ENSG00000135040

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361671 ENSG00000135040 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA35 protein_coding protein_coding 12.31689 3.69869 20.07116 0.3774033 0.5167702 2.436861 3.3724007 2.1544441 2.960406 0.2446720 0.6134222 0.4566634 0.3565625 0.5905667 0.14896667 -0.44160000 0.0001733581 0.0001733581 FALSE TRUE
ENST00000376040 ENSG00000135040 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA35 protein_coding protein_coding 12.31689 3.69869 20.07116 0.3774033 0.5167702 2.436861 0.8763083 0.4377761 1.015625 0.1783314 0.4219095 1.1956537 0.0619875 0.1117000 0.04956667 -0.06213333 0.4413422164 0.0001733581 FALSE TRUE
ENST00000416045 ENSG00000135040 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA35 protein_coding processed_transcript 12.31689 3.69869 20.07116 0.3774033 0.5167702 2.436861 4.5128685 0.4357105 8.488120 0.2790945 0.5527112 4.2529648 0.2932833 0.1055667 0.42233333 0.31676667 0.0949004061 0.0001733581 FALSE FALSE
MSTRG.32932.1 ENSG00000135040 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA35 protein_coding   12.31689 3.69869 20.07116 0.3774033 0.5167702 2.436861 1.7025529 0.3262511 3.840653 0.1536661 0.5505581 3.5174922 0.1302458 0.0890000 0.19026667 0.10126667 0.2817051640 0.0001733581 FALSE TRUE
MSTRG.32932.4 ENSG00000135040 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA35 protein_coding   12.31689 3.69869 20.07116 0.3774033 0.5167702 2.436861 1.8527564 0.3445077 3.766354 0.1756436 0.5565077 3.4131051 0.1579167 0.1031333 0.18883333 0.08570000 0.6162844377 0.0001733581 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000135040 E001 0.4482035 0.0267811773 4.823453e-01 6.204981e-01 9 85941142 85941145 4 + 0.187 0.000 -9.340
ENSG00000135040 E002 1.5220486 0.0256022427 2.880714e-01 4.286176e-01 9 85941146 85941181 36 + 0.417 0.202 -1.451
ENSG00000135040 E003 23.5008167 0.0008326492 5.325127e-04 2.281490e-03 9 85941182 85941273 92 + 1.402 1.087 -1.110
ENSG00000135040 E004 14.5934648 0.0203613507 6.118742e-04 2.576580e-03 9 85941274 85941405 132 + 1.234 0.756 -1.777
ENSG00000135040 E005 6.0344703 0.0026935436 7.962678e-03 2.368252e-02 9 85941467 85941528 62 + 0.883 0.443 -1.905
ENSG00000135040 E006 28.1736222 0.0037553857 8.937549e-03 2.612225e-02 9 85941529 85941874 346 + 1.465 1.244 -0.768
ENSG00000135040 E007 82.3693658 0.0094885601 1.630208e-02 4.339501e-02 9 85942155 85942283 129 + 1.906 1.749 -0.532
ENSG00000135040 E008 58.3890538 0.0103953454 4.292396e-02 9.640335e-02 9 85956360 85956393 34 + 1.757 1.609 -0.502
ENSG00000135040 E009 85.3537765 0.0014985998 3.396370e-03 1.142782e-02 9 85958472 85958586 115 + 1.918 1.779 -0.470
ENSG00000135040 E010 83.3699609 0.0008163819 2.453740e-03 8.625493e-03 9 85959793 85959867 75 + 1.909 1.770 -0.471
ENSG00000135040 E011 124.8168385 0.0002998970 3.039877e-03 1.038230e-02 9 85962013 85962180 168 + 2.076 1.969 -0.358
ENSG00000135040 E012 0.8793535 0.1605875538 6.426743e-01 7.554116e-01 9 85966596 85966672 77 + 0.234 0.335 0.698
ENSG00000135040 E013 84.7426188 0.0007072513 6.379299e-04 2.672848e-03 9 85974967 85975033 67 + 1.919 1.761 -0.532
ENSG00000135040 E014 80.6185022 0.0004944847 9.603690e-04 3.823163e-03 9 85975114 85975157 44 + 1.897 1.743 -0.519
ENSG00000135040 E015 79.1881070 0.0012557175 3.367659e-02 7.911029e-02 9 85976685 85976735 51 + 1.875 1.775 -0.340
ENSG00000135040 E016 86.4577283 0.0060544047 4.012493e-01 5.449490e-01 9 85977363 85977446 84 + 1.899 1.852 -0.159
ENSG00000135040 E017 89.5413631 0.0034614834 8.208378e-01 8.870528e-01 9 85978267 85978381 115 + 1.899 1.912 0.045
ENSG00000135040 E018 2.6819761 0.0340677667 2.026060e-03 7.307588e-03 9 85986473 85987041 569 + 0.317 0.840 2.458
ENSG00000135040 E019 86.6090444 0.0003150867 1.436127e-01 2.529260e-01 9 85996399 85996577 179 + 1.872 1.938 0.219
ENSG00000135040 E020 55.2739807 0.0004625212 1.786701e-01 2.994826e-01 9 86003585 86003644 60 + 1.678 1.752 0.251
ENSG00000135040 E021 75.1473847 0.0003693185 1.054715e-01 1.988145e-01 9 86007358 86007464 107 + 1.811 1.887 0.258
ENSG00000135040 E022 76.4684598 0.0003561713 1.896297e-01 3.132857e-01 9 86009865 86009931 67 + 1.821 1.884 0.211
ENSG00000135040 E023 81.7303727 0.0003469784 1.203832e-01 2.205185e-01 9 86013046 86013144 99 + 1.845 1.916 0.239
ENSG00000135040 E024 117.9184169 0.0002817335 1.629676e-01 2.790114e-01 9 86013719 86013897 179 + 2.009 2.063 0.182
ENSG00000135040 E025 102.3093989 0.0032496592 1.913335e-02 4.963066e-02 9 86016539 86016675 137 + 1.929 2.040 0.371
ENSG00000135040 E026 88.7337446 0.0004112223 5.056087e-03 1.608525e-02 9 86017498 86017565 68 + 1.866 1.985 0.400
ENSG00000135040 E027 120.5300748 0.0100335120 9.170263e-02 1.777940e-01 9 86018255 86018395 141 + 2.002 2.113 0.371
ENSG00000135040 E028 115.6537427 0.0078865989 6.440324e-03 1.976735e-02 9 86018699 86018821 123 + 1.968 2.126 0.530
ENSG00000135040 E029 78.0734521 0.0005723239 1.240793e-06 1.010118e-05 9 86020889 86020969 81 + 1.781 1.993 0.714
ENSG00000135040 E030 380.7927887 0.0002046250 5.833094e-01 7.074391e-01 9 86021901 86025692 3792 + 2.525 2.540 0.048