ENSG00000135469

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308197 ENSG00000135469 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ10A protein_coding protein_coding 19.1325 31.54625 13.13404 1.643724 0.5009632 -1.263517 4.8351946 7.4136700 4.7778724 1.5783789 1.43465646 -0.6327479 0.24338750 0.23920000 0.36896667 0.129766667 0.6812473081 5.96935e-05 FALSE TRUE
ENST00000433805 ENSG00000135469 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ10A protein_coding protein_coding 19.1325 31.54625 13.13404 1.643724 0.5009632 -1.263517 6.6429431 14.5329445 2.2559614 1.2098379 0.65347812 -2.6821242 0.31564167 0.45973333 0.17256667 -0.287166667 0.0104928198 5.96935e-05 FALSE TRUE
ENST00000546544 ENSG00000135469 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ10A protein_coding protein_coding 19.1325 31.54625 13.13404 1.643724 0.5009632 -1.263517 1.5200012 2.1304177 0.8041889 1.7010078 0.80418892 -1.3944569 0.09076667 0.06273333 0.05816667 -0.004566667 0.6930268726 5.96935e-05 FALSE TRUE
ENST00000549545 ENSG00000135469 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ10A protein_coding retained_intron 19.1325 31.54625 13.13404 1.643724 0.5009632 -1.263517 0.9905583 0.7913170 0.8788028 0.1201171 0.03151326 0.1494903 0.06164167 0.02523333 0.06730000 0.042066667 0.0008828121 5.96935e-05 FALSE TRUE
ENST00000551566 ENSG00000135469 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ10A protein_coding retained_intron 19.1325 31.54625 13.13404 1.643724 0.5009632 -1.263517 0.9894134 0.8840013 0.8127311 0.8840013 0.47491632 -0.1198560 0.05847083 0.02803333 0.05936667 0.031333333 0.5185692932 5.96935e-05   FALSE
ENST00000551911 ENSG00000135469 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ10A protein_coding retained_intron 19.1325 31.54625 13.13404 1.643724 0.5009632 -1.263517 2.6325349 3.0200442 1.9072984 0.2171844 0.25886120 -0.6602640 0.15351250 0.09630000 0.14640000 0.050100000 0.2729055624 5.96935e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135469 E001 12.190523 0.0014397370 8.618324e-01 9.149236e-01 12 56266890 56266890 1 + 1.069 1.052 -0.059
ENSG00000135469 E002 34.190183 0.0070443511 6.165065e-01 7.345525e-01 12 56266891 56266941 51 + 1.506 1.467 -0.135
ENSG00000135469 E003 91.689686 0.0206862311 6.537248e-02 1.356639e-01 12 56266942 56267252 311 + 2.001 1.856 -0.485
ENSG00000135469 E004 1.805844 0.0078288038 1.883823e-01 3.116905e-01 12 56267283 56267284 2 + 0.186 0.444 1.733
ENSG00000135469 E005 3.682651 0.0045579491 4.070045e-01 5.506376e-01 12 56267285 56267328 44 + 0.497 0.640 0.650
ENSG00000135469 E006 16.012669 0.0011991637 7.549939e-02 1.523101e-01 12 56267329 56267433 105 + 1.027 1.210 0.658
ENSG00000135469 E007 2.062679 0.0069555017 3.655412e-01 5.098492e-01 12 56267682 56267793 112 + 0.566 0.412 -0.761
ENSG00000135469 E008 40.170627 0.0009183328 1.456227e-01 2.557028e-01 12 56267794 56267799 6 + 1.609 1.522 -0.298
ENSG00000135469 E009 121.043875 0.0003004298 3.221227e-03 1.091880e-02 12 56267800 56267940 141 + 2.090 1.990 -0.337
ENSG00000135469 E010 11.707692 0.0015056823 1.566576e-09 2.241395e-08 12 56267941 56268116 176 + 1.400 0.828 -2.072
ENSG00000135469 E011 37.014508 0.0007085497 4.701136e-17 2.102989e-15 12 56268117 56269058 942 + 1.822 1.342 -1.641
ENSG00000135469 E012 110.541265 0.0003316325 4.618853e-01 6.018020e-01 12 56269059 56269108 50 + 1.996 1.970 -0.086
ENSG00000135469 E013 137.071637 0.0005830330 1.677429e-01 2.852587e-01 12 56269109 56269182 74 + 2.030 2.080 0.169
ENSG00000135469 E014 134.248682 0.0009880483 3.016868e-01 4.434934e-01 12 56269183 56269251 69 + 2.034 2.074 0.135
ENSG00000135469 E015 20.550307 0.0031687552 1.665362e-03 6.171226e-03 12 56269252 56269459 208 + 1.444 1.189 -0.891
ENSG00000135469 E016 165.183667 0.0002278191 3.973980e-01 5.411499e-01 12 56269460 56269535 76 + 2.130 2.159 0.096
ENSG00000135469 E017 126.527949 0.0003956525 1.923071e-01 3.166568e-01 12 56269536 56269561 26 + 1.998 2.048 0.167
ENSG00000135469 E018 235.109777 0.0002231057 3.615817e-01 5.059799e-01 12 56270150 56270318 169 + 2.284 2.309 0.086
ENSG00000135469 E019 229.627314 0.0002419881 3.738688e-01 5.182927e-01 12 56270319 56270450 132 + 2.275 2.301 0.085
ENSG00000135469 E020 394.464157 0.0018125475 7.980149e-05 4.268856e-04 12 56270451 56270966 516 + 2.446 2.550 0.347