ENSG00000135801

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258281 ENSG00000135801 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF5L protein_coding protein_coding 31.52157 31.57183 39.07052 2.202909 1.113793 0.307355 23.8209920 26.07264207 26.474330 2.12881894 0.5235680 0.022049 0.7633292 0.824533333 0.67853333 -0.14600000 3.294480e-05 2.342081e-05 FALSE TRUE
ENST00000366675 ENSG00000135801 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF5L protein_coding protein_coding 31.52157 31.57183 39.07052 2.202909 1.113793 0.307355 3.5254235 2.19134561 5.715425 0.09048043 0.1631469 1.378997 0.1081083 0.070500000 0.14650000 0.07600000 2.342081e-05 2.342081e-05 FALSE TRUE
MSTRG.3235.8 ENSG00000135801 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF5L protein_coding   31.52157 31.57183 39.07052 2.202909 1.113793 0.307355 0.5628201 0.04915898 2.233666 0.04915898 0.8667561 5.245117 0.0156375 0.001566667 0.05663333 0.05506667 4.794675e-03 2.342081e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135801 E001 17.4422540 0.0033739298 4.866338e-03 1.555814e-02 1 229593121 229593189 69 - 1.120 1.370 0.880
ENSG00000135801 E002 318.1279191 0.0077369813 1.606524e-08 1.906007e-07 1 229593190 229593412 223 - 2.342 2.607 0.884
ENSG00000135801 E003 202.8913760 0.0077337022 8.546584e-09 1.066969e-07 1 229593413 229593446 34 - 2.130 2.420 0.967
ENSG00000135801 E004 382.5035579 0.0052739715 3.388076e-12 7.625767e-11 1 229593447 229593817 371 - 2.418 2.689 0.903
ENSG00000135801 E005 279.1641295 0.0013296437 6.612203e-13 1.671999e-11 1 229593818 229594058 241 - 2.331 2.532 0.668
ENSG00000135801 E006 1156.4574083 0.0003842834 3.324087e-04 1.510055e-03 1 229594059 229595094 1036 - 3.039 3.086 0.156
ENSG00000135801 E007 137.7732231 0.0011718735 9.986892e-04 3.953500e-03 1 229599194 229600350 1157 - 2.194 2.090 -0.351
ENSG00000135801 E008 31.6438323 0.0394737837 2.214167e-01 3.521229e-01 1 229600351 229600468 118 - 1.574 1.440 -0.461
ENSG00000135801 E009 179.8149037 0.0121229522 8.988225e-14 2.571029e-12 1 229600469 229602194 1726 - 2.440 1.992 -1.499
ENSG00000135801 E010 867.3335154 0.0008699278 9.375452e-18 4.627804e-16 1 229602195 229602919 725 - 3.006 2.874 -0.439
ENSG00000135801 E011 25.1694668 0.0018450191 1.078912e-01 2.024069e-01 1 229606119 229606193 75 - 1.475 1.370 -0.362
ENSG00000135801 E012 5.8367618 0.0043674346 2.053744e-01 3.328904e-01 1 229606418 229606420 3 - 0.906 0.750 -0.608
ENSG00000135801 E013 11.0257492 0.0098381519 1.442655e-02 3.919217e-02 1 229606421 229606544 124 - 1.197 0.935 -0.953
ENSG00000135801 E014 10.9563830 0.0527025995 1.859536e-01 3.086853e-01 1 229606545 229606642 98 - 1.178 0.967 -0.767
ENSG00000135801 E015 16.9777539 0.0017525022 5.445891e-02 1.170595e-01 1 229606643 229606833 191 - 1.326 1.173 -0.540
ENSG00000135801 E016 8.0673158 0.0143067833 2.311070e-01 3.637903e-01 1 229606834 229606876 43 - 1.026 0.882 -0.539
ENSG00000135801 E017 10.6545764 0.0016434682 9.349806e-03 2.715628e-02 1 229607774 229607835 62 - 1.188 0.934 -0.925
ENSG00000135801 E018 253.2284508 0.0096642252 2.558363e-04 1.199570e-03 1 229610106 229610210 105 - 2.497 2.306 -0.637
ENSG00000135801 E019 0.8963053 0.1890911908 4.673870e-01 6.068884e-01 1 229614157 229614340 184 - 0.359 0.217 -0.989
ENSG00000135801 E020 232.4557611 0.0057330862 3.294176e-04 1.498551e-03 1 229614341 229614485 145 - 2.443 2.291 -0.506
ENSG00000135801 E021 9.2666389 0.0019029562 7.671744e-02 1.542401e-01 1 229625598 229625884 287 - 1.098 0.917 -0.667
ENSG00000135801 E022 102.3079874 0.0029909023 9.877320e-04 3.916589e-03 1 229625885 229626107 223 - 2.083 1.945 -0.464