ENSG00000135387

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341394 ENSG00000135387 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPRIN1 protein_coding protein_coding 74.74 41.68149 111.5096 5.28359 4.477229 1.419473 31.631127 13.413518 46.09581542 2.1910745 2.40232051 1.780186 0.4297292 0.32493333 0.4134333 0.08850000 4.037497e-01 4.870493e-12 FALSE TRUE
ENST00000530820 ENSG00000135387 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPRIN1 protein_coding protein_coding 74.74 41.68149 111.5096 5.28359 4.477229 1.419473 13.503856 5.602102 22.38630349 0.8210341 0.84183001 1.996647 0.1639333 0.13440000 0.2008333 0.06643333 2.843250e-04 4.870493e-12 FALSE TRUE
ENST00000531668 ENSG00000135387 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPRIN1 protein_coding processed_transcript 74.74 41.68149 111.5096 5.28359 4.477229 1.419473 1.543402 4.078626 0.00000000 3.5035452 0.00000000 -8.675472 0.0315250 0.08133333 0.0000000 -0.08133333 9.864383e-02 4.870493e-12 FALSE FALSE
ENST00000532820 ENSG00000135387 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPRIN1 protein_coding protein_coding 74.74 41.68149 111.5096 5.28359 4.477229 1.419473 19.517865 9.822290 31.23645907 1.9976085 0.90016049 1.668093 0.2552583 0.24226667 0.2807000 0.03843333 7.601216e-01 4.870493e-12 FALSE TRUE
ENST00000533657 ENSG00000135387 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPRIN1 protein_coding processed_transcript 74.74 41.68149 111.5096 5.28359 4.477229 1.419473 1.598510 6.529281 0.09646978 2.5215013 0.05122661 -5.940616 0.0409875 0.16210000 0.0009000 -0.16120000 1.464389e-05 4.870493e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135387 E001 46.1740403 4.631635e-03 2.256402e-08 2.605087e-07 11 34051382 34051730 349 + 1.697 1.364 -1.141
ENSG00000135387 E002 46.0352103 3.687455e-03 1.160253e-08 1.414092e-07 11 34051731 34051731 1 + 1.696 1.364 -1.135
ENSG00000135387 E003 75.8304539 2.211177e-03 5.391865e-15 1.846146e-13 11 34051732 34051750 19 + 1.912 1.542 -1.256
ENSG00000135387 E004 121.2168416 5.389535e-04 1.861713e-31 3.454417e-29 11 34051751 34051871 121 + 2.122 1.684 -1.475
ENSG00000135387 E005 0.0000000       11 34052033 34052054 22 +      
ENSG00000135387 E006 0.0000000       11 34052055 34052162 108 +      
ENSG00000135387 E007 29.8207510 1.398983e-02 4.628875e-02 1.025597e-01 11 34052210 34052328 119 + 1.467 1.355 -0.388
ENSG00000135387 E008 116.9427340 1.914103e-03 8.140469e-10 1.226959e-08 11 34052329 34052420 92 + 2.068 1.872 -0.657
ENSG00000135387 E009 573.4589785 5.752909e-03 2.768618e-16 1.127971e-14 11 34052421 34052636 216 + 2.768 2.505 -0.874
ENSG00000135387 E010 3.6889617 1.517966e-01 6.578588e-01 7.671448e-01 11 34052637 34052867 231 + 0.591 0.711 0.514
ENSG00000135387 E011 2.2037885 6.769588e-03 9.223248e-01 9.549787e-01 11 34052981 34053185 205 + 0.449 0.523 0.364
ENSG00000135387 E012 0.5891098 1.826087e-02 2.394010e-01 3.734264e-01 11 34053451 34053519 69 + 0.237 0.000 -10.113
ENSG00000135387 E013 0.6234514 5.351509e-01 9.467114e-01 9.705478e-01 11 34053522 34053671 150 + 0.189 0.201 0.111
ENSG00000135387 E014 0.0000000       11 34055686 34055737 52 +      
ENSG00000135387 E015 0.0000000       11 34055738 34055740 3 +      
ENSG00000135387 E016 0.0000000       11 34055741 34055805 65 +      
ENSG00000135387 E017 0.3289534 2.974504e-02 4.736481e-01   11 34056486 34056571 86 + 0.072 0.200 1.686
ENSG00000135387 E018 0.1515154 4.385383e-02 1.000000e+00   11 34063052 34063363 312 + 0.072 0.000 -8.114
ENSG00000135387 E019 449.8140900 7.044809e-04 1.902072e-36 5.147741e-34 11 34071726 34071788 63 + 2.656 2.433 -0.746
ENSG00000135387 E020 528.2775030 5.702091e-04 6.810843e-24 6.692395e-22 11 34071901 34071987 87 + 2.708 2.574 -0.447
ENSG00000135387 E021 870.1381958 7.652130e-03 5.128206e-05 2.881832e-04 11 34076236 34076474 239 + 2.916 2.813 -0.344
ENSG00000135387 E022 475.5215420 6.564835e-03 2.982666e-03 1.021194e-02 11 34076560 34076642 83 + 2.642 2.592 -0.170
ENSG00000135387 E023 659.4665771 3.861465e-03 8.916814e-06 5.998379e-05 11 34079628 34079765 138 + 2.790 2.715 -0.249
ENSG00000135387 E024 469.4690079 9.944580e-04 1.802038e-14 5.717478e-13 11 34082825 34082877 53 + 2.651 2.545 -0.353
ENSG00000135387 E025 567.3546907 1.666603e-04 3.600811e-23 3.253042e-21 11 34082955 34083041 87 + 2.731 2.636 -0.316
ENSG00000135387 E026 669.1203928 1.600883e-04 1.384376e-23 1.308059e-21 11 34086064 34086219 156 + 2.799 2.717 -0.275
ENSG00000135387 E027 626.2969772 1.265189e-04 1.957395e-14 6.174204e-13 11 34086305 34086413 109 + 2.762 2.718 -0.144
ENSG00000135387 E028 567.0458702 1.493845e-04 9.960789e-11 1.758004e-09 11 34089395 34089456 62 + 2.715 2.685 -0.098
ENSG00000135387 E029 2.0464109 7.940322e-02 3.816491e-01 5.259534e-01 11 34090026 34090178 153 + 0.477 0.337 -0.768
ENSG00000135387 E030 722.0788023 1.208244e-04 3.530232e-09 4.726111e-08 11 34090179 34090289 111 + 2.814 2.807 -0.021
ENSG00000135387 E031 806.4341407 8.911456e-05 1.746629e-02 4.596894e-02 11 34090529 34090678 150 + 2.845 2.896 0.169
ENSG00000135387 E032 2.3542467 1.272257e-02 5.214623e-01 6.553329e-01 11 34091619 34091905 287 + 0.502 0.440 -0.313
ENSG00000135387 E033 790.4678407 3.317162e-04 2.785406e-02 6.772770e-02 11 34091906 34092056 151 + 2.815 2.932 0.390
ENSG00000135387 E034 1.3619978 9.894440e-03 1.803336e-01 3.015886e-01 11 34095819 34095851 33 + 0.237 0.523 1.687
ENSG00000135387 E035 5.3063349 3.956704e-02 1.956099e-01 3.207319e-01 11 34096160 34096478 319 + 0.666 0.934 1.060
ENSG00000135387 E036 693.1682357 1.427984e-04 2.734434e-02 6.669632e-02 11 34096479 34096592 114 + 2.759 2.876 0.391
ENSG00000135387 E037 464.3711976 2.279435e-03 6.169570e-01 7.348878e-01 11 34096593 34096629 37 + 2.592 2.685 0.309
ENSG00000135387 E038 518.2268963 5.480059e-03 6.486912e-01 7.601542e-01 11 34096630 34096673 44 + 2.638 2.731 0.309
ENSG00000135387 E039 706.1498776 4.863752e-04 1.048449e-01 1.978654e-01 11 34097196 34097296 101 + 2.768 2.879 0.370
ENSG00000135387 E040 591.0389078 4.905541e-04 4.046563e-02 9.187686e-02 11 34097698 34097761 64 + 2.688 2.810 0.405
ENSG00000135387 E041 255.1277887 6.742101e-03 4.391548e-07 3.928257e-06 11 34097762 34099058 1297 + 2.248 2.568 1.066
ENSG00000135387 E042 4366.2108342 4.476516e-03 1.324796e-21 1.011603e-19 11 34099303 34102610 3308 + 3.480 3.794 1.045