ENSG00000135164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331242 ENSG00000135164 HEK293_OSMI2_2hA HEK293_TMG_2hB DMTF1 protein_coding protein_coding 22.7863 8.606166 27.27679 0.7116631 1.156071 1.663085 2.383551 0.56092330 4.1138504 0.28453488 0.8496566 2.85262316 0.09254167 0.061400000 0.15050000 0.08910000 4.666236e-01 8.879204e-27 FALSE TRUE
ENST00000454008 ENSG00000135164 HEK293_OSMI2_2hA HEK293_TMG_2hB DMTF1 protein_coding protein_coding 22.7863 8.606166 27.27679 0.7116631 1.156071 1.663085 1.420216 2.26879868 0.0000000 0.44739642 0.0000000 -7.83212967 0.11577500 0.260100000 0.00000000 -0.26010000 8.879204e-27 8.879204e-27 FALSE TRUE
ENST00000488352 ENSG00000135164 HEK293_OSMI2_2hA HEK293_TMG_2hB DMTF1 protein_coding retained_intron 22.7863 8.606166 27.27679 0.7116631 1.156071 1.663085 1.343110 0.13269788 1.8765214 0.05386372 0.2611261 3.72469260 0.05633333 0.016133333 0.06980000 0.05366667 6.567133e-03 8.879204e-27 FALSE TRUE
ENST00000580803 ENSG00000135164 HEK293_OSMI2_2hA HEK293_TMG_2hB DMTF1 protein_coding retained_intron 22.7863 8.606166 27.27679 0.7116631 1.156071 1.663085 1.987261 0.22689795 2.0004773 0.04567335 0.3534351 3.08520042 0.07699583 0.026133333 0.07256667 0.04643333 9.844134e-03 8.879204e-27 FALSE TRUE
ENST00000582887 ENSG00000135164 HEK293_OSMI2_2hA HEK293_TMG_2hB DMTF1 protein_coding retained_intron 22.7863 8.606166 27.27679 0.7116631 1.156071 1.663085 1.063148 0.03566004 1.9069312 0.03566004 0.4413666 5.39172272 0.03632083 0.003633333 0.07133333 0.06770000 3.105342e-03 8.879204e-27 FALSE TRUE
ENST00000583751 ENSG00000135164 HEK293_OSMI2_2hA HEK293_TMG_2hB DMTF1 protein_coding processed_transcript 22.7863 8.606166 27.27679 0.7116631 1.156071 1.663085 1.376582 2.16103540 2.1878316 0.80123041 0.7850837 0.01769762 0.07274583 0.244766667 0.07850000 -0.16626667 1.240170e-01 8.879204e-27   FALSE
MSTRG.30166.10 ENSG00000135164 HEK293_OSMI2_2hA HEK293_TMG_2hB DMTF1 protein_coding   22.7863 8.606166 27.27679 0.7116631 1.156071 1.663085 0.541167 0.03425741 1.8809394 0.03425741 0.5258501 5.41704042 0.01780417 0.004666667 0.06763333 0.06296667 3.171248e-04 8.879204e-27 FALSE TRUE
MSTRG.30166.17 ENSG00000135164 HEK293_OSMI2_2hA HEK293_TMG_2hB DMTF1 protein_coding   22.7863 8.606166 27.27679 0.7116631 1.156071 1.663085 1.828469 0.45138218 0.7542495 0.24741506 0.7542495 0.72808142 0.06465833 0.057966667 0.02920000 -0.02876667 5.179149e-01 8.879204e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135164 E001 0.1817044 0.0403759707 1.209451e-01   7 87152409 87152411 3 + 0.000 0.216 10.974
ENSG00000135164 E002 0.4720498 0.2054934257 6.172031e-01 7.350726e-01 7 87152412 87152425 14 + 0.123 0.216 0.971
ENSG00000135164 E003 0.4720498 0.2054934257 6.172031e-01 7.350726e-01 7 87152426 87152431 6 + 0.123 0.216 0.971
ENSG00000135164 E004 0.6172225 0.4233335859 7.673858e-01 8.496277e-01 7 87152432 87152435 4 + 0.174 0.216 0.394
ENSG00000135164 E005 1.7159328 0.1629275046 9.001802e-01 9.403045e-01 7 87152436 87152439 4 + 0.394 0.362 -0.181
ENSG00000135164 E006 3.1969798 0.0314633633 4.782816e-01 6.167109e-01 7 87152440 87152447 8 + 0.540 0.685 0.637
ENSG00000135164 E007 4.5203827 0.0140532813 2.524463e-01 3.887974e-01 7 87152448 87152449 2 + 0.633 0.831 0.812
ENSG00000135164 E008 4.6655554 0.0267851779 3.102824e-01 4.526538e-01 7 87152450 87152451 2 + 0.649 0.831 0.742
ENSG00000135164 E009 4.6655554 0.0267851779 3.102824e-01 4.526538e-01 7 87152452 87152452 1 + 0.649 0.831 0.742
ENSG00000135164 E010 11.1861372 0.0017400991 1.162440e-01 2.146066e-01 7 87152453 87152464 12 + 0.965 1.161 0.713
ENSG00000135164 E011 19.4116208 0.0018727260 2.873663e-01 4.278637e-01 7 87152465 87152467 3 + 1.213 1.334 0.425
ENSG00000135164 E012 30.9399649 0.0006565995 1.163383e-01 2.147305e-01 7 87152468 87152497 30 + 1.399 1.537 0.475
ENSG00000135164 E013 37.1839589 0.0010319434 4.235268e-02 9.536452e-02 7 87152498 87152530 33 + 1.472 1.631 0.543
ENSG00000135164 E014 38.7466668 0.0005778044 8.874153e-02 1.731955e-01 7 87152531 87152545 15 + 1.496 1.631 0.463
ENSG00000135164 E015 31.4457982 0.0006606909 7.277295e-01 8.203342e-01 7 87152546 87152553 8 + 1.432 1.485 0.184
ENSG00000135164 E016 28.8491155 0.0056486478 8.135012e-01 8.817526e-01 7 87152554 87152555 2 + 1.399 1.446 0.164
ENSG00000135164 E017 0.5911862 0.0183601279 3.638535e-01 5.082739e-01 7 87152556 87152612 57 + 0.220 0.000 -13.735
ENSG00000135164 E018 0.7728905 0.0153787590 9.623891e-01 9.802770e-01 7 87152613 87152628 16 + 0.220 0.216 -0.035
ENSG00000135164 E019 0.7728905 0.0153787590 9.623891e-01 9.802770e-01 7 87152629 87152630 2 + 0.220 0.216 -0.035
ENSG00000135164 E020 2.1003338 0.0116421371 9.931611e-01 9.998621e-01 7 87152631 87152791 161 + 0.449 0.466 0.088
ENSG00000135164 E021 1.1769600 0.3957409419 7.724654e-01 8.531362e-01 7 87152792 87152795 4 + 0.332 0.212 -0.868
ENSG00000135164 E022 2.2067848 0.1591304987 5.332574e-01 6.654810e-01 7 87152796 87152944 149 + 0.496 0.355 -0.757
ENSG00000135164 E023 2.6687179 0.0339804115 6.169729e-01 7.349002e-01 7 87154228 87154278 51 + 0.541 0.465 -0.367
ENSG00000135164 E024 23.3209239 0.0017056198 2.189080e-01 3.490893e-01 7 87154390 87154456 67 + 1.289 1.416 0.442
ENSG00000135164 E025 23.0204834 0.0035141818 1.081944e-02 3.073168e-02 7 87154457 87154528 72 + 1.250 1.485 0.813
ENSG00000135164 E026 7.9680512 0.0371360333 1.724364e-03 6.359517e-03 7 87155455 87155497 43 + 0.736 1.209 1.770
ENSG00000135164 E027 3.4718068 0.0046711740 1.394053e-02 3.808865e-02 7 87155498 87155559 62 + 0.474 0.871 1.700
ENSG00000135164 E028 3.1587517 0.0772485417 4.710062e-01 6.101807e-01 7 87162798 87162881 84 + 0.599 0.464 -0.635
ENSG00000135164 E029 5.5903307 0.0127881743 2.301864e-01 3.626822e-01 7 87162882 87163219 338 + 0.798 0.624 -0.716
ENSG00000135164 E030 3.1117232 0.0159450768 4.733125e-01 6.122873e-01 7 87163220 87163238 19 + 0.580 0.467 -0.537
ENSG00000135164 E031 8.9692013 0.0018596908 9.316561e-01 9.609486e-01 7 87163239 87163286 48 + 0.925 0.940 0.058
ENSG00000135164 E032 9.9647862 0.0016722869 2.374285e-01 3.711874e-01 7 87163287 87163332 46 + 0.995 0.871 -0.468
ENSG00000135164 E033 8.2455094 0.0020746168 9.279923e-04 3.712734e-03 7 87163333 87163494 162 + 0.981 0.467 -2.151
ENSG00000135164 E034 63.3443976 0.0030503940 3.890549e-01 5.331497e-01 7 87163495 87163617 123 + 1.741 1.721 -0.068
ENSG00000135164 E035 0.0000000       7 87164254 87164331 78 +      
ENSG00000135164 E036 47.1566395 0.0005470930 9.570218e-03 2.770848e-02 7 87164934 87165050 117 + 1.640 1.503 -0.467
ENSG00000135164 E037 51.5512564 0.0004277408 8.600625e-03 2.528927e-02 7 87166483 87166605 123 + 1.676 1.545 -0.447
ENSG00000135164 E038 7.4481889 0.0029736335 9.619291e-02 1.846648e-01 7 87167957 87168043 87 + 0.908 0.686 -0.877
ENSG00000135164 E039 49.3034231 0.0009654315 5.368549e-03 1.693173e-02 7 87170995 87171089 95 + 1.661 1.512 -0.507
ENSG00000135164 E040 52.7199321 0.0004267476 7.126351e-02 1.454278e-01 7 87173535 87173649 115 + 1.675 1.598 -0.263
ENSG00000135164 E041 50.2663724 0.0011611640 7.224369e-02 1.470654e-01 7 87174593 87174669 77 + 1.658 1.576 -0.279
ENSG00000135164 E042 66.0367167 0.0046467960 6.361526e-03 1.956099e-02 7 87179545 87179702 158 + 1.784 1.640 -0.487
ENSG00000135164 E043 0.9350151 0.3051692919 8.844831e-01 9.301690e-01 7 87181196 87181308 113 + 0.262 0.216 -0.361
ENSG00000135164 E044 39.3073444 0.1541133992 3.160610e-01 4.588254e-01 7 87181309 87181341 33 + 1.556 1.455 -0.348
ENSG00000135164 E045 6.2490036 0.0111209525 7.696772e-01 8.512669e-01 7 87182017 87182055 39 + 0.808 0.788 -0.080
ENSG00000135164 E046 24.7318892 0.0068405693 6.063362e-03 1.877705e-02 7 87182056 87182197 142 + 1.387 1.143 -0.859
ENSG00000135164 E047 14.4719119 0.0011894115 5.029331e-03 1.601196e-02 7 87182198 87182227 30 + 1.176 0.871 -1.123
ENSG00000135164 E048 35.0621875 0.0007707345 5.970940e-04 2.522977e-03 7 87182228 87182246 19 + 1.531 1.293 -0.821
ENSG00000135164 E049 56.3256506 0.0004291012 1.532752e-05 9.760515e-05 7 87182247 87182337 91 + 1.731 1.495 -0.807
ENSG00000135164 E050 90.4728089 0.0003197937 9.522599e-08 9.705858e-07 7 87184397 87184625 229 + 1.933 1.703 -0.774
ENSG00000135164 E051 0.2214452 0.0373789674 1.207258e-01   7 87184820 87184848 29 + 0.000 0.216 13.777
ENSG00000135164 E052 0.2214452 0.0373789674 1.207258e-01   7 87184849 87184892 44 + 0.000 0.216 13.777
ENSG00000135164 E053 0.2966881 0.0272796210 1.000000e+00   7 87184893 87185020 128 + 0.124 0.000 -12.766
ENSG00000135164 E054 72.0993530 0.0004048094 1.584394e-03 5.908288e-03 7 87185829 87185980 152 + 1.821 1.686 -0.455
ENSG00000135164 E055 7.9307767 0.1110810590 6.737194e-02 1.389852e-01 7 87185981 87185995 15 + 0.952 0.556 -1.614
ENSG00000135164 E056 86.2737078 0.0083305468 5.419626e-12 1.177715e-10 7 87185996 87188038 2043 + 1.946 1.474 -1.601
ENSG00000135164 E057 8.9860700 0.0021815464 2.033407e-01 3.303798e-01 7 87188039 87188091 53 + 0.973 0.831 -0.539
ENSG00000135164 E058 26.1804123 0.0013364739 5.042195e-01 6.401179e-01 7 87188092 87188092 1 + 1.372 1.347 -0.089
ENSG00000135164 E059 53.8049650 0.0004366445 3.339065e-01 4.776790e-01 7 87188093 87188197 105 + 1.676 1.650 -0.088
ENSG00000135164 E060 55.2455782 0.0004855483 4.929670e-01 6.300544e-01 7 87188198 87188301 104 + 1.684 1.675 -0.031
ENSG00000135164 E061 52.8611972 0.0006421636 7.939441e-01 8.683233e-01 7 87190945 87191027 83 + 1.648 1.692 0.149
ENSG00000135164 E062 17.8632897 0.0116657557 1.930650e-05 1.201958e-04 7 87192477 87193197 721 + 1.286 0.741 -2.020
ENSG00000135164 E063 65.5448669 0.0004345792 2.630672e-01 4.009323e-01 7 87193198 87193300 103 + 1.730 1.815 0.287
ENSG00000135164 E064 46.9564731 0.0006122321 4.921221e-01 6.293230e-01 7 87193301 87193353 53 + 1.593 1.663 0.236
ENSG00000135164 E065 9.0101067 0.0018960657 1.894470e-02 4.921046e-02 7 87193354 87193493 140 + 0.995 0.686 -1.206
ENSG00000135164 E066 101.4773621 0.0003063683 9.655232e-01 9.823339e-01 7 87193725 87193953 229 + 1.931 1.962 0.104
ENSG00000135164 E067 82.5625865 0.0006526922 2.639037e-01 4.018274e-01 7 87193954 87194102 149 + 1.831 1.911 0.269
ENSG00000135164 E068 8.8453610 0.0511555351 8.685918e-01 9.195344e-01 7 87194103 87194683 581 + 0.917 0.971 0.202
ENSG00000135164 E069 77.1781811 0.0014488447 4.176351e-02 9.429904e-02 7 87194684 87194828 145 + 1.787 1.914 0.427
ENSG00000135164 E070 4.5675856 0.0170253509 6.717129e-01 7.778824e-01 7 87194829 87195030 202 + 0.649 0.743 0.389
ENSG00000135164 E071 74.5764174 0.0083246316 7.666394e-02 1.541522e-01 7 87195031 87195125 95 + 1.768 1.910 0.478
ENSG00000135164 E072 301.7449441 0.0058100235 3.355435e-16 1.351354e-14 7 87195126 87196337 1212 + 2.301 2.643 1.141
ENSG00000135164 E073 0.8824620 0.2225672574 8.624992e-01 9.153288e-01 7 87201198 87201226 29 + 0.261 0.214 -0.373
ENSG00000135164 E074 9.2644237 0.0132424443 3.724212e-02 8.593677e-02 7 87202180 87202690 511 + 0.861 1.142 1.040