ENSG00000135049

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357081 ENSG00000135049 HEK293_OSMI2_2hA HEK293_TMG_2hB AGTPBP1 protein_coding protein_coding 11.09251 2.611027 20.14629 0.07194685 0.7207719 2.943026 6.63602 2.33510199 10.93951 0.11492114 1.2726590 2.223144 0.6246125 0.89460000 0.5404667 -0.3541333 0.001412719 0.001412719 FALSE TRUE
MSTRG.32921.8 ENSG00000135049 HEK293_OSMI2_2hA HEK293_TMG_2hB AGTPBP1 protein_coding   11.09251 2.611027 20.14629 0.07194685 0.7207719 2.943026 2.63486 0.08475222 4.78774 0.08475222 0.7377975 5.662051 0.2001125 0.03076667 0.2355667 0.2048000 0.034229735 0.001412719 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135049 E001 3.837690 0.0041345881 8.393107e-03 2.477213e-02 9 85546539 85546539 1 - 0.650 0.001 -10.498
ENSG00000135049 E002 23.582142 0.0011412257 7.312611e-03 2.203203e-02 9 85546540 85546670 131 - 1.228 1.458 0.804
ENSG00000135049 E003 40.926968 0.0069479425 5.061421e-09 6.599705e-08 9 85546671 85546827 157 - 1.396 1.818 1.438
ENSG00000135049 E004 22.591783 0.0010633863 1.651999e-09 2.351539e-08 9 85546828 85546850 23 - 1.128 1.609 1.674
ENSG00000135049 E005 48.226953 0.0006293493 4.305761e-10 6.823771e-09 9 85546851 85547013 163 - 1.486 1.850 1.235
ENSG00000135049 E006 120.738274 0.0002688162 3.395162e-08 3.785776e-07 9 85547014 85547286 273 - 1.916 2.133 0.727
ENSG00000135049 E007 5.193613 0.0122914975 2.244086e-02 5.659631e-02 9 85553873 85554272 400 - 0.744 0.253 -2.519
ENSG00000135049 E008 104.988480 0.0003391063 2.120836e-06 1.640305e-05 9 85575315 85575475 161 - 1.859 2.061 0.680
ENSG00000135049 E009 123.174017 0.0003415936 1.224721e-03 4.724107e-03 9 85578920 85579096 177 - 1.943 2.076 0.445
ENSG00000135049 E010 105.411660 0.0002853820 1.346682e-05 8.681875e-05 9 85585463 85585594 132 - 1.866 2.052 0.625
ENSG00000135049 E011 87.098861 0.0035534053 1.836275e-05 1.148867e-04 9 85586831 85586960 130 - 1.773 2.001 0.766
ENSG00000135049 E012 93.702513 0.0131495555 1.728811e-02 4.558227e-02 9 85588298 85588478 181 - 1.816 1.990 0.584
ENSG00000135049 E013 76.493996 0.0003200678 1.748905e-01 2.945345e-01 9 85589528 85589681 154 - 1.751 1.825 0.248
ENSG00000135049 E014 67.015258 0.0004604141 4.869761e-01 6.246821e-01 9 85592560 85592704 145 - 1.704 1.746 0.143
ENSG00000135049 E015 61.984146 0.0025733508 5.704477e-01 6.969309e-01 9 85596362 85596449 88 - 1.683 1.649 -0.113
ENSG00000135049 E016 77.979420 0.0070801954 3.464920e-01 4.906117e-01 9 85618983 85619131 149 - 1.784 1.721 -0.211
ENSG00000135049 E017 57.358023 0.0004512463 9.439811e-01 9.688929e-01 9 85619215 85619301 87 - 1.643 1.642 -0.006
ENSG00000135049 E018 66.742790 0.0005456085 5.563929e-01 6.850459e-01 9 85621202 85621285 84 - 1.712 1.679 -0.109
ENSG00000135049 E019 129.263797 0.0002271996 3.962810e-02 9.034097e-02 9 85632662 85633037 376 - 2.004 1.917 -0.290
ENSG00000135049 E020 52.930497 0.0025214573 2.542176e-01 3.908645e-01 9 85633038 85633136 99 - 1.622 1.545 -0.261
ENSG00000135049 E021 96.471963 0.0003245216 4.875820e-04 2.112737e-03 9 85633137 85633374 238 - 1.890 1.707 -0.617
ENSG00000135049 E022 74.376876 0.0057199946 2.260675e-04 1.075076e-03 9 85642827 85642943 117 - 1.789 1.516 -0.930
ENSG00000135049 E023 67.271501 0.0014188893 5.173798e-07 4.562919e-06 9 85646321 85646418 98 - 1.755 1.394 -1.233
ENSG00000135049 E024 53.817893 0.0005286102 2.204252e-04 1.051200e-03 9 85655143 85655200 58 - 1.653 1.380 -0.934
ENSG00000135049 E025 28.472534 0.0006867810 1.194785e-01 2.192024e-01 9 85655201 85655215 15 - 1.370 1.227 -0.500
ENSG00000135049 E026 48.807301 0.0062162143 1.055029e-01 1.988698e-01 9 85655216 85655320 105 - 1.593 1.460 -0.455
ENSG00000135049 E027 26.068286 0.0343325864 9.677769e-02 1.855505e-01 9 85657435 85657437 3 - 1.341 1.115 -0.798
ENSG00000135049 E028 27.059285 0.0160262007 1.553694e-01 2.688921e-01 9 85657438 85657453 16 - 1.349 1.187 -0.571
ENSG00000135049 E029 74.881229 0.0004042024 2.829969e-04 1.310573e-03 9 85657454 85657643 190 - 1.786 1.565 -0.751
ENSG00000135049 E030 31.153108 0.0007547661 4.094578e-02 9.278108e-02 9 85660936 85660973 38 - 1.412 1.227 -0.647
ENSG00000135049 E031 49.937828 0.0020781144 6.916193e-05 3.759962e-04 9 85669485 85669578 94 - 1.626 1.302 -1.117
ENSG00000135049 E032 68.490165 0.0010454796 2.174723e-03 7.764404e-03 9 85672550 85672681 132 - 1.749 1.555 -0.662
ENSG00000135049 E033 80.710319 0.0003196944 1.211741e-02 3.381762e-02 9 85677436 85677582 147 - 1.811 1.672 -0.470
ENSG00000135049 E034 50.982996 0.0004418281 1.662935e-03 6.162958e-03 9 85678335 85678398 64 - 1.626 1.394 -0.794
ENSG00000135049 E035 56.616091 0.0004403673 1.530967e-03 5.736836e-03 9 85681268 85681335 68 - 1.668 1.447 -0.756
ENSG00000135049 E036 61.782784 0.0003782263 3.109685e-05 1.843825e-04 9 85692689 85692813 125 - 1.712 1.421 -0.992
ENSG00000135049 E037 33.401303 0.0352116190 2.069104e-01 3.348587e-01 9 85712502 85712566 65 - 1.438 1.286 -0.527
ENSG00000135049 E038 0.000000       9 85723729 85723754 26 -      
ENSG00000135049 E039 26.856617 0.0026878581 8.314521e-03 2.457848e-02 9 85741775 85742029 255 - 1.360 1.083 -0.979