ENSG00000135341

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369327 ENSG00000135341 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K7 protein_coding protein_coding 20.09059 6.269307 31.72669 0.215703 0.7772434 2.337474 2.118076 0.5650219 1.130142 0.2215483 0.6221878 0.9875244 0.09965833 0.0926000 0.0347000 -0.0579000 6.290493e-01 5.004203e-16 FALSE TRUE
ENST00000369332 ENSG00000135341 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K7 protein_coding protein_coding 20.09059 6.269307 31.72669 0.215703 0.7772434 2.337474 5.183134 3.3031367 10.600827 0.6467606 0.4614479 1.6792675 0.30147083 0.5251333 0.3338333 -0.1913000 2.583079e-01 5.004203e-16 FALSE TRUE
MSTRG.28649.11 ENSG00000135341 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K7 protein_coding   20.09059 6.269307 31.72669 0.215703 0.7772434 2.337474 1.731321 0.0000000 3.882564 0.0000000 0.2053595 8.6045770 0.05657917 0.0000000 0.1228000 0.1228000 5.004203e-16 5.004203e-16 FALSE TRUE
MSTRG.28649.8 ENSG00000135341 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K7 protein_coding   20.09059 6.269307 31.72669 0.215703 0.7772434 2.337474 8.230266 1.5815099 11.902142 0.4228599 0.1690637 2.9039649 0.39519167 0.2529667 0.3755000 0.1225333 3.882031e-01 5.004203e-16 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135341 E001 0.5117019 0.0449089698 4.695976e-03 1.508501e-02 6 90513573 90513578 6 - 0.000 0.467 12.405
ENSG00000135341 E002 6.3736588 0.0573989556 1.902787e-03 6.923336e-03 6 90513579 90513628 50 - 0.633 1.137 1.945
ENSG00000135341 E003 27.4020773 0.0373390917 7.553065e-05 4.067961e-04 6 90513629 90513652 24 - 1.226 1.691 1.603
ENSG00000135341 E004 53.5234655 0.0204328478 1.312537e-06 1.062679e-05 6 90513653 90513733 81 - 1.524 1.956 1.463
ENSG00000135341 E005 72.6038316 0.0103774940 3.941937e-09 5.234007e-08 6 90513734 90513818 85 - 1.665 2.072 1.370
ENSG00000135341 E006 314.7679367 0.0012145492 3.306806e-06 2.453356e-05 6 90513819 90515040 1222 - 2.392 2.533 0.470
ENSG00000135341 E007 36.9564989 0.0127816452 1.977628e-01 3.234322e-01 6 90515041 90515092 52 - 1.474 1.606 0.451
ENSG00000135341 E008 22.4970209 0.0011867992 7.786223e-01 8.575628e-01 6 90515093 90515109 17 - 1.302 1.294 -0.029
ENSG00000135341 E009 100.5576857 0.0003227661 5.516279e-01 6.810448e-01 6 90515110 90515625 516 - 1.937 1.928 -0.029
ENSG00000135341 E010 20.9491105 0.0042812780 6.290293e-01 7.444818e-01 6 90515626 90515633 8 - 1.261 1.321 0.210
ENSG00000135341 E011 23.1339715 0.0115890120 5.457848e-01 6.760600e-01 6 90515634 90515663 30 - 1.298 1.371 0.254
ENSG00000135341 E012 20.9906903 0.0111653076 8.034407e-01 8.748826e-01 6 90515664 90515682 19 - 1.269 1.307 0.134
ENSG00000135341 E013 121.4319048 0.0002720685 1.532156e-10 2.620169e-09 6 90515683 90515907 225 - 1.950 2.190 0.805
ENSG00000135341 E014 162.6413310 0.0002439669 2.536388e-16 1.039393e-14 6 90515908 90516131 224 - 2.067 2.329 0.877
ENSG00000135341 E015 139.8642147 0.0016165006 1.061288e-07 1.072995e-06 6 90516132 90516283 152 - 2.019 2.234 0.718
ENSG00000135341 E016 290.0239408 0.0002312950 5.843620e-04 2.475916e-03 6 90516284 90516681 398 - 2.369 2.467 0.326
ENSG00000135341 E017 150.3670050 0.0002263471 7.005998e-01 8.000342e-01 6 90518447 90518562 116 - 2.108 2.111 0.011
ENSG00000135341 E018 126.7953617 0.0002786065 2.522127e-01 3.885419e-01 6 90519258 90519319 62 - 2.041 2.015 -0.089
ENSG00000135341 E019 138.4560429 0.0002763169 1.459687e-03 5.506108e-03 6 90523678 90523783 106 - 2.097 1.995 -0.342
ENSG00000135341 E020 115.8355628 0.0005737421 5.383781e-03 1.697045e-02 6 90536337 90536401 65 - 2.020 1.921 -0.331
ENSG00000135341 E021 9.4570360 0.0018566201 1.025306e-01 1.943637e-01 6 90536402 90537218 817 - 0.995 0.789 -0.784
ENSG00000135341 E022 6.5401937 0.0635090090 6.335738e-01 7.482477e-01 6 90544552 90544632 81 - 0.831 0.744 -0.346
ENSG00000135341 E023 143.7524712 0.0002201558 9.143371e-04 3.664602e-03 6 90547258 90547387 130 - 2.114 2.009 -0.350
ENSG00000135341 E024 142.8937750 0.0002826816 9.705030e-05 5.082484e-04 6 90548047 90548177 131 - 2.115 1.987 -0.431
ENSG00000135341 E025 121.8959879 0.0002516344 3.602241e-05 2.099054e-04 6 90550468 90550549 82 - 2.049 1.897 -0.509
ENSG00000135341 E026 16.7678241 0.0205558805 5.381065e-03 1.696274e-02 6 90550550 90552048 1499 - 1.242 0.873 -1.347
ENSG00000135341 E027 143.5394673 0.0002458201 6.815191e-05 3.712294e-04 6 90552049 90552179 131 - 2.116 1.984 -0.442
ENSG00000135341 E028 134.8966537 0.0021103060 1.890308e-05 1.179051e-04 6 90553458 90553582 125 - 2.097 1.919 -0.595
ENSG00000135341 E029 59.5969990 0.0003901536 1.616341e-05 1.024083e-04 6 90553583 90553586 4 - 1.758 1.513 -0.832
ENSG00000135341 E030 127.3421698 0.0009428389 1.157879e-06 9.485694e-06 6 90556500 90556624 125 - 2.076 1.883 -0.646
ENSG00000135341 E031 114.4604486 0.0035588592 2.017876e-03 7.281811e-03 6 90560076 90560214 139 - 2.021 1.877 -0.485
ENSG00000135341 E032 59.1180703 0.0004211117 7.389697e-03 2.223105e-02 6 90561622 90561667 46 - 1.737 1.598 -0.471
ENSG00000135341 E033 79.8025317 0.0003540343 3.447125e-04 1.558846e-03 6 90568558 90568623 66 - 1.869 1.704 -0.557
ENSG00000135341 E034 116.9774840 0.0004271435 5.540111e-09 7.173310e-08 6 90571697 90571807 111 - 2.046 1.807 -0.804
ENSG00000135341 E035 140.3211632 0.0003127859 1.288398e-07 1.281276e-06 6 90586764 90587073 310 - 2.117 1.928 -0.632