ENSG00000134900

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376065 ENSG00000134900 HEK293_OSMI2_2hA HEK293_TMG_2hB TPP2 protein_coding protein_coding 10.69829 4.30373 17.19339 0.3535403 0.7782837 1.995685 1.4163688 1.0715758 0.9675087 0.08184912 0.9675087 -0.1459534 0.18778333 0.24926667 0.0545000 -0.1947666667 0.090908439 0.003277677 FALSE TRUE
ENST00000466153 ENSG00000134900 HEK293_OSMI2_2hA HEK293_TMG_2hB TPP2 protein_coding processed_transcript 10.69829 4.30373 17.19339 0.3535403 0.7782837 1.995685 0.1700028 0.6829231 0.0000000 0.36973727 0.0000000 -6.1146234 0.04005000 0.14906667 0.0000000 -0.1490666667 0.045742038 0.003277677 FALSE TRUE
ENST00000490010 ENSG00000134900 HEK293_OSMI2_2hA HEK293_TMG_2hB TPP2 protein_coding processed_transcript 10.69829 4.30373 17.19339 0.3535403 0.7782837 1.995685 0.3609366 0.8109788 0.2644056 0.12767821 0.1336186 -1.5810350 0.07200833 0.18690000 0.0147000 -0.1722000000 0.003277677 0.003277677 FALSE TRUE
ENST00000650757 ENSG00000134900 HEK293_OSMI2_2hA HEK293_TMG_2hB TPP2 protein_coding protein_coding 10.69829 4.30373 17.19339 0.3535403 0.7782837 1.995685 1.2286444 0.2915254 1.3476713 0.29152542 0.5983678 2.1707826 0.11292917 0.07513333 0.0758000 0.0006666667 0.526477811 0.003277677 FALSE FALSE
ENST00000651448 ENSG00000134900 HEK293_OSMI2_2hA HEK293_TMG_2hB TPP2 protein_coding nonsense_mediated_decay 10.69829 4.30373 17.19339 0.3535403 0.7782837 1.995685 0.6964906 0.1442081 1.0849183 0.02809924 0.3164165 2.8278726 0.06131667 0.03293333 0.0640000 0.0310666667 0.618149364 0.003277677 TRUE TRUE
MSTRG.9039.3 ENSG00000134900 HEK293_OSMI2_2hA HEK293_TMG_2hB TPP2 protein_coding   10.69829 4.30373 17.19339 0.3535403 0.7782837 1.995685 4.8925388 0.5629530 10.3021744 0.30025180 0.6840189 4.1697880 0.33553333 0.13223333 0.6023333 0.4701000000 0.107956762 0.003277677 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134900 E001 2.8559364 0.0054142933 1.574290e-01 2.716896e-01 13 102596986 102596990 5 + 0.544 0.246 -1.711
ENSG00000134900 E002 2.8559364 0.0054142933 1.574290e-01 2.716896e-01 13 102596991 102596991 1 + 0.544 0.246 -1.711
ENSG00000134900 E003 12.1266785 0.0104712575 1.394089e-02 3.808908e-02 13 102596992 102597002 11 + 1.057 0.683 -1.446
ENSG00000134900 E004 23.0806478 0.0154449096 1.068251e-03 4.195122e-03 13 102597003 102597020 18 + 1.322 0.897 -1.537
ENSG00000134900 E005 29.2034963 0.0041840395 6.462881e-04 2.702751e-03 13 102597021 102597032 12 + 1.415 1.068 -1.225
ENSG00000134900 E006 33.0997397 0.0046350830 3.642455e-04 1.635660e-03 13 102597033 102597050 18 + 1.467 1.121 -1.213
ENSG00000134900 E007 50.7168099 0.0005492494 1.707672e-03 6.305935e-03 13 102597051 102597203 153 + 1.633 1.418 -0.734
ENSG00000134900 E008 51.2452490 0.0004751900 4.689144e-01 6.082536e-01 13 102604793 102604894 102 + 1.611 1.576 -0.120
ENSG00000134900 E009 36.7591565 0.0005780257 7.463941e-01 8.341816e-01 13 102604895 102604921 27 + 1.467 1.455 -0.043
ENSG00000134900 E010 6.4558756 0.0033188896 1.523177e-15 5.623880e-14 13 102607632 102608022 391 + 0.352 1.350 4.098
ENSG00000134900 E011 59.8070782 0.0003748665 6.082470e-04 2.563299e-03 13 102614101 102614196 96 + 1.704 1.488 -0.735
ENSG00000134900 E012 64.5355222 0.0004151592 6.891027e-04 2.859330e-03 13 102616396 102616500 105 + 1.734 1.529 -0.695
ENSG00000134900 E013 0.5943067 0.0217686188 6.201495e-01 7.374320e-01 13 102616956 102617051 96 + 0.151 0.246 0.872
ENSG00000134900 E014 69.1825686 0.0003880912 1.237753e-03 4.768353e-03 13 102618722 102618846 125 + 1.761 1.576 -0.628
ENSG00000134900 E015 73.4198060 0.0003784413 4.684360e-04 2.039431e-03 13 102622877 102623040 164 + 1.789 1.593 -0.665
ENSG00000134900 E016 0.1472490 0.0425849177 1.000000e+00   13 102626900 102627011 112 + 0.056 0.000 -9.323
ENSG00000134900 E017 66.4350983 0.0060638260 4.021554e-02 9.143041e-02 13 102627012 102627145 134 + 1.737 1.602 -0.457
ENSG00000134900 E018 34.2562638 0.0169386628 2.434470e-01 3.782244e-01 13 102627146 102627166 21 + 1.456 1.348 -0.375
ENSG00000134900 E019 42.6632265 0.0006454594 3.957619e-01 5.395464e-01 13 102627848 102627924 77 + 1.537 1.488 -0.168
ENSG00000134900 E020 46.5577951 0.0005784048 8.895749e-01 9.334055e-01 13 102629482 102629609 128 + 1.564 1.567 0.009
ENSG00000134900 E021 40.4346553 0.0005718000 9.233228e-01 9.556591e-01 13 102630096 102630195 100 + 1.501 1.519 0.064
ENSG00000134900 E022 0.5932745 0.0291315580 1.157202e-01 2.138439e-01 13 102631280 102631532 253 + 0.106 0.402 2.454
ENSG00000134900 E023 59.9345498 0.0004018135 9.543821e-03 2.764388e-02 13 102633950 102634098 149 + 1.694 1.539 -0.528
ENSG00000134900 E024 50.5918862 0.0006053980 8.868637e-02 1.731100e-01 13 102635587 102635702 116 + 1.614 1.509 -0.357
ENSG00000134900 E025 54.6208632 0.0020449728 3.796810e-01 5.239309e-01 13 102636224 102636392 169 + 1.639 1.593 -0.157
ENSG00000134900 E026 63.7820645 0.0009079698 6.384007e-01 7.520402e-01 13 102637082 102637239 158 + 1.700 1.684 -0.053
ENSG00000134900 E027 49.7015468 0.0004721984 1.939612e-01 3.187710e-01 13 102638239 102638315 77 + 1.605 1.529 -0.259
ENSG00000134900 E028 40.4890522 0.0005188718 1.643678e-01 2.808629e-01 13 102640270 102640295 26 + 1.523 1.431 -0.317
ENSG00000134900 E029 59.5219105 0.0004656611 7.226380e-02 1.471041e-01 13 102640296 102640376 81 + 1.685 1.584 -0.343
ENSG00000134900 E030 76.1806865 0.0003369851 2.144776e-02 5.453247e-02 13 102643222 102643376 155 + 1.794 1.677 -0.394
ENSG00000134900 E031 63.9038057 0.0021924813 1.782586e-01 2.989629e-01 13 102644557 102644673 117 + 1.713 1.641 -0.246
ENSG00000134900 E032 65.8666786 0.0003630782 1.674820e-01 2.849225e-01 13 102644909 102645009 101 + 1.725 1.656 -0.233
ENSG00000134900 E033 33.5629614 0.0006103975 6.707258e-03 2.046299e-02 13 102645010 102646293 1284 + 1.459 1.231 -0.792
ENSG00000134900 E034 64.2522685 0.0017226213 7.186217e-01 8.136549e-01 13 102646294 102646390 97 + 1.701 1.691 -0.033
ENSG00000134900 E035 71.5656747 0.0015605270 7.382610e-01 8.281844e-01 13 102647207 102647344 138 + 1.740 1.771 0.105
ENSG00000134900 E036 58.0614244 0.0006016321 8.254037e-01 8.900353e-01 13 102648907 102648992 86 + 1.652 1.677 0.087
ENSG00000134900 E037 46.5753702 0.0005048730 7.466416e-01 8.343303e-01 13 102648993 102649054 62 + 1.559 1.593 0.115
ENSG00000134900 E038 65.4424427 0.0004050045 6.282893e-01 7.438523e-01 13 102649055 102649151 97 + 1.713 1.698 -0.052
ENSG00000134900 E039 1.0351233 0.0119557348 2.590669e-01 3.964318e-01 13 102649152 102649407 256 + 0.295 0.000 -12.130
ENSG00000134900 E040 72.0935247 0.0007725392 8.252711e-01 8.899478e-01 13 102649408 102649486 79 + 1.747 1.771 0.082
ENSG00000134900 E041 0.8793415 0.1787958796 4.025514e-01 5.463101e-01 13 102651339 102651358 20 + 0.263 0.000 -11.904
ENSG00000134900 E042 8.8019726 0.0119328757 1.272515e-01 2.303052e-01 13 102651359 102651397 39 + 0.922 0.683 -0.943
ENSG00000134900 E043 0.2934659 0.0299816764 2.247891e-01   13 102654942 102655007 66 + 0.056 0.246 2.457
ENSG00000134900 E044 0.0000000       13 102656679 102656811 133 +      
ENSG00000134900 E045 0.5954526 0.0183359843 5.918419e-01 7.145154e-01 13 102656942 102656981 40 + 0.192 0.000 -11.323
ENSG00000134900 E046 0.9286724 0.0143848784 9.779949e-01 9.903655e-01 13 102656982 102657055 74 + 0.229 0.246 0.138
ENSG00000134900 E047 91.9821661 0.0024300672 1.297006e-02 3.584133e-02 13 102657056 102657207 152 + 1.827 1.963 0.457
ENSG00000134900 E048 72.5301593 0.0024166910 1.682912e-04 8.278741e-04 13 102663648 102663744 97 + 1.708 1.921 0.717
ENSG00000134900 E049 92.0909727 0.0034977947 3.413198e-05 2.001920e-04 13 102664795 102664925 131 + 1.807 2.029 0.746
ENSG00000134900 E050 4.6296165 0.0237430908 2.660156e-01 4.041400e-01 13 102664926 102664936 11 + 0.608 0.804 0.813
ENSG00000134900 E051 5.1962605 0.0031388441 3.867837e-02 8.858626e-02 13 102667758 102667883 126 + 0.622 0.936 1.258
ENSG00000134900 E052 0.2987644 0.0290785164 1.000000e+00   13 102673836 102674282 447 + 0.106 0.000 -10.323
ENSG00000134900 E053 110.3763142 0.0002845517 4.459132e-05 2.542954e-04 13 102674283 102674490 208 + 1.894 2.071 0.596
ENSG00000134900 E054 73.1646360 0.0038459004 5.112459e-06 3.630825e-05 13 102676296 102676415 120 + 1.692 1.958 0.896
ENSG00000134900 E055 153.3119339 0.0032023397 1.953952e-15 7.110457e-14 13 102678227 102679467 1241 + 1.990 2.324 1.118
ENSG00000134900 E056 1.5690626 0.1337394837 7.214587e-01 8.158293e-01 13 102679468 102679958 491 + 0.325 0.403 0.457
ENSG00000134900 E057 0.5138669 0.0214685861 4.248370e-01 5.677741e-01 13 102683795 102683846 52 + 0.106 0.247 1.462