ENSG00000135362

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378867 ENSG00000135362 HEK293_OSMI2_2hA HEK293_TMG_2hB PRR5L protein_coding protein_coding 1.049843 1.094344 1.097749 0.1119408 0.2293667 0.004440675 0.19145128 0.24573541 0.00000000 0.12296844 0.00000000 -4.676580 0.18837917 0.20820000 0.00000000 -0.20820000 1.590719e-01 3.390047e-08 FALSE TRUE
ENST00000526682 ENSG00000135362 HEK293_OSMI2_2hA HEK293_TMG_2hB PRR5L protein_coding protein_coding 1.049843 1.094344 1.097749 0.1119408 0.2293667 0.004440675 0.14167784 0.19358012 0.00000000 0.13212092 0.00000000 -4.347525 0.12808333 0.16423333 0.00000000 -0.16423333 1.505389e-01 3.390047e-08   FALSE
ENST00000527487 ENSG00000135362 HEK293_OSMI2_2hA HEK293_TMG_2hB PRR5L protein_coding protein_coding 1.049843 1.094344 1.097749 0.1119408 0.2293667 0.004440675 0.04699547 0.10768524 0.00000000 0.08400848 0.00000000 -3.556861 0.04780000 0.08863333 0.00000000 -0.08863333 2.354813e-01 3.390047e-08 FALSE TRUE
ENST00000527751 ENSG00000135362 HEK293_OSMI2_2hA HEK293_TMG_2hB PRR5L protein_coding processed_transcript 1.049843 1.094344 1.097749 0.1119408 0.2293667 0.004440675 0.02615760 0.00000000 0.20926082 0.00000000 0.20926082 4.454576 0.01695833 0.00000000 0.13566667 0.13566667 7.826967e-01 3.390047e-08   FALSE
ENST00000530050 ENSG00000135362 HEK293_OSMI2_2hA HEK293_TMG_2hB PRR5L protein_coding protein_coding 1.049843 1.094344 1.097749 0.1119408 0.2293667 0.004440675 0.05751952 0.06615104 0.00000000 0.06615104 0.00000000 -2.928864 0.05791250 0.05106667 0.00000000 -0.05106667 7.208822e-01 3.390047e-08   FALSE
ENST00000530252 ENSG00000135362 HEK293_OSMI2_2hA HEK293_TMG_2hB PRR5L protein_coding protein_coding 1.049843 1.094344 1.097749 0.1119408 0.2293667 0.004440675 0.07144242 0.04962123 0.00000000 0.04962123 0.00000000 -2.575826 0.05504167 0.05463333 0.00000000 -0.05463333 7.362018e-01 3.390047e-08   FALSE
ENST00000530639 ENSG00000135362 HEK293_OSMI2_2hA HEK293_TMG_2hB PRR5L protein_coding protein_coding 1.049843 1.094344 1.097749 0.1119408 0.2293667 0.004440675 0.23483987 0.26843894 0.37738579 0.16699535 0.00710730 0.476410 0.25543333 0.28213333 0.37086667 0.08873333 7.828508e-01 3.390047e-08 FALSE TRUE
ENST00000531269 ENSG00000135362 HEK293_OSMI2_2hA HEK293_TMG_2hB PRR5L protein_coding processed_transcript 1.049843 1.094344 1.097749 0.1119408 0.2293667 0.004440675 0.07365680 0.00000000 0.37826636 0.00000000 0.04294281 5.278975 0.06615833 0.00000000 0.35760000 0.35760000 3.390047e-08 3.390047e-08   FALSE
ENST00000532578 ENSG00000135362 HEK293_OSMI2_2hA HEK293_TMG_2hB PRR5L protein_coding processed_transcript 1.049843 1.094344 1.097749 0.1119408 0.2293667 0.004440675 0.13339369 0.00000000 0.06951540 0.00000000 0.06951540 2.991234 0.12153333 0.00000000 0.07143333 0.07143333 8.009332e-01 3.390047e-08   FALSE
ENST00000532843 ENSG00000135362 HEK293_OSMI2_2hA HEK293_TMG_2hB PRR5L protein_coding processed_transcript 1.049843 1.094344 1.097749 0.1119408 0.2293667 0.004440675 0.01927985 0.11761758 0.03662124 0.11761758 0.03662124 -1.452768 0.01950000 0.10890000 0.04710000 -0.06180000 9.866233e-01 3.390047e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135362 E001 0.6590396 0.019579047 0.126624384 0.2294440965 11 36296288 36296438 151 + 0.361 0.095 -2.402
ENSG00000135362 E002 0.1515154 0.042952422 0.292082254   11 36297371 36297431 61 + 0.156 0.000 -13.006
ENSG00000135362 E003 0.0000000       11 36300961 36301070 110 +      
ENSG00000135362 E004 1.1845624 0.010920345 0.000129609 0.0006570695 11 36329118 36329341 224 + 0.649 0.000 -15.259
ENSG00000135362 E005 0.0000000       11 36349868 36350065 198 +      
ENSG00000135362 E006 0.0000000       11 36362108 36362181 74 +      
ENSG00000135362 E007 0.0000000       11 36376005 36376037 33 +      
ENSG00000135362 E008 0.0000000       11 36376038 36376158 121 +      
ENSG00000135362 E009 0.0000000       11 36376202 36376237 36 +      
ENSG00000135362 E010 0.1817044 0.039346235 0.785891599   11 36376381 36376381 1 + 0.000 0.095 10.842
ENSG00000135362 E011 0.4751703 0.022243598 0.912796592 0.9487489631 11 36376382 36376400 19 + 0.156 0.173 0.179
ENSG00000135362 E012 0.6568746 0.018932793 0.618037258 0.7357747308 11 36376401 36376401 1 + 0.156 0.239 0.765
ENSG00000135362 E013 1.1416099 0.014260652 0.748203093 0.8354970238 11 36376402 36376543 142 + 0.361 0.297 -0.405
ENSG00000135362 E014 1.4530467 0.096068252 0.327770986 0.4712430847 11 36376544 36376628 85 + 0.501 0.296 -1.149
ENSG00000135362 E015 1.6671024 0.149812855 0.396554349 0.5403079033 11 36376629 36376704 76 + 0.271 0.440 1.015
ENSG00000135362 E016 0.3634088 0.226311885 0.448534616   11 36377522 36377724 203 + 0.000 0.174 11.577
ENSG00000135362 E017 0.7718438 0.059099001 0.619068521 0.7365673582 11 36379381 36379467 87 + 0.156 0.241 0.778
ENSG00000135362 E018 0.2214452 0.039488021 0.784212540   11 36380520 36380588 69 + 0.000 0.095 10.844
ENSG00000135362 E019 0.0000000       11 36381640 36381695 56 +      
ENSG00000135362 E020 2.0617600 0.015468947 0.804288805 0.8754990360 11 36393846 36394011 166 + 0.436 0.472 0.182
ENSG00000135362 E021 0.0000000       11 36394396 36394434 39 +      
ENSG00000135362 E022 0.1515154 0.042952422 0.292082254   11 36396114 36396196 83 + 0.156 0.000 -13.006
ENSG00000135362 E023 0.1515154 0.042952422 0.292082254   11 36398412 36398827 416 + 0.156 0.000 -13.006
ENSG00000135362 E024 3.4894331 0.005283202 0.251502294 0.3877532861 11 36400997 36401064 68 + 0.500 0.670 0.767
ENSG00000135362 E025 5.3568774 0.007100469 0.417206928 0.5605847093 11 36401065 36401285 221 + 0.689 0.790 0.408
ENSG00000135362 E026 3.6553196 0.203282334 0.957946607 0.9776349484 11 36403298 36403378 81 + 0.648 0.633 -0.062
ENSG00000135362 E027 4.2527336 0.032056367 0.794186248 0.8684841958 11 36419255 36419303 49 + 0.726 0.672 -0.225
ENSG00000135362 E028 3.7774762 0.007124945 0.830419255 0.8936020985 11 36431853 36431910 58 + 0.689 0.646 -0.182
ENSG00000135362 E029 4.0127673 0.004557949 0.256397822 0.3933544064 11 36437385 36437476 92 + 0.792 0.621 -0.705
ENSG00000135362 E030 5.9261192 0.003060550 0.806026542 0.8766893798 11 36446300 36446440 141 + 0.848 0.805 -0.168
ENSG00000135362 E031 5.5710147 0.006713806 0.844054889 0.9029157273 11 36451209 36451335 127 + 0.792 0.805 0.052
ENSG00000135362 E032 0.0000000       11 36453950 36453958 9 +      
ENSG00000135362 E033 0.1451727 0.043004819 0.292847872   11 36453959 36454021 63 + 0.156 0.000 -13.005
ENSG00000135362 E034 0.1451727 0.043004819 0.292847872   11 36454022 36454106 85 + 0.156 0.000 -13.005
ENSG00000135362 E035 0.0000000       11 36454669 36454818 150 +      
ENSG00000135362 E036 0.0000000       11 36455289 36455446 158 +      
ENSG00000135362 E037 41.8390582 0.026337262 0.386449303 0.5306346390 11 36462342 36465204 2863 + 1.577 1.615 0.128