ENSG00000134874

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000347108 ENSG00000134874 HEK293_OSMI2_2hA HEK293_TMG_2hB DZIP1 protein_coding protein_coding 19.9711 14.21036 26.94759 0.4910947 0.09670873 0.9227336 0.9401234 1.1274786 1.1322754 0.1706623 0.22980782 0.006071195 0.05514583 0.07966667 0.04203333 -0.03763333 0.1596674402 0.0003578456 FALSE TRUE
ENST00000479518 ENSG00000134874 HEK293_OSMI2_2hA HEK293_TMG_2hB DZIP1 protein_coding processed_transcript 19.9711 14.21036 26.94759 0.4910947 0.09670873 0.9227336 2.2469764 3.0823432 1.7152727 0.5521094 0.26353233 -0.841876016 0.12593333 0.21630000 0.06356667 -0.15273333 0.0003578456 0.0003578456 FALSE TRUE
ENST00000485031 ENSG00000134874 HEK293_OSMI2_2hA HEK293_TMG_2hB DZIP1 protein_coding processed_transcript 19.9711 14.21036 26.94759 0.4910947 0.09670873 0.9227336 1.0742199 0.9877016 0.9259815 0.3311796 0.64206055 -0.092128326 0.06722917 0.07100000 0.03443333 -0.03656667 0.5010705140 0.0003578456 FALSE TRUE
MSTRG.8960.1 ENSG00000134874 HEK293_OSMI2_2hA HEK293_TMG_2hB DZIP1 protein_coding   19.9711 14.21036 26.94759 0.4910947 0.09670873 0.9227336 3.1078220 1.1400044 5.9926788 0.5936504 0.58913660 2.383967131 0.14112917 0.08033333 0.22223333 0.14190000 0.4765619247 0.0003578456 TRUE TRUE
MSTRG.8960.13 ENSG00000134874 HEK293_OSMI2_2hA HEK293_TMG_2hB DZIP1 protein_coding   19.9711 14.21036 26.94759 0.4910947 0.09670873 0.9227336 5.9385073 2.3219997 9.4751184 1.2023924 0.29895853 2.024098178 0.27221250 0.16066667 0.35166667 0.19100000 0.6127636350 0.0003578456 FALSE TRUE
MSTRG.8960.15 ENSG00000134874 HEK293_OSMI2_2hA HEK293_TMG_2hB DZIP1 protein_coding   19.9711 14.21036 26.94759 0.4910947 0.09670873 0.9227336 1.0711572 1.1755601 1.1333167 0.1504221 0.04456567 -0.052343648 0.05211667 0.08346667 0.04206667 -0.04140000 0.0191677301 0.0003578456 FALSE TRUE
MSTRG.8960.2 ENSG00000134874 HEK293_OSMI2_2hA HEK293_TMG_2hB DZIP1 protein_coding   19.9711 14.21036 26.94759 0.4910947 0.09670873 0.9227336 0.4452239 0.8894069 0.0000000 0.8894069 0.00000000 -6.490901987 0.02907917 0.06403333 0.00000000 -0.06403333 0.7121757869 0.0003578456 TRUE TRUE
MSTRG.8960.3 ENSG00000134874 HEK293_OSMI2_2hA HEK293_TMG_2hB DZIP1 protein_coding   19.9711 14.21036 26.94759 0.4910947 0.09670873 0.9227336 1.8820287 1.4466587 2.1880120 0.1864000 0.09740196 0.593536436 0.09361250 0.10116667 0.08116667 -0.02000000 0.5300277434 0.0003578456 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134874 E001 8.9677675 0.0019426131 1.542276e-03 5.772815e-03 13 95577597 95577656 60 - 0.824 1.160 1.245
ENSG00000134874 E002 8.2678557 0.0025963559 1.177283e-03 4.564358e-03 13 95577657 95577726 70 - 0.792 1.146 1.320
ENSG00000134874 E003 3.9739543 0.0041407709 3.102650e-04 1.421322e-03 13 95577727 95577735 9 - 0.424 0.935 2.202
ENSG00000134874 E004 6.2613997 0.0027252606 1.031605e-05 6.838153e-05 13 95577736 95577780 45 - 0.556 1.102 2.164
ENSG00000134874 E005 0.7332358 0.4784288496 6.150383e-01 7.333843e-01 13 95578202 95578202 1 - 0.167 0.289 1.008
ENSG00000134874 E006 31.3466232 0.0081769815 1.084506e-05 7.147799e-05 13 95578203 95579330 1128 - 1.348 1.671 1.109
ENSG00000134874 E007 5.3968636 0.0076801031 3.426338e-01 4.866436e-01 13 95579331 95579385 55 - 0.740 0.862 0.484
ENSG00000134874 E008 9.3534903 0.0125176962 5.010602e-02 1.093510e-01 13 95579386 95579447 62 - 0.895 1.119 0.825
ENSG00000134874 E009 13.6338922 0.0012812965 1.574721e-01 2.717458e-01 13 95579448 95579754 307 - 1.100 1.222 0.438
ENSG00000134874 E010 4.3480133 0.0132097269 7.627108e-01 8.462717e-01 13 95579755 95579796 42 - 0.700 0.739 0.159
ENSG00000134874 E011 196.0889279 0.0025736342 1.118685e-12 2.721256e-11 13 95579797 95581954 2158 - 2.174 2.413 0.799
ENSG00000134874 E012 21.1083203 0.0013733933 8.920725e-01 9.350700e-01 13 95581955 95581969 15 - 1.343 1.325 -0.061
ENSG00000134874 E013 22.4775000 0.0079453871 3.068158e-01 4.490004e-01 13 95581970 95581980 11 - 1.329 1.408 0.275
ENSG00000134874 E014 75.5205177 0.0004253685 1.828307e-03 6.690891e-03 13 95581981 95582049 69 - 1.818 1.940 0.411
ENSG00000134874 E015 241.9691104 0.0001835388 8.544083e-05 4.537340e-04 13 95582050 95582313 264 - 2.338 2.422 0.278
ENSG00000134874 E016 6.3260204 0.0114314772 2.022374e-04 9.734556e-04 13 95584578 95584735 158 - 0.610 1.086 1.865
ENSG00000134874 E017 236.3402442 0.0002369685 1.222868e-05 7.961122e-05 13 95584736 95584910 175 - 2.323 2.419 0.320
ENSG00000134874 E018 195.0604987 0.0002115071 2.456320e-01 3.807993e-01 13 95586006 95586136 131 - 2.272 2.295 0.076
ENSG00000134874 E019 212.6393067 0.0003236093 8.763923e-01 9.246705e-01 13 95587539 95587714 176 - 2.320 2.316 -0.011
ENSG00000134874 E020 80.1977670 0.0003595348 8.025258e-01 8.742229e-01 13 95587715 95587729 15 - 1.895 1.898 0.009
ENSG00000134874 E021 3.9696534 0.1617727853 5.408170e-01 6.719009e-01 13 95587730 95588133 404 - 0.657 0.737 0.335
ENSG00000134874 E022 112.2259176 0.0002621719 1.269813e-01 2.299445e-01 13 95589154 95589207 54 - 2.022 2.067 0.150
ENSG00000134874 E023 171.7213103 0.0011214986 9.373785e-01 9.646317e-01 13 95589803 95589932 130 - 2.226 2.217 -0.030
ENSG00000134874 E024 211.1225060 0.0033124333 3.348279e-01 4.785561e-01 13 95590279 95590441 163 - 2.327 2.288 -0.131
ENSG00000134874 E025 183.9546187 0.0026284356 8.575221e-02 1.685917e-01 13 95593944 95594086 143 - 2.277 2.210 -0.224
ENSG00000134874 E026 2.4691298 0.0092048116 5.171238e-02 1.122053e-01 13 95599357 95599364 8 - 0.634 0.278 -1.883
ENSG00000134874 E027 50.8315914 0.0122486704 7.047181e-02 1.441198e-01 13 95599365 95599424 60 - 1.747 1.609 -0.468
ENSG00000134874 E028 88.2008576 0.0003478824 1.027196e-01 1.946420e-01 13 95606003 95606059 57 - 1.965 1.893 -0.243
ENSG00000134874 E029 71.2782538 0.0014347926 1.523773e-01 2.649166e-01 13 95609457 95609513 57 - 1.873 1.799 -0.252
ENSG00000134874 E030 74.9344154 0.0033803108 6.450314e-01 7.572379e-01 13 95611445 95611493 49 - 1.880 1.849 -0.105
ENSG00000134874 E031 144.8099078 0.0008884464 6.092600e-03 1.885434e-02 13 95612037 95612177 141 - 2.188 2.088 -0.333
ENSG00000134874 E032 110.2242607 0.0042665553 1.553244e-04 7.707511e-04 13 95619885 95619947 63 - 2.100 1.910 -0.638
ENSG00000134874 E033 139.5155784 0.0021202672 4.686991e-08 5.085255e-07 13 95622343 95622480 138 - 2.209 1.987 -0.743
ENSG00000134874 E034 165.2987991 0.0029739369 3.952420e-04 1.756160e-03 13 95624768 95624929 162 - 2.259 2.113 -0.487
ENSG00000134874 E035 143.3205857 0.0055762275 4.183961e-03 1.366100e-02 13 95629989 95630113 125 - 2.198 2.055 -0.480
ENSG00000134874 E036 8.8616310 0.0019138610 2.105073e-01 3.391357e-01 13 95630714 95630813 100 - 1.038 0.888 -0.562
ENSG00000134874 E037 111.3279832 0.0053806533 5.131920e-03 1.628684e-02 13 95633234 95633321 88 - 2.091 1.943 -0.498
ENSG00000134874 E038 10.1830280 0.0023165489 2.905906e-08 3.279219e-07 13 95637009 95637176 168 - 0.720 1.297 2.146
ENSG00000134874 E039 221.7016861 0.0001882692 7.917719e-03 2.357101e-02 13 95641295 95641855 561 - 2.362 2.288 -0.247
ENSG00000134874 E040 0.5891098 0.0183390606 1.393767e-01 2.471914e-01 13 95641856 95641993 138 - 0.289 0.000 -10.529
ENSG00000134874 E041 83.8581586 0.0019050331 3.966513e-01 5.404166e-01 13 95641994 95642241 248 - 1.904 1.934 0.100
ENSG00000134874 E042 95.1224785 0.0023098858 3.746743e-02 8.634204e-02 13 95643043 95643179 137 - 1.940 2.021 0.273
ENSG00000134874 E043 58.5730046 0.0008771773 3.953400e-01 5.391575e-01 13 95643180 95643257 78 - 1.752 1.786 0.113
ENSG00000134874 E044 0.6621601 0.0163476605 5.190681e-01 6.531993e-01 13 95643258 95643263 6 - 0.168 0.278 0.924
ENSG00000134874 E045 8.0319264 0.0021347984 6.857760e-02 1.410085e-01 13 95643523 95643600 78 - 0.854 1.053 0.747
ENSG00000134874 E046 68.1499192 0.0062835686 6.720206e-01 7.781163e-01 13 95643601 95643698 98 - 1.842 1.810 -0.108
ENSG00000134874 E047 76.1257587 0.0196903609 1.386378e-01 2.462152e-01 13 95644377 95644706 330 - 1.917 1.797 -0.403