ENSG00000135829

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367549 ENSG00000135829 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX9 protein_coding protein_coding 118.7242 66.54225 168.2823 10.11195 1.581313 1.33841 97.729311 38.756153 148.266114 3.375982 2.6762944 1.935417 0.77783333 0.60950000 0.88096667 0.2714667 2.205903e-02 2.091764e-27 FALSE TRUE
ENST00000473076 ENSG00000135829 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX9 protein_coding processed_transcript 118.7242 66.54225 168.2823 10.11195 1.581313 1.33841 3.730638 10.994698 0.000000 5.828136 0.0000000 -10.103904 0.05417917 0.14906667 0.00000000 -0.1490667 3.819742e-14 2.091764e-27 FALSE TRUE
MSTRG.2712.4 ENSG00000135829 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX9 protein_coding   118.7242 66.54225 168.2823 10.11195 1.581313 1.33841 2.609606 4.697882 2.085722 2.777884 0.4263998 -1.167631 0.02961667 0.06273333 0.01233333 -0.0504000 1.727700e-01 2.091764e-27 FALSE TRUE
MSTRG.2712.5 ENSG00000135829 HEK293_OSMI2_2hA HEK293_TMG_2hB DHX9 protein_coding   118.7242 66.54225 168.2823 10.11195 1.581313 1.33841 3.819984 9.433100 0.000000 3.155894 0.0000000 -9.883117 0.05318333 0.13600000 0.00000000 -0.1360000 2.091764e-27 2.091764e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135829 E001 0.1515154 4.369361e-02 1.000000e+00   1 182838714 182839314 601 + 0.078 0.000 -9.456
ENSG00000135829 E002 0.2966881 2.711239e-02 6.338714e-01   1 182839315 182839320 6 + 0.144 0.000 -10.408
ENSG00000135829 E003 2.5088957 5.964765e-03 8.043749e-01 8.755584e-01 1 182839321 182839323 3 + 0.527 0.498 -0.140
ENSG00000135829 E004 18.9953279 1.038767e-03 4.422175e-03 1.432425e-02 1 182839324 182839346 23 + 1.333 1.089 -0.864
ENSG00000135829 E005 398.0370347 7.360489e-03 1.239451e-09 1.803735e-08 1 182839347 182839456 110 + 2.636 2.352 -0.945
ENSG00000135829 E006 0.1515154 4.369361e-02 1.000000e+00   1 182839634 182839697 64 + 0.078 0.000 -9.408
ENSG00000135829 E007 3.4300543 1.339792e-02 3.154510e-01 4.582250e-01 1 182839698 182839733 36 + 0.658 0.498 -0.723
ENSG00000135829 E008 15.4193118 5.158037e-02 8.312675e-01 8.942153e-01 1 182839734 182839935 202 + 1.187 1.176 -0.040
ENSG00000135829 E009 619.0208873 7.572812e-03 2.648735e-08 3.014870e-07 1 182842545 182842677 133 + 2.820 2.571 -0.830
ENSG00000135829 E010 628.5000313 8.535316e-03 1.621111e-05 1.026693e-04 1 182843294 182843434 141 + 2.817 2.616 -0.667
ENSG00000135829 E011 537.2077166 6.987456e-03 1.866021e-05 1.165706e-04 1 182852233 182852344 112 + 2.745 2.565 -0.599
ENSG00000135829 E012 629.7715587 6.037146e-03 3.614859e-05 2.105597e-04 1 182853306 182853418 113 + 2.809 2.646 -0.543
ENSG00000135829 E013 397.7027892 6.150762e-03 3.574423e-04 1.608924e-03 1 182854030 182854040 11 + 2.606 2.459 -0.491
ENSG00000135829 E014 778.0584415 2.026333e-03 5.148261e-12 1.124291e-10 1 182854041 182854178 138 + 2.903 2.733 -0.568
ENSG00000135829 E015 55.2429028 8.247708e-03 2.563526e-07 2.405529e-06 1 182855577 182855713 137 + 1.801 1.427 -1.272
ENSG00000135829 E016 524.5257832 1.240788e-04 4.602853e-23 4.107380e-21 1 182856532 182856578 47 + 2.732 2.568 -0.543
ENSG00000135829 E017 761.2217123 1.884435e-03 6.476616e-11 1.178538e-09 1 182858104 182858240 137 + 2.891 2.734 -0.521
ENSG00000135829 E018 662.0759343 1.385682e-03 1.966934e-15 7.152202e-14 1 182858551 182858640 90 + 2.835 2.656 -0.598
ENSG00000135829 E019 751.1305022 2.841265e-03 4.473071e-10 7.071177e-09 1 182858733 182858829 97 + 2.889 2.714 -0.584
ENSG00000135829 E020 700.7076534 3.079673e-03 1.741321e-10 2.948852e-09 1 182858830 182858894 65 + 2.862 2.674 -0.625
ENSG00000135829 E021 636.9177210 1.760225e-03 2.903220e-11 5.604874e-10 1 182859040 182859117 78 + 2.814 2.654 -0.534
ENSG00000135829 E022 996.1536712 1.300347e-03 1.413243e-10 2.431299e-09 1 182859993 182860184 192 + 3.000 2.875 -0.416
ENSG00000135829 E023 0.8952612 1.460907e-02 5.311249e-01 6.636241e-01 1 182860185 182860305 121 + 0.298 0.187 -0.879
ENSG00000135829 E024 780.8126490 8.151896e-04 6.700999e-06 4.635015e-05 1 182866444 182866581 138 + 2.881 2.807 -0.246
ENSG00000135829 E025 312.3407582 2.186045e-04 5.122970e-01 6.471978e-01 1 182866582 182866585 4 + 2.461 2.466 0.016
ENSG00000135829 E026 508.0516514 2.547427e-04 1.322604e-01 2.372627e-01 1 182866961 182867043 83 + 2.677 2.668 -0.029
ENSG00000135829 E027 800.0801806 1.326672e-03 1.676346e-01 2.851130e-01 1 182872337 182872493 157 + 2.875 2.860 -0.052
ENSG00000135829 E028 876.9091739 1.084321e-03 6.314195e-02 1.319427e-01 1 182874854 182874954 101 + 2.917 2.895 -0.073
ENSG00000135829 E029 783.1374891 2.731805e-03 6.663805e-01 7.738277e-01 1 182876050 182876128 79 + 2.861 2.861 0.003
ENSG00000135829 E030 946.0719365 1.889376e-03 7.472521e-01 8.348007e-01 1 182876129 182876263 135 + 2.941 2.947 0.019
ENSG00000135829 E031 789.2338504 8.131920e-05 3.776770e-01 5.219875e-01 1 182876447 182876541 95 + 2.863 2.871 0.026
ENSG00000135829 E032 3.2590859 5.503454e-03 1.462030e-01 2.565246e-01 1 182876542 182876749 208 + 0.658 0.417 -1.140
ENSG00000135829 E033 642.2416909 1.101749e-04 6.663668e-01 7.738166e-01 1 182876830 182876903 74 + 2.771 2.785 0.044
ENSG00000135829 E034 4.3022510 2.417880e-02 7.956789e-03 2.366723e-02 1 182876914 182877047 134 + 0.801 0.317 -2.310
ENSG00000135829 E035 10.8415143 1.567180e-03 8.040367e-04 3.273285e-03 1 182877418 182878020 603 + 1.128 0.724 -1.532
ENSG00000135829 E036 1047.1973916 7.967073e-05 3.841318e-01 5.283026e-01 1 182878021 182878173 153 + 2.985 2.994 0.031
ENSG00000135829 E037 1157.0119458 4.131645e-04 2.428882e-01 3.775761e-01 1 182879250 182879410 161 + 3.020 3.055 0.116
ENSG00000135829 E038 490.4540481 1.216042e-03 1.942301e-01 3.190623e-01 1 182880497 182880498 2 + 2.643 2.692 0.164
ENSG00000135829 E039 893.4350784 4.421633e-04 8.551303e-03 2.516856e-02 1 182880499 182880608 110 + 2.899 2.960 0.202
ENSG00000135829 E040 562.5696280 1.158416e-04 5.241296e-04 2.249805e-03 1 182881264 182881284 21 + 2.693 2.771 0.258
ENSG00000135829 E041 936.3403132 1.804832e-04 5.602155e-11 1.031000e-09 1 182881285 182881425 141 + 2.904 3.013 0.365
ENSG00000135829 E042 913.1166138 1.607951e-03 5.954212e-06 4.167619e-05 1 182881520 182881647 128 + 2.887 3.011 0.412
ENSG00000135829 E043 703.3451277 2.480694e-03 1.881568e-07 1.812004e-06 1 182883139 182883216 78 + 2.757 2.924 0.556
ENSG00000135829 E044 868.8408700 1.544071e-03 2.493847e-16 1.022844e-14 1 182883217 182883319 103 + 2.833 3.038 0.682
ENSG00000135829 E045 766.5346334 8.747415e-04 5.307851e-18 2.685781e-16 1 182883320 182883368 49 + 2.787 2.975 0.626
ENSG00000135829 E046 1100.9387885 2.246692e-03 3.989194e-11 7.523553e-10 1 182883520 182883635 116 + 2.943 3.129 0.618
ENSG00000135829 E047 1624.1395817 5.781686e-03 5.093226e-04 2.194343e-03 1 182884613 182884813 201 + 3.125 3.275 0.497
ENSG00000135829 E048 2408.5183581 6.454356e-03 9.810636e-10 1.457265e-08 1 182887083 182887982 900 + 3.254 3.505 0.836