ENSG00000135913

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258399 ENSG00000135913 HEK293_OSMI2_2hA HEK293_TMG_2hB USP37 protein_coding protein_coding 6.302746 1.661288 10.8396 0.02256716 0.5057887 2.698609 4.2467602 1.130866892 6.9213069 0.074522101 0.04693668 2.602997 0.7166042 0.681233333 0.64116667 -0.04006667 0.787376254 0.001682075 FALSE  
MSTRG.19960.12 ENSG00000135913 HEK293_OSMI2_2hA HEK293_TMG_2hB USP37 protein_coding   6.302746 1.661288 10.8396 0.02256716 0.5057887 2.698609 1.1298536 0.489270980 2.1108827 0.086804454 0.41415657 2.086770 0.1858000 0.293866667 0.19400000 -0.09986667 0.444984396 0.001682075 FALSE  
MSTRG.19960.4 ENSG00000135913 HEK293_OSMI2_2hA HEK293_TMG_2hB USP37 protein_coding   6.302746 1.661288 10.8396 0.02256716 0.5057887 2.698609 0.3743644 0.003599357 0.9190186 0.003599357 0.20340273 6.094097 0.0343875 0.002233333 0.08426667 0.08203333 0.001682075 0.001682075 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135913 E001 339.5321163 0.0225830398 9.303047e-12 1.948733e-10 2 218450251 218453267 3017 - 2.220 2.762 1.808
ENSG00000135913 E002 35.9517754 0.0148483967 4.004082e-01 5.441109e-01 2 218453268 218453500 233 - 1.328 1.566 0.822
ENSG00000135913 E003 141.1907938 0.0140497487 2.754113e-01 4.147121e-01 2 218453501 218454814 1314 - 1.930 2.013 0.278
ENSG00000135913 E004 33.0813638 0.0006954776 3.089819e-02 7.371882e-02 2 218454815 218455017 203 - 1.332 1.275 -0.197
ENSG00000135913 E005 27.7155032 0.0018482049 2.139293e-04 1.023803e-03 2 218455580 218455718 139 - 1.278 0.973 -1.095
ENSG00000135913 E006 25.5184107 0.0007452051 5.136194e-05 2.885722e-04 2 218457092 218457161 70 - 1.249 0.863 -1.410
ENSG00000135913 E007 32.6541627 0.0014842001 2.071469e-06 1.606030e-05 2 218459790 218459905 116 - 1.352 0.922 -1.547
ENSG00000135913 E008 29.4167423 0.0007639931 5.869993e-04 2.485645e-03 2 218463306 218463366 61 - 1.300 1.061 -0.852
ENSG00000135913 E009 34.7302809 0.0006304923 1.510875e-03 5.671417e-03 2 218466010 218466132 123 - 1.363 1.196 -0.587
ENSG00000135913 E010 17.6415940 0.0010147624 2.681316e-03 9.317594e-03 2 218466133 218466176 44 - 1.093 0.796 -1.117
ENSG00000135913 E011 0.0000000       2 218473190 218473246 57 -      
ENSG00000135913 E012 34.9231075 0.0005732437 6.257213e-04 2.627472e-03 2 218474630 218474749 120 - 1.365 1.166 -0.700
ENSG00000135913 E013 37.4441751 0.0005916006 1.708935e-05 1.076449e-04 2 218474750 218474885 136 - 1.401 1.099 -1.067
ENSG00000135913 E014 0.1451727 0.0429639427 7.633068e-01   2 218474886 218474923 38 - 0.042 0.000 -8.637
ENSG00000135913 E015 31.9385741 0.0006239187 4.626306e-05 2.628557e-04 2 218476840 218476942 103 - 1.336 1.019 -1.129
ENSG00000135913 E016 22.4898529 0.0007985784 4.075160e-04 1.803403e-03 2 218476943 218476981 39 - 1.194 0.863 -1.214
ENSG00000135913 E017 22.3590607 0.0008785277 1.204091e-02 3.363038e-02 2 218479650 218479715 66 - 1.179 1.019 -0.578
ENSG00000135913 E018 38.0836455 0.0005467723 3.020278e-04 1.387748e-03 2 218482070 218482234 165 - 1.401 1.196 -0.719
ENSG00000135913 E019 25.8011460 0.0007437303 2.383599e-01 3.722411e-01 2 218485664 218485743 80 - 1.221 1.251 0.105
ENSG00000135913 E020 0.1515154 0.0434258333 7.652791e-01   2 218486116 218486378 263 - 0.042 0.000 -8.638
ENSG00000135913 E021 29.0283940 0.0007021629 8.015550e-02 1.597839e-01 2 218488304 218488421 118 - 1.275 1.251 -0.087
ENSG00000135913 E022 15.4877835 0.0038071616 3.035553e-02 7.266670e-02 2 218495760 218495774 15 - 1.037 0.863 -0.649
ENSG00000135913 E023 32.4219243 0.0007261776 1.051723e-04 5.459389e-04 2 218495775 218495950 176 - 1.342 1.061 -0.998
ENSG00000135913 E024 14.0428438 0.0012369619 1.666507e-03 6.174923e-03 2 218497734 218497768 35 - 1.012 0.618 -1.558
ENSG00000135913 E025 24.1533134 0.0008438702 5.051178e-04 2.179300e-03 2 218497769 218497857 89 - 1.221 0.922 -1.088
ENSG00000135913 E026 27.4351909 0.0008308670 6.360456e-05 3.490843e-04 2 218498026 218498157 132 - 1.275 0.922 -1.279
ENSG00000135913 E027 0.0000000       2 218498253 218498413 161 -      
ENSG00000135913 E028 18.8333289 0.0022616291 4.492208e-03 1.452080e-02 2 218509979 218510006 28 - 1.117 0.863 -0.941
ENSG00000135913 E029 30.6829491 0.0038285978 3.598739e-03 1.200765e-02 2 218510007 218510140 134 - 1.309 1.134 -0.618
ENSG00000135913 E030 0.1472490 0.0435780662 7.649168e-01   2 218514260 218514428 169 - 0.042 0.000 -8.637
ENSG00000135913 E031 14.4619569 0.0012969676 9.620517e-07 8.009572e-06 2 218526560 218526726 167 - 0.860 1.498 2.285
ENSG00000135913 E032 1.5950989 0.0098973865 1.390330e-01 2.467574e-01 2 218528271 218528800 530 - 0.232 0.618 2.159
ENSG00000135913 E033 37.2307879 0.0017890630 2.179681e-01 3.479736e-01 2 218529956 218530040 85 - 1.338 1.589 0.866
ENSG00000135913 E034 38.3034049 0.0005717184 6.655069e-01 7.731781e-01 2 218534609 218534706 98 - 1.363 1.552 0.651
ENSG00000135913 E035 33.1102755 0.0006015297 9.327258e-01 9.616179e-01 2 218546221 218546298 78 - 1.307 1.468 0.558
ENSG00000135913 E036 45.6612687 0.0004771937 6.270682e-01 7.429222e-01 2 218546919 218547091 173 - 1.446 1.565 0.408
ENSG00000135913 E037 31.6464213 0.0007239887 3.041338e-01 4.461402e-01 2 218549809 218549909 101 - 1.304 1.363 0.203
ENSG00000135913 E038 40.1580471 0.0012149330 3.009836e-01 4.427600e-01 2 218553553 218553724 172 - 1.400 1.468 0.235
ENSG00000135913 E039 39.3543599 0.0039444408 6.821475e-01 7.856501e-01 2 218558498 218558677 180 - 1.382 1.499 0.404
ENSG00000135913 E040 8.3452614 0.0157270775 8.896726e-01 9.334873e-01 2 218558678 218558717 40 - 0.766 0.922 0.606
ENSG00000135913 E041 21.0979807 0.0199352090 9.033361e-01 9.424792e-01 2 218560820 218560883 64 - 1.126 1.252 0.446
ENSG00000135913 E042 20.6705575 0.0206837707 7.790622e-01 8.579076e-01 2 218562673 218562717 45 - 1.120 1.226 0.375
ENSG00000135913 E043 28.4954849 0.0076565912 3.003810e-01 4.420592e-01 2 218562718 218562813 96 - 1.261 1.299 0.135
ENSG00000135913 E044 21.2354693 0.0009025702 9.084117e-02 1.764670e-01 2 218568178 218568351 174 - 1.149 1.099 -0.182