ENSG00000134909

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310343 ENSG00000134909 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP32 protein_coding protein_coding 2.969819 2.0338 3.402992 0.2550437 0.1430303 0.739783 0.5638723 0.50466749 0.0000000 0.06205139 0.000000000 -5.6855688 0.20620000 0.24973333 0.00000000 -0.24973333 6.009278e-14 6.009278e-14 FALSE TRUE
ENST00000524655 ENSG00000134909 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP32 protein_coding protein_coding 2.969819 2.0338 3.402992 0.2550437 0.1430303 0.739783 0.1775630 0.06167816 0.3189316 0.04819340 0.009897406 2.1981821 0.05853333 0.02616667 0.09383333 0.06766667 7.627643e-02 6.009278e-14 FALSE TRUE
ENST00000527272 ENSG00000134909 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP32 protein_coding protein_coding 2.969819 2.0338 3.402992 0.2550437 0.1430303 0.739783 0.4118154 0.19807279 0.0000000 0.10508325 0.000000000 -4.3790164 0.13385000 0.11016667 0.00000000 -0.11016667 1.063538e-01 6.009278e-14 FALSE TRUE
ENST00000682385 ENSG00000134909 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP32 protein_coding protein_coding 2.969819 2.0338 3.402992 0.2550437 0.1430303 0.739783 1.0286087 1.06724902 1.4241309 0.12838070 0.090692542 0.4128249 0.36785417 0.52576667 0.41790000 -0.10786667 2.729056e-01 6.009278e-14 FALSE TRUE
MSTRG.6559.6 ENSG00000134909 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP32 protein_coding   2.969819 2.0338 3.402992 0.2550437 0.1430303 0.739783 0.4535984 0.00000000 1.2870200 0.00000000 0.113276085 7.0190569 0.13438750 0.00000000 0.38003333 0.38003333 1.472174e-13 6.009278e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134909 E001 124.1500533 0.0003486157 4.424450e-22 3.554702e-20 11 128965060 128967924 2865 - 1.929 2.237 1.030
ENSG00000134909 E002 2.4012712 0.0478985967 5.272905e-01 6.604012e-01 11 128967925 128967946 22 - 0.458 0.579 0.577
ENSG00000134909 E003 43.5002069 0.0039680834 9.802208e-05 5.127383e-04 11 128967947 128968762 816 - 1.523 1.768 0.832
ENSG00000134909 E004 12.0349604 0.0014815213 3.132659e-04 1.433717e-03 11 128968763 128968868 106 - 0.915 1.275 1.303
ENSG00000134909 E005 181.6457006 0.0035407783 1.483165e-06 1.187428e-05 11 128968869 128970866 1998 - 2.173 2.344 0.572
ENSG00000134909 E006 13.2028381 0.0026727878 3.660505e-01 5.103897e-01 11 128970867 128970981 115 - 1.097 1.195 0.351
ENSG00000134909 E007 14.7818032 0.0138510992 6.189604e-01 7.364711e-01 11 128970982 128971159 178 - 1.165 1.227 0.221
ENSG00000134909 E008 7.0430117 0.0045359354 2.283779e-03 8.101245e-03 11 128971160 128972452 1293 - 1.037 0.659 -1.474
ENSG00000134909 E009 74.0951458 0.0003829081 2.863095e-01 4.267040e-01 11 128972453 128973432 980 - 1.886 1.859 -0.092
ENSG00000134909 E010 4.3879827 0.0037472756 2.219909e-01 3.527812e-01 11 128973433 128974123 691 - 0.784 0.620 -0.681
ENSG00000134909 E011 55.3298454 0.0004270920 8.811824e-07 7.404957e-06 11 128974124 128975002 879 - 1.833 1.613 -0.747
ENSG00000134909 E012 12.8558267 0.0014418439 7.358272e-03 2.214777e-02 11 128976563 128976634 72 - 1.232 0.987 -0.882
ENSG00000134909 E013 16.5302657 0.0024942844 1.130032e-02 3.187867e-02 11 128978770 128978915 146 - 1.318 1.110 -0.735
ENSG00000134909 E014 0.5149242 0.1646749107 4.302796e-01 5.729128e-01 11 128980487 128980552 66 - 0.103 0.254 1.570
ENSG00000134909 E015 20.1030010 0.0104197131 2.971171e-02 7.139181e-02 11 128980553 128980748 196 - 1.390 1.207 -0.640
ENSG00000134909 E016 12.2033202 0.0016032627 3.471619e-04 1.568912e-03 11 128981416 128981561 146 - 1.238 0.888 -1.277
ENSG00000134909 E017 12.0929390 0.0016536137 1.210974e-02 3.379819e-02 11 128981829 128981936 108 - 1.204 0.969 -0.849
ENSG00000134909 E018 0.1817044 0.0387234729 3.465802e-01   11 128985879 128986002 124 - 0.000 0.145 10.076
ENSG00000134909 E019 11.9360378 0.0017080155 4.239097e-02 9.542918e-02 11 128986003 128986085 83 - 1.189 1.004 -0.666
ENSG00000134909 E020 17.6662466 0.0010657542 1.962531e-01 3.215371e-01 11 128986524 128986668 145 - 1.307 1.216 -0.319
ENSG00000134909 E021 14.2501893 0.0012670777 8.370864e-02 1.653548e-01 11 128988023 128988125 103 - 1.238 1.096 -0.507
ENSG00000134909 E022 20.5901098 0.0020572330 6.607720e-02 1.368415e-01 11 128998319 128998468 150 - 1.385 1.256 -0.451
ENSG00000134909 E023 0.0000000       11 129023859 129024193 335 -      
ENSG00000134909 E024 14.9913793 0.0015635164 5.750289e-02 1.223398e-01 11 129040928 129041009 82 - 1.264 1.110 -0.549
ENSG00000134909 E025 14.2291997 0.0021022792 3.193931e-02 7.573943e-02 11 129062280 129062357 78 - 1.252 1.068 -0.656
ENSG00000134909 E026 17.1286512 0.0010986681 1.603529e-02 4.281383e-02 11 129063902 129064024 123 - 1.334 1.148 -0.657
ENSG00000134909 E027 17.7660082 0.0010453214 4.851078e-03 1.551721e-02 11 129064841 129064933 93 - 1.355 1.136 -0.774
ENSG00000134909 E028 10.7935081 0.0016678915 6.816499e-02 1.403207e-01 11 129066731 129066743 13 - 1.141 0.969 -0.627
ENSG00000134909 E029 17.5722706 0.0013998387 6.346500e-03 1.952429e-02 11 129066744 129066868 125 - 1.350 1.136 -0.756
ENSG00000134909 E030 14.9072065 0.0033787280 3.853355e-02 8.833575e-02 11 129093621 129093707 87 - 1.271 1.096 -0.621
ENSG00000134909 E031 15.5465514 0.0021565948 4.788293e-02 1.054162e-01 11 129123446 129123530 85 - 1.283 1.123 -0.568
ENSG00000134909 E032 6.7139383 0.0025493207 6.903923e-01 7.920976e-01 11 129123888 129123929 42 - 0.901 0.865 -0.135
ENSG00000134909 E033 13.0656426 0.0013215262 6.667645e-02 1.378647e-01 11 129124803 129124894 92 - 1.211 1.053 -0.567
ENSG00000134909 E034 1.3922013 0.1420414089 8.471277e-01 9.050529e-01 11 129127212 129127305 94 - 0.368 0.409 0.231
ENSG00000134909 E035 7.3656954 0.0024121561 1.146283e-02 3.226457e-02 11 129164319 129164427 109 - 1.026 0.729 -1.144
ENSG00000134909 E036 0.1451727 0.0426185978 6.770673e-01   11 129192083 129192325 243 - 0.103 0.000 -9.864
ENSG00000134909 E037 5.1723943 0.0041125663 1.250506e-07 1.246998e-06 11 129279146 129279508 363 - 1.004 0.145 -4.522