ENSG00000135315

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000403245 ENSG00000135315 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP162 protein_coding protein_coding 2.128635 0.7351208 3.495872 0.098061 0.4559516 2.234227 1.19981433 0.12266102 1.8877166 0.06391306 0.0657233 3.8384482 0.47515833 0.19343333 0.5575333 0.36410000 0.117347009 0.001518953 FALSE TRUE
ENST00000435955 ENSG00000135315 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP162 protein_coding nonsense_mediated_decay 2.128635 0.7351208 3.495872 0.098061 0.4559516 2.234227 0.15311932 0.03201461 0.4927441 0.03201461 0.2993808 3.5808613 0.04974583 0.03443333 0.1226667 0.08823333 0.770652711 0.001518953   FALSE
ENST00000461137 ENSG00000135315 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP162 protein_coding processed_transcript 2.128635 0.7351208 3.495872 0.098061 0.4559516 2.234227 0.01916034 0.12223527 0.0000000 0.12223527 0.0000000 -3.7250352 0.01966667 0.13140000 0.0000000 -0.13140000 0.477702107 0.001518953 FALSE TRUE
ENST00000487999 ENSG00000135315 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP162 protein_coding retained_intron 2.128635 0.7351208 3.495872 0.098061 0.4559516 2.234227 0.63380313 0.44851723 0.8664025 0.02881437 0.1664348 0.9346176 0.38462917 0.63030000 0.2434333 -0.38686667 0.001518953 0.001518953 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135315 E001 0.4386386 0.159599611 3.862206e-01 0.5304113170 6 84124241 84124241 1 - 0.101 0.255 1.606
ENSG00000135315 E002 0.5901540 0.020535058 5.486849e-01 0.6785186835 6 84124242 84124249 8 - 0.144 0.256 1.030
ENSG00000135315 E003 13.7926389 0.002521373 5.246935e-04 0.0022518601 6 84124250 84124954 705 - 0.968 1.325 1.283
ENSG00000135315 E004 18.5896203 0.021576563 4.558042e-05 0.0002593972 6 84124955 84125276 322 - 1.061 1.491 1.514
ENSG00000135315 E005 17.8985699 0.001127786 8.778560e-05 0.0004646620 6 84126378 84126512 135 - 1.071 1.428 1.259
ENSG00000135315 E006 13.1461168 0.001530861 3.764746e-04 0.0016832336 6 84146687 84146785 99 - 0.936 1.309 1.344
ENSG00000135315 E007 12.8248350 0.034273484 1.842058e-01 0.3065113643 6 84149562 84149703 142 - 0.986 1.167 0.654
ENSG00000135315 E008 37.8492464 0.005659038 1.640958e-01 0.2804891570 6 84152545 84153179 635 - 1.442 1.552 0.376
ENSG00000135315 E009 15.9859547 0.003366854 3.735069e-01 0.5179425250 6 84155298 84155510 213 - 1.090 1.190 0.360
ENSG00000135315 E010 0.5879639 0.020471518 5.492086e-01 0.6789692092 6 84155511 84155594 84 - 0.144 0.256 1.030
ENSG00000135315 E011 8.5830963 0.001927428 8.865450e-02 0.1730707284 6 84160812 84160916 105 - 0.901 0.626 -1.112
ENSG00000135315 E012 11.0788541 0.001861154 4.367100e-01 0.5787454524 6 84161746 84161909 164 - 0.974 0.872 -0.383
ENSG00000135315 E013 10.0152248 0.002300890 6.925246e-01 0.7937403742 6 84163144 84163270 127 - 0.922 0.872 -0.189
ENSG00000135315 E014 8.2443114 0.036034392 3.407943e-01 0.4847311660 6 84169328 84169433 106 - 0.871 0.704 -0.662
ENSG00000135315 E015 9.1896976 0.001960181 1.812248e-02 0.0473917715 6 84171606 84171718 113 - 0.936 0.534 -1.656
ENSG00000135315 E016 10.6135980 0.001737315 5.234500e-01 0.6571464687 6 84174048 84174188 141 - 0.955 0.872 -0.314
ENSG00000135315 E017 5.5306037 0.003004555 9.592758e-01 0.9784579181 6 84174727 84174771 45 - 0.705 0.702 -0.016
ENSG00000135315 E018 8.8908565 0.001923709 5.991076e-01 0.7205774964 6 84174772 84174954 183 - 0.894 0.822 -0.277
ENSG00000135315 E019 0.0000000       6 84175210 84175213 4 -      
ENSG00000135315 E020 6.9673959 0.002481747 2.544934e-01 0.3911901682 6 84175214 84175347 134 - 0.814 0.626 -0.776
ENSG00000135315 E021 10.5157820 0.007467714 5.342729e-01 0.6663489330 6 84185187 84185448 262 - 0.955 0.872 -0.314
ENSG00000135315 E022 11.9199263 0.002000251 1.465267e-01 0.2569639671 6 84186332 84186623 292 - 1.020 0.822 -0.746
ENSG00000135315 E023 5.4648160 0.008605002 1.801800e-02 0.0471719533 6 84193609 84193690 82 - 0.758 0.257 -2.554
ENSG00000135315 E024 11.9869912 0.033163729 1.287396e-03 0.0049346241 6 84194884 84195075 192 - 1.051 0.418 -2.663
ENSG00000135315 E025 8.6903650 0.035888259 1.342527e-02 0.0369056824 6 84200789 84200905 117 - 0.922 0.418 -2.187
ENSG00000135315 E026 4.1581105 0.006796423 6.193810e-02 0.1298811968 6 84201737 84201767 31 - 0.658 0.257 -2.138
ENSG00000135315 E027 6.6212894 0.011693473 1.354778e-01 0.2417840982 6 84203981 84204096 116 - 0.805 0.534 -1.156
ENSG00000135315 E028 5.8526772 0.002797085 4.629507e-01 0.6028057525 6 84212957 84213024 68 - 0.748 0.626 -0.514
ENSG00000135315 E029 9.5987917 0.018829293 1.441765e-01 0.2536877788 6 84215282 84215407 126 - 0.943 0.701 -0.948
ENSG00000135315 E030 6.5766799 0.056974229 7.064071e-02 0.1444043290 6 84215408 84215465 58 - 0.814 0.417 -1.774
ENSG00000135315 E031 10.5963391 0.003175512 5.694514e-03 0.0178024163 6 84215776 84215922 147 - 0.997 0.534 -1.887
ENSG00000135315 E032 0.0000000       6 84215923 84215966 44 -      
ENSG00000135315 E033 0.1472490 0.042867982 9.538915e-01   6 84217799 84217860 62 - 0.054 0.001 -5.719
ENSG00000135315 E034 2.0225647 0.355292345 6.836447e-01 0.7867860821 6 84219103 84219214 112 - 0.413 0.261 -0.947
ENSG00000135315 E035 0.0000000       6 84221045 84221056 12 -      
ENSG00000135315 E036 10.1255545 0.002231079 3.596132e-01 0.5039473430 6 84221057 84221171 115 - 0.949 0.822 -0.483
ENSG00000135315 E037 8.0263786 0.002163675 2.945003e-01 0.4355805229 6 84226337 84226452 116 - 0.864 0.702 -0.647
ENSG00000135315 E038 4.9438002 0.003681700 1.383725e-01 0.2458282374 6 84227580 84227643 64 - 0.705 0.417 -1.338