ENSG00000135127

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397558 ENSG00000135127 HEK293_OSMI2_2hA HEK293_TMG_2hB BICDL1 protein_coding protein_coding 2.568999 2.64951 2.412183 0.2232254 0.3350725 -0.1348526 0.8802619 1.4418353 0.5144474 0.07210291 0.17751366 -1.4690079 0.34662917 0.54746667 0.20093333 -0.346533333 0.001774747 0.001774747 FALSE TRUE
ENST00000548673 ENSG00000135127 HEK293_OSMI2_2hA HEK293_TMG_2hB BICDL1 protein_coding protein_coding 2.568999 2.64951 2.412183 0.2232254 0.3350725 -0.1348526 0.4109419 0.3959677 0.3039571 0.07806609 0.15848747 -0.3707978 0.16650417 0.14730000 0.14936667 0.002066667 0.875679147 0.001774747 FALSE TRUE
ENST00000550197 ENSG00000135127 HEK293_OSMI2_2hA HEK293_TMG_2hB BICDL1 protein_coding retained_intron 2.568999 2.64951 2.412183 0.2232254 0.3350725 -0.1348526 0.2000918 0.2671713 0.1657521 0.14366230 0.10363046 -0.6572361 0.06571667 0.09736667 0.06476667 -0.032600000 0.916960524 0.001774747 FALSE TRUE
MSTRG.8131.4 ENSG00000135127 HEK293_OSMI2_2hA HEK293_TMG_2hB BICDL1 protein_coding   2.568999 2.64951 2.412183 0.2232254 0.3350725 -0.1348526 0.7178280 0.1222469 1.0035322 0.12224689 0.09693088 2.9380862 0.28338333 0.05300000 0.42233333 0.369333333 0.031706549 0.001774747 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135127 E001 5.0915412 0.1630904536 0.655846942 0.76566940 12 119989236 119989868 633 + 0.811 0.730 -0.326
ENSG00000135127 E002 0.1817044 0.0392973643 0.770516152   12 119989869 119989879 11 + 0.000 0.097 9.752
ENSG00000135127 E003 2.9294707 0.0703440446 0.585327240 0.70904196 12 119989880 119989997 118 + 0.493 0.605 0.521
ENSG00000135127 E004 7.9386486 0.0380930376 0.701464297 0.80063083 12 119989998 119990152 155 + 0.956 0.907 -0.182
ENSG00000135127 E005 16.0233636 0.0258088922 0.333058750 0.47673129 12 119990153 119990297 145 + 1.272 1.165 -0.379
ENSG00000135127 E006 1.9530953 0.0077496076 0.377726287 0.52203420 12 119992420 119993409 990 + 0.548 0.399 -0.753
ENSG00000135127 E007 25.6815926 0.0008007401 0.382194450 0.52642532 12 119998521 119998736 216 + 1.441 1.381 -0.206
ENSG00000135127 E008 0.3299976 0.0274424043 0.379452616   12 119999761 119999852 92 + 0.000 0.176 10.715
ENSG00000135127 E009 0.6934063 0.0980525345 0.128658953 0.23228648 12 119999853 119999912 60 + 0.000 0.301 11.448
ENSG00000135127 E010 1.4748046 0.0102137345 0.079143708 0.15814634 12 120000270 120000554 285 + 0.548 0.244 -1.751
ENSG00000135127 E011 0.0000000       12 120061694 120061709 16 +      
ENSG00000135127 E012 16.1146334 0.0043102672 0.855769648 0.91080588 12 120061710 120061826 117 + 1.198 1.212 0.049
ENSG00000135127 E013 0.0000000       12 120064637 120064732 96 +      
ENSG00000135127 E014 17.5573853 0.0100052482 0.818288308 0.88516373 12 120064733 120064879 147 + 1.253 1.227 -0.090
ENSG00000135127 E015 15.2857502 0.0020942736 0.182150538 0.30389757 12 120071622 120071801 180 + 1.263 1.147 -0.410
ENSG00000135127 E016 14.1290696 0.0198503811 0.167059505 0.28437459 12 120072511 120072729 219 + 1.047 1.199 0.547
ENSG00000135127 E017 2.3728194 0.5575537184 0.974593106 0.98816527 12 120074443 120074443 1 + 0.638 0.435 -0.954
ENSG00000135127 E018 6.0314231 0.0431211237 0.839754210 0.89990053 12 120074444 120074586 143 + 0.812 0.842 0.119
ENSG00000135127 E019 0.1817044 0.0392973643 0.770516152   12 120080681 120080886 206 + 0.000 0.097 9.752
ENSG00000135127 E020 15.4668865 0.0012419731 0.401846952 0.54554164 12 120080887 120080957 71 + 1.242 1.170 -0.257
ENSG00000135127 E021 15.6059316 0.0013008175 0.141745343 0.25042880 12 120080958 120081017 60 + 1.273 1.147 -0.444
ENSG00000135127 E022 0.0000000       12 120081018 120081018 1 +      
ENSG00000135127 E023 18.0739871 0.0013403910 0.642026637 0.75493142 12 120089951 120090071 121 + 1.282 1.244 -0.134
ENSG00000135127 E024 1.1717857 0.0121152688 0.629681891 0.74499819 12 120090072 120090190 119 + 0.266 0.353 0.569
ENSG00000135127 E025 0.7458221 0.0163431118 0.053731568 0.11578553 12 120090755 120090910 156 + 0.430 0.097 -2.754
ENSG00000135127 E026 0.7427016 0.0155447516 0.003451828 0.01158716 12 120090911 120091019 109 + 0.493 0.000 -13.882
ENSG00000135127 E027 1.2585551 0.0129050059 0.987754953 0.99640957 12 120091247 120091401 155 + 0.355 0.352 -0.018
ENSG00000135127 E028 11.4945931 0.0220314163 0.806409002 0.87695035 12 120093000 120093018 19 + 1.094 1.061 -0.119
ENSG00000135127 E029 21.4549403 0.0012091246 0.144852199 0.25463551 12 120093019 120093222 204 + 1.253 1.363 0.384
ENSG00000135127 E030 52.5484841 0.0006352018 0.086135649 0.16921212 12 120093223 120094202 980 + 1.648 1.727 0.268
ENSG00000135127 E031 12.8680836 0.0202824714 0.004687469 0.01506254 12 120094203 120094494 292 + 0.865 1.214 1.277