 105339585 3 + 1.633 1.616 -0.058
ENSG00000135974 E007 134.3956436 0.0020751168 3.759014e-01 5.202919e-01 2 105339586 105339749 164 + 2.086 2.127 0.138
ENSG00000135974 E008 132.3415700 0.0010452954 1.155602e-04 5.935027e-04 2 105342848 105342974 127 + 2.047 2.187 0.469
ENSG00000135974 E009 91.4235416 0.0044012445 1.911360e-02 4.958662e-02 2 105342975 105343100 126 + 1.893 2.017 0.417
ENSG00000135974 E010 118.7216779 0.0003317604 9.829739e-04 3.901396e-03 2 105343101 105343223 123 + 2.007 2.129 0.407
ENSG00000135974 E011 76.6817724 0.0004006809 1.543893e-02 4.148855e-02 2 105345315 105345389 75 + 1.820 1.934 0.381
ENSG00000135974 E012 339.9484659 0.0001874730 2.408632e-34 5.661391e-32 2 105345390 105347665 2276 + 2.562 2.329 -0.777
ENSG00000135974 E013 180.3408918 0.0129358619 4.181328e-01 5.614232e-01 2 105347666 105349211 1546 + 2.205 2.275 0.234
ENSG00000135974 E014 8.8819024 0.0081475722 1.255614e-05 8.156370e-05 2 105349251 105349532 282 + 0.732 1.242 1.904
ENSG00000135974 E015 13.2136279 0.0013231394 3.050775e-03 1.041539e-02 2 105359745 105360250 506 + 1.017 1.303 1.022
ENSG00000135974 E016 0.1451727 0.0432746219 1.000000e+00   2 105381698 105381745 48 + 0.079 0.000 -10.848