ENSG00000135048

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377044 ENSG00000135048 HEK293_OSMI2_2hA HEK293_TMG_2hB CEMIP2 protein_coding protein_coding 6.379389 4.165266 8.238102 0.3615242 0.1591157 0.9821939 4.0953214 1.87510888 5.9541471 0.29932912 0.5347142 1.661668 0.6134375 0.450366667 0.7256667 0.27530000 0.1114248 0.03056533 FALSE TRUE
ENST00000377057 ENSG00000135048 HEK293_OSMI2_2hA HEK293_TMG_2hB CEMIP2 protein_coding retained_intron 6.379389 4.165266 8.238102 0.3615242 0.1591157 0.9821939 1.1032424 2.16015476 0.5441832 0.27516844 0.3587817 -1.969363 0.2208458 0.521500000 0.0647000 -0.45680000 0.0340480 0.03056533 FALSE TRUE
ENST00000377066 ENSG00000135048 HEK293_OSMI2_2hA HEK293_TMG_2hB CEMIP2 protein_coding protein_coding 6.379389 4.165266 8.238102 0.3615242 0.1591157 0.9821939 0.4183834 0.01118088 0.5442965 0.01118088 0.3085952 4.709823 0.0567250 0.002366667 0.0649000 0.06253333 0.3630791 0.03056533 FALSE TRUE
ENST00000396272 ENSG00000135048 HEK293_OSMI2_2hA HEK293_TMG_2hB CEMIP2 protein_coding protein_coding 6.379389 4.165266 8.238102 0.3615242 0.1591157 0.9821939 0.1422251 0.00000000 0.5272712 0.00000000 0.2642352 5.747579 0.0184625 0.000000000 0.0647000 0.06470000 0.2843619 0.03056533 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135048 E001 0.0000000       9 71683366 71683371 6 -      
ENSG00000135048 E002 16.3590523 0.0010723453 6.581789e-08 6.927608e-07 9 71683372 71683570 199 - 1.003 1.471 1.655
ENSG00000135048 E003 87.6807311 0.0176882772 2.145252e-06 1.657402e-05 9 71683571 71683984 414 - 1.768 2.132 1.222
ENSG00000135048 E004 194.0998935 0.0008678739 1.086403e-22 9.334053e-21 9 71683985 71685055 1071 - 2.154 2.434 0.934
ENSG00000135048 E005 81.8057978 0.0005564238 5.290931e-01 6.619324e-01 9 71685056 71685393 338 - 1.881 1.926 0.151
ENSG00000135048 E006 40.8259373 0.0005406151 3.632735e-01 5.076985e-01 9 71685743 71685846 104 - 1.574 1.645 0.240
ENSG00000135048 E007 2.5863036 0.0057285219 1.213930e-02 3.386673e-02 9 71685847 71687428 1582 - 0.641 0.177 -2.751
ENSG00000135048 E008 43.9762044 0.0005509840 6.004940e-01 7.217179e-01 9 71690092 71690246 155 - 1.612 1.659 0.162
ENSG00000135048 E009 27.0856521 0.0043259992 6.500027e-01 7.611117e-01 9 71694509 71694556 48 - 1.427 1.409 -0.063
ENSG00000135048 E010 23.9792391 0.0231036922 9.129326e-01 9.488643e-01 9 71694557 71694607 51 - 1.361 1.387 0.092
ENSG00000135048 E011 0.8846626 0.0135640180 2.391644e-02 5.963424e-02 9 71697828 71697984 157 - 0.083 0.478 3.249
ENSG00000135048 E012 55.4775989 0.0004483052 5.728235e-01 6.988736e-01 9 71697985 71698204 220 - 1.731 1.722 -0.030
ENSG00000135048 E013 0.9005597 0.1987959537 1.233503e-01 2.247366e-01 9 71698205 71698241 37 - 0.356 0.000 -13.101
ENSG00000135048 E014 0.4482035 0.0300388139 3.104810e-01 4.528947e-01 9 71699192 71699449 258 - 0.213 0.000 -12.931
ENSG00000135048 E015 53.8507597 0.0005115475 9.895293e-02 1.888742e-01 9 71700642 71700824 183 - 1.742 1.678 -0.219
ENSG00000135048 E016 0.0000000       9 71704417 71704594 178 -      
ENSG00000135048 E017 50.3138981 0.0005102784 1.041320e-01 1.967888e-01 9 71704595 71704799 205 - 1.711 1.645 -0.226
ENSG00000135048 E018 16.0339767 0.0012525767 8.578081e-01 9.121882e-01 9 71704800 71704803 4 - 1.204 1.206 0.007
ENSG00000135048 E019 0.4375944 0.0262393362 3.101921e-01 4.525575e-01 9 71704804 71704932 129 - 0.213 0.000 -12.964
ENSG00000135048 E020 48.5917754 0.0049077623 7.313512e-01 8.230357e-01 9 71709259 71709474 216 - 1.674 1.669 -0.017
ENSG00000135048 E021 50.2571472 0.0004888140 9.470529e-01 9.707573e-01 9 71712083 71712260 178 - 1.682 1.705 0.077
ENSG00000135048 E022 0.2214452 0.0495229080 2.107974e-01   9 71712261 71712443 183 - 0.000 0.177 12.078
ENSG00000135048 E023 42.7705815 0.0029536558 7.076956e-01 8.055196e-01 9 71714934 71715089 156 - 1.607 1.649 0.142
ENSG00000135048 E024 20.6266937 0.0394707105 8.206942e-01 8.869306e-01 9 71716517 71716552 36 - 1.300 1.327 0.095
ENSG00000135048 E025 32.9721298 0.0042587843 3.601198e-01 5.044371e-01 9 71717948 71718079 132 - 1.525 1.478 -0.160
ENSG00000135048 E026 23.6116398 0.0032160424 9.306567e-03 2.704848e-02 9 71722427 71722515 89 - 1.427 1.232 -0.683
ENSG00000135048 E027 26.5025675 0.0013795370 1.494362e-02 4.035916e-02 9 71725581 71725709 129 - 1.467 1.302 -0.569
ENSG00000135048 E028 19.0750481 0.0016159744 7.017820e-02 1.436587e-01 9 71729845 71729914 70 - 1.328 1.191 -0.480
ENSG00000135048 E029 27.6527269 0.0007667242 1.287486e-02 3.562243e-02 9 71730048 71730152 105 - 1.485 1.323 -0.559
ENSG00000135048 E030 29.8764276 0.0007750090 1.363973e-04 6.875833e-04 9 71730153 71730253 101 - 1.539 1.280 -0.894
ENSG00000135048 E031 20.0110317 0.0029517180 2.580489e-03 9.006039e-03 9 71730705 71730738 34 - 1.369 1.115 -0.894
ENSG00000135048 E032 34.4600823 0.0007110070 5.013172e-03 1.596722e-02 9 71730739 71730914 176 - 1.574 1.408 -0.571
ENSG00000135048 E033 0.0000000       9 71730915 71730984 70 -      
ENSG00000135048 E034 44.1905841 0.0016000741 5.791557e-03 1.806525e-02 9 71732351 71732520 170 - 1.674 1.527 -0.503
ENSG00000135048 E035 45.9484082 0.0039644281 8.546866e-02 1.681599e-01 9 71734806 71734994 189 - 1.676 1.587 -0.304
ENSG00000135048 E036 41.3505708 0.0005408137 3.490935e-03 1.169884e-02 9 71740063 71740232 170 - 1.654 1.500 -0.528
ENSG00000135048 E037 77.4913894 0.0004052042 9.599371e-07 7.993372e-06 9 71745018 71745579 562 - 1.930 1.730 -0.674
ENSG00000135048 E038 26.5140514 0.0009246856 6.223400e-01 7.391599e-01 9 71746201 71746341 141 - 1.424 1.408 -0.056
ENSG00000135048 E039 0.1482932 0.0412687690 2.127478e-01   9 71750001 71750042 42 - 0.000 0.176 12.145
ENSG00000135048 E040 37.0784265 0.0172070028 1.296545e-02 3.583018e-02 9 71750043 71750318 276 - 1.614 1.410 -0.699
ENSG00000135048 E041 16.3949399 0.0013476438 1.607482e-02 4.290220e-02 9 71750319 71750385 67 - 1.273 1.062 -0.750
ENSG00000135048 E042 20.5420795 0.0013301935 9.892238e-04 3.921602e-03 9 71768357 71768513 157 - 1.384 1.115 -0.948
ENSG00000135048 E043 0.0000000       9 71814955 71815292 338 -      
ENSG00000135048 E044 0.0000000       9 71816563 71816690 128 -