ENSG00000135506

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257966 ENSG00000135506 HEK293_OSMI2_2hA HEK293_TMG_2hB OS9 protein_coding protein_coding 132.9392 147.9099 119.1701 7.754082 2.731955 -0.3116724 43.185359 43.64862 39.75704 2.0157577 0.7733664 -0.1346934 0.32591250 0.29633333 0.3337667 0.037433333 4.370709e-01 9.519871e-65 FALSE TRUE
ENST00000315970 ENSG00000135506 HEK293_OSMI2_2hA HEK293_TMG_2hB OS9 protein_coding protein_coding 132.9392 147.9099 119.1701 7.754082 2.731955 -0.3116724 21.170267 21.94620 24.72371 0.7793411 1.3506838 0.1718498 0.16009167 0.14863333 0.2077000 0.059066667 5.951641e-03 9.519871e-65 FALSE TRUE
ENST00000389142 ENSG00000135506 HEK293_OSMI2_2hA HEK293_TMG_2hB OS9 protein_coding protein_coding 132.9392 147.9099 119.1701 7.754082 2.731955 -0.3116724 32.874060 34.30059 28.30309 2.5397682 0.8421426 -0.2771848 0.24766667 0.23170000 0.2380667 0.006366667 9.327585e-01 9.519871e-65 FALSE TRUE
ENST00000413095 ENSG00000135506 HEK293_OSMI2_2hA HEK293_TMG_2hB OS9 protein_coding protein_coding 132.9392 147.9099 119.1701 7.754082 2.731955 -0.3116724 9.027554 25.56910 0.00000 3.5771621 0.0000000 -11.3207495 0.06312083 0.17166667 0.0000000 -0.171666667 9.519871e-65 9.519871e-65 FALSE TRUE
ENST00000550202 ENSG00000135506 HEK293_OSMI2_2hA HEK293_TMG_2hB OS9 protein_coding retained_intron 132.9392 147.9099 119.1701 7.754082 2.731955 -0.3116724 15.263298 14.06858 16.13982 0.8986597 2.8182389 0.1980160 0.11612500 0.09526667 0.1346667 0.039400000 3.226359e-01 9.519871e-65 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135506 E001 0.9651910 1.219891e-02 2.210019e-01 3.516289e-01 12 57693955 57694022 68 + 0.403 0.192 -1.462
ENSG00000135506 E002 4.6509780 3.382511e-03 8.089961e-01 8.786792e-01 12 57694023 57694113 91 + 0.716 0.757 0.166
ENSG00000135506 E003 8.1603606 1.999292e-03 9.475151e-01 9.709841e-01 12 57694114 57694131 18 + 0.955 0.956 0.003
ENSG00000135506 E004 8.6074183 2.010488e-03 7.862435e-01 8.631001e-01 12 57694132 57694136 5 + 0.991 0.969 -0.080
ENSG00000135506 E005 8.9041064 1.934389e-03 5.627022e-01 6.902636e-01 12 57694137 57694137 1 + 1.023 0.969 -0.200
ENSG00000135506 E006 8.9041064 1.934389e-03 5.627022e-01 6.902636e-01 12 57694138 57694138 1 + 1.023 0.969 -0.200
ENSG00000135506 E007 10.2337397 1.691498e-03 1.790497e-01 2.999448e-01 12 57694139 57694142 4 + 1.121 0.994 -0.463
ENSG00000135506 E008 10.4154441 1.641060e-03 2.181469e-01 3.481834e-01 12 57694143 57694144 2 + 1.121 1.006 -0.419
ENSG00000135506 E009 11.0088203 1.618121e-03 8.032425e-02 1.600697e-01 12 57694145 57694145 1 + 1.169 1.006 -0.588
ENSG00000135506 E010 11.9989017 1.464883e-03 1.171694e-01 2.159028e-01 12 57694146 57694146 1 + 1.191 1.051 -0.501
ENSG00000135506 E011 42.8421903 5.181788e-03 3.313412e-02 7.807218e-02 12 57694147 57694153 7 + 1.708 1.585 -0.417
ENSG00000135506 E012 183.1971822 1.033165e-03 1.109451e-35 2.821238e-33 12 57694154 57694159 6 + 2.446 2.076 -1.234
ENSG00000135506 E013 719.3352529 3.318001e-03 8.123205e-07 6.878148e-06 12 57694160 57694323 164 + 2.930 2.782 -0.490
ENSG00000135506 E014 3.6805797 4.331768e-03 3.129854e-01 4.554991e-01 12 57694706 57694749 44 + 0.747 0.607 -0.588
ENSG00000135506 E015 980.6616650 1.832870e-03 4.400472e-05 2.513284e-04 12 57694750 57694926 177 + 3.033 2.942 -0.300
ENSG00000135506 E016 1.6284995 8.331156e-03 2.550701e-05 1.543251e-04 12 57694927 57695148 222 + 0.716 0.000 -14.003
ENSG00000135506 E017 0.7490443 7.348890e-02 8.978021e-03 2.622557e-02 12 57695496 57695542 47 + 0.464 0.000 -11.764
ENSG00000135506 E018 3.4114169 9.482961e-03 4.123676e-03 1.348835e-02 12 57695543 57695677 135 + 0.852 0.425 -1.878
ENSG00000135506 E019 2.7763253 5.309693e-03 2.032446e-03 7.327271e-03 12 57695678 57695779 102 + 0.803 0.324 -2.270
ENSG00000135506 E020 614.8648359 1.005654e-03 1.449844e-04 7.253509e-04 12 57695780 57695843 64 + 2.821 2.748 -0.244
ENSG00000135506 E021 1.9324582 1.213682e-02 8.730010e-02 1.710403e-01 12 57695844 57695961 118 + 0.608 0.324 -1.462
ENSG00000135506 E022 366.5377618 1.907002e-03 8.242180e-03 2.439824e-02 12 57695962 57695976 15 + 2.595 2.527 -0.225
ENSG00000135506 E023 343.0377114 1.694884e-03 4.237899e-02 9.541468e-02 12 57695977 57695981 5 + 2.555 2.506 -0.163
ENSG00000135506 E024 567.9575285 1.562404e-04 1.092122e-04 5.644040e-04 12 57695982 57696038 57 + 2.777 2.724 -0.175
ENSG00000135506 E025 25.1898634 1.702188e-03 4.946204e-04 2.139369e-03 12 57696039 57696274 236 + 1.534 1.298 -0.817
ENSG00000135506 E026 492.8649826 1.295085e-04 3.774140e-05 2.189020e-04 12 57696275 57696313 39 + 2.720 2.661 -0.198
ENSG00000135506 E027 482.7323926 1.167687e-04 5.674581e-02 1.210227e-01 12 57696314 57696373 60 + 2.688 2.665 -0.077
ENSG00000135506 E028 1.5039483 1.590918e-02 8.674313e-01 9.187553e-01 12 57715706 57715759 54 + 0.403 0.378 -0.139
ENSG00000135506 E029 850.0524543 2.355495e-04 7.093051e-01 8.067271e-01 12 57715760 57715970 211 + 2.910 2.923 0.043
ENSG00000135506 E030 3.8126065 4.276618e-03 1.088552e-04 5.628353e-04 12 57715971 57715976 6 + 0.936 0.378 -2.463
ENSG00000135506 E031 11.1291782 2.147811e-03 5.131766e-03 1.628663e-02 12 57715977 57716088 112 + 1.222 0.956 -0.962
ENSG00000135506 E032 97.5081026 8.255813e-04 8.007620e-02 1.596728e-01 12 57716089 57716091 3 + 2.016 1.957 -0.199
ENSG00000135506 E033 610.4204362 5.787006e-04 1.495141e-01 2.610069e-01 12 57716092 57716193 102 + 2.786 2.767 -0.065
ENSG00000135506 E034 19.5624591 4.750501e-03 4.164607e-01 5.598129e-01 12 57716333 57716411 79 + 1.335 1.273 -0.215
ENSG00000135506 E035 705.9349697 1.007676e-04 1.679330e-02 4.448136e-02 12 57716412 57716512 101 + 2.853 2.829 -0.083
ENSG00000135506 E036 502.2494735 2.741280e-04 1.035406e-04 5.383832e-04 12 57716693 57716720 28 + 2.727 2.667 -0.199
ENSG00000135506 E037 430.4605559 1.407574e-04 9.647106e-09 1.193506e-07 12 57716721 57716744 24 + 2.679 2.586 -0.310
ENSG00000135506 E038 824.5327150 1.055662e-04 1.041200e-08 1.279031e-07 12 57717870 57717958 89 + 2.945 2.879 -0.219
ENSG00000135506 E039 8.4152937 1.980909e-03 2.924287e-01 4.333963e-01 12 57717959 57718052 94 + 1.023 0.914 -0.405
ENSG00000135506 E040 1479.1509291 6.736076e-05 3.598343e-05 2.097201e-04 12 57718146 57718335 190 + 3.128 3.177 0.162
ENSG00000135506 E041 803.6641593 1.114639e-04 1.904389e-15 6.943435e-14 12 57718336 57718376 41 + 2.818 2.935 0.388
ENSG00000135506 E042 669.5161692 1.361808e-04 7.398068e-12 1.573175e-10 12 57718377 57718421 45 + 2.743 2.854 0.370
ENSG00000135506 E043 1483.7521400 2.421527e-04 4.793556e-12 1.051679e-10 12 57718993 57719182 190 + 3.104 3.191 0.292
ENSG00000135506 E044 27.1683756 9.535298e-03 2.376973e-02 5.934351e-02 12 57719183 57720098 916 + 1.535 1.356 -0.614
ENSG00000135506 E045 204.7582332 1.762677e-03 4.151932e-04 1.832559e-03 12 57720099 57720210 112 + 2.363 2.256 -0.358
ENSG00000135506 E046 158.7695577 9.056023e-04 1.550947e-03 5.800804e-03 12 57720211 57720263 53 + 2.246 2.155 -0.304
ENSG00000135506 E047 9.9434277 5.791779e-02 5.458596e-01 6.761305e-01 12 57720264 57720405 142 + 1.068 0.995 -0.266
ENSG00000135506 E048 1027.8046750 1.054957e-03 1.214700e-06 9.908340e-06 12 57720406 57720518 113 + 2.936 3.035 0.328
ENSG00000135506 E049 2684.5464571 1.038395e-03 2.485606e-15 8.928530e-14 12 57720784 57721557 774 + 3.332 3.460 0.424