ENSG00000135720

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258198 ENSG00000135720 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC1LI2 protein_coding protein_coding 34.00236 14.49427 54.17545 0.5449753 0.73715 1.901428 23.324469 11.3167988 35.131638 0.31306941 0.9498057 1.633441 0.70271250 0.78206667 0.6482667 -0.13380000 2.228005e-03 9.669307e-06 FALSE TRUE
ENST00000561727 ENSG00000135720 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC1LI2 protein_coding retained_intron 34.00236 14.49427 54.17545 0.5449753 0.73715 1.901428 3.231221 0.7772975 6.022623 0.35782379 0.6313344 2.937805 0.08600417 0.05216667 0.1111333 0.05896667 2.081188e-01 9.669307e-06 FALSE FALSE
ENST00000567499 ENSG00000135720 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC1LI2 protein_coding retained_intron 34.00236 14.49427 54.17545 0.5449753 0.73715 1.901428 3.897932 0.7692383 7.214711 0.02365744 0.4679793 3.212803 0.10944167 0.05333333 0.1334333 0.08010000 1.017336e-05 9.669307e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135720 E001 1631.6737782 0.0064511413 8.173866e-12 1.726111e-10 16 66720893 66723477 2585 - 3.055 3.331 0.917
ENSG00000135720 E002 173.8236898 0.0023289137 2.645506e-01 4.025113e-01 16 66723478 66723569 92 - 2.154 2.198 0.145
ENSG00000135720 E003 82.6568809 0.0009054298 1.094407e-01 2.047402e-01 16 66723570 66723584 15 - 1.845 1.855 0.036
ENSG00000135720 E004 78.4977582 0.0003156135 2.618391e-01 3.995605e-01 16 66723585 66723600 16 - 1.789 1.926 0.463
ENSG00000135720 E005 67.5408727 0.0003536676 9.356007e-02 1.806889e-01 16 66723601 66723605 5 - 1.716 1.883 0.564
ENSG00000135720 E006 211.1961229 0.0003491425 6.772861e-01 7.820432e-01 16 66723606 66723822 217 - 2.225 2.324 0.332
ENSG00000135720 E007 8.5606343 0.0040038933 1.201146e-01 2.201558e-01 16 66724662 66724748 87 - 0.827 1.092 0.990
ENSG00000135720 E008 70.5343467 0.0102048336 4.772531e-01 6.158374e-01 16 66725828 66725848 21 - 1.745 1.883 0.465
ENSG00000135720 E009 145.5115990 0.0013187469 4.315083e-01 5.740606e-01 16 66725849 66725944 96 - 2.076 2.134 0.194
ENSG00000135720 E010 163.9758821 0.0002660854 5.535159e-02 1.185953e-01 16 66727688 66727805 118 - 2.133 2.158 0.081
ENSG00000135720 E011 2.8462696 0.0053836787 8.718944e-01 9.216172e-01 16 66727997 66728200 204 - 0.529 0.564 0.163
ENSG00000135720 E012 114.2954267 0.0002782373 5.681655e-03 1.777101e-02 16 66728201 66728242 42 - 1.989 1.966 -0.079
ENSG00000135720 E013 130.4545823 0.0002588961 1.028165e-02 2.946076e-02 16 66729040 66729099 60 - 2.041 2.032 -0.029
ENSG00000135720 E014 186.4862987 0.0002875055 6.914405e-02 1.419576e-01 16 66730112 66730223 112 - 2.185 2.216 0.103
ENSG00000135720 E015 111.4189405 0.0024465333 7.512759e-03 2.254685e-02 16 66730224 66730914 691 - 1.981 1.943 -0.130
ENSG00000135720 E016 172.6976161 0.0048724880 3.620037e-06 2.661357e-05 16 66730915 66732008 1094 - 2.188 2.049 -0.465
ENSG00000135720 E017 56.2930425 0.0024853071 1.961696e-08 2.291653e-07 16 66732009 66732338 330 - 1.731 1.432 -1.023
ENSG00000135720 E018 143.8568594 0.0067793859 4.643756e-02 1.028233e-01 16 66732339 66732447 109 - 2.085 2.064 -0.070
ENSG00000135720 E019 101.4006003 0.0002909110 7.470378e-02 1.510621e-01 16 66732448 66732474 27 - 1.928 1.940 0.041
ENSG00000135720 E020 79.6556175 0.0003079784 1.360375e-08 1.635583e-07 16 66732475 66733546 1072 - 1.868 1.660 -0.702
ENSG00000135720 E021 24.3826487 0.0082255804 4.351130e-03 1.412576e-02 16 66733973 66734217 245 - 1.363 1.158 -0.721
ENSG00000135720 E022 173.2269694 0.0002082009 5.899667e-03 1.834508e-02 16 66734218 66734311 94 - 2.161 2.160 -0.006
ENSG00000135720 E023 127.2599694 0.0002509623 6.745360e-03 2.056202e-02 16 66736075 66736101 27 - 2.032 2.016 -0.052
ENSG00000135720 E024 150.1767706 0.0002863620 4.202131e-04 1.851911e-03 16 66736102 66736167 66 - 2.107 2.069 -0.128
ENSG00000135720 E025 143.0005978 0.0010216420 9.276650e-03 2.697643e-02 16 66736168 66736244 77 - 2.080 2.067 -0.045
ENSG00000135720 E026 85.2630682 0.0003500663 1.447275e-02 3.929853e-02 16 66742438 66742450 13 - 1.862 1.835 -0.091
ENSG00000135720 E027 160.0051710 0.0002495570 7.683931e-05 4.131279e-04 16 66742451 66742554 104 - 2.137 2.088 -0.164
ENSG00000135720 E028 165.9170612 0.0002189860 8.173905e-06 5.540207e-05 16 66742555 66742668 114 - 2.157 2.093 -0.214
ENSG00000135720 E029 158.0279547 0.0002383774 1.081939e-07 1.092009e-06 16 66749197 66749313 117 - 2.143 2.043 -0.337
ENSG00000135720 E030 91.9105123 0.0003606897 7.876140e-06 5.358247e-05 16 66751273 66751303 31 - 1.913 1.790 -0.413
ENSG00000135720 E031 86.5579789 0.0011224489 1.600558e-06 1.271473e-05 16 66751304 66751346 43 - 1.894 1.736 -0.534
ENSG00000135720 E032 0.4545463 0.6470913890 8.595012e-01 9.133689e-01 16 66751347 66751386 40 - 0.171 0.000 -10.916
ENSG00000135720 E033 73.2186273 0.0044274322 1.637085e-04 8.079950e-04 16 66751485 66751609 125 - 1.821 1.673 -0.501