ENSG00000134852

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309964 ENSG00000134852 HEK293_OSMI2_2hA HEK293_TMG_2hB CLOCK protein_coding protein_coding 2.866853 0.5057189 5.760603 0.03054751 0.451222 3.484065 0.92554474 0.0000000 1.8066529 0.00000000 0.38236320 7.5051389 0.2981458 0.0000000 0.3076000 0.3076000 8.891257e-05 4.608613e-06 FALSE TRUE
ENST00000479384 ENSG00000134852 HEK293_OSMI2_2hA HEK293_TMG_2hB CLOCK protein_coding retained_intron 2.866853 0.5057189 5.760603 0.03054751 0.451222 3.484065 0.26783721 0.0000000 0.9505542 0.00000000 0.07261778 6.5857951 0.0942375 0.0000000 0.1674667 0.1674667 4.006021e-03 4.608613e-06 FALSE TRUE
ENST00000513033 ENSG00000134852 HEK293_OSMI2_2hA HEK293_TMG_2hB CLOCK protein_coding processed_transcript 2.866853 0.5057189 5.760603 0.03054751 0.451222 3.484065 0.06736112 0.0000000 0.5388889 0.00000000 0.37993465 5.7784423 0.0106875 0.0000000 0.0855000 0.0855000 6.931254e-01 4.608613e-06   FALSE
ENST00000513440 ENSG00000134852 HEK293_OSMI2_2hA HEK293_TMG_2hB CLOCK protein_coding protein_coding 2.866853 0.5057189 5.760603 0.03054751 0.451222 3.484065 0.73228669 0.4603449 0.8436948 0.04298758 0.12163827 0.8600013 0.3872625 0.9145333 0.1504667 -0.7640667 4.608613e-06 4.608613e-06 FALSE TRUE
MSTRG.24907.6 ENSG00000134852 HEK293_OSMI2_2hA HEK293_TMG_2hB CLOCK protein_coding   2.866853 0.5057189 5.760603 0.03054751 0.451222 3.484065 0.35089535 0.0000000 0.6955446 0.00000000 0.02747777 6.1406653 0.0683375 0.0000000 0.1227000 0.1227000 1.750789e-02 4.608613e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134852 E001 0.1817044 0.0404870771 4.876511e-02   4 55427780 55427902 123 - 0.000 0.271 12.558
ENSG00000134852 E002 211.5512799 0.0014673910 1.433676e-25 1.665271e-23 4 55427903 55432475 4573 - 2.119 2.412 0.979
ENSG00000134852 E003 83.4909338 0.0005656687 1.920452e-04 9.298061e-04 4 55432476 55434822 2347 - 1.801 1.583 -0.740
ENSG00000134852 E004 44.8904738 0.0005474927 7.013758e-01 8.005733e-01 4 55434823 55435525 703 - 1.507 1.542 0.119
ENSG00000134852 E005 11.9222927 0.0050583595 7.608982e-01 8.448691e-01 4 55435526 55435594 69 - 0.980 0.944 -0.133
ENSG00000134852 E006 0.1515154 0.0427097343 7.874154e-01   4 55438210 55438281 72 - 0.050 0.000 -12.384
ENSG00000134852 E007 11.6258201 0.0015779666 3.408317e-01 4.847595e-01 4 55438282 55438407 126 - 0.980 0.849 -0.495
ENSG00000134852 E008 11.1809405 0.0015974358 3.971235e-02 9.048948e-02 4 55438408 55438537 130 - 0.980 0.650 -1.302
ENSG00000134852 E009 1.0393897 0.0119010908 3.828869e-01 5.270610e-01 4 55442278 55442431 154 - 0.268 0.000 -15.098
ENSG00000134852 E010 25.3848155 0.0023461495 2.372962e-01 3.710449e-01 4 55442432 55442634 203 - 1.289 1.173 -0.409
ENSG00000134852 E011 24.6652711 0.0019261384 6.306153e-02 1.318095e-01 4 55443687 55443896 210 - 1.286 1.089 -0.700
ENSG00000134852 E012 21.7419668 0.0123670128 7.925179e-01 8.673307e-01 4 55444633 55444785 153 - 1.208 1.243 0.124
ENSG00000134852 E013 16.9672638 0.0010481244 8.926069e-02 1.740141e-01 4 55448779 55448868 90 - 1.079 1.263 0.658
ENSG00000134852 E014 16.5584143 0.0017312637 9.222732e-01 9.549680e-01 4 55449396 55449496 101 - 1.100 1.119 0.065
ENSG00000134852 E015 19.8672360 0.0130035574 1.636188e-01 2.798480e-01 4 55450091 55450232 142 - 1.198 1.023 -0.629
ENSG00000134852 E016 15.8741862 0.0231955213 1.222286e-03 4.716057e-03 4 55453054 55453129 76 - 1.136 0.557 -2.285
ENSG00000134852 E017 12.4938244 0.0014180999 1.686633e-02 4.463673e-02 4 55453677 55453759 83 - 1.027 0.650 -1.476
ENSG00000134852 E018 12.8981199 0.0014685809 4.142101e-02 9.366300e-02 4 55453760 55453824 65 - 1.032 0.727 -1.172
ENSG00000134852 E019 14.3125611 0.0012871449 1.691000e-02 4.473542e-02 4 55455897 55456003 107 - 1.079 0.727 -1.342
ENSG00000134852 E020 12.0959959 0.0014711380 1.454936e-01 2.555307e-01 4 55456218 55456300 83 - 1.002 0.793 -0.797
ENSG00000134852 E021 10.9911985 0.0162284559 3.444388e-05 2.017590e-04 4 55458892 55459010 119 - 1.002 0.000 -17.375
ENSG00000134852 E022 8.9945538 0.0020249483 4.864848e-02 1.067704e-01 4 55459148 55459261 114 - 0.901 0.556 -1.421
ENSG00000134852 E023 4.2126236 0.0038898759 7.270850e-01 8.199273e-01 4 55463685 55463697 13 - 0.581 0.650 0.305
ENSG00000134852 E024 10.2689775 0.0032855272 8.852951e-01 9.306467e-01 4 55463698 55463805 108 - 0.914 0.900 -0.054
ENSG00000134852 E025 6.9754362 0.0037137981 4.120263e-01 5.555867e-01 4 55470717 55470743 27 - 0.787 0.650 -0.564
ENSG00000134852 E026 11.0575247 0.0015668140 1.126846e-01 2.094663e-01 4 55470744 55470806 63 - 0.969 0.727 -0.938
ENSG00000134852 E027 15.0558890 0.0012493280 4.289655e-01 5.716935e-01 4 55475963 55476054 92 - 1.079 0.985 -0.343
ENSG00000134852 E028 8.8930961 0.0311781894 5.892716e-01 7.123351e-01 4 55478815 55478846 32 - 0.852 0.942 0.341
ENSG00000134852 E029 15.3514443 0.0013523434 5.855838e-01 7.092575e-01 4 55478847 55478963 117 - 1.083 1.023 -0.221
ENSG00000134852 E030 0.0000000       4 55478964 55479060 97 -      
ENSG00000134852 E031 13.9022236 0.0021900983 4.119422e-01 5.554970e-01 4 55479640 55479699 60 - 1.047 0.945 -0.378
ENSG00000134852 E032 11.6350609 0.0279228472 1.265291e-01 2.293142e-01 4 55482739 55482772 34 - 0.992 0.728 -1.022
ENSG00000134852 E033 13.3508814 0.0027191804 7.528431e-02 1.519832e-01 4 55482773 55482828 56 - 1.047 0.792 -0.963
ENSG00000134852 E034 1.1888288 0.0131790099 3.123096e-01 4.548493e-01 4 55486393 55486393 1 - 0.296 0.000 -15.245
ENSG00000134852 E035 2.5291730 0.0735633866 8.435732e-02 1.663881e-01 4 55486394 55486549 156 - 0.489 0.000 -15.876
ENSG00000134852 E036 14.2864376 0.0012729673 1.536651e-02 4.131860e-02 4 55489374 55489465 92 - 1.083 0.727 -1.359
ENSG00000134852 E037 11.1974133 0.0015330309 9.564245e-02 1.838595e-01 4 55509912 55510065 154 - 0.980 0.727 -0.980
ENSG00000134852 E038 0.1472490 0.0430691751 7.873113e-01   4 55510066 55510066 1 - 0.050 0.000 -12.382
ENSG00000134852 E039 0.4741261 0.0210698490 3.162430e-01 4.589941e-01 4 55545453 55545932 480 - 0.095 0.271 1.828
ENSG00000134852 E040 2.2217620 0.0065879672 8.941353e-02 1.742350e-01 4 55546482 55546655 174 - 0.452 0.000 -15.967
ENSG00000134852 E041 3.0916628 0.0049913329 3.499740e-01 4.941606e-01 4 55546782 55546924 143 - 0.470 0.650 0.828