ENSG00000135451

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257909 ENSG00000135451 HEK293_OSMI2_2hA HEK293_TMG_2hB TROAP protein_coding protein_coding 96.9181 139.5407 71.16222 1.792594 1.80311 -0.9714035 4.771526 15.344097 0.000000 1.434722 0.0000000 -10.5844079 0.03562500 0.11026667 0.00000000 -0.11026667 4.423115e-44 4.423115e-44 FALSE TRUE
ENST00000380327 ENSG00000135451 HEK293_OSMI2_2hA HEK293_TMG_2hB TROAP protein_coding protein_coding 96.9181 139.5407 71.16222 1.792594 1.80311 -0.9714035 8.791260 16.303269 5.364660 1.760213 0.6930282 -1.6018005 0.08665833 0.11670000 0.07556667 -0.04113333 1.445698e-01 4.423115e-44 FALSE TRUE
ENST00000548311 ENSG00000135451 HEK293_OSMI2_2hA HEK293_TMG_2hB TROAP protein_coding protein_coding 96.9181 139.5407 71.16222 1.792594 1.80311 -0.9714035 23.780037 39.341624 14.861334 3.715274 1.5323630 -1.4038891 0.23962917 0.28206667 0.20966667 -0.07240000 3.272434e-01 4.423115e-44 FALSE FALSE
ENST00000550709 ENSG00000135451 HEK293_OSMI2_2hA HEK293_TMG_2hB TROAP protein_coding protein_coding 96.9181 139.5407 71.16222 1.792594 1.80311 -0.9714035 12.507866 21.114827 7.504603 1.515760 0.7897398 -1.4911706 0.12432500 0.15150000 0.10503333 -0.04646667 8.305335e-02 4.423115e-44   FALSE
ENST00000551245 ENSG00000135451 HEK293_OSMI2_2hA HEK293_TMG_2hB TROAP protein_coding protein_coding 96.9181 139.5407 71.16222 1.792594 1.80311 -0.9714035 15.138821 12.069517 14.123163 1.450671 1.4468008 0.2265216 0.16896667 0.08643333 0.19770000 0.11126667 2.307525e-05 4.423115e-44 FALSE TRUE
MSTRG.7247.18 ENSG00000135451 HEK293_OSMI2_2hA HEK293_TMG_2hB TROAP protein_coding   96.9181 139.5407 71.16222 1.792594 1.80311 -0.9714035 8.374383 2.015518 12.096179 1.052678 0.4675782 2.5793808 0.10226250 0.01426667 0.17046667 0.15620000 1.011017e-01 4.423115e-44 FALSE TRUE
MSTRG.7247.2 ENSG00000135451 HEK293_OSMI2_2hA HEK293_TMG_2hB TROAP protein_coding   96.9181 139.5407 71.16222 1.792594 1.80311 -0.9714035 8.355989 12.933041 4.909114 1.414697 0.4705996 -1.3957063 0.08429583 0.09246667 0.06876667 -0.02370000 3.007678e-01 4.423115e-44   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135451 E001 0.4847352 0.2689424318 3.596599e-01 5.039905e-01 12 49322029 49322218 190 + 0.273 0.095 -1.838
ENSG00000135451 E002 0.4847352 0.2689424318 3.596599e-01 5.039905e-01 12 49323136 49323180 45 + 0.273 0.095 -1.839
ENSG00000135451 E003 1.9594250 0.0076188788 3.086254e-01 4.508996e-01 12 49323181 49323219 39 + 0.558 0.391 -0.839
ENSG00000135451 E004 3.2094723 0.0065068319 9.750551e-01 9.884538e-01 12 49323220 49323227 8 + 0.607 0.619 0.052
ENSG00000135451 E005 4.9130087 0.0425055539 6.611110e-01 7.696427e-01 12 49323228 49323235 8 + 0.794 0.744 -0.200
ENSG00000135451 E006 6.7899030 0.0043926182 8.729299e-01 9.223310e-01 12 49323236 49323243 8 + 0.877 0.865 -0.046
ENSG00000135451 E007 9.3687405 0.0029102490 3.057989e-01 4.479426e-01 12 49323244 49323254 11 + 1.059 0.956 -0.380
ENSG00000135451 E008 9.5202559 0.0026001356 2.355239e-01 3.689924e-01 12 49323255 49323255 1 + 1.075 0.956 -0.439
ENSG00000135451 E009 9.4805151 0.0020365187 2.338846e-01 3.669946e-01 12 49323256 49323256 1 + 1.075 0.956 -0.439
ENSG00000135451 E010 43.3807135 0.0026945540 3.948373e-03 1.299797e-02 12 49323257 49323272 16 + 1.722 1.562 -0.545
ENSG00000135451 E011 164.9458430 0.0032105269 3.292233e-01 4.727319e-01 12 49323273 49323278 6 + 2.156 2.206 0.166
ENSG00000135451 E012 190.3070087 0.0029323854 3.404554e-01 4.844030e-01 12 49323279 49323282 4 + 2.220 2.266 0.155
ENSG00000135451 E013 348.3806197 0.0018466516 4.801851e-02 1.056644e-01 12 49323283 49323309 27 + 2.466 2.533 0.222
ENSG00000135451 E014 488.9723240 0.0015461076 1.096894e-02 3.108905e-02 12 49323310 49323349 40 + 2.608 2.681 0.244
ENSG00000135451 E015 3.8236891 0.0192315744 8.085373e-02 1.608744e-01 12 49323374 49323603 230 + 0.823 0.565 -1.081
ENSG00000135451 E016 878.0482732 0.0015296809 4.861174e-05 2.747419e-04 12 49323604 49323752 149 + 2.843 2.942 0.327
ENSG00000135451 E017 6.3775079 0.0025521400 8.774661e-03 2.571997e-02 12 49323753 49323844 92 + 1.024 0.711 -1.210
ENSG00000135451 E018 728.9938213 0.0028191806 6.997076e-08 7.321193e-07 12 49323845 49323946 102 + 2.714 2.878 0.544
ENSG00000135451 E019 585.3879975 0.0013782772 1.869619e-10 3.148109e-09 12 49323947 49324037 91 + 2.622 2.782 0.531
ENSG00000135451 E020 122.2907198 0.0089636394 5.016629e-05 2.826509e-04 12 49324038 49324154 117 + 1.877 2.126 0.834
ENSG00000135451 E021 143.4499947 0.0002763413 4.186405e-16 1.660935e-14 12 49324155 49324211 57 + 1.911 2.202 0.976
ENSG00000135451 E022 147.2620887 0.0002352420 5.431892e-10 8.461238e-09 12 49324212 49324230 19 + 1.982 2.197 0.720
ENSG00000135451 E023 309.7124221 0.0045936296 3.440836e-08 3.829942e-07 12 49324231 49324416 186 + 2.291 2.523 0.774
ENSG00000135451 E024 9.9868331 0.0017353654 1.005359e-12 2.467448e-11 12 49325453 49325500 48 + 1.365 0.620 -2.810
ENSG00000135451 E025 158.3222690 0.0030480900 3.319085e-04 1.508253e-03 12 49325501 49325560 60 + 2.253 2.120 -0.443
ENSG00000135451 E026 181.7166636 0.0028316116 5.573140e-04 2.374912e-03 12 49325561 49325658 98 + 2.306 2.186 -0.404
ENSG00000135451 E027 240.3959975 0.0025826449 4.381897e-05 2.503279e-04 12 49325747 49325884 138 + 2.433 2.303 -0.433
ENSG00000135451 E028 196.6189421 0.0053635462 1.141310e-02 3.214609e-02 12 49326076 49326158 83 + 2.328 2.226 -0.340
ENSG00000135451 E029 5.7583890 0.0028176056 1.936890e-06 1.511339e-05 12 49326641 49326667 27 + 1.105 0.504 -2.422
ENSG00000135451 E030 175.6569141 0.0042577242 6.072440e-03 1.880147e-02 12 49326668 49326720 53 + 2.280 2.176 -0.350
ENSG00000135451 E031 111.8854533 0.0026705218 3.829343e-05 2.217711e-04 12 49327209 49327226 18 + 2.122 1.957 -0.553
ENSG00000135451 E032 235.5043822 0.0026786065 5.082592e-04 2.190857e-03 12 49327227 49327330 104 + 2.411 2.301 -0.369
ENSG00000135451 E033 2.9527060 0.0122880267 1.833622e-04 8.923184e-04 12 49327331 49327331 1 + 0.877 0.295 -2.745
ENSG00000135451 E034 281.6348265 0.0030642597 1.499313e-01 2.615882e-01 12 49328927 49329055 129 + 2.443 2.404 -0.131
ENSG00000135451 E035 5.6369990 0.0030057394 3.716979e-03 1.234607e-02 12 49329056 49329061 6 + 1.006 0.644 -1.423
ENSG00000135451 E036 250.1120153 0.0042535156 1.211805e-01 2.216211e-01 12 49329161 49329244 84 + 2.398 2.350 -0.159
ENSG00000135451 E037 212.7702989 0.0010524913 6.714848e-02 1.386161e-01 12 49329395 49329454 60 + 2.326 2.281 -0.150
ENSG00000135451 E038 172.3399221 0.0024097739 2.824053e-52 1.945485e-49 12 49329455 49329856 402 + 2.493 1.955 -1.798
ENSG00000135451 E039 137.9258148 0.0020486963 5.978195e-07 5.208808e-06 12 49329857 49329862 6 + 2.222 2.044 -0.595
ENSG00000135451 E040 337.4972646 0.0013516043 9.128344e-05 4.810035e-04 12 49329863 49329991 129 + 2.557 2.463 -0.313
ENSG00000135451 E041 617.4043575 0.0010396478 1.567361e-02 4.200794e-02 12 49330145 49330506 362 + 2.785 2.744 -0.138
ENSG00000135451 E042 268.7482344 0.0036420015 5.118257e-01 6.467619e-01 12 49330507 49330573 67 + 2.372 2.408 0.119
ENSG00000135451 E043 170.0033761 0.0025688406 9.275575e-01 9.584281e-01 12 49330574 49330605 32 + 2.194 2.199 0.017
ENSG00000135451 E044 212.8865214 0.0037821920 9.742431e-02 1.865448e-01 12 49330606 49330660 55 + 2.334 2.277 -0.190
ENSG00000135451 E045 142.7240474 0.0003280728 1.806329e-01 3.019746e-01 12 49330661 49330666 6 + 2.150 2.115 -0.114
ENSG00000135451 E046 151.0951443 0.0003848594 4.883833e-01 6.259531e-01 12 49330667 49330672 6 + 2.159 2.145 -0.045
ENSG00000135451 E047 464.6564561 0.0023602666 5.254147e-01 6.587919e-01 12 49330673 49330943 271 + 2.617 2.644 0.088
ENSG00000135451 E048 189.6321507 0.0073833525 2.015995e-08 2.349436e-07 12 49330944 49331213 270 + 2.411 2.144 -0.892
ENSG00000135451 E049 453.8539112 0.0010105233 8.831452e-02 1.725495e-01 12 49331214 49331407 194 + 2.591 2.640 0.164
ENSG00000135451 E050 199.8491175 0.0058083879 5.337698e-03 1.685070e-02 12 49331573 49331731 159 + 2.172 2.311 0.465