ENSG00000135541

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327035 ENSG00000135541 HEK293_OSMI2_2hA HEK293_TMG_2hB AHI1 protein_coding protein_coding 4.544905 1.081253 6.912131 0.201805 0.4690249 2.66523 0.26616946 0.08697478 0.4878023 0.052983771 0.11458698 2.3598914 0.06562500 0.08293333 0.073066667 -0.009866667 1.0000000000 2.96666e-05 FALSE TRUE
ENST00000457866 ENSG00000135541 HEK293_OSMI2_2hA HEK293_TMG_2hB AHI1 protein_coding protein_coding 4.544905 1.081253 6.912131 0.201805 0.4690249 2.66523 0.03913707 0.06474426 0.0000000 0.064744264 0.00000000 -2.9019629 0.01346667 0.07796667 0.000000000 -0.077966667 0.4564077394 2.96666e-05 FALSE TRUE
ENST00000528103 ENSG00000135541 HEK293_OSMI2_2hA HEK293_TMG_2hB AHI1 protein_coding retained_intron 4.544905 1.081253 6.912131 0.201805 0.4690249 2.66523 0.02912017 0.04961031 0.0000000 0.030884319 0.00000000 -2.5755618 0.01262083 0.05503333 0.000000000 -0.055033333 0.0278835476 2.96666e-05   FALSE
ENST00000679450 ENSG00000135541 HEK293_OSMI2_2hA HEK293_TMG_2hB AHI1 protein_coding protein_coding 4.544905 1.081253 6.912131 0.201805 0.4690249 2.66523 0.81257653 0.00000000 1.4175151 0.000000000 0.32395741 7.1573622 0.11776250 0.00000000 0.200566667 0.200566667 0.0000296666 2.96666e-05 FALSE TRUE
ENST00000679668 ENSG00000135541 HEK293_OSMI2_2hA HEK293_TMG_2hB AHI1 protein_coding nonsense_mediated_decay 4.544905 1.081253 6.912131 0.201805 0.4690249 2.66523 0.03167715 0.07296989 0.0433751 0.036874971 0.04337510 -0.6364211 0.02496250 0.08263333 0.007133333 -0.075500000 0.2299624549 2.96666e-05 TRUE TRUE
ENST00000679742 ENSG00000135541 HEK293_OSMI2_2hA HEK293_TMG_2hB AHI1 protein_coding nonsense_mediated_decay 4.544905 1.081253 6.912131 0.201805 0.4690249 2.66523 0.27304830 0.16934567 0.4230878 0.006799428 0.06775554 1.2719166 0.08070833 0.16596667 0.061266667 -0.104700000 0.0532078939 2.96666e-05 TRUE TRUE
ENST00000679943 ENSG00000135541 HEK293_OSMI2_2hA HEK293_TMG_2hB AHI1 protein_coding nonsense_mediated_decay 4.544905 1.081253 6.912131 0.201805 0.4690249 2.66523 0.85123327 0.04829171 1.5259685 0.048291709 0.23904247 4.7197142 0.16377500 0.03263333 0.225466667 0.192833333 0.0305141855 2.96666e-05 TRUE TRUE
ENST00000681301 ENSG00000135541 HEK293_OSMI2_2hA HEK293_TMG_2hB AHI1 protein_coding protein_coding 4.544905 1.081253 6.912131 0.201805 0.4690249 2.66523 0.62489188 0.17036729 0.9884822 0.170367286 0.21840547 2.4687990 0.10060417 0.11506667 0.141333333 0.026266667 0.6355002619 2.96666e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135541 E001 0.0000000       6 135283407 135283457 51 -      
ENSG00000135541 E002 0.2903454 0.3317743084 1.000000e+00   6 135283458 135283531 74 - 0.113 0.000 -9.302
ENSG00000135541 E003 0.2903454 0.3317743084 1.000000e+00   6 135283532 135283544 13 - 0.113 0.000 -11.731
ENSG00000135541 E004 0.4355181 0.6052274616 1.000000e+00 1.000000e+00 6 135283545 135283631 87 - 0.160 0.000 -12.033
ENSG00000135541 E005 0.2903454 0.3317743084 1.000000e+00   6 135283632 135283762 131 - 0.113 0.000 -11.731
ENSG00000135541 E006 0.5181333 0.0200990336 4.817776e-01 6.199698e-01 6 135283763 135283985 223 - 0.113 0.233 1.253
ENSG00000135541 E007 0.0000000       6 135283986 135283991 6 -      
ENSG00000135541 E008 0.0000000       6 135283992 135283999 8 -      
ENSG00000135541 E009 0.0000000       6 135284000 135284005 6 -      
ENSG00000135541 E010 0.1515154 0.0427326196 1.000000e+00   6 135284006 135284024 19 - 0.060 0.000 -11.291
ENSG00000135541 E011 15.7312574 0.0012874464 2.110238e-07 2.013997e-06 6 135284025 135284418 394 - 0.991 1.458 1.654
ENSG00000135541 E012 7.7543446 0.0022745667 1.083535e-03 4.247924e-03 6 135284419 135284558 140 - 0.738 1.139 1.514
ENSG00000135541 E013 9.0693201 0.0026305644 1.803755e-01 3.016453e-01 6 135284559 135284895 337 - 0.870 1.039 0.634
ENSG00000135541 E014 8.3600192 0.0108239562 5.527496e-01 6.819851e-01 6 135284896 135285104 209 - 0.861 0.946 0.324
ENSG00000135541 E015 6.5743589 0.0024415944 5.822090e-01 7.066093e-01 6 135285105 135285294 190 - 0.804 0.721 -0.333
ENSG00000135541 E016 2.8797826 0.0051029678 4.020097e-01 5.457136e-01 6 135285295 135285326 32 - 0.548 0.384 -0.836
ENSG00000135541 E017 3.9471832 0.0040380638 8.116092e-01 8.804339e-01 6 135285327 135285380 54 - 0.616 0.658 0.180
ENSG00000135541 E018 17.1830672 0.0011849681 6.081506e-02 1.280080e-01 6 135285381 135285642 262 - 1.126 1.305 0.631
ENSG00000135541 E019 7.1495462 0.0024141970 1.262662e-01 2.289579e-01 6 135285643 135285644 2 - 0.772 0.979 0.792
ENSG00000135541 E020 7.2967952 0.0024001401 1.462401e-01 2.565655e-01 6 135285645 135285647 3 - 0.783 0.979 0.749
ENSG00000135541 E021 0.7352129 0.1484392282 8.758638e-01 9.242676e-01 6 135286399 135286548 150 - 0.203 0.231 0.241
ENSG00000135541 E022 12.5843200 0.0013981772 9.053364e-02 1.759688e-01 6 135290423 135290525 103 - 0.998 1.182 0.667
ENSG00000135541 E023 0.1817044 0.0421431362 8.498786e-02   6 135290526 135290733 208 - 0.000 0.233 13.589
ENSG00000135541 E024 0.1472490 0.0437875087 1.000000e+00   6 135290734 135290754 21 - 0.060 0.000 -11.288
ENSG00000135541 E025 1.8466338 0.0079065327 1.880955e-01 3.113320e-01 6 135290755 135293385 2631 - 0.341 0.584 1.250
ENSG00000135541 E026 1.3275425 0.0097950679 1.828907e-01 3.048157e-01 6 135297432 135297492 61 - 0.242 0.496 1.515
ENSG00000135541 E027 12.2112656 0.0014681499 1.748935e-04 8.564168e-04 6 135300500 135300558 59 - 0.920 1.305 1.392
ENSG00000135541 E028 3.8330150 0.0707283469 6.823807e-02 1.404430e-01 6 135300559 135301407 849 - 0.529 0.863 1.401
ENSG00000135541 E029 4.5705277 0.0036274204 9.868583e-05 5.157160e-04 6 135301408 135301504 97 - 0.490 1.039 2.251
ENSG00000135541 E030 2.5400271 0.0064555684 3.281516e-03 1.109596e-02 6 135301505 135301539 35 - 0.341 0.824 2.250
ENSG00000135541 E031 13.3239983 0.0158219907 1.808757e-03 6.627026e-03 6 135301540 135302372 833 - 0.971 1.320 1.249
ENSG00000135541 E032 5.8547761 0.0183186247 3.517450e-01 4.959736e-01 6 135302373 135302669 297 - 0.727 0.868 0.559
ENSG00000135541 E033 2.2550715 0.0071260178 6.670715e-01 7.744069e-01 6 135302670 135302711 42 - 0.468 0.384 -0.450
ENSG00000135541 E034 4.1072023 0.0127649248 2.066047e-01 3.344753e-01 6 135302712 135302817 106 - 0.567 0.777 0.894
ENSG00000135541 E035 0.5159433 0.2444589284 5.065460e-01 6.422028e-01 6 135302818 135302841 24 - 0.113 0.236 1.276
ENSG00000135541 E036 6.5778713 0.0715619308 9.738214e-01 9.876803e-01 6 135302842 135304967 2126 - 0.795 0.780 -0.059
ENSG00000135541 E037 0.0000000       6 135309924 135309956 33 -      
ENSG00000135541 E038 0.0000000       6 135309957 135309990 34 -      
ENSG00000135541 E039 0.0000000       6 135309991 135310038 48 -      
ENSG00000135541 E040 7.5726599 0.0028360803 6.432816e-01 7.558797e-01 6 135310039 135311298 1260 - 0.843 0.908 0.250
ENSG00000135541 E041 1.2618922 0.1620375380 6.128021e-01 7.316664e-01 6 135311989 135312778 790 - 0.278 0.385 0.667
ENSG00000135541 E042 2.5442684 0.0063997526 5.990973e-02 1.264564e-01 6 135315902 135316040 139 - 0.396 0.721 1.514
ENSG00000135541 E043 0.0000000       6 135316605 135316611 7 -      
ENSG00000135541 E044 0.1482932 0.0426376917 8.540000e-02   6 135316612 135316636 25 - 0.000 0.233 13.583
ENSG00000135541 E045 0.5985731 0.0229815531 6.926095e-01 7.938091e-01 6 135316637 135316861 225 - 0.161 0.233 0.664
ENSG00000135541 E046 0.8920269 0.2111341164 3.553924e-01 4.997404e-01 6 135316862 135318433 1572 - 0.278 0.000 -13.301
ENSG00000135541 E047 0.0000000       6 135318434 135318518 85 -      
ENSG00000135541 E048 14.6260461 0.0098061451 2.252223e-01 3.566937e-01 6 135318519 135318616 98 - 1.064 1.204 0.504
ENSG00000135541 E049 17.7059583 0.0132939611 7.870885e-01 8.636685e-01 6 135323162 135323320 159 - 1.164 1.206 0.150
ENSG00000135541 E050 7.3809246 0.0149459718 7.813771e-01 8.595497e-01 6 135323321 135323324 4 - 0.824 0.870 0.176
ENSG00000135541 E051 0.0000000       6 135323325 135323660 336 -      
ENSG00000135541 E052 0.0000000       6 135323661 135325003 1343 -      
ENSG00000135541 E053 0.4396707 0.0323961842 7.470835e-01 8.346867e-01 6 135346675 135346796 122 - 0.161 0.000 -12.740
ENSG00000135541 E054 12.8226564 0.0016543447 9.269342e-01 9.580138e-01 6 135358132 135358187 56 - 1.047 1.039 -0.028
ENSG00000135541 E055 0.0000000       6 135368791 135368868 78 -      
ENSG00000135541 E056 0.0000000       6 135368869 135369033 165 -      
ENSG00000135541 E057 3.7217329 0.2994402919 2.602865e-01 3.977743e-01 6 135387784 135388033 250 - 0.512 0.853 1.447
ENSG00000135541 E058 2.4357437 0.0059238791 4.506963e-01 5.917626e-01 6 135394322 135394775 454 - 0.446 0.584 0.665
ENSG00000135541 E059 24.6170603 0.0089293931 1.906919e-01 3.146180e-01 6 135394776 135394896 121 - 1.290 1.412 0.427
ENSG00000135541 E060 17.2180790 0.0031972936 1.829200e-01 3.048532e-01 6 135404951 135404977 27 - 1.141 1.273 0.469
ENSG00000135541 E061 0.5870335 0.1176550828 5.497292e-01 6.794310e-01 6 135405735 135405856 122 - 0.203 0.000 -12.937
ENSG00000135541 E062 40.6286130 0.0018093649 3.172710e-01 4.601279e-01 6 135411348 135411544 197 - 1.510 1.579 0.238
ENSG00000135541 E063 31.0059363 0.0006411061 1.645572e-01 2.811029e-01 6 135427167 135427307 141 - 1.431 1.320 -0.384
ENSG00000135541 E064 31.8228184 0.0006320180 4.598181e-01 5.999031e-01 6 135428629 135428759 131 - 1.431 1.375 -0.191
ENSG00000135541 E065 27.2892155 0.0007059163 5.150028e-01 6.497226e-01 6 135429882 135430000 119 - 1.346 1.400 0.189
ENSG00000135541 E066 28.6332966 0.0008335377 6.561237e-01 7.658263e-01 6 135431208 135431314 107 - 1.382 1.349 -0.117
ENSG00000135541 E067 35.4149864 0.0025212845 2.676964e-01 4.060351e-01 6 135433027 135433256 230 - 1.485 1.401 -0.290
ENSG00000135541 E068 0.0000000       6 135435157 135435232 76 -      
ENSG00000135541 E069 15.7781474 0.0023781731 4.376169e-01 5.795273e-01 6 135438375 135438498 124 - 1.150 1.067 -0.301
ENSG00000135541 E070 10.2702175 0.0500856735 9.226745e-01 9.552321e-01 6 135442582 135442671 90 - 0.963 0.951 -0.046
ENSG00000135541 E071 8.8532516 0.0094246266 2.993968e-01 4.409020e-01 6 135442672 135442714 43 - 0.927 0.777 -0.580
ENSG00000135541 E072 0.1472490 0.0437875087 1.000000e+00   6 135442715 135442984 270 - 0.060 0.000 -11.288
ENSG00000135541 E073 19.6485580 0.0011648676 8.634535e-03 2.537244e-02 6 135447008 135447124 117 - 1.266 0.979 -1.034
ENSG00000135541 E074 13.9653181 0.0012943883 7.889851e-02 1.577529e-01 6 135447125 135447160 36 - 1.122 0.909 -0.784
ENSG00000135541 E075 28.8004167 0.0007537191 7.307141e-03 2.201765e-02 6 135448290 135448475 186 - 1.421 1.182 -0.836
ENSG00000135541 E076 0.0000000       6 135452469 135453340 872 -      
ENSG00000135541 E077 19.4962368 0.0012113205 7.358009e-02 1.492566e-01 6 135453341 135453436 96 - 1.252 1.066 -0.662
ENSG00000135541 E078 26.6628417 0.0007812822 1.464364e-02 3.969200e-02 6 135455734 135455926 193 - 1.385 1.161 -0.786
ENSG00000135541 E079 0.1515154 0.0427326196 1.000000e+00   6 135455927 135456188 262 - 0.060 0.000 -11.291
ENSG00000135541 E080 0.1451727 0.0431389568 1.000000e+00   6 135456189 135456373 185 - 0.060 0.000 -11.289
ENSG00000135541 E081 0.0000000       6 135456374 135456533 160 -      
ENSG00000135541 E082 29.3671729 0.0007399486 5.495115e-02 1.179093e-01 6 135457494 135457713 220 - 1.418 1.256 -0.565
ENSG00000135541 E083 12.4529351 0.0013954334 4.943739e-02 1.081597e-01 6 135463125 135463136 12 - 1.081 0.825 -0.958
ENSG00000135541 E084 23.7791584 0.0008200861 2.198041e-02 5.563438e-02 6 135463137 135463306 170 - 1.337 1.116 -0.780
ENSG00000135541 E085 0.0000000       6 135463307 135465813 2507 -      
ENSG00000135541 E086 68.6102498 0.0023703723 3.296537e-05 1.941309e-04 6 135465814 135466373 560 - 1.788 1.528 -0.886
ENSG00000135541 E087 16.1457118 0.0303593660 2.522172e-01 3.885457e-01 6 135467581 135467634 54 - 1.164 1.016 -0.536
ENSG00000135541 E088 0.0000000       6 135467751 135467946 196 -      
ENSG00000135541 E089 0.0000000       6 135489917 135489918 2 -      
ENSG00000135541 E090 1.6972954 0.0277721426 1.489596e-01 2.602740e-01 6 135489919 135490225 307 - 0.310 0.583 1.440
ENSG00000135541 E091 0.0000000       6 135490458 135490459 2 -      
ENSG00000135541 E092 0.1817044 0.0421431362 8.498786e-02   6 135490460 135490477 18 - 0.000 0.233 13.589
ENSG00000135541 E093 1.2166362 0.4328815698 9.972496e-03 2.869601e-02 6 135490478 135490622 145 - 0.060 0.750 4.956
ENSG00000135541 E094 27.6821814 0.0077305596 6.657605e-01 7.733874e-01 6 135490623 135490747 125 - 1.372 1.335 -0.130
ENSG00000135541 E095 17.7568601 0.0055184990 2.036649e-01 3.307931e-01 6 135492228 135492291 64 - 1.206 1.067 -0.500
ENSG00000135541 E096 3.0355633 0.1434505660 7.850201e-01 8.621632e-01 6 135492292 135494363 2072 - 0.530 0.580 0.232
ENSG00000135541 E097 1.0373134 0.0117106414 2.132446e-01 3.423664e-01 6 135494364 135495312 949 - 0.311 0.000 -13.767
ENSG00000135541 E098 0.4439371 0.0215815796 7.460707e-01 8.339284e-01 6 135495313 135495538 226 - 0.161 0.000 -12.761
ENSG00000135541 E099 0.5975289 0.0291815605 5.113889e-01 6.464373e-01 6 135495539 135495709 171 - 0.203 0.000 -13.097
ENSG00000135541 E100 0.1472490 0.0437875087 1.000000e+00   6 135495710 135495813 104 - 0.060 0.000 -11.288
ENSG00000135541 E101 6.0481999 0.0034128096 1.879637e-01 3.111519e-01 6 135495814 135495898 85 - 0.804 0.584 -0.919
ENSG00000135541 E102 1.0277339 0.0727131682 3.778982e-01 5.222010e-01 6 135495899 135497187 1289 - 0.203 0.386 1.267
ENSG00000135541 E103 8.4432458 0.0057655126 1.866300e-01 3.095066e-01 6 135497188 135497249 62 - 0.920 0.721 -0.778
ENSG00000135541 E104 0.8513531 0.0155564340 2.385129e-01 3.724146e-01 6 135497250 135497582 333 - 0.161 0.384 1.668
ENSG00000135541 E105 10.6432630 0.0436558239 1.596346e-01 2.746278e-01 6 135497583 135498434 852 - 1.018 0.777 -0.918