ENSG00000135424

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257879 ENSG00000135424 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA7 protein_coding protein_coding 5.391925 5.585546 4.677521 0.3738705 0.3783738 -0.2554537 0.9399922 0.84009375 1.17926593 0.43805582 0.23420099 0.48437749 0.17010833 0.14073333 0.247333333 0.106600000 6.705806e-01 5.600677e-07 FALSE TRUE
ENST00000347027 ENSG00000135424 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA7 protein_coding protein_coding 5.391925 5.585546 4.677521 0.3738705 0.3783738 -0.2554537 0.3490088 0.33080867 0.03698894 0.14530500 0.03698894 -2.85856881 0.06838333 0.06323333 0.006900000 -0.056333333 1.190045e-01 5.600677e-07 FALSE TRUE
ENST00000553276 ENSG00000135424 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA7 protein_coding processed_transcript 5.391925 5.585546 4.677521 0.3738705 0.3783738 -0.2554537 0.2923343 0.08189371 0.30165036 0.06662427 0.02855822 1.76189034 0.05154167 0.01380000 0.065100000 0.051300000 5.597676e-02 5.600677e-07   FALSE
ENST00000553737 ENSG00000135424 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA7 protein_coding retained_intron 5.391925 5.585546 4.677521 0.3738705 0.3783738 -0.2554537 0.2851581 0.28678564 0.31716046 0.22371248 0.22262441 0.14057709 0.05463333 0.05123333 0.066366667 0.015133333 9.767877e-01 5.600677e-07   FALSE
ENST00000553804 ENSG00000135424 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA7 protein_coding protein_coding 5.391925 5.585546 4.677521 0.3738705 0.3783738 -0.2554537 0.3309023 0.52328560 0.02799829 0.08004043 0.02799829 -3.81090193 0.06395000 0.09613333 0.006033333 -0.090100000 3.041831e-04 5.600677e-07 FALSE TRUE
ENST00000553893 ENSG00000135424 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA7 protein_coding nonsense_mediated_decay 5.391925 5.585546 4.677521 0.3738705 0.3783738 -0.2554537 0.1603729 0.58274435 0.08691548 0.18647192 0.08691548 -2.61261094 0.02890000 0.10093333 0.016233333 -0.084700000 1.149136e-01 5.600677e-07 FALSE TRUE
ENST00000554327 ENSG00000135424 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA7 protein_coding nonsense_mediated_decay 5.391925 5.585546 4.677521 0.3738705 0.3783738 -0.2554537 0.1071176 0.57046811 0.00000000 0.16793299 0.00000000 -5.85914491 0.01905000 0.10086667 0.000000000 -0.100866667 5.600677e-07 5.600677e-07 FALSE TRUE
ENST00000554543 ENSG00000135424 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA7 protein_coding retained_intron 5.391925 5.585546 4.677521 0.3738705 0.3783738 -0.2554537 0.3352864 0.19614646 0.19136306 0.09846641 0.19136306 -0.03387059 0.05689583 0.03310000 0.035766667 0.002666667 7.673373e-01 5.600677e-07 FALSE FALSE
ENST00000557058 ENSG00000135424 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA7 protein_coding retained_intron 5.391925 5.585546 4.677521 0.3738705 0.3783738 -0.2554537 0.3847124 0.27612730 0.30853862 0.22135222 0.11429544 0.15481112 0.06757083 0.04916667 0.070833333 0.021666667 7.501749e-01 5.600677e-07 FALSE TRUE
ENST00000688413 ENSG00000135424 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA7 protein_coding retained_intron 5.391925 5.585546 4.677521 0.3738705 0.3783738 -0.2554537 0.7948494 0.42102885 0.92147394 0.02825656 0.10519778 1.11173096 0.15496667 0.07663333 0.201300000 0.124666667 1.151967e-02 5.600677e-07 FALSE TRUE
ENST00000691846 ENSG00000135424 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA7 protein_coding nonsense_mediated_decay 5.391925 5.585546 4.677521 0.3738705 0.3783738 -0.2554537 0.1222673 0.25728737 0.00000000 0.25728737 0.00000000 -4.74031975 0.02351250 0.05283333 0.000000000 -0.052833333 8.049247e-01 5.600677e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135424 E001 0.1451727 0.0435663141 0.298851798   12 55684568 55684571 4 - 0.153 0.000 -12.537
ENSG00000135424 E002 0.3666179 0.0286766140 0.710476456 0.807652026 12 55684572 55684584 13 - 0.153 0.097 -0.748
ENSG00000135424 E003 0.6664265 0.0177454501 0.615238398 0.733549007 12 55684585 55684600 16 - 0.266 0.177 -0.751
ENSG00000135424 E004 8.2811880 0.0020558852 0.129311323 0.233213200 12 55684601 55684621 21 - 0.812 0.990 0.678
ENSG00000135424 E005 19.8357880 0.0032855891 0.030614348 0.073174317 12 55684622 55684702 81 - 1.162 1.344 0.642
ENSG00000135424 E006 34.0982632 0.0006697520 0.011495374 0.032338389 12 55684703 55684857 155 - 1.406 1.564 0.541
ENSG00000135424 E007 41.8209040 0.0030983131 0.068684697 0.141190426 12 55684858 55685016 159 - 1.531 1.640 0.372
ENSG00000135424 E008 26.6412435 0.0008535033 0.014813002 0.040072047 12 55685017 55685057 41 - 1.292 1.464 0.597
ENSG00000135424 E009 26.8062363 0.0007215818 0.014387682 0.039104911 12 55685058 55685110 53 - 1.292 1.464 0.598
ENSG00000135424 E010 32.3689322 0.0006198931 0.022699539 0.057129414 12 55685111 55685198 88 - 1.392 1.536 0.497
ENSG00000135424 E011 31.3243126 0.0007028916 0.164456185 0.280979300 12 55685199 55685288 90 - 1.420 1.507 0.297
ENSG00000135424 E012 0.0000000       12 55686202 55686314 113 -      
ENSG00000135424 E013 37.1210269 0.0006108626 0.248971371 0.384712278 12 55687971 55688096 126 - 1.508 1.573 0.220
ENSG00000135424 E014 32.5222495 0.0007212482 0.191413875 0.315520616 12 55688202 55688300 99 - 1.441 1.520 0.273
ENSG00000135424 E015 33.4563436 0.0008201942 0.118216267 0.217373181 12 55688844 55688957 114 - 1.441 1.536 0.328
ENSG00000135424 E016 0.6685028 0.0174596124 0.616807383 0.734769628 12 55688958 55690915 1958 - 0.266 0.177 -0.751
ENSG00000135424 E017 34.2334108 0.0033677644 0.091372467 0.177270016 12 55692844 55692975 132 - 1.441 1.552 0.382
ENSG00000135424 E018 27.6400848 0.0007154396 0.017131144 0.045231406 12 55693141 55693212 72 - 1.310 1.475 0.571
ENSG00000135424 E019 33.3992374 0.0006443127 0.154537993 0.267800547 12 55693213 55693317 105 - 1.447 1.533 0.294
ENSG00000135424 E020 1.0287780 0.0205033192 0.542398435 0.673165582 12 55693619 55694020 402 - 0.355 0.244 -0.748
ENSG00000135424 E021 32.3931413 0.0006540913 0.827245797 0.891384106 12 55694021 55694123 103 - 1.491 1.500 0.030
ENSG00000135424 E022 0.7708142 0.0155959463 0.055054372 0.118092002 12 55694124 55694255 132 - 0.430 0.097 -2.750
ENSG00000135424 E023 26.0994988 0.0007995995 0.596612356 0.718522231 12 55694256 55694330 75 - 1.384 1.416 0.112
ENSG00000135424 E024 32.7182946 0.0007701534 0.858373778 0.912611046 12 55694443 55694522 80 - 1.497 1.503 0.022
ENSG00000135424 E025 32.6909751 0.0118393028 0.534926633 0.666892029 12 55694615 55694695 81 - 1.473 1.520 0.161
ENSG00000135424 E026 1.6389026 0.4547105259 0.737475658 0.827627057 12 55694696 55694777 82 - 0.357 0.432 0.416
ENSG00000135424 E027 42.3415979 0.0034989305 0.434559346 0.576903898 12 55694778 55694970 193 - 1.582 1.624 0.146
ENSG00000135424 E028 8.2848438 0.0795121777 0.524367586 0.657901349 12 55694971 55695521 551 - 1.012 0.897 -0.430
ENSG00000135424 E029 17.1027547 0.0011542762 0.637507517 0.751385116 12 55695522 55695553 32 - 1.263 1.219 -0.154
ENSG00000135424 E030 22.2893513 0.0040549235 0.452415720 0.593267766 12 55695554 55695637 84 - 1.301 1.358 0.201
ENSG00000135424 E031 34.6684516 0.0030273259 0.875666671 0.924147953 12 55696283 55696432 150 - 1.514 1.521 0.025
ENSG00000135424 E032 41.3235213 0.0151227010 0.155364469 0.268885959 12 55696899 55697050 152 - 1.660 1.554 -0.361
ENSG00000135424 E033 17.2472027 0.0011093427 0.018392680 0.047995676 12 55697051 55697068 18 - 1.353 1.155 -0.695
ENSG00000135424 E034 22.2690519 0.0008594304 0.026677915 0.065320293 12 55697216 55697277 62 - 1.441 1.275 -0.578
ENSG00000135424 E035 25.7798284 0.0025979246 0.111613088 0.207917213 12 55697451 55697546 96 - 1.473 1.354 -0.411
ENSG00000135424 E036 16.1642509 0.0072230342 0.551036086 0.680561108 12 55697695 55697751 57 - 1.162 1.214 0.187
ENSG00000135424 E037 8.5595425 0.0152686700 0.695297889 0.795932778 12 55697752 55697758 7 - 0.913 0.958 0.171
ENSG00000135424 E038 10.7620834 0.0017049973 0.931361848 0.960755918 12 55697759 55697770 12 - 1.047 1.033 -0.049
ENSG00000135424 E039 18.9443752 0.0009801198 0.655072840 0.765039110 12 55697771 55697822 52 - 1.292 1.251 -0.143
ENSG00000135424 E040 22.9280849 0.0008519856 0.352879519 0.497125651 12 55697938 55698026 89 - 1.392 1.319 -0.253
ENSG00000135424 E041 0.4439371 0.0216088188 0.030596640 0.073138452 12 55698027 55698162 136 - 0.355 0.000 -14.137
ENSG00000135424 E042 16.2968821 0.0012572574 0.540584437 0.671715182 12 55698383 55698423 41 - 1.242 1.185 -0.202
ENSG00000135424 E043 18.9100376 0.0010113981 0.102560969 0.194411438 12 55698424 55698510 87 - 1.353 1.219 -0.468
ENSG00000135424 E044 11.5195325 0.0015260573 0.716502323 0.812151497 12 55698511 55698522 12 - 1.093 1.053 -0.148
ENSG00000135424 E045 15.1165465 0.0020206675 0.712116505 0.808963017 12 55698523 55698576 54 - 1.149 1.178 0.105
ENSG00000135424 E046 24.0036483 0.0009498468 0.602479507 0.723443481 12 55698710 55698857 148 - 1.392 1.349 -0.148
ENSG00000135424 E047 17.2063633 0.0029552604 0.338684784 0.482557807 12 55698858 55698917 60 - 1.292 1.205 -0.304
ENSG00000135424 E048 2.4786050 0.0060605436 0.012700639 0.035209815 12 55699511 55699571 61 - 0.752 0.353 -1.889
ENSG00000135424 E049 15.8987153 0.0011330071 0.625744566 0.741817669 12 55699870 55699961 92 - 1.232 1.185 -0.166
ENSG00000135424 E050 7.8802310 0.0021467881 0.847666651 0.905409208 12 55699962 55699977 16 - 0.913 0.931 0.069
ENSG00000135424 E051 5.9752110 0.0043034269 0.708972889 0.806484811 12 55699978 55699989 12 - 0.865 0.814 -0.200
ENSG00000135424 E052 4.9274815 0.0149294254 0.135596301 0.241940858 12 55699990 55700261 272 - 0.889 0.677 -0.847
ENSG00000135424 E053 7.0329408 0.0043354527 0.063911564 0.133210287 12 55700262 55700393 132 - 0.718 0.955 0.925
ENSG00000135424 E054 3.0731126 0.0052363971 0.001614748 0.006007523 12 55700566 55700671 106 - 0.840 0.353 -2.235
ENSG00000135424 E055 3.2924815 0.0157271026 0.005009067 0.015954952 12 55700672 55700775 104 - 0.840 0.400 -1.968
ENSG00000135424 E056 1.7275716 0.0345626524 0.174095283 0.293494887 12 55700776 55700782 7 - 0.548 0.303 -1.324
ENSG00000135424 E057 2.5422938 0.0057326026 0.002645941 0.009209025 12 55700783 55700898 116 - 0.783 0.302 -2.335
ENSG00000135424 E058 18.9267729 0.0010352647 0.380571285 0.524845950 12 55700899 55700971 73 - 1.319 1.245 -0.261
ENSG00000135424 E059 15.2219824 0.0012028683 0.368674606 0.513079781 12 55700972 55700996 25 - 1.232 1.148 -0.297
ENSG00000135424 E060 24.5042861 0.0063631105 0.034353590 0.080437332 12 55700997 55701133 137 - 1.479 1.310 -0.585
ENSG00000135424 E061 13.7669674 0.0155025556 0.009814324 0.028304499 12 55701134 55701154 21 - 1.301 1.026 -0.983
ENSG00000135424 E062 0.2965864 0.2303520326 0.444060609   12 55701379 55701416 38 - 0.000 0.173 11.741
ENSG00000135424 E063 0.0000000       12 55702828 55702871 44 -      
ENSG00000135424 E064 18.1993185 0.0269581449 0.015103751 0.040722411 12 55702872 55702951 80 - 1.413 1.145 -0.940
ENSG00000135424 E065 0.1817044 0.0397476818 0.772770364   12 55702952 55703050 99 - 0.000 0.097 10.776
ENSG00000135424 E066 23.1616697 0.0045751831 0.014913944 0.040292660 12 55703051 55703178 128 - 1.473 1.281 -0.666
ENSG00000135424 E067 18.3821406 0.0014679783 0.050333860 0.109756693 12 55707477 55707904 428 - 1.361 1.199 -0.568
ENSG00000135424 E068 6.1926155 0.0756690179 0.870350776 0.920607149 12 55712063 55712134 72 - 0.813 0.836 0.088
ENSG00000135424 E069 0.2214452 0.0373614518 0.772681676   12 55712135 55712256 122 - 0.000 0.097 10.779
ENSG00000135424 E070 0.0000000       12 55712257 55712411 155 -      
ENSG00000135424 E071 4.1987221 0.0271826314 0.684857198 0.787717983 12 55715919 55716043 125 - 0.641 0.703 0.258
ENSG00000135424 E072 1.1436731 0.0110785934 0.775261884 0.855209058 12 55716278 55716404 127 - 0.355 0.302 -0.336