ENSG00000134905

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257347 ENSG00000134905 HEK293_OSMI2_2hA HEK293_TMG_2hB CARS2 protein_coding protein_coding 38.53125 61.49245 23.41532 4.513537 0.3907923 -1.392575 23.282742 34.68562 16.0787 3.322231 0.499437 -1.108706 0.6154333 0.5622667 0.6869333 0.1246667 1.463240e-02 1.827595e-51 FALSE TRUE
ENST00000481787 ENSG00000134905 HEK293_OSMI2_2hA HEK293_TMG_2hB CARS2 protein_coding retained_intron 38.53125 61.49245 23.41532 4.513537 0.3907923 -1.392575 5.197633 15.70342 0.0000 2.044504 0.000000 -10.617781 0.1012042 0.2537333 0.0000000 -0.2537333 1.827595e-51 1.827595e-51 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134905 E001 2.2119274 0.0785088120 4.641377e-01 6.038969e-01 13 110641412 110641416 5 - 0.331 0.501 0.929
ENSG00000134905 E002 4.4292395 0.0202398959 1.086690e-01 2.035679e-01 13 110641417 110641418 2 - 0.433 0.733 1.366
ENSG00000134905 E003 39.8479115 0.0095927026 3.558365e-01 5.002015e-01 13 110641419 110641442 24 - 1.470 1.553 0.282
ENSG00000134905 E004 225.8820342 0.0019537438 6.715832e-02 1.386319e-01 13 110641443 110641583 141 - 2.221 2.288 0.224
ENSG00000134905 E005 158.5958978 0.0006659070 1.821312e-01 3.038760e-01 13 110641584 110641586 3 - 2.084 2.134 0.167
ENSG00000134905 E006 196.8465571 0.0021314204 6.010728e-01 7.222262e-01 13 110641587 110641608 22 - 2.198 2.220 0.074
ENSG00000134905 E007 284.0217555 0.0028798321 2.756725e-02 6.714640e-02 13 110642315 110642386 72 - 2.307 2.388 0.270
ENSG00000134905 E008 247.1570483 0.0022116831 1.062850e-02 3.028057e-02 13 110642387 110642446 60 - 2.239 2.330 0.306
ENSG00000134905 E009 221.7759630 0.0002053054 7.211417e-03 2.177355e-02 13 110642447 110642497 51 - 2.203 2.284 0.270
ENSG00000134905 E010 170.1929239 0.0002307968 1.500678e-02 4.050246e-02 13 110642498 110642510 13 - 2.086 2.169 0.279
ENSG00000134905 E011 173.4711589 0.0002056024 4.952586e-02 1.083270e-01 13 110642511 110642521 11 - 2.108 2.174 0.223
ENSG00000134905 E012 37.1827162 0.0095984142 2.510308e-02 6.208813e-02 13 110642522 110643752 1231 - 1.630 1.456 -0.594
ENSG00000134905 E013 17.7502028 0.0010667031 5.418749e-03 1.706648e-02 13 110643753 110643955 203 - 1.366 1.128 -0.838
ENSG00000134905 E014 8.9455313 0.0071956855 1.035503e-03 4.081128e-03 13 110643956 110643980 25 - 1.183 0.806 -1.403
ENSG00000134905 E015 13.3152589 0.0116870843 3.461258e-02 8.092473e-02 13 110643981 110644064 84 - 1.244 1.013 -0.830
ENSG00000134905 E016 28.5909690 0.0084486264 5.216916e-02 1.130206e-01 13 110644065 110644182 118 - 1.510 1.346 -0.565
ENSG00000134905 E017 5.3570461 0.0031731908 9.642091e-03 2.788547e-02 13 110644183 110644384 202 - 0.980 0.638 -1.357
ENSG00000134905 E018 159.9913699 0.0002078635 1.577459e-01 2.721150e-01 13 110644385 110644386 2 - 2.086 2.136 0.168
ENSG00000134905 E019 296.4904021 0.0007136809 1.097114e-03 4.294227e-03 13 110644387 110644483 97 - 2.319 2.412 0.310
ENSG00000134905 E020 13.8620635 0.0056864761 8.792596e-05 4.652750e-04 13 110644484 110644606 123 - 1.356 0.972 -1.372
ENSG00000134905 E021 25.3803304 0.0339547921 1.115502e-05 7.330574e-05 13 110644607 110645633 1027 - 1.668 1.170 -1.725
ENSG00000134905 E022 3.9792409 0.0181154940 8.327223e-02 1.646909e-01 13 110645930 110645966 37 - 0.826 0.556 -1.134
ENSG00000134905 E023 339.5686302 0.0001738049 9.250163e-03 2.690973e-02 13 110645967 110646090 124 - 2.402 2.466 0.211
ENSG00000134905 E024 41.4913540 0.0005488626 3.198058e-10 5.181411e-09 13 110646091 110646466 376 - 1.797 1.443 -1.204
ENSG00000134905 E025 10.8716865 0.0016012789 1.594079e-05 1.011331e-04 13 110646467 110646504 38 - 1.297 0.864 -1.576
ENSG00000134905 E026 22.5287115 0.0008447418 1.096840e-04 5.665334e-04 13 110646505 110646631 127 - 1.502 1.210 -1.016
ENSG00000134905 E027 13.1350832 0.0015052898 8.334528e-05 4.438319e-04 13 110646632 110646678 47 - 1.333 0.962 -1.330
ENSG00000134905 E028 19.3870342 0.0009564442 2.634514e-05 1.588380e-04 13 110646679 110646850 172 - 1.470 1.134 -1.176
ENSG00000134905 E029 4.3502284 0.0036830347 6.767225e-04 2.813877e-03 13 110646851 110646860 10 - 0.980 0.509 -1.941
ENSG00000134905 E030 23.6588810 0.0008560077 1.055145e-04 5.474149e-04 13 110646861 110647100 240 - 1.518 1.230 -1.000
ENSG00000134905 E031 355.4510808 0.0001394876 9.542479e-06 6.373102e-05 13 110647101 110647239 139 - 2.387 2.492 0.349
ENSG00000134905 E032 8.3304223 0.0020273409 7.251952e-02 1.475445e-01 13 110648318 110649297 980 - 1.052 0.841 -0.789
ENSG00000134905 E033 13.3785868 0.0074404485 6.955439e-02 1.426254e-01 13 110650247 110650636 390 - 0.894 1.116 0.819
ENSG00000134905 E034 24.3213624 0.0157551863 3.313157e-02 7.806812e-02 13 110650637 110651033 397 - 1.132 1.364 0.820
ENSG00000134905 E035 222.9856253 0.0011141005 9.323562e-08 9.519893e-07 13 110651034 110651100 67 - 2.119 2.301 0.607
ENSG00000134905 E036 2.3969281 0.0061057100 7.922834e-01 8.671792e-01 13 110651101 110651207 107 - 0.433 0.483 0.255
ENSG00000134905 E037 6.9531772 0.0028318703 6.169639e-05 3.397435e-04 13 110662838 110663050 213 - 1.150 0.673 -1.821
ENSG00000134905 E038 227.8663347 0.0008319792 1.370246e-03 5.209346e-03 13 110663451 110663518 68 - 2.195 2.296 0.337
ENSG00000134905 E039 24.1540110 0.0008536372 4.955401e-05 2.795253e-04 13 110663519 110663861 343 - 1.532 1.234 -1.034
ENSG00000134905 E040 5.5982747 0.0029996573 4.607766e-04 2.009501e-03 13 110665528 110665791 264 - 1.052 0.599 -1.788
ENSG00000134905 E041 267.1733093 0.0006818627 7.536687e-01 8.395333e-01 13 110667340 110667435 96 - 2.339 2.348 0.031
ENSG00000134905 E042 177.3021171 0.0038162969 3.170899e-01 4.599357e-01 13 110667436 110667473 38 - 2.203 2.158 -0.153
ENSG00000134905 E043 142.6757017 0.0021205988 2.479096e-01 3.834720e-01 13 110676974 110676998 25 - 2.112 2.067 -0.149
ENSG00000134905 E044 272.3071098 0.0001865689 8.616398e-03 2.532829e-02 13 110676999 110677095 97 - 2.404 2.342 -0.209
ENSG00000134905 E045 152.7497610 0.0002415190 8.821902e-02 1.724074e-01 13 110677096 110677103 8 - 2.148 2.095 -0.180
ENSG00000134905 E046 0.1515154 0.0428307302 1.518135e-01   13 110677923 110678093 171 - 0.196 0.000 -11.694
ENSG00000134905 E047 261.0367578 0.0003318607 1.156009e-01 2.136963e-01 13 110683051 110683134 84 - 2.367 2.327 -0.133
ENSG00000134905 E048 0.1515154 0.0428307302 1.518135e-01   13 110683135 110683139 5 - 0.196 0.000 -11.694
ENSG00000134905 E049 138.7992695 0.0017420461 7.810562e-02 1.564301e-01 13 110687721 110687721 1 - 2.116 2.044 -0.239
ENSG00000134905 E050 159.7818311 0.0008320853 3.152321e-02 7.492506e-02 13 110687722 110687731 10 - 2.179 2.105 -0.247
ENSG00000134905 E051 207.1246097 0.0012268950 1.651833e-01 2.819233e-01 13 110687732 110687791 60 - 2.270 2.224 -0.155
ENSG00000134905 E052 187.8384972 0.0003054997 4.568715e-01 5.972463e-01 13 110687792 110687826 35 - 2.176 2.201 0.086
ENSG00000134905 E053 204.7383418 0.0002177391 9.486831e-01 9.718288e-01 13 110687947 110688018 72 - 2.230 2.235 0.015
ENSG00000134905 E054 0.4804688 0.0221599313 1.269620e-01 2.299216e-01 13 110688785 110688904 120 - 0.331 0.074 -2.619
ENSG00000134905 E055 1.5124665 0.1553053479 9.950236e-01 1.000000e+00 13 110697918 110697967 50 - 0.331 0.332 0.009
ENSG00000134905 E056 0.1451727 0.0430703751 1.517865e-01   13 110701351 110701437 87 - 0.196 0.000 -11.690
ENSG00000134905 E057 183.0421103 0.0002913882 9.244600e-01 9.564116e-01 13 110701438 110701501 64 - 2.179 2.184 0.017
ENSG00000134905 E058 153.3638595 0.0003502600 1.204609e-01 2.206224e-01 13 110701502 110701555 54 - 2.148 2.099 -0.164
ENSG00000134905 E059 131.5423081 0.0003273045 6.716088e-02 1.386327e-01 13 110705521 110705571 51 - 2.092 2.030 -0.209
ENSG00000134905 E060 0.3268771 0.0274424043 4.132821e-01   13 110705572 110705797 226 - 0.196 0.074 -1.618
ENSG00000134905 E061 110.4119132 0.0002941444 6.393662e-15 2.168385e-13 13 110705870 110706133 264 - 2.169 1.892 -0.929
ENSG00000134905 E062 0.0000000       13 110706371 110706505 135 -      
ENSG00000134905 E063 0.0000000       13 110707338 110707643 306 -      
ENSG00000134905 E064 1.9530928 0.0074761682 6.181543e-01 7.358586e-01 13 110712232 110712486 255 - 0.331 0.427 0.552
ENSG00000134905 E065 4.9003072 0.0384286462 7.493525e-01 8.363236e-01 13 110713137 110713302 166 - 0.745 0.689 -0.230
ENSG00000134905 E066 5.3690461 0.0955820470 7.333806e-01 8.245994e-01 13 110713303 110713603 301 - 0.698 0.747 0.201