ENSG00000135837

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367607 ENSG00000135837 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP350 protein_coding protein_coding 7.097347 2.854487 10.29953 0.1516802 0.13763 1.84763 1.5176938 0.33900282 2.254157 0.08538780 0.32448936 2.6976632 0.18388333 0.116366667 0.2197667 0.1034000 2.144776e-01 5.136109e-21 FALSE TRUE
ENST00000417046 ENSG00000135837 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP350 protein_coding protein_coding 7.097347 2.854487 10.29953 0.1516802 0.13763 1.84763 1.3344693 1.92548922 1.032724 0.13820074 0.18952562 -0.8923415 0.30881667 0.673566667 0.1000000 -0.5735667 5.136109e-21 5.136109e-21 FALSE TRUE
ENST00000429851 ENSG00000135837 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP350 protein_coding protein_coding 7.097347 2.854487 10.29953 0.1516802 0.13763 1.84763 1.6905257 0.55801967 2.294401 0.06836966 0.11845793 2.0203789 0.25256667 0.198866667 0.2226667 0.0238000 7.841546e-01 5.136109e-21 FALSE TRUE
MSTRG.2682.2 ENSG00000135837 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP350 protein_coding   7.097347 2.854487 10.29953 0.1516802 0.13763 1.84763 0.8258627 0.02052216 2.087122 0.02052216 0.26765642 6.1024097 0.08104583 0.007533333 0.2022000 0.1946667 1.470975e-08 5.136109e-21 FALSE TRUE
MSTRG.2682.8 ENSG00000135837 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP350 protein_coding   7.097347 2.854487 10.29953 0.1516802 0.13763 1.84763 0.8497347 0.00000000 1.611252 0.00000000 0.07969164 7.3409645 0.07799167 0.000000000 0.1563000 0.1563000 5.508165e-12 5.136109e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135837 E001 0.5848434 0.0243045839 7.281824e-01 8.207071e-01 1 179954773 179954787 15 + 0.169 0.000 -9.365
ENSG00000135837 E002 1.3932084 0.2221482341 9.129791e-01 9.488832e-01 1 179954788 179954792 5 + 0.290 0.279 -0.078
ENSG00000135837 E003 2.4411309 0.0059821494 3.373373e-01 4.812061e-01 1 179954793 179954808 16 + 0.446 0.276 -1.012
ENSG00000135837 E004 2.5863036 0.0057605884 2.962621e-01 4.374657e-01 1 179954809 179954809 1 + 0.464 0.276 -1.105
ENSG00000135837 E005 7.3223737 0.0023025478 2.419543e-01 3.765012e-01 1 179954810 179954939 130 + 0.796 0.658 -0.564
ENSG00000135837 E006 12.5517117 0.0125449456 2.996344e-01 4.411832e-01 1 179954940 179955142 203 + 0.993 0.910 -0.311
ENSG00000135837 E007 0.2924217 0.0294381313 1.000000e+00   1 179955245 179955256 12 + 0.093 0.000 -10.392
ENSG00000135837 E008 2.5215706 0.0059948320 2.958213e-01 4.369646e-01 1 179955257 179955418 162 + 0.464 0.276 -1.106
ENSG00000135837 E009 8.0830738 0.0031032195 1.291021e-02 3.570406e-02 1 179986169 179986180 12 + 0.858 0.443 -1.806
ENSG00000135837 E010 7.6506762 0.0166443278 8.299029e-02 1.642303e-01 1 179986181 179986181 1 + 0.828 0.564 -1.108
ENSG00000135837 E011 13.4773052 0.0294883228 1.019638e-02 2.924873e-02 1 179986182 179986254 73 + 1.053 0.658 -1.536
ENSG00000135837 E012 2.0871985 0.0239916194 8.714987e-02 1.708229e-01 1 179987240 179987242 3 + 0.427 0.000 -12.982
ENSG00000135837 E013 13.1646843 0.0138448979 1.911327e-03 6.951072e-03 1 179987243 179987286 44 + 1.047 0.564 -1.931
ENSG00000135837 E014 14.9453646 0.0011823379 1.059319e-03 4.164189e-03 1 179990507 179990621 115 + 1.095 0.658 -1.691
ENSG00000135837 E015 19.5830812 0.0135991909 1.053188e-04 5.465516e-04 1 179992062 179992221 160 + 1.209 0.658 -2.095
ENSG00000135837 E016 42.0352565 0.0005309782 5.413977e-09 7.018831e-08 1 179996553 179996945 393 + 1.525 0.994 -1.871
ENSG00000135837 E017 26.1804461 0.0007629999 8.530212e-08 8.774627e-07 1 179996946 179997175 230 + 1.333 0.658 -2.532
ENSG00000135837 E018 17.3485555 0.0012204834 3.179665e-06 2.364956e-05 1 180003174 180003287 114 + 1.168 0.443 -2.951
ENSG00000135837 E019 18.4131622 0.0128035298 8.839106e-04 3.557784e-03 1 180006454 180006567 114 + 1.178 0.736 -1.662
ENSG00000135837 E020 22.7036462 0.0195078990 4.124772e-04 1.822185e-03 1 180011929 180012075 147 + 1.265 0.802 -1.703
ENSG00000135837 E021 22.1661685 0.0556221563 6.525820e-03 1.998993e-02 1 180013847 180013981 135 + 1.253 0.858 -1.443
ENSG00000135837 E022 60.9893986 0.0003921810 2.706038e-07 2.526244e-06 1 180013982 180014505 524 + 1.668 1.348 -1.098
ENSG00000135837 E023 26.0383684 0.0028961508 2.139731e-05 1.317362e-04 1 180015849 180015970 122 + 1.323 0.858 -1.691
ENSG00000135837 E024 95.3059851 0.0003859036 1.488097e-10 2.549784e-09 1 180019949 180021009 1061 + 1.860 1.541 -1.084
ENSG00000135837 E025 26.6662364 0.0006988765 3.687985e-04 1.653401e-03 1 180022698 180022848 151 + 1.326 0.994 -1.185
ENSG00000135837 E026 11.6907951 0.0027859226 9.429090e-02 1.818204e-01 1 180024419 180024430 12 + 0.982 0.801 -0.691
ENSG00000135837 E027 29.0577714 0.0017689225 9.281859e-05 4.882738e-04 1 180024431 180024582 152 + 1.363 0.994 -1.315
ENSG00000135837 E028 27.3375431 0.0007233229 2.788924e-04 1.293873e-03 1 180031320 180031494 175 + 1.333 0.995 -1.210
ENSG00000135837 E029 32.5497681 0.0021423024 8.545156e-04 3.453703e-03 1 180033862 180034082 221 + 1.398 1.128 -0.948
ENSG00000135837 E030 30.7209438 0.0028272281 1.300301e-04 6.589927e-04 1 180036926 180037089 164 + 1.383 1.032 -1.247
ENSG00000135837 E031 24.3372178 0.0022593067 8.140778e-04 3.309541e-03 1 180041138 180041202 65 + 1.285 0.954 -1.193
ENSG00000135837 E032 20.7579623 0.0039692009 3.165172e-03 1.075323e-02 1 180041203 180041248 46 + 1.218 0.909 -1.128
ENSG00000135837 E033 31.5700037 0.0065909993 1.011668e-02 2.904913e-02 1 180041662 180041802 141 + 1.381 1.182 -0.698
ENSG00000135837 E034 30.5777548 0.0114437702 3.819980e-02 8.772563e-02 1 180043056 180043192 137 + 1.364 1.207 -0.549
ENSG00000135837 E035 22.1385104 0.0009134335 1.633845e-02 4.347279e-02 1 180044051 180044173 123 + 1.236 1.032 -0.734
ENSG00000135837 E036 26.6346336 0.0007325210 3.038320e-03 1.037791e-02 1 180048536 180048705 170 + 1.316 1.066 -0.887
ENSG00000135837 E037 0.4460135 0.0271020250 1.000000e+00 1.000000e+00 1 180052224 180052316 93 + 0.133 0.000 -10.966
ENSG00000135837 E038 40.8893416 0.0005347199 4.018491e-04 1.781590e-03 1 180052970 180053166 197 + 1.492 1.252 -0.835
ENSG00000135837 E039 38.7702766 0.0018939851 1.927551e-02 4.993350e-02 1 180053750 180053934 185 + 1.461 1.331 -0.452
ENSG00000135837 E040 25.3857604 0.0014553020 9.341590e-02 1.804564e-01 1 180054415 180054502 88 + 1.282 1.182 -0.353
ENSG00000135837 E041 30.7962086 0.0027049894 3.052955e-01 4.473595e-01 1 180062220 180062366 147 + 1.352 1.331 -0.073
ENSG00000135837 E042 28.6789605 0.0056262472 2.129913e-01 3.420583e-01 1 180065115 180065272 158 + 1.326 1.274 -0.182
ENSG00000135837 E043 0.1472490 0.0425060733 8.995295e-01   1 180073819 180073908 90 + 0.049 0.000 -9.334
ENSG00000135837 E044 36.1209461 0.0007604416 2.065747e-05 1.277209e-04 1 180075022 180075221 200 + 1.452 1.098 -1.245
ENSG00000135837 E045 34.9996381 0.0006679343 4.443588e-02 9.917701e-02 1 180078463 180078674 212 + 1.416 1.312 -0.360
ENSG00000135837 E046 30.2846460 0.0049209655 4.938753e-02 1.080718e-01 1 180080517 180080661 145 + 1.356 1.230 -0.441
ENSG00000135837 E047 33.9082353 0.0080316620 4.850919e-02 1.065239e-01 1 180084018 180084178 161 + 1.402 1.275 -0.442
ENSG00000135837 E048 0.2903454 0.3328170996 1.000000e+00   1 180084179 180084280 102 + 0.093 0.000 -9.564
ENSG00000135837 E049 0.0000000       1 180085580 180085603 24 +      
ENSG00000135837 E050 0.1515154 0.0425196947 8.993879e-01   1 180085604 180085928 325 + 0.049 0.000 -9.334
ENSG00000135837 E051 0.0000000       1 180087165 180087288 124 +      
ENSG00000135837 E052 31.3751637 0.0011531086 1.137554e-01 2.109992e-01 1 180087578 180087717 140 + 1.365 1.293 -0.252
ENSG00000135837 E053 31.2502934 0.0006634322 4.140547e-02 9.363569e-02 1 180090714 180090796 83 + 1.370 1.252 -0.412
ENSG00000135837 E054 151.1252091 0.0022810180 1.721389e-03 6.349911e-03 1 180092614 180093713 1100 + 2.035 1.961 -0.246
ENSG00000135837 E055 148.9393532 0.0002154895 1.856362e-01 3.082877e-01 1 180093714 180094616 903 + 1.998 2.125 0.424
ENSG00000135837 E056 0.0000000       1 180095147 180095198 52 +      
ENSG00000135837 E057 88.6010686 0.0003576339 1.873202e-04 9.093697e-04 1 180095523 180095930 408 + 1.751 2.002 0.844
ENSG00000135837 E058 48.4960659 0.0005106635 1.094028e-01 2.046813e-01 1 180096038 180096184 147 + 1.510 1.689 0.610
ENSG00000135837 E059 52.1214927 0.0004392238 1.687962e-01 2.866177e-01 1 180098863 180098985 123 + 1.543 1.705 0.552
ENSG00000135837 E060 54.6301980 0.0004522373 2.913304e-02 7.025852e-02 1 180110997 180111195 199 + 1.554 1.762 0.705
ENSG00000135837 E061 123.3451553 0.0003381229 1.175039e-02 3.293694e-02 1 180111196 180112436 1241 + 1.906 2.085 0.603
ENSG00000135837 E062 374.4487053 0.0036906136 1.158337e-67 1.567454e-64 1 180112437 180114875 2439 + 2.274 2.851 1.924