ENSG00000135409

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
MSTRG.7353.10 ENSG00000135409 HEK293_OSMI2_2hA HEK293_TMG_2hB AMHR2 protein_coding   2.534665 4.554486 1.789803 0.2984676 0.2961953 -1.342614 0.5300361 1.2333596 0.1125300 0.66626534 0.11253004 -3.3430362 0.1700042 0.26036667 0.05883333 -0.20153333 0.571116795 0.005890741   FALSE
MSTRG.7353.11 ENSG00000135409 HEK293_OSMI2_2hA HEK293_TMG_2hB AMHR2 protein_coding   2.534665 4.554486 1.789803 0.2984676 0.2961953 -1.342614 0.3615536 0.6678159 0.1955694 0.08670123 0.03457677 -1.7212677 0.1475500 0.14976667 0.12343333 -0.02633333 0.814112415 0.005890741   FALSE
MSTRG.7353.12 ENSG00000135409 HEK293_OSMI2_2hA HEK293_TMG_2hB AMHR2 protein_coding   2.534665 4.554486 1.789803 0.2984676 0.2961953 -1.342614 0.1885449 0.4373601 0.5332709 0.43736009 0.26707844 0.2802351 0.0838250 0.10123333 0.34026667 0.23903333 0.470940418 0.005890741 FALSE TRUE
MSTRG.7353.13 ENSG00000135409 HEK293_OSMI2_2hA HEK293_TMG_2hB AMHR2 protein_coding   2.534665 4.554486 1.789803 0.2984676 0.2961953 -1.342614 0.1634231 0.2280060 0.0000000 0.01902099 0.00000000 -4.5729258 0.0494625 0.05043333 0.00000000 -0.05043333 0.005890741 0.005890741 FALSE TRUE
MSTRG.7353.8 ENSG00000135409 HEK293_OSMI2_2hA HEK293_TMG_2hB AMHR2 protein_coding   2.534665 4.554486 1.789803 0.2984676 0.2961953 -1.342614 0.5280545 0.4919816 0.3278891 0.24812810 0.17177230 -0.5710845 0.2481167 0.10723333 0.16140000 0.05416667 0.921501105 0.005890741 FALSE TRUE
MSTRG.7353.9 ENSG00000135409 HEK293_OSMI2_2hA HEK293_TMG_2hB AMHR2 protein_coding   2.534665 4.554486 1.789803 0.2984676 0.2961953 -1.342614 0.6017759 1.2992788 0.4830623 0.40768765 0.24239081 -1.4089307 0.2310542 0.28990000 0.23543333 -0.05446667 0.871557967 0.005890741 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135409 E001 0.0000000       12 53423855 53423865 11 +      
ENSG00000135409 E002 0.0000000       12 53423866 53423934 69 +      
ENSG00000135409 E003 0.0000000       12 53423935 53423983 49 +      
ENSG00000135409 E004 0.0000000       12 53424278 53424287 10 +      
ENSG00000135409 E005 0.0000000       12 53424288 53424470 183 +      
ENSG00000135409 E006 0.0000000       12 53424709 53424900 192 +      
ENSG00000135409 E007 0.0000000       12 53424901 53425075 175 +      
ENSG00000135409 E008 0.0000000       12 53425076 53425081 6 +      
ENSG00000135409 E009 0.0000000       12 53425082 53425115 34 +      
ENSG00000135409 E010 0.0000000       12 53425116 53425164 49 +      
ENSG00000135409 E011 0.0000000       12 53425165 53425242 78 +      
ENSG00000135409 E012 0.1515154 0.0435956523 0.18741516   12 53425455 53425487 33 + 0.180 0.000 -11.696
ENSG00000135409 E013 0.1472490 0.0516811895 0.18702712   12 53425488 53425573 86 + 0.180 0.000 -13.716
ENSG00000135409 E014 0.4772466 0.0225587456 0.84144023 0.90111094 12 53425574 53425685 112 + 0.180 0.150 -0.323
ENSG00000135409 E015 0.3299976 0.0274424043 0.60971834   12 53425686 53425688 3 + 0.000 0.150 11.818
ENSG00000135409 E016 1.7327935 0.0091320969 0.91154153 0.94785530 12 53425689 53425919 231 + 0.405 0.388 -0.099
ENSG00000135409 E017 0.0000000       12 53427239 53427243 5 +      
ENSG00000135409 E018 0.3268771 0.0277709425 0.49730420   12 53427244 53427245 2 + 0.180 0.081 -1.321
ENSG00000135409 E019 8.7834256 0.0027607355 0.42004752 0.56327149 12 53427246 53427282 37 + 0.856 0.956 0.379
ENSG00000135409 E020 1.3640716 0.0693745570 0.07088390 0.14481082 12 53427883 53427933 51 + 0.000 0.390 13.284
ENSG00000135409 E021 7.4237989 0.0026950015 0.07081363 0.14470317 12 53428896 53429010 115 + 1.011 0.803 -0.790
ENSG00000135409 E022 32.7332574 0.0007291924 0.58107185 0.70566946 12 53429453 53429625 173 + 1.435 1.472 0.125
ENSG00000135409 E023 7.6095142 0.0047581531 0.11719506 0.21594371 12 53429626 53429645 20 + 0.709 0.925 0.848
ENSG00000135409 E024 0.8062000 0.0198878420 0.57287911 0.69891894 12 53429646 53429830 185 + 0.307 0.209 -0.738
ENSG00000135409 E025 2.5953099 0.0092539796 0.02157411 0.05479766 12 53429831 53429978 148 + 0.750 0.388 -1.683
ENSG00000135409 E026 0.3299976 0.0274424043 0.60971834   12 53429979 53430145 167 + 0.000 0.150 11.818
ENSG00000135409 E027 4.2654456 0.0040594697 0.26748666 0.40581191 12 53430146 53430149 4 + 0.789 0.633 -0.644
ENSG00000135409 E028 7.8771226 0.0022474000 0.38831109 0.53240808 12 53430150 53430282 133 + 0.965 0.868 -0.368
ENSG00000135409 E029 1.0017226 0.0144855526 0.26687278 0.40513688 12 53430283 53431176 894 + 0.405 0.209 -1.322
ENSG00000135409 E030 39.2633458 0.0009116798 0.26934739 0.40786730 12 53431177 53431672 496 + 1.496 1.559 0.213