ENSG00000135597

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258062 ENSG00000135597 HEK293_OSMI2_2hA HEK293_TMG_2hB REPS1 protein_coding protein_coding 33.74333 37.61404 34.02271 3.418716 0.5933358 -0.1447327 11.227135 10.304234 12.473884 0.9852122 0.54731876 0.275430198 0.3331958 0.2759000 0.36703333 0.09113333 1.179270e-01 4.756555e-13 FALSE TRUE
ENST00000367663 ENSG00000135597 HEK293_OSMI2_2hA HEK293_TMG_2hB REPS1 protein_coding protein_coding 33.74333 37.61404 34.02271 3.418716 0.5933358 -0.1447327 6.969094 7.032156 7.079256 0.4520754 0.05255238 0.009617066 0.2074042 0.1879333 0.20816667 0.02023333 5.212963e-01 4.756555e-13 FALSE TRUE
ENST00000478483 ENSG00000135597 HEK293_OSMI2_2hA HEK293_TMG_2hB REPS1 protein_coding protein_coding 33.74333 37.61404 34.02271 3.418716 0.5933358 -0.1447327 5.224172 11.160297 2.728536 1.7702106 0.16409438 -2.028190969 0.1475875 0.2948667 0.08013333 -0.21473333 4.756555e-13 4.756555e-13 FALSE FALSE
MSTRG.29044.11 ENSG00000135597 HEK293_OSMI2_2hA HEK293_TMG_2hB REPS1 protein_coding   33.74333 37.61404 34.02271 3.418716 0.5933358 -0.1447327 5.500350 6.299552 6.532469 0.8515575 0.34106766 0.052297771 0.1615458 0.1682000 0.19176667 0.02356667 6.890457e-01 4.756555e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135597 E001 1.9563190 0.0072065659 9.337468e-02 1.803915e-01 6 138903493 138904016 524 - 0.618 0.344 -1.381
ENSG00000135597 E002 17.8727095 0.0040048372 5.837893e-01 7.078262e-01 6 138904017 138904859 843 - 1.299 1.261 -0.134
ENSG00000135597 E003 5.3275462 0.0043138497 1.943838e-01 3.192661e-01 6 138904860 138904860 1 - 0.686 0.867 0.724
ENSG00000135597 E004 9.8948476 0.0020547987 2.279181e-02 5.731216e-02 6 138904861 138904865 5 - 0.863 1.118 0.944
ENSG00000135597 E005 9.8948476 0.0020547987 2.279181e-02 5.731216e-02 6 138904866 138904866 1 - 0.863 1.118 0.944
ENSG00000135597 E006 10.0463630 0.0019479462 3.456864e-02 8.084096e-02 6 138904867 138904869 3 - 0.884 1.118 0.866
ENSG00000135597 E007 12.8549761 0.0016872798 4.160955e-02 9.401864e-02 6 138904870 138904870 1 - 1.004 1.208 0.735
ENSG00000135597 E008 26.5190572 0.0072719325 2.850328e-03 9.824717e-03 6 138904871 138904890 20 - 1.275 1.520 0.846
ENSG00000135597 E009 33.2315815 0.0006517647 3.348990e-04 1.520020e-03 6 138904891 138904891 1 - 1.382 1.615 0.801
ENSG00000135597 E010 312.9952304 0.0010154884 1.597453e-15 5.884359e-14 6 138904892 138905132 241 - 2.361 2.570 0.697
ENSG00000135597 E011 0.3268771 0.0300034169 9.089656e-01   6 138907372 138907494 123 - 0.130 0.115 -0.208
ENSG00000135597 E012 242.1146620 0.0033699417 3.874298e-07 3.501618e-06 6 138907495 138907534 40 - 2.262 2.454 0.641
ENSG00000135597 E013 289.7278985 0.0035463206 1.575708e-05 1.000581e-04 6 138907535 138907600 66 - 2.360 2.521 0.536
ENSG00000135597 E014 427.4568967 0.0022788746 6.364455e-06 4.425985e-05 6 138908668 138908794 127 - 2.546 2.680 0.446
ENSG00000135597 E015 221.4661689 0.0030092462 1.778795e-02 4.668127e-02 6 138908795 138908816 22 - 2.289 2.384 0.316
ENSG00000135597 E016 1.1909051 0.0107142101 8.891808e-04 3.576109e-03 6 138908817 138908912 96 - 0.580 0.000 -13.405
ENSG00000135597 E017 2.4432178 0.0166119266 4.002287e-02 9.107873e-02 6 138910923 138911245 323 - 0.686 0.345 -1.665
ENSG00000135597 E018 0.5954526 0.0183638068 2.581294e-02 6.355509e-02 6 138911246 138911275 30 - 0.380 0.000 -12.405
ENSG00000135597 E019 316.3934977 0.0011248233 1.505368e-07 1.477349e-06 6 138911276 138911371 96 - 2.412 2.555 0.474
ENSG00000135597 E020 1.3432612 0.4508710454 8.089127e-01 8.786540e-01 6 138912675 138912764 90 - 0.382 0.381 -0.005
ENSG00000135597 E021 302.5139142 0.0016939698 5.664665e-05 3.148648e-04 6 138912765 138912865 101 - 2.405 2.525 0.399
ENSG00000135597 E022 254.7349949 0.0013321959 2.099987e-02 5.359001e-02 6 138912866 138912950 85 - 2.363 2.436 0.243
ENSG00000135597 E023 236.4624526 0.0002279661 2.510468e-02 6.209128e-02 6 138914697 138914761 65 - 2.336 2.397 0.204
ENSG00000135597 E024 3.5613205 0.2667875906 1.911228e-01 3.151452e-01 6 138914762 138915187 426 - 0.817 0.515 -1.290
ENSG00000135597 E025 293.8777015 0.0001486541 5.776953e-01 7.029206e-01 6 138915858 138915976 119 - 2.457 2.476 0.066
ENSG00000135597 E026 4.2241777 0.0038859940 1.517859e-05 9.675433e-05 6 138915977 138916214 238 - 0.973 0.344 -2.795
ENSG00000135597 E027 223.8224049 0.0001974110 3.945427e-02 9.002247e-02 6 138917555 138917624 70 - 2.316 2.374 0.193
ENSG00000135597 E028 103.2308646 0.0004321605 8.411713e-01 9.009146e-01 6 138917625 138917627 3 - 2.008 2.023 0.050
ENSG00000135597 E029 3.5858613 0.0045193759 7.319092e-03 2.204735e-02 6 138917628 138917646 19 - 0.842 0.450 -1.712
ENSG00000135597 E030 256.4955822 0.0028976398 1.131300e-01 2.100944e-01 6 138920215 138920301 87 - 2.435 2.384 -0.171
ENSG00000135597 E031 173.5082298 0.0010993821 1.362417e-01 2.428066e-01 6 138920302 138920316 15 - 2.261 2.220 -0.135
ENSG00000135597 E032 185.1139267 0.0002370176 2.396781e-01 3.737329e-01 6 138921037 138921063 27 - 2.280 2.257 -0.078
ENSG00000135597 E033 229.9710647 0.0001756973 1.397994e-01 2.477487e-01 6 138921064 138921124 61 - 2.376 2.350 -0.089
ENSG00000135597 E034 193.8160846 0.0002043391 8.297614e-04 3.365573e-03 6 138926401 138926478 78 - 2.331 2.254 -0.258
ENSG00000135597 E035 91.5663277 0.0003251468 6.765806e-03 2.061406e-02 6 138926479 138926481 3 - 2.018 1.927 -0.306
ENSG00000135597 E036 8.8786345 0.0021364841 3.842605e-09 5.111525e-08 6 138926482 138929976 3495 - 1.250 0.571 -2.623
ENSG00000135597 E037 271.2987070 0.0001649018 1.360466e-03 5.177940e-03 6 138929977 138930098 122 - 2.468 2.407 -0.203
ENSG00000135597 E038 1.2178718 0.0103750478 9.819958e-02 1.877853e-01 6 138934225 138934288 64 - 0.491 0.206 -1.795
ENSG00000135597 E039 0.2966881 0.0271693462 1.632799e-01   6 138934289 138934326 38 - 0.230 0.000 -11.405
ENSG00000135597 E040 272.0836796 0.0003073072 7.075340e-03 2.142209e-02 6 138941335 138941489 155 - 2.463 2.410 -0.177
ENSG00000135597 E041 155.1195284 0.0025839982 5.553755e-01 6.842490e-01 6 138943513 138943576 64 - 2.200 2.182 -0.059
ENSG00000135597 E042 260.7376210 0.0011348440 1.047919e-02 2.992812e-02 6 138943853 138944015 163 - 2.450 2.386 -0.212
ENSG00000135597 E043 159.6494436 0.0002167887 1.054531e-06 8.709084e-06 6 138944498 138944560 63 - 2.273 2.144 -0.431
ENSG00000135597 E044 158.8835017 0.0002739914 5.743941e-07 5.023880e-06 6 138944561 138944622 62 - 2.275 2.141 -0.447
ENSG00000135597 E045 238.4831344 0.0002062961 2.418777e-14 7.513201e-13 6 138945219 138945372 154 - 2.467 2.298 -0.563
ENSG00000135597 E046 245.3789975 0.0004298454 2.979817e-14 9.141983e-13 6 138945501 138945697 197 - 2.482 2.307 -0.584
ENSG00000135597 E047 121.5915696 0.0055021160 1.407959e-03 5.333154e-03 6 138947790 138947881 92 - 2.166 2.017 -0.497
ENSG00000135597 E048 78.4861816 0.0055759787 1.460702e-03 5.509508e-03 6 138947882 138947913 32 - 1.984 1.818 -0.561
ENSG00000135597 E049 1.5908456 0.2087019350 2.295791e-01 3.619355e-01 6 138951042 138951160 119 - 0.539 0.282 -1.427
ENSG00000135597 E050 203.7830863 0.0119069634 8.162588e-07 6.908407e-06 6 138987530 138988261 732 - 2.448 2.164 -0.950