ENSG00000135299

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339746 ENSG00000135299 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD6 protein_coding protein_coding 2.735274 2.544549 2.972643 0.4546267 0.2924473 0.2235227 0.6347246 0.11943340 1.41791585 0.11943340 0.07095933 3.4636291 0.23562500 0.06190000 0.48990000 0.42800000 3.357381e-02 1.451929e-11 FALSE TRUE
ENST00000447838 ENSG00000135299 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD6 protein_coding protein_coding 2.735274 2.544549 2.972643 0.4546267 0.2924473 0.2235227 0.1758648 0.61146116 0.00000000 0.04065298 0.00000000 -5.9575923 0.06939583 0.25153333 0.00000000 -0.25153333 1.451929e-11 1.451929e-11 FALSE TRUE
ENST00000485637 ENSG00000135299 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD6 protein_coding protein_coding 2.735274 2.544549 2.972643 0.4546267 0.2924473 0.2235227 0.1279677 0.03986624 0.03480761 0.02272681 0.03480761 -0.1543197 0.05197500 0.01470000 0.00980000 -0.00490000 8.399572e-01 1.451929e-11 FALSE TRUE
ENST00000518150 ENSG00000135299 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD6 protein_coding protein_coding 2.735274 2.544549 2.972643 0.4546267 0.2924473 0.2235227 0.4537961 0.14517130 0.35500093 0.14517130 0.17956170 1.2340384 0.15737500 0.06386667 0.11593333 0.05206667 6.612906e-01 1.451929e-11 FALSE FALSE
ENST00000521004 ENSG00000135299 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD6 protein_coding protein_coding 2.735274 2.544549 2.972643 0.4546267 0.2924473 0.2235227 0.3794561 0.65042916 0.17897597 0.31594401 0.11004968 -1.8052011 0.13552500 0.23760000 0.06620000 -0.17140000 3.399757e-01 1.451929e-11 FALSE TRUE
MSTRG.28650.5 ENSG00000135299 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD6 protein_coding   2.735274 2.544549 2.972643 0.4546267 0.2924473 0.2235227 0.2171737 0.44287392 0.22392321 0.12391355 0.07592374 -0.9530745 0.08826250 0.17236667 0.07213333 -0.10023333 1.073459e-01 1.451929e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135299 E001 0.2944980 0.3183679975 0.3701188522   6 89433152 89433169 18 + 0.193 0.000 -9.995
ENSG00000135299 E002 1.0457324 0.0130557355 0.0098864296 0.028484015 6 89433170 89433203 34 + 0.472 0.000 -14.454
ENSG00000135299 E003 1.3381542 0.0099350423 0.0028616189 0.009857754 6 89433204 89433212 9 + 0.547 0.000 -14.752
ENSG00000135299 E004 5.4691790 0.0044183768 0.0002810582 0.001302709 6 89433213 89433350 138 + 0.974 0.461 -2.153
ENSG00000135299 E005 4.6909012 0.0035690919 0.0242693545 0.060368908 6 89433351 89433375 25 + 0.872 0.562 -1.285
ENSG00000135299 E006 0.0000000       6 89483403 89483558 156 +      
ENSG00000135299 E007 0.0000000       6 89504957 89505003 47 +      
ENSG00000135299 E008 0.0000000       6 89508846 89508958 113 +      
ENSG00000135299 E009 0.0000000       6 89509153 89509249 97 +      
ENSG00000135299 E010 0.0000000       6 89562401 89562630 230 +      
ENSG00000135299 E011 0.0000000       6 89562631 89562785 155 +      
ENSG00000135299 E012 0.0000000       6 89562786 89562844 59 +      
ENSG00000135299 E013 0.0000000       6 89562845 89562898 54 +      
ENSG00000135299 E014 0.0000000       6 89562899 89562923 25 +      
ENSG00000135299 E015 9.8956164 0.0017197803 0.2166208392 0.346325345 6 89566834 89566929 96 + 1.087 0.969 -0.432
ENSG00000135299 E016 10.4826328 0.0017145949 0.6776709369 0.782325391 6 89566930 89566975 46 + 1.066 1.035 -0.116
ENSG00000135299 E017 15.1182879 0.0013111099 0.5052622415 0.641072216 6 89566976 89567096 121 + 1.223 1.176 -0.167
ENSG00000135299 E018 12.7535589 0.0156285573 0.9220241076 0.954793523 6 89595916 89596014 99 + 1.125 1.143 0.062
ENSG00000135299 E019 0.0000000       6 89602993 89603028 36 +      
ENSG00000135299 E020 16.5482951 0.0127418759 0.4507208068 0.591774294 6 89603029 89603127 99 + 1.271 1.208 -0.224
ENSG00000135299 E021 15.1446390 0.0225751565 0.8224177678 0.888037504 6 89606007 89606105 99 + 1.193 1.234 0.147
ENSG00000135299 E022 14.5340106 0.0012585607 0.6850298304 0.787836815 6 89612272 89612370 99 + 1.200 1.176 -0.087
ENSG00000135299 E023 6.0432560 0.0027401081 0.7414025616 0.830592364 6 89613792 89613792 1 + 0.820 0.871 0.197
ENSG00000135299 E024 11.4893393 0.0016979932 0.6884823989 0.790598697 6 89613793 89613890 98 + 1.106 1.078 -0.103
ENSG00000135299 E025 0.5202097 0.0201865770 0.7380228782 0.828020445 6 89616398 89616558 161 + 0.193 0.139 -0.567
ENSG00000135299 E026 13.4665835 0.0020173701 0.5942877908 0.716547158 6 89616559 89616657 99 + 1.168 1.130 -0.138
ENSG00000135299 E027 0.1817044 0.0395321911 0.3764350261   6 89616874 89616956 83 + 0.000 0.139 11.470
ENSG00000135299 E028 11.3159001 0.0021731870 0.7774009710 0.856755566 6 89617954 89618031 78 + 1.066 1.104 0.138
ENSG00000135299 E029 1.0059890 0.0154358530 0.7392793698 0.828969451 6 89618032 89618410 379 + 0.265 0.329 0.431
ENSG00000135299 E030 2.0315328 0.0086401921 0.9184859631 0.952473777 6 89621214 89621865 652 + 0.472 0.461 -0.052
ENSG00000135299 E031 1.1187827 0.0131112439 0.4315657485 0.574108815 6 89621866 89621921 56 + 0.381 0.244 -0.891
ENSG00000135299 E032 15.3434172 0.0012042619 0.7756327180 0.855459650 6 89621922 89622026 105 + 1.192 1.227 0.123
ENSG00000135299 E033 18.6367419 0.0010092176 0.9568076764 0.976913488 6 89623410 89623544 135 + 1.284 1.299 0.052
ENSG00000135299 E034 13.9328627 0.0013508828 0.0354754396 0.082568131 6 89623872 89623966 95 + 1.244 1.064 -0.644
ENSG00000135299 E035 14.3515896 0.0030626660 0.2530649816 0.389528604 6 89623967 89624057 91 + 1.223 1.130 -0.331
ENSG00000135299 E036 23.8364515 0.0014393338 0.2484488562 0.384099122 6 89624539 89624655 117 + 1.423 1.353 -0.244
ENSG00000135299 E037 15.1419044 0.0013123444 0.7070021096 0.805030885 6 89624656 89624691 36 + 1.185 1.227 0.151
ENSG00000135299 E038 24.6039123 0.0009000714 0.3432604577 0.487310702 6 89627583 89627696 114 + 1.370 1.444 0.259
ENSG00000135299 E039 0.5891098 0.0193874923 0.0673778122 0.138992600 6 89628247 89628285 39 + 0.327 0.000 -13.754
ENSG00000135299 E040 0.2987644 0.0274424043 0.2859288718   6 89628286 89628341 56 + 0.193 0.000 -12.827
ENSG00000135299 E041 0.4386386 0.2108317175 0.7660776062 0.848675241 6 89628782 89629111 330 + 0.193 0.138 -0.583
ENSG00000135299 E042 20.2843780 0.0024291785 0.2566764908 0.393647009 6 89629112 89629223 112 + 1.284 1.381 0.338
ENSG00000135299 E043 7.2640710 0.0060836401 0.1912124692 0.315254457 6 89629224 89629238 15 + 0.838 1.002 0.621
ENSG00000135299 E044 2.5638838 0.0079072973 0.0041219083 0.013483728 6 89629239 89629476 238 + 0.265 0.743 2.431
ENSG00000135299 E045 128.5104602 0.0106878795 0.0772411984 0.155067389 6 89630433 89633834 3402 + 2.067 2.160 0.311