ENSG00000135372

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257829 ENSG00000135372 HEK293_OSMI2_2hA HEK293_TMG_2hB NAT10 protein_coding protein_coding 67.70098 85.13266 50.24019 2.847629 0.3812606 -0.7607532 59.16207 77.05017 41.46494 2.445576 0.6608537 -0.8937455 0.8664792 0.9054333 0.8254333 -0.08 0.02208778 0.02208778 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135372 E001 1.7576733 0.0442958963 4.572063e-01 5.975727e-01 11 34105559 34105560 2 + 0.511 0.382 -0.671
ENSG00000135372 E002 3.4977414 0.0129549267 4.892667e-01 6.267122e-01 11 34105561 34105577 17 + 0.703 0.608 -0.405
ENSG00000135372 E003 4.7197779 0.0257419097 2.989981e-01 4.404860e-01 11 34105578 34105589 12 + 0.835 0.696 -0.558
ENSG00000135372 E004 10.6217513 0.0287531717 8.743762e-03 2.564448e-02 11 34105590 34105613 24 + 1.234 0.916 -1.156
ENSG00000135372 E005 15.6290459 0.0116491953 1.193711e-05 7.792188e-05 11 34105614 34105616 3 + 1.432 1.018 -1.467
ENSG00000135372 E006 31.1076801 0.0182454251 4.362003e-06 3.146392e-05 11 34105617 34105628 12 + 1.709 1.304 -1.391
ENSG00000135372 E007 296.3711188 0.0072839753 8.091187e-06 5.487992e-05 11 34105629 34105792 164 + 2.562 2.367 -0.649
ENSG00000135372 E008 2.3085539 0.1008485090 3.188008e-02 7.562149e-02 11 34106029 34106038 10 + 0.741 0.335 -1.955
ENSG00000135372 E009 1.9378705 0.1297405705 2.218607e-02 5.605840e-02 11 34106039 34106074 36 + 0.704 0.234 -2.506
ENSG00000135372 E010 2.6626012 0.0069507494 3.997167e-04 1.773256e-03 11 34106075 34106147 73 + 0.835 0.288 -2.631
ENSG00000135372 E011 11.4451924 0.0098901165 3.127095e-04 1.431447e-03 11 34107053 34107319 267 + 1.278 0.908 -1.341
ENSG00000135372 E012 1.5877094 0.0338278627 5.332861e-01 6.655018e-01 11 34108209 34108210 2 + 0.447 0.339 -0.601
ENSG00000135372 E013 200.9696715 0.0041263154 4.430288e-06 3.191273e-05 11 34108211 34108240 30 + 2.380 2.208 -0.573
ENSG00000135372 E014 353.5337301 0.0026488099 1.179703e-07 1.182556e-06 11 34108241 34108333 93 + 2.613 2.459 -0.513
ENSG00000135372 E015 350.6047865 0.0025085073 4.206965e-08 4.608250e-07 11 34108742 34108833 92 + 2.612 2.455 -0.523
ENSG00000135372 E016 533.8808340 0.0027410092 1.446868e-08 1.731225e-07 11 34112052 34112223 172 + 2.793 2.638 -0.515
ENSG00000135372 E017 446.7567332 0.0014585148 1.745050e-10 2.954374e-09 11 34113716 34113838 123 + 2.711 2.565 -0.488
ENSG00000135372 E018 308.6966048 0.0063964743 3.290097e-03 1.112061e-02 11 34115823 34115884 62 + 2.532 2.416 -0.386
ENSG00000135372 E019 393.7280599 0.0075827770 1.447444e-02 3.930199e-02 11 34118180 34118294 115 + 2.626 2.528 -0.326
ENSG00000135372 E020 355.9574691 0.0054500316 1.468247e-03 5.534209e-03 11 34118396 34118503 108 + 2.593 2.478 -0.381
ENSG00000135372 E021 421.7626199 0.0045869163 2.883295e-05 1.722422e-04 11 34122459 34122592 134 + 2.683 2.541 -0.473
ENSG00000135372 E022 307.7367383 0.0014854704 8.745511e-04 3.525054e-03 11 34123762 34123855 94 + 2.507 2.427 -0.268
ENSG00000135372 E023 342.6477767 0.0035112172 2.189673e-02 5.546484e-02 11 34124302 34124400 99 + 2.545 2.478 -0.223
ENSG00000135372 E024 461.4326105 0.0018207906 1.660176e-02 4.406395e-02 11 34127463 34127599 137 + 2.663 2.612 -0.170
ENSG00000135372 E025 479.0283515 0.0008505940 2.488987e-05 1.510447e-04 11 34130813 34130937 125 + 2.698 2.619 -0.263
ENSG00000135372 E026 531.9195444 0.0005248948 2.979494e-04 1.371204e-03 11 34131381 34131531 151 + 2.728 2.672 -0.188
ENSG00000135372 E027 455.6549968 0.0001597239 5.723638e-06 4.020280e-05 11 34132125 34132221 97 + 2.669 2.600 -0.228
ENSG00000135372 E028 501.6608193 0.0002742407 1.698582e-04 8.344774e-04 11 34133026 34133142 117 + 2.701 2.646 -0.182
ENSG00000135372 E029 461.0690219 0.0006467695 1.745978e-01 2.941750e-01 11 34134319 34134420 102 + 2.638 2.623 -0.052
ENSG00000135372 E030 344.3097056 0.0003751464 1.549436e-01 2.683328e-01 11 34134512 34134586 75 + 2.468 2.514 0.151
ENSG00000135372 E031 463.2453619 0.0003423441 7.877771e-03 2.347263e-02 11 34135175 34135291 117 + 2.583 2.649 0.220
ENSG00000135372 E032 562.1055650 0.0001094060 2.401379e-01 3.742957e-01 11 34136642 34136775 134 + 2.691 2.725 0.111
ENSG00000135372 E033 427.4250089 0.0001256244 1.258891e-01 2.284165e-01 11 34136978 34137026 49 + 2.605 2.591 -0.049
ENSG00000135372 E034 12.4243769 0.0107938633 1.375547e-03 5.226805e-03 11 34138872 34139190 319 + 1.289 0.967 -1.158
ENSG00000135372 E035 521.6598775 0.0001460113 8.673758e-01 9.187171e-01 11 34139191 34139287 97 + 2.673 2.684 0.036
ENSG00000135372 E036 542.2364642 0.0001467373 8.769371e-03 2.570606e-02 11 34139385 34139495 111 + 2.657 2.715 0.196
ENSG00000135372 E037 0.5848434 0.0233394619 6.663213e-03 2.034762e-02 11 34139496 34139511 16 + 0.447 0.000 -13.298
ENSG00000135372 E038 650.3052522 0.0001328118 8.730781e-04 3.520016e-03 11 34140400 34140572 173 + 2.731 2.798 0.221
ENSG00000135372 E039 328.3033791 0.0008681852 2.504656e-03 8.777601e-03 11 34141089 34141115 27 + 2.417 2.509 0.305
ENSG00000135372 E040 588.4504553 0.0002089598 1.163869e-08 1.417951e-07 11 34141116 34141208 93 + 2.654 2.767 0.375
ENSG00000135372 E041 789.7789189 0.0010002723 1.442090e-05 9.232524e-05 11 34141719 34141817 99 + 2.788 2.890 0.340
ENSG00000135372 E042 7.1421587 0.0387622854 2.367530e-03 8.360451e-03 11 34141987 34142274 288 + 1.133 0.715 -1.590
ENSG00000135372 E043 761.3100963 0.0024008383 2.285339e-03 8.106019e-03 11 34142275 34142348 74 + 2.775 2.873 0.325
ENSG00000135372 E044 833.6460895 0.0024191822 2.399494e-04 1.133156e-03 11 34143445 34143528 84 + 2.803 2.916 0.377
ENSG00000135372 E045 569.9436887 0.0016838290 1.767534e-06 1.390994e-05 11 34146084 34146105 22 + 2.621 2.757 0.456
ENSG00000135372 E046 1979.1073655 0.0038482757 1.458151e-11 2.955412e-10 11 34146106 34146719 614 + 3.101 3.314 0.708
ENSG00000135372 E047 544.7384478 0.0065590490 2.158522e-07 2.055728e-06 11 34146720 34146857 138 + 2.519 2.761 0.807
ENSG00000135372 E048 165.1939125 0.0049810114 4.491104e-05 2.559184e-04 11 34146858 34146909 52 + 2.031 2.241 0.701
ENSG00000135372 E049 10.0496805 0.0016608604 4.353362e-03 1.413131e-02 11 34146910 34147011 102 + 1.187 0.907 -1.024
ENSG00000135372 E050 13.1321055 0.0048774958 3.819779e-06 2.791939e-05 11 34147543 34147666 124 + 1.362 0.932 -1.543
ENSG00000135372 E051 0.2966881 0.0271331725 7.358146e-02   11 34147667 34147670 4 + 0.278 0.000 -12.298
ENSG00000135372 E052 18.7339696 0.0094314999 5.467872e-07 4.800593e-06 11 34149046 34149286 241 + 1.511 1.074 -1.535