ENSG00000135903

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258387 ENSG00000135903 HEK293_OSMI2_2hA HEK293_TMG_2hB PAX3 protein_coding protein_coding 4.034663 3.506435 5.218009 0.08847237 0.2693683 0.5721481 0.04360937 0.22918805 0.0000000 0.09346825 0.00000000 -4.5800734 0.01236250 0.065666667 0.00000000 -0.065666667 0.0002570227 0.0002570227 FALSE TRUE
ENST00000350526 ENSG00000135903 HEK293_OSMI2_2hA HEK293_TMG_2hB PAX3 protein_coding protein_coding 4.034663 3.506435 5.218009 0.08847237 0.2693683 0.5721481 0.18569568 0.02519499 0.3181468 0.01486679 0.05195596 3.2208995 0.04457083 0.007266667 0.06223333 0.054966667 0.0031525901 0.0002570227 FALSE TRUE
ENST00000392070 ENSG00000135903 HEK293_OSMI2_2hA HEK293_TMG_2hB PAX3 protein_coding protein_coding 4.034663 3.506435 5.218009 0.08847237 0.2693683 0.5721481 2.93664343 2.78769719 3.3576131 0.08979282 0.01697758 0.2674866 0.73388333 0.794966667 0.64696667 -0.148000000 0.0314804581 0.0002570227 FALSE TRUE
ENST00000409551 ENSG00000135903 HEK293_OSMI2_2hA HEK293_TMG_2hB PAX3 protein_coding protein_coding 4.034663 3.506435 5.218009 0.08847237 0.2693683 0.5721481 0.32590443 0.17681829 0.2005199 0.12695942 0.20051988 0.1723208 0.07735833 0.048966667 0.03940000 -0.009566667 0.6749744274 0.0002570227 FALSE TRUE
MSTRG.19998.6 ENSG00000135903 HEK293_OSMI2_2hA HEK293_TMG_2hB PAX3 protein_coding   4.034663 3.506435 5.218009 0.08847237 0.2693683 0.5721481 0.09505700 0.00000000 0.6234321 0.00000000 0.35015534 5.9851181 0.01813333 0.000000000 0.11586667 0.115866667 0.2363367239 0.0002570227 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135903 E001 0.1817044 0.0398144194 0.3783398493   2 222199887 222199887 1 - 0.000 0.140 11.529
ENSG00000135903 E002 127.0143871 0.0115697302 0.0088174664 0.025827060 2 222199888 222201110 1223 - 2.028 2.184 0.522
ENSG00000135903 E003 17.7982955 0.0082650341 0.3670270851 0.511393879 2 222201111 222201152 42 - 1.227 1.325 0.346
ENSG00000135903 E004 17.5562197 0.0016718666 0.0333016451 0.078392812 2 222201153 222201165 13 - 1.165 1.356 0.672
ENSG00000135903 E005 24.9431229 0.0008831539 0.7777618631 0.856994698 2 222201166 222201240 75 - 1.411 1.411 0.000
ENSG00000135903 E006 24.4708604 0.0008200181 0.8128718129 0.881359392 2 222201241 222201331 91 - 1.401 1.404 0.011
ENSG00000135903 E007 17.0471331 0.0011239606 0.2791890870 0.418900862 2 222201332 222201357 26 - 1.281 1.211 -0.246
ENSG00000135903 E008 19.8500976 0.0041558085 0.3611706932 0.505557845 2 222201358 222201411 54 - 1.340 1.286 -0.188
ENSG00000135903 E009 24.0268518 0.0008665409 0.6173905414 0.735212719 2 222201412 222201442 31 - 1.406 1.391 -0.052
ENSG00000135903 E010 5.0114501 0.0060789736 0.0090423815 0.026384079 2 222201713 222201943 231 - 0.915 0.564 -1.441
ENSG00000135903 E011 42.2949125 0.0006079305 0.1444818738 0.254118924 2 222201944 222202136 193 - 1.658 1.600 -0.196
ENSG00000135903 E012 21.0953414 0.0080326709 0.0476474432 0.104994186 2 222202137 222202190 54 - 1.401 1.251 -0.523
ENSG00000135903 E013 0.2987644 0.0269510167 0.2835194895   2 222214387 222214810 424 - 0.192 0.000 -11.901
ENSG00000135903 E014 40.1417240 0.0029376909 0.3505821945 0.494767318 2 222220140 222220354 215 - 1.628 1.592 -0.120
ENSG00000135903 E015 31.6216206 0.0007337811 0.7279186346 0.820469199 2 222221222 222221387 166 - 1.488 1.528 0.139
ENSG00000135903 E016 0.0000000       2 222221388 222221410 23 -      
ENSG00000135903 E017 0.0000000       2 222221484 222221597 114 -      
ENSG00000135903 E018 0.0000000       2 222221598 222221715 118 -      
ENSG00000135903 E019 29.1503466 0.0069852482 0.8977171762 0.938705832 2 222232078 222232283 206 - 1.472 1.482 0.035
ENSG00000135903 E020 1.0747755 0.0186972624 0.4295526978 0.572259615 2 222232969 222233057 89 - 0.379 0.246 -0.870
ENSG00000135903 E021 1.6734477 0.0519299877 0.8623932814 0.915273311 2 222242378 222242688 311 - 0.427 0.403 -0.127
ENSG00000135903 E022 5.6785349 0.0287073992 0.0106071960 0.030227158 2 222262544 222263184 641 - 0.608 1.002 1.563
ENSG00000135903 E023 10.1826145 0.2819111650 0.3770389937 0.521378878 2 222263185 222265125 1941 - 1.111 0.971 -0.512
ENSG00000135903 E024 0.8115105 0.0159388788 0.0979586917 0.187395667 2 222287376 222287529 154 - 0.107 0.402 2.451
ENSG00000135903 E025 0.0000000       2 222293630 222293634 5 -      
ENSG00000135903 E026 1.5123648 0.0212254413 0.0006026929 0.002543231 2 222293635 222293757 123 - 0.000 0.608 14.536
ENSG00000135903 E027 0.9545924 0.0136968632 0.0075670730 0.022687567 2 222293758 222294166 409 - 0.000 0.463 13.856
ENSG00000135903 E028 33.0448041 0.0079512807 0.3605802031 0.504902899 2 222294167 222294301 135 - 1.554 1.507 -0.160
ENSG00000135903 E029 34.9869693 0.0045027013 0.0263467991 0.064641033 2 222295528 222295654 127 - 1.608 1.482 -0.429
ENSG00000135903 E030 10.6129325 0.0017295820 0.1640464108 0.280412347 2 222295655 222295657 3 - 1.113 0.990 -0.449
ENSG00000135903 E031 39.1616741 0.0171363577 0.6938095108 0.794795680 2 222296978 222297213 236 - 1.605 1.592 -0.042
ENSG00000135903 E032 34.9564446 0.0009504465 0.9174625632 0.951870018 2 222298531 222298998 468 - 1.536 1.562 0.087