ENSG00000135525

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354570 ENSG00000135525 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7 protein_coding protein_coding 4.206477 3.092074 6.348822 0.3300365 0.4446359 1.035527 2.1767857 2.2303013 2.9261747 0.1534257 0.08137935 0.39024507 0.5529083 0.7405000 0.46390000 -0.27660000 2.036098e-01 8.205725e-15 FALSE TRUE
ENST00000544465 ENSG00000135525 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7 protein_coding protein_coding 4.206477 3.092074 6.348822 0.3300365 0.4446359 1.035527 1.0244180 0.0000000 2.1070211 0.0000000 0.14938172 7.72589183 0.2007500 0.0000000 0.33630000 0.33630000 8.205725e-15 8.205725e-15 FALSE TRUE
ENST00000611373 ENSG00000135525 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7 protein_coding protein_coding 4.206477 3.092074 6.348822 0.3300365 0.4446359 1.035527 0.6783022 0.7212954 0.7125245 0.3632275 0.36740294 -0.01740778 0.1639792 0.2140667 0.10606667 -0.10800000 8.767111e-01 8.205725e-15 FALSE TRUE
ENST00000618822 ENSG00000135525 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7 protein_coding protein_coding 4.206477 3.092074 6.348822 0.3300365 0.4446359 1.035527 0.1743499 0.0000000 0.4715337 0.0000000 0.03620772 5.58956500 0.0337750 0.0000000 0.07506667 0.07506667 8.522442e-06 8.205725e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135525 E001 5.2714928 0.0030045323 0.0075580675 0.022666306 6 136342281 136342733 453 - 0.924 0.543 -1.572
ENSG00000135525 E002 69.6095039 0.0004508389 0.0040072229 0.013162203 6 136342734 136343542 809 - 1.794 1.911 0.394
ENSG00000135525 E003 33.7472933 0.0007015850 0.0006144106 0.002586226 6 136343543 136343781 239 - 1.444 1.645 0.687
ENSG00000135525 E004 13.4044678 0.0182423354 0.2744715265 0.413626442 6 136343782 136343818 37 - 1.105 1.231 0.447
ENSG00000135525 E005 10.0446485 0.0018048702 0.1287433325 0.232405600 6 136343819 136343839 21 - 0.974 1.128 0.563
ENSG00000135525 E006 61.7749299 0.0004092029 0.0245610050 0.060974286 6 136343840 136344238 399 - 1.755 1.852 0.327
ENSG00000135525 E007 57.5663676 0.0005623043 0.0017057521 0.006300687 6 136345856 136346079 224 - 1.703 1.844 0.476
ENSG00000135525 E008 40.0165181 0.0005879520 0.0150510969 0.040604140 6 136356692 136356794 103 - 1.550 1.680 0.445
ENSG00000135525 E009 30.3042798 0.0008425439 0.2193081374 0.349539122 6 136359820 136359877 58 - 1.463 1.539 0.259
ENSG00000135525 E010 30.0190811 0.0006410990 0.3640976143 0.508502284 6 136359981 136360031 51 - 1.467 1.523 0.192
ENSG00000135525 E011 33.3239297 0.0006195492 0.1391143632 0.246844072 6 136360697 136360798 102 - 1.496 1.584 0.298
ENSG00000135525 E012 47.9812287 0.0042121902 0.8593458552 0.913258938 6 136361005 136361179 175 - 1.692 1.680 -0.044
ENSG00000135525 E013 55.1632575 0.0008082577 0.3377551350 0.481653446 6 136362450 136362702 253 - 1.767 1.720 -0.159
ENSG00000135525 E014 56.9718946 0.0004646675 0.0060350123 0.018702161 6 136365735 136366018 284 - 1.813 1.684 -0.438
ENSG00000135525 E015 36.9315761 0.0013903145 0.0399611901 0.090962967 6 136366327 136366439 113 - 1.629 1.506 -0.420
ENSG00000135525 E016 31.8408198 0.0006946286 0.0540355718 0.116326826 6 136372501 136372625 125 - 1.562 1.440 -0.418
ENSG00000135525 E017 0.1817044 0.0409163303 0.3007259172   6 136372626 136372649 24 - 0.000 0.151 9.784
ENSG00000135525 E018 29.3853084 0.0006957696 0.0806029024 0.160493337 6 136377755 136377868 114 - 1.527 1.413 -0.392
ENSG00000135525 E019 27.7089580 0.0014891444 0.0025777418 0.008997779 6 136383671 136383781 111 - 1.537 1.329 -0.719
ENSG00000135525 E020 33.9008633 0.0014993921 0.0145714312 0.039525693 6 136388393 136388510 118 - 1.600 1.446 -0.525
ENSG00000135525 E021 0.0000000       6 136388511 136388529 19 -      
ENSG00000135525 E022 43.7460606 0.0005548369 0.0357982947 0.083191810 6 136389354 136389517 164 - 1.692 1.579 -0.385
ENSG00000135525 E023 29.2221012 0.0094284611 0.0703516405 0.143940765 6 136411620 136411697 78 - 1.533 1.385 -0.512
ENSG00000135525 E024 27.5015621 0.0007507293 0.1093439377 0.204599500 6 136421701 136421799 99 - 1.493 1.385 -0.374
ENSG00000135525 E025 0.1451727 0.0425434133 0.7838442567   6 136466761 136466875 115 - 0.099 0.000 -8.655
ENSG00000135525 E026 0.0000000       6 136525832 136525971 140 -      
ENSG00000135525 E027 0.0000000       6 136525972 136526213 242 -      
ENSG00000135525 E028 0.5483223 0.0209045414 0.3181422205 0.461091308 6 136526362 136526592 231 - 0.099 0.263 1.704
ENSG00000135525 E029 0.0000000       6 136526593 136526660 68 -      
ENSG00000135525 E030 20.3632864 0.0009824086 0.8951251604 0.936982144 6 136550342 136550819 478 - 1.320 1.329 0.031