ENSG00000135185

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257637 ENSG00000135185 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM243 protein_coding protein_coding 21.13219 17.32449 28.75907 2.083546 1.028222 0.7308736 8.6893706 8.4976380 11.3035317 1.8196341 2.1677724 0.41121880 0.41879583 0.4779667 0.38883333 -0.08913333 6.208261e-01 9.322991e-08 FALSE  
ENST00000433078 ENSG00000135185 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM243 protein_coding protein_coding 21.13219 17.32449 28.75907 2.083546 1.028222 0.7308736 7.9907502 6.2893932 12.8373641 0.5140515 0.4451749 1.02818763 0.36727500 0.3703333 0.44846667 0.07813333 4.622338e-01 9.322991e-08 FALSE  
ENST00000455575 ENSG00000135185 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM243 protein_coding protein_coding 21.13219 17.32449 28.75907 2.083546 1.028222 0.7308736 1.2127380 1.1456408 0.9136423 0.3225133 0.1603154 -0.32328685 0.06102917 0.0680000 0.03213333 -0.03586667 2.896226e-01 9.322991e-08    
MSTRG.30167.1 ENSG00000135185 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM243 protein_coding   21.13219 17.32449 28.75907 2.083546 1.028222 0.7308736 1.3673694 0.9240336 0.9453442 0.2491237 0.4224950 0.03254623 0.06282500 0.0589000 0.03310000 -0.02580000 6.367082e-01 9.322991e-08 FALSE  
MSTRG.30167.5 ENSG00000135185 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM243 protein_coding   21.13219 17.32449 28.75907 2.083546 1.028222 0.7308736 0.8675876 0.0000000 2.0364290 0.0000000 0.5473955 7.67696483 0.03629583 0.0000000 0.07230000 0.07230000 9.322991e-08 9.322991e-08    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135185 E001 2.3552909 0.0077749466 0.25163364 0.38789902 7 87196160 87196161 2 - 0.598 0.410 -0.916
ENSG00000135185 E002 230.9186347 0.0043238425 0.04051293 0.09195976 7 87196162 87196599 438 - 2.330 2.405 0.252
ENSG00000135185 E003 171.6951246 0.0021875852 0.70618361 0.80437447 7 87196600 87196712 113 - 2.230 2.246 0.056
ENSG00000135185 E004 148.0770861 0.0025979297 0.35301384 0.49725942 7 87196713 87196758 46 - 2.182 2.154 -0.096
ENSG00000135185 E005 0.5963950 0.2328768271 0.29856268 0.44001559 7 87197701 87197717 17 - 0.104 0.330 2.076
ENSG00000135185 E006 2.2915003 0.0287763867 0.72957364 0.82173817 7 87197718 87197940 223 - 0.499 0.572 0.340
ENSG00000135185 E007 147.4855141 0.0003253027 0.19736569 0.32293183 7 87197941 87197982 42 - 2.182 2.152 -0.101
ENSG00000135185 E008 157.6505318 0.0002807802 0.63779844 0.75160255 7 87197983 87198045 63 - 2.201 2.196 -0.019
ENSG00000135185 E009 0.8856962 0.0133085364 0.69426245 0.79512704 7 87198228 87199006 779 - 0.318 0.251 -0.459
ENSG00000135185 E010 137.4390550 0.0002673615 0.85364364 0.90945004 7 87199007 87199057 51 - 2.141 2.144 0.007
ENSG00000135185 E011 4.9343167 0.0512235344 0.54003323 0.67123092 7 87199058 87199613 556 - 0.726 0.834 0.431
ENSG00000135185 E012 0.4417591 0.0455910034 0.39282544 0.53672617 7 87202964 87203043 80 - 0.104 0.251 1.535
ENSG00000135185 E013 0.0000000       7 87216740 87216921 182 -      
ENSG00000135185 E014 125.0194587 0.0024321274 0.96432446 0.98151621 7 87219426 87219488 63 - 2.099 2.107 0.027
ENSG00000135185 E015 184.2153334 0.0020396081 0.75787223 0.84256107 7 87219489 87219718 230 - 2.269 2.265 -0.015
ENSG00000135185 E016 6.9428696 0.0028531444 0.59110725 0.71391182 7 87219719 87219732 14 - 0.857 0.928 0.268
ENSG00000135185 E017 14.3379657 0.0510536403 0.42812265 0.57092870 7 87220217 87220360 144 - 1.119 1.234 0.410
ENSG00000135185 E018 69.3057228 0.0005278534 0.17992998 0.30109703 7 87220361 87220523 163 - 1.868 1.818 -0.168
ENSG00000135185 E019 22.0470326 0.0009063062 0.19594520 0.32115402 7 87220524 87220613 90 - 1.402 1.315 -0.305