ENSG00000134882

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000403766 ENSG00000134882 HEK293_OSMI2_2hA HEK293_TMG_2hB UBAC2 protein_coding protein_coding 50.59684 63.13545 37.6791 2.57364 0.16487 -0.7445312 38.476352 38.76474 32.5763807 3.5020824 1.1977400 -0.250848 0.77584167 0.61543333 0.86436667 0.2489333 0.003511207 0.003511207 FALSE TRUE
ENST00000494576 ENSG00000134882 HEK293_OSMI2_2hA HEK293_TMG_2hB UBAC2 protein_coding processed_transcript 50.59684 63.13545 37.6791 2.57364 0.16487 -0.7445312 4.769988 15.04387 0.6432421 4.6372492 0.6432421 -4.526373 0.07865417 0.23646667 0.01716667 -0.2193000 0.037472272 0.003511207 FALSE TRUE
MSTRG.9000.3 ENSG00000134882 HEK293_OSMI2_2hA HEK293_TMG_2hB UBAC2 protein_coding   50.59684 63.13545 37.6791 2.57364 0.16487 -0.7445312 2.647014 3.42297 1.0397907 0.4520844 0.3180094 -1.709356 0.05163333 0.05466667 0.02766667 -0.0270000 0.271410447 0.003511207 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134882 E001 0.9244034 0.0142110235 4.127625e-01 5.563345e-01 13 99200774 99200779 6 + 0.145 0.316 1.432
ENSG00000134882 E002 1.5531654 0.0089139654 8.171990e-01 8.843893e-01 13 99200780 99200794 15 + 0.340 0.416 0.431
ENSG00000134882 E003 13.5587510 0.0091278153 4.315215e-01 5.740741e-01 13 99200795 99200853 59 + 1.053 1.188 0.485
ENSG00000134882 E004 50.0351141 0.0005045901 2.069856e-01 3.349145e-01 13 99200854 99200886 33 + 1.693 1.686 -0.025
ENSG00000134882 E005 53.5405582 0.0005169828 1.431007e-01 2.522457e-01 13 99200887 99200891 5 + 1.727 1.712 -0.052
ENSG00000134882 E006 121.6560099 0.0002854127 1.499219e-08 1.788893e-07 13 99200892 99200908 17 + 2.148 2.022 -0.422
ENSG00000134882 E007 146.0358259 0.0009271947 2.306369e-08 2.657269e-07 13 99200909 99200915 7 + 2.224 2.101 -0.411
ENSG00000134882 E008 173.6800556 0.0002707962 9.162299e-09 1.137688e-07 13 99200916 99200939 24 + 2.287 2.188 -0.333
ENSG00000134882 E009 1.4048722 0.0113342568 9.824891e-01 9.931021e-01 13 99200940 99201184 245 + 0.340 0.369 0.169
ENSG00000134882 E010 1.2522254 0.0102670530 9.748164e-01 9.883228e-01 13 99201185 99201428 244 + 0.340 0.368 0.165
ENSG00000134882 E011 7.1092279 0.0024779834 1.168324e-01 2.154411e-01 13 99201429 99201567 139 + 0.729 0.979 0.969
ENSG00000134882 E012 1.9436295 0.0084206907 4.948869e-01 6.317925e-01 13 99231434 99231513 80 + 0.340 0.497 0.847
ENSG00000134882 E013 282.6547568 0.0023653856 8.436038e-05 4.487007e-04 13 99238427 99238554 128 + 2.475 2.411 -0.215
ENSG00000134882 E014 280.1272315 0.0046770204 1.424670e-01 2.513896e-01 13 99243832 99243951 120 + 2.432 2.431 -0.002
ENSG00000134882 E015 303.0910031 0.0025159422 6.165687e-02 1.294161e-01 13 99244515 99244624 110 + 2.467 2.465 -0.005
ENSG00000134882 E016 0.2944980 0.3670540561 1.587575e-01   13 99307952 99307980 29 + 0.253 0.000 -14.123
ENSG00000134882 E017 0.2214452 0.0423249910 7.756096e-01   13 99308683 99308809 127 + 0.000 0.103 11.715
ENSG00000134882 E018 0.1515154 0.0432559885 2.955048e-01   13 99312783 99313387 605 + 0.145 0.000 -13.125
ENSG00000134882 E019 374.4219538 0.0005403078 3.157439e-02 7.502036e-02 13 99314097 99314220 124 + 2.550 2.562 0.042
ENSG00000134882 E020 0.0000000       13 99314708 99314839 132 +      
ENSG00000134882 E021 227.4862651 0.0002138456 4.757535e-01 6.144339e-01 13 99318022 99318069 48 + 2.315 2.355 0.136
ENSG00000134882 E022 525.0600788 0.0001274965 1.213289e-03 4.686209e-03 13 99340320 99340565 246 + 2.699 2.707 0.025
ENSG00000134882 E023 328.6544949 0.0015764626 4.100835e-02 9.289398e-02 13 99367787 99367906 120 + 2.499 2.500 0.005
ENSG00000134882 E024 8.7913102 0.0022847902 8.621975e-01 9.151408e-01 13 99376918 99377650 733 + 0.931 1.003 0.269
ENSG00000134882 E025 1816.2629310 0.0041974917 6.989178e-09 8.868578e-08 13 99385228 99386504 1277 + 3.115 3.299 0.610