ENSG00000135486

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330752 ENSG00000135486 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPA1 protein_coding protein_coding 2093.822 2105.009 2601.475 96.32736 48.9593 0.3055023 618.5386 750.723133 620.1708 61.781104 23.873481 -0.2756112 0.29984167 0.3554667 0.23826667 -0.11720000 2.332138e-07 7.455849e-33 FALSE TRUE
ENST00000547566 ENSG00000135486 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPA1 protein_coding nonsense_mediated_decay 2093.822 2105.009 2601.475 96.32736 48.9593 0.3055023 414.6598 246.593096 597.3872 27.623493 49.121794 1.2764995 0.19353750 0.1179333 0.22966667 0.11173333 2.870498e-03 7.455849e-33 TRUE TRUE
ENST00000547708 ENSG00000135486 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPA1 protein_coding protein_coding 2093.822 2105.009 2601.475 96.32736 48.9593 0.3055023 66.4406 3.202678 210.7142 2.346248 42.803296 6.0354355 0.02731667 0.0016000 0.08130000 0.07970000 2.258519e-02 7.455849e-33 FALSE FALSE
ENST00000677249 ENSG00000135486 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPA1 protein_coding protein_coding 2093.822 2105.009 2601.475 96.32736 48.9593 0.3055023 148.3597 180.959966 154.5664 8.244919 1.851779 -0.2274301 0.07000000 0.0860000 0.05943333 -0.02656667 7.605475e-14 7.455849e-33 FALSE TRUE
MSTRG.7414.16 ENSG00000135486 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPA1 protein_coding   2093.822 2105.009 2601.475 96.32736 48.9593 0.3055023 650.7270 788.702856 750.4220 24.533891 44.704785 -0.0717788 0.31380417 0.3756000 0.28810000 -0.08750000 1.145274e-02 7.455849e-33 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135486 E001 2.253007 6.774510e-03 6.374764e-02 1.329343e-01 12 54280193 54280662 470 + 0.671 0.354 -1.549
ENSG00000135486 E002 1.357746 1.754264e-02 3.105090e-01 4.529146e-01 12 54280663 54280690 28 + 0.479 0.289 -1.090
ENSG00000135486 E003 1.212573 1.085087e-02 4.652234e-01 6.049400e-01 12 54280691 54280697 7 + 0.428 0.289 -0.826
ENSG00000135486 E004 1.508217 9.132097e-03 4.946800e-02 1.082167e-01 12 54280698 54280703 6 + 0.566 0.212 -2.088
ENSG00000135486 E005 1.801683 8.514687e-03 7.554598e-02 1.523894e-01 12 54280704 54280708 5 + 0.604 0.289 -1.674
ENSG00000135486 E006 85.950325 3.504307e-03 4.569084e-01 5.972780e-01 12 54280709 54280725 17 + 1.966 1.908 -0.195
ENSG00000135486 E007 311.344167 1.819028e-03 2.471963e-02 6.130221e-02 12 54280726 54280747 22 + 2.539 2.451 -0.292
ENSG00000135486 E008 313.906456 1.674203e-03 2.374401e-02 5.928710e-02 12 54280748 54280748 1 + 2.542 2.455 -0.288
ENSG00000135486 E009 349.991803 1.558297e-03 1.495960e-03 5.622672e-03 12 54280749 54280755 7 + 2.600 2.491 -0.361
ENSG00000135486 E010 974.455258 1.308283e-04 3.187158e-95 8.504189e-92 12 54280756 54280762 7 + 3.123 2.841 -0.938
ENSG00000135486 E011 6221.386699 5.159793e-03 1.612118e-05 1.021612e-04 12 54280763 54280774 12 + 3.881 3.704 -0.591
ENSG00000135486 E012 6559.089112 4.541134e-03 1.183197e-05 7.730218e-05 12 54280775 54280779 5 + 3.901 3.731 -0.566
ENSG00000135486 E013 7522.981983 3.447209e-03 1.261960e-05 8.192818e-05 12 54280780 54280807 28 + 3.951 3.800 -0.502
ENSG00000135486 E014 8023.232327 2.850451e-03 4.606017e-06 3.306290e-05 12 54280808 54280822 15 + 3.977 3.831 -0.482
ENSG00000135486 E015 18.153157 9.959231e-04 1.621693e-27 2.210251e-25 12 54280823 54280871 49 + 1.598 0.462 -4.348
ENSG00000135486 E016 29.326174 3.963381e-03 1.056443e-40 3.834098e-38 12 54280872 54281005 134 + 1.809 0.507 -4.843
ENSG00000135486 E017 24.903730 5.119871e-03 4.205453e-37 1.203490e-34 12 54281006 54281094 89 + 1.746 0.355 -5.437
ENSG00000135486 E018 33.480524 1.454312e-03 5.250759e-50 3.178085e-47 12 54281095 54281295 201 + 1.866 0.584 -4.674
ENSG00000135486 E019 20.805364 8.510447e-04 1.907479e-27 2.577505e-25 12 54281296 54281352 57 + 1.643 0.619 -3.766
ENSG00000135486 E020 21.589476 8.276447e-04 7.665116e-23 6.691858e-21 12 54281353 54281385 33 + 1.640 0.782 -3.077
ENSG00000135486 E021 13109.477572 1.649139e-03 2.164104e-08 2.507082e-07 12 54281386 54281502 117 + 4.185 4.050 -0.447
ENSG00000135486 E022 64.677652 1.243595e-03 3.781446e-51 2.453369e-48 12 54281503 54281794 292 + 2.095 1.271 -2.804
ENSG00000135486 E023 12041.549328 6.351114e-04 7.168883e-07 6.143687e-06 12 54281795 54281896 102 + 4.124 4.038 -0.284
ENSG00000135486 E024 5957.729365 4.035516e-04 1.205878e-01 2.208064e-01 12 54281897 54281908 12 + 3.794 3.755 -0.131
ENSG00000135486 E025 8167.706778 3.738167e-04 9.336076e-01 9.621710e-01 12 54281909 54281941 33 + 3.922 3.899 -0.077
ENSG00000135486 E026 7.677134 3.126335e-03 1.349331e-05 8.697981e-05 12 54281942 54281945 4 + 1.159 0.619 -2.088
ENSG00000135486 E027 6.709779 2.365217e-03 1.184858e-05 7.740534e-05 12 54282052 54282089 38 + 1.117 0.547 -2.258
ENSG00000135486 E028 8491.985805 2.565347e-04 8.905056e-02 1.736813e-01 12 54282090 54282138 49 + 3.931 3.923 -0.025
ENSG00000135486 E029 13949.217401 5.465488e-04 3.460276e-01 4.901702e-01 12 54282139 54282300 162 + 4.148 4.136 -0.042
ENSG00000135486 E030 12447.314009 5.161945e-04 8.932106e-01 9.357691e-01 12 54282394 54282486 93 + 4.106 4.081 -0.081
ENSG00000135486 E031 19.764068 2.585523e-02 1.251008e-07 1.247307e-06 12 54282487 54282572 86 + 1.560 0.944 -2.179
ENSG00000135486 E032 7308.894715 6.882661e-04 9.709842e-01 9.858806e-01 12 54282573 54282596 24 + 3.874 3.850 -0.079
ENSG00000135486 E033 6607.271156 1.869357e-04 7.110734e-01 8.081018e-01 12 54282597 54282611 15 + 3.831 3.807 -0.081
ENSG00000135486 E034 8020.022883 4.041879e-04 6.962441e-01 7.966646e-01 12 54282612 54282641 30 + 3.916 3.889 -0.089
ENSG00000135486 E035 7982.107340 4.157532e-04 2.932439e-01 4.342918e-01 12 54282642 54282662 21 + 3.918 3.885 -0.109
ENSG00000135486 E036 7412.405822 3.263234e-04 8.334893e-01 8.956935e-01 12 54282663 54282665 3 + 3.878 3.859 -0.061
ENSG00000135486 E037 18.825428 1.148688e-03 2.328895e-14 7.256745e-13 12 54282666 54282669 4 + 1.551 0.882 -2.383
ENSG00000135486 E038 35.161561 5.744040e-04 2.099830e-24 2.165522e-22 12 54282670 54282799 130 + 1.809 1.134 -2.328
ENSG00000135486 E039 8947.688584 3.998317e-04 1.145951e-01 2.122492e-01 12 54282800 54282820 21 + 3.970 3.932 -0.125
ENSG00000135486 E040 6266.345936 5.402008e-04 8.653331e-03 2.541624e-02 12 54282821 54282823 3 + 3.823 3.771 -0.174
ENSG00000135486 E041 7339.379610 5.422534e-04 4.959050e-01 6.326489e-01 12 54282824 54282841 18 + 3.879 3.850 -0.096
ENSG00000135486 E042 6000.263933 4.994149e-04 8.875457e-01 9.321127e-01 12 54282842 54282842 1 + 3.788 3.766 -0.073
ENSG00000135486 E043 7623.466669 5.824838e-04 2.605022e-01 3.980362e-01 12 54282843 54282865 23 + 3.883 3.877 -0.022
ENSG00000135486 E044 6924.452074 5.793972e-04 6.007864e-01 7.219703e-01 12 54282866 54282874 9 + 3.845 3.832 -0.046
ENSG00000135486 E045 25.982136 2.161578e-03 1.748972e-14 5.563086e-13 12 54282875 54282878 4 + 1.662 1.069 -2.067
ENSG00000135486 E046 28.739913 6.823743e-04 1.077957e-34 2.598163e-32 12 54282879 54282932 54 + 1.774 0.782 -3.531
ENSG00000135486 E047 41.225042 4.871391e-04 2.618416e-49 1.516976e-46 12 54282933 54283062 130 + 1.931 0.917 -3.536
ENSG00000135486 E048 22.987942 8.196098e-04 1.304272e-17 6.314022e-16 12 54283063 54283078 16 + 1.636 0.949 -2.422
ENSG00000135486 E049 419.689184 1.095181e-03 8.422742e-03 2.484528e-02 12 54283079 54283093 15 + 2.667 2.587 -0.268
ENSG00000135486 E050 512.675633 6.503032e-04 4.243114e-03 1.382246e-02 12 54283094 54283132 39 + 2.751 2.676 -0.251
ENSG00000135486 E051 486.994825 1.266115e-04 5.030720e-02 1.097105e-01 12 54283133 54283162 30 + 2.717 2.666 -0.169
ENSG00000135486 E052 498.526180 1.204286e-04 3.195550e-02 7.577201e-02 12 54283163 54283207 45 + 2.728 2.674 -0.178
ENSG00000135486 E053 328.778049 1.485767e-04 1.641536e-02 4.364690e-02 12 54283208 54283213 6 + 2.555 2.488 -0.221
ENSG00000135486 E054 328.192468 1.438663e-04 7.430610e-03 2.233746e-02 12 54283214 54283225 12 + 2.557 2.485 -0.239
ENSG00000135486 E055 257.848111 1.631379e-04 5.465056e-04 2.333946e-03 12 54283226 54283228 3 + 2.465 2.369 -0.320
ENSG00000135486 E056 276.310145 1.490500e-04 1.556316e-04 7.721946e-04 12 54283229 54283234 6 + 2.496 2.396 -0.335
ENSG00000135486 E057 190.905018 1.891229e-02 7.665787e-01 8.490417e-01 12 54283235 54283238 4 + 2.280 2.278 -0.008
ENSG00000135486 E058 101.984397 4.605300e-03 9.806931e-66 1.222298e-62 12 54283239 54283665 427 + 2.316 1.307 -3.418
ENSG00000135486 E059 49.221834 1.344205e-03 1.372479e-53 1.035905e-50 12 54283666 54283722 57 + 2.006 0.993 -3.505
ENSG00000135486 E060 45.595514 4.727032e-04 8.687802e-58 8.188447e-55 12 54283723 54283778 56 + 1.979 0.900 -3.763
ENSG00000135486 E061 36.161657 1.403357e-03 2.357425e-44 1.055809e-41 12 54283779 54283791 13 + 1.880 0.804 -3.801
ENSG00000135486 E062 58.248259 1.764572e-03 1.075424e-29 1.762421e-27 12 54283792 54283811 20 + 2.011 1.381 -2.140
ENSG00000135486 E063 6514.987938 4.075336e-04 6.478606e-01 7.594768e-01 12 54283812 54283815 4 + 3.826 3.800 -0.086
ENSG00000135486 E064 6805.788692 1.400797e-04 5.531113e-04 2.358276e-03 12 54283816 54283826 11 + 3.829 3.833 0.014
ENSG00000135486 E065 7071.624754 1.626499e-04 1.400284e-12 3.348222e-11 12 54283827 54283835 9 + 3.829 3.862 0.108
ENSG00000135486 E066 6125.518555 1.184000e-04 8.936281e-23 7.733904e-21 12 54283836 54283836 1 + 3.758 3.806 0.161
ENSG00000135486 E067 9329.586559 9.453287e-05 1.673674e-40 6.014881e-38 12 54283837 54283891 55 + 3.934 3.993 0.197
ENSG00000135486 E068 5910.802536 3.059134e-05 1.133358e-62 1.255621e-59 12 54283892 54283895 4 + 3.730 3.800 0.233
ENSG00000135486 E069 6455.772872 2.039699e-05 6.925823e-125 4.232505e-121 12 54283896 54283907 12 + 3.752 3.850 0.326
ENSG00000135486 E070 7879.491867 3.727865e-05 5.308241e-97 1.500941e-93 12 54283908 54283937 30 + 3.846 3.930 0.281
ENSG00000135486 E071 8237.834459 1.331275e-04 2.324621e-41 8.737946e-39 12 54283938 54283967 30 + 3.872 3.944 0.238
ENSG00000135486 E072 62.650179 1.396269e-03 5.055240e-18 2.561380e-16 12 54283968 54284239 272 + 1.993 1.549 -1.499
ENSG00000135486 E073 26.587983 7.196479e-04 6.662766e-08 7.004667e-07 12 54284240 54284257 18 + 1.612 1.225 -1.339
ENSG00000135486 E074 10849.374459 4.800173e-04 8.224805e-30 1.360842e-27 12 54284258 54284317 60 + 3.971 4.075 0.347
ENSG00000135486 E075 82.860157 8.569587e-03 3.532851e-21 2.589122e-19 12 54284318 54284321 4 + 2.161 1.539 -2.098
ENSG00000135486 E076 302.154567 8.684993e-03 4.793622e-39 1.565754e-36 12 54284322 54284517 196 + 2.741 2.021 -2.405
ENSG00000135486 E077 162.825176 3.979180e-03 1.020356e-49 6.059667e-47 12 54284518 54284548 31 + 2.468 1.777 -2.315
ENSG00000135486 E078 7680.310053 9.594245e-04 8.641826e-15 2.871217e-13 12 54284549 54284601 53 + 3.823 3.923 0.332
ENSG00000135486 E079 6304.100098 1.033141e-03 6.869646e-23 6.025156e-21 12 54284602 54284708 107 + 3.712 3.853 0.466
ENSG00000135486 E080 3217.299314 1.507744e-03 2.414890e-13 6.502185e-12 12 54284709 54284739 31 + 3.428 3.556 0.425
ENSG00000135486 E081 5900.888308 2.922800e-03 1.161178e-07 1.165960e-06 12 54284740 54284936 197 + 3.693 3.818 0.416
ENSG00000135486 E082 3355.268502 2.554372e-03 2.336856e-01 3.667644e-01 12 54284937 54285807 871 + 3.550 3.501 -0.161
ENSG00000135486 E083 121.188243 4.680318e-03 6.559623e-18 3.284162e-16 12 54285808 54285841 34 + 2.273 1.845 -1.437
ENSG00000135486 E084 47.668871 4.712651e-04 1.088558e-20 7.584555e-19 12 54285842 54285906 65 + 1.899 1.381 -1.762
ENSG00000135486 E085 159.544666 5.898118e-03 1.389689e-23 1.311985e-21 12 54285907 54285946 40 + 2.416 1.905 -1.710
ENSG00000135486 E086 159.837087 5.852331e-03 8.423773e-24 8.182039e-22 12 54285947 54285950 4 + 2.417 1.905 -1.714
ENSG00000135486 E087 193.743347 4.529668e-03 2.334819e-30 4.028455e-28 12 54285951 54285973 23 + 2.503 1.984 -1.734
ENSG00000135486 E088 202.055571 4.613609e-03 1.881057e-30 3.275373e-28 12 54285974 54285984 11 + 2.521 2.002 -1.733
ENSG00000135486 E089 357.927409 6.075306e-03 4.536464e-32 8.796515e-30 12 54285985 54286112 128 + 2.775 2.230 -1.818
ENSG00000135486 E090 339.344526 7.446278e-03 1.274087e-23 1.209885e-21 12 54286113 54286246 134 + 2.740 2.237 -1.677
ENSG00000135486 E091 188.569055 1.167041e-02 1.293680e-12 3.114547e-11 12 54286247 54286282 36 + 2.469 2.021 -1.498
ENSG00000135486 E092 98.045437 1.189495e-02 1.511184e-07 1.482596e-06 12 54286283 54286286 4 + 2.158 1.797 -1.212
ENSG00000135486 E093 451.748668 4.542894e-03 1.174115e-14 3.821866e-13 12 54286287 54286661 375 + 2.800 2.492 -1.025
ENSG00000135486 E094 259.522869 1.490514e-03 3.462807e-14 1.052492e-12 12 54286662 54286665 4 + 2.534 2.296 -0.792
ENSG00000135486 E095 237.421154 3.062765e-03 2.314246e-04 1.097521e-03 12 54286666 54286679 14 + 2.455 2.307 -0.493
ENSG00000135486 E096 286.760996 2.654729e-03 5.275220e-04 2.262616e-03 12 54286680 54286732 53 + 2.528 2.398 -0.433
ENSG00000135486 E097 71.661103 2.013184e-02 1.731284e-05 1.089367e-04 12 54286733 54286836 104 + 2.026 1.665 -1.216
ENSG00000135486 E098 47.393437 6.567939e-03 6.542477e-07 5.654180e-06 12 54286837 54286864 28 + 1.842 1.506 -1.140
ENSG00000135486 E099 49.741939 4.672411e-04 7.549668e-08 7.849956e-07 12 54286865 54286952 88 + 1.844 1.557 -0.974
ENSG00000135486 E100 223.185263 4.870387e-03 7.454042e-02 1.508091e-01 12 54286953 54287088 136 + 2.399 2.310 -0.298