ENSG00000135845

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344529 ENSG00000135845 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGC protein_coding protein_coding 26.91298 24.97316 28.79464 2.642661 0.2163117 0.2053456 23.221862 22.54420 23.112598 2.2748474 0.4112492 0.03590755 0.867925 0.90363333 0.80260000 -0.10103333 5.964473e-05 5.964473e-05 FALSE TRUE
MSTRG.2598.7 ENSG00000135845 HEK293_OSMI2_2hA HEK293_TMG_2hB PIGC protein_coding   26.91298 24.97316 28.79464 2.642661 0.2163117 0.2053456 1.664292 1.04451 2.715877 0.2578025 0.1695627 1.37014750 0.059000 0.04066667 0.09433333 0.05366667 6.371011e-04 5.964473e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135845 E001 2.3059851 0.1523701050 3.690935e-01 5.135328e-01 1 172370189 172370311 123 - 0.633 0.412 -1.056
ENSG00000135845 E002 0.1472490 0.0429716921 4.886630e-01   1 172376131 172376430 300 - 0.124 0.000 -10.167
ENSG00000135845 E003 1.5351839 0.0816152332 5.625588e-01 6.901280e-01 1 172376554 172376636 83 - 0.474 0.356 -0.639
ENSG00000135845 E004 0.2934659 0.0280951749 1.000000e+00   1 172378131 172378258 128 - 0.124 0.120 -0.049
ENSG00000135845 E005 0.0000000       1 172380743 172380906 164 -      
ENSG00000135845 E006 0.0000000       1 172380921 172380973 53 -      
ENSG00000135845 E007 0.5117019 0.0345849423 8.911970e-02 1.737858e-01 1 172386781 172386848 68 - 0.000 0.292 10.692
ENSG00000135845 E008 0.3268771 0.0287660479 1.000000e+00   1 172386849 172386906 58 - 0.124 0.121 -0.046
ENSG00000135845 E009 0.1451727 0.0426783565 4.886553e-01   1 172386907 172386907 1 - 0.124 0.000 -10.169
ENSG00000135845 E010 0.3666179 0.0274015355 1.000000e+00 1.000000e+00 1 172386908 172386957 50 - 0.124 0.121 -0.043
ENSG00000135845 E011 10.9360397 0.0015665496 2.151103e-04 1.028883e-03 1 172393134 172393702 569 - 1.244 0.869 -1.369
ENSG00000135845 E012 55.6162978 0.0006099005 2.748060e-07 2.562697e-06 1 172393703 172394410 708 - 1.870 1.626 -0.824
ENSG00000135845 E013 1.5262013 0.0112115867 6.892411e-03 2.094422e-02 1 172397164 172397272 109 - 0.600 0.121 -3.217
ENSG00000135845 E014 21.4272603 0.0013860100 7.760092e-06 5.287083e-05 1 172399819 172399916 98 - 1.506 1.169 -1.176
ENSG00000135845 E015 7.0319188 0.0421917307 1.113588e-01 2.075456e-01 1 172415294 172415374 81 - 1.012 0.768 -0.932
ENSG00000135845 E016 0.0000000       1 172415375 172415376 2 -      
ENSG00000135845 E017 548.3733512 0.0001939418 5.684387e-23 5.029846e-21 1 172441457 172442330 874 - 2.678 2.789 0.369
ENSG00000135845 E018 391.0164757 0.0003664030 7.185910e-02 1.464367e-01 1 172442331 172442830 500 - 2.613 2.581 -0.107
ENSG00000135845 E019 10.0889213 0.0038609733 4.019397e-02 9.139526e-02 1 172442831 172443702 872 - 1.143 0.923 -0.807
ENSG00000135845 E020 8.8932669 0.0482467014 1.301581e-01 2.343878e-01 1 172443703 172443987 285 - 1.112 0.882 -0.849
ENSG00000135845 E021 95.9527766 0.0050819809 3.482036e-04 1.572907e-03 1 172443988 172444127 140 - 2.073 1.894 -0.603