ENSG00000135698

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258169 ENSG00000135698 HEK293_OSMI2_2hA HEK293_TMG_2hB MPHOSPH6 protein_coding protein_coding 52.30561 46.15957 68.08943 2.411396 3.777933 0.5607004 30.96832 32.981481 34.53184 3.185337 1.979488 0.06625159 0.6175042 0.7121667 0.5070667 -0.2051000 0.008571154 0.001542296 FALSE TRUE
MSTRG.13122.1 ENSG00000135698 HEK293_OSMI2_2hA HEK293_TMG_2hB MPHOSPH6 protein_coding   52.30561 46.15957 68.08943 2.411396 3.777933 0.5607004 17.60509 9.038743 28.75324 1.916633 1.693767 1.66843681 0.3065458 0.1988000 0.4222333 0.2234333 0.015321092 0.001542296 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135698 E001 0.9588482 0.0128853919 5.317224e-01 6.641288e-01 16 82132912 82132941 30 - 0.342 0.233 -0.755
ENSG00000135698 E002 0.8115992 0.0148879984 7.883009e-01 8.644534e-01 16 82147798 82147857 60 - 0.278 0.233 -0.341
ENSG00000135698 E003 337.9018338 0.0019924730 3.250704e-06 2.413695e-05 16 82148162 82148615 454 - 2.459 2.591 0.440
ENSG00000135698 E004 158.2524922 0.0002482713 3.299141e-03 1.114680e-02 16 82148616 82148658 43 - 2.157 2.244 0.291
ENSG00000135698 E005 545.2471795 0.0001743517 2.849621e-01 4.252546e-01 16 82148659 82148863 205 - 2.727 2.747 0.067
ENSG00000135698 E006 398.8811477 0.0001654065 4.504863e-02 1.002859e-01 16 82149309 82149381 73 - 2.616 2.587 -0.099
ENSG00000135698 E007 241.6789551 0.0001917910 2.586971e-01 3.960099e-01 16 82149382 82149403 22 - 2.394 2.373 -0.069
ENSG00000135698 E008 5.9304518 0.0027524434 5.072537e-01 6.428369e-01 16 82151084 82151166 83 - 0.880 0.800 -0.308
ENSG00000135698 E009 5.7518653 0.0028308876 5.310522e-01 6.635596e-01 16 82151167 82151237 71 - 0.784 0.868 0.327
ENSG00000135698 E010 9.4522021 0.0210495298 9.060490e-01 9.442638e-01 16 82151238 82151352 115 - 1.023 1.010 -0.050
ENSG00000135698 E011 3.2428730 0.0213122975 9.217697e-01 9.546345e-01 16 82151353 82151423 71 - 0.632 0.655 0.098
ENSG00000135698 E012 353.1528307 0.0001526095 1.971772e-03 7.138280e-03 16 82151424 82151514 91 - 2.574 2.523 -0.173
ENSG00000135698 E013 1.8206993 0.0889568695 1.211959e-02 3.382220e-02 16 82162212 82162313 102 - 0.633 0.132 -3.216
ENSG00000135698 E014 8.9509490 0.0061962894 2.352162e-04 1.113552e-03 16 82163876 82164074 199 - 0.715 1.150 1.650
ENSG00000135698 E015 8.4253416 0.0021020194 1.220611e-04 6.232578e-04 16 82164075 82164081 7 - 0.689 1.138 1.714
ENSG00000135698 E016 225.3580619 0.0001753136 9.240669e-01 9.561679e-01 16 82164082 82164114 33 - 2.351 2.358 0.023
ENSG00000135698 E017 288.0703119 0.0002203194 6.628717e-03 2.025959e-02 16 82164115 82164194 80 - 2.485 2.433 -0.171
ENSG00000135698 E018 2.1550770 0.1308060175 1.470652e-01 2.576959e-01 16 82164652 82164741 90 - 0.633 0.314 -1.641
ENSG00000135698 E019 1.3661650 0.0097520262 4.427566e-01 5.843322e-01 16 82164742 82164940 199 - 0.446 0.314 -0.757
ENSG00000135698 E020 0.8846375 0.7672381688 9.623074e-01 9.802149e-01 16 82167540 82167597 58 - 0.278 0.247 -0.227
ENSG00000135698 E021 3.1471078 0.0050202022 3.211951e-01 4.644322e-01 16 82170093 82170124 32 - 0.689 0.541 -0.650
ENSG00000135698 E022 189.8871441 0.0023506054 4.515669e-02 1.004808e-01 16 82170125 82170224 100 - 2.311 2.248 -0.211