ENSG00000134779

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000383056 ENSG00000134779 HEK293_OSMI2_2hA HEK293_TMG_2hB TPGS2 protein_coding protein_coding 141.507 194.838 136.4124 13.73878 1.381315 -0.5142689 28.426880 49.450530 14.635041 4.359077 3.980684 -1.7558654 0.19341250 0.25316667 0.10763333 -0.145533333 4.621144e-02 2.380592e-43 FALSE TRUE
ENST00000590500 ENSG00000134779 HEK293_OSMI2_2hA HEK293_TMG_2hB TPGS2 protein_coding protein_coding 141.507 194.838 136.4124 13.73878 1.381315 -0.5142689 8.955089 3.068429 18.272567 3.068429 1.118918 2.5702025 0.06853750 0.01516667 0.13390000 0.118733333 4.773336e-02 2.380592e-43 FALSE FALSE
ENST00000591906 ENSG00000134779 HEK293_OSMI2_2hA HEK293_TMG_2hB TPGS2 protein_coding protein_coding 141.507 194.838 136.4124 13.73878 1.381315 -0.5142689 8.776172 11.503344 7.159618 1.215587 1.052084 -0.6833387 0.06316667 0.05876667 0.05236667 -0.006400000 7.792678e-01 2.380592e-43 FALSE TRUE
ENST00000593035 ENSG00000134779 HEK293_OSMI2_2hA HEK293_TMG_2hB TPGS2 protein_coding protein_coding 141.507 194.838 136.4124 13.73878 1.381315 -0.5142689 34.942602 53.434836 37.463455 2.486241 4.585706 -0.5121816 0.24245833 0.27603333 0.27416667 -0.001866667 1.000000e+00 2.380592e-43 FALSE TRUE
MSTRG.15712.14 ENSG00000134779 HEK293_OSMI2_2hA HEK293_TMG_2hB TPGS2 protein_coding   141.507 194.838 136.4124 13.73878 1.381315 -0.5142689 4.155988 10.453730 0.000000 1.593656 0.000000 -10.0311815 0.02426250 0.05316667 0.00000000 -0.053166667 2.380592e-43 2.380592e-43 FALSE TRUE
MSTRG.15712.19 ENSG00000134779 HEK293_OSMI2_2hA HEK293_TMG_2hB TPGS2 protein_coding   141.507 194.838 136.4124 13.73878 1.381315 -0.5142689 16.020791 19.095281 18.451577 2.551903 1.064344 -0.0494457 0.11528750 0.09933333 0.13540000 0.036066667 3.712171e-01 2.380592e-43 FALSE TRUE
MSTRG.15712.6 ENSG00000134779 HEK293_OSMI2_2hA HEK293_TMG_2hB TPGS2 protein_coding   141.507 194.838 136.4124 13.73878 1.381315 -0.5142689 17.679525 24.698062 17.383262 2.495120 0.685672 -0.5064533 0.12539167 0.12623333 0.12750000 0.001266667 9.921824e-01 2.380592e-43 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134779 E001 71.5403751 0.0005005145 3.401811e-15 1.200157e-13 18 36777647 36780013 2367 - 2.022 1.702 -1.079
ENSG00000134779 E002 3.6721486 0.0049262106 1.787504e-02 4.686891e-02 18 36780014 36780023 10 - 0.844 0.509 -1.421
ENSG00000134779 E003 3.2991985 0.0115457247 4.300763e-01 5.727146e-01 18 36780024 36780026 3 - 0.685 0.572 -0.494
ENSG00000134779 E004 7.3097863 0.0034675061 7.284821e-01 8.209606e-01 18 36780027 36780072 46 - 0.917 0.886 -0.117
ENSG00000134779 E005 29.0679410 0.0143641154 1.467369e-01 2.572445e-01 18 36780073 36780121 49 - 1.350 1.496 0.507
ENSG00000134779 E006 67.3262676 0.0005025743 5.577067e-02 1.192975e-01 18 36780122 36780188 67 - 1.742 1.844 0.344
ENSG00000134779 E007 108.7491884 0.0016690535 5.575489e-01 6.859541e-01 18 36781799 36781922 124 - 1.993 2.031 0.127
ENSG00000134779 E008 8.6098609 0.0092248628 7.851035e-03 2.340780e-02 18 36782985 36783131 147 - 1.127 0.827 -1.115
ENSG00000134779 E009 3.2932109 0.0296793745 2.822502e-02 6.845923e-02 18 36786485 36786572 88 - 0.816 0.474 -1.491
ENSG00000134779 E010 5.4282156 0.0029279175 2.856786e-05 1.707663e-04 18 36786573 36786623 51 - 1.067 0.541 -2.107
ENSG00000134779 E011 12.1923876 0.0015598909 7.760044e-06 5.287083e-05 18 36786624 36786717 94 - 1.324 0.913 -1.481
ENSG00000134779 E012 15.4461103 0.0015233331 3.535663e-06 2.605394e-05 18 36786718 36786800 83 - 1.411 1.028 -1.358
ENSG00000134779 E013 108.0619578 0.0118132210 3.489036e-01 4.931160e-01 18 36786801 36786982 182 - 1.960 2.037 0.258
ENSG00000134779 E014 101.6457960 0.0286617015 3.968271e-01 5.405940e-01 18 36786983 36787079 97 - 1.916 2.016 0.338
ENSG00000134779 E015 17.6200792 0.0081847193 5.980626e-09 7.702322e-08 18 36788693 36790151 1459 - 1.519 1.007 -1.808
ENSG00000134779 E016 19.6486419 0.0026258459 4.858646e-01 6.236939e-01 18 36794108 36794223 116 - 1.247 1.318 0.249
ENSG00000134779 E017 269.5966139 0.0010984632 2.034009e-01 3.304635e-01 18 36794224 36796071 1848 - 2.422 2.399 -0.077
ENSG00000134779 E018 1870.7213810 0.0012816421 1.090607e-12 2.656918e-11 18 36796072 36796513 442 - 3.146 3.285 0.460
ENSG00000134779 E019 2298.3365391 0.0005260651 3.948511e-08 4.347769e-07 18 36796514 36796925 412 - 3.280 3.357 0.257
ENSG00000134779 E020 1187.6545491 0.0001225694 2.424719e-01 3.770651e-01 18 36796926 36797050 125 - 3.031 3.057 0.085
ENSG00000134779 E021 66.9110467 0.0004112800 7.850887e-02 1.570982e-01 18 36798018 36798377 360 - 1.742 1.837 0.319
ENSG00000134779 E022 37.5464675 0.0136918165 1.485923e-01 2.597568e-01 18 36798378 36798448 71 - 1.465 1.603 0.470
ENSG00000134779 E023 787.4045722 0.0001750120 3.942231e-01 5.380875e-01 18 36798449 36798466 18 - 2.855 2.880 0.083
ENSG00000134779 E024 1681.2485888 0.0001625122 9.630801e-02 1.848426e-01 18 36798467 36798609 143 - 3.180 3.210 0.098
ENSG00000134779 E025 936.4551862 0.0006598358 9.103170e-02 1.767618e-01 18 36800198 36800224 27 - 2.918 2.959 0.137
ENSG00000134779 E026 1414.3630035 0.0002540343 1.016523e-02 2.917174e-02 18 36800225 36800311 87 - 3.137 3.119 -0.061
ENSG00000134779 E027 929.9747146 0.0002137839 1.925093e-05 1.198735e-04 18 36805374 36805397 24 - 2.973 2.927 -0.152
ENSG00000134779 E028 1304.0943395 0.0002701922 2.074158e-05 1.281949e-04 18 36805398 36805502 105 - 3.116 3.076 -0.135
ENSG00000134779 E029 0.6172225 0.4621061346 3.098462e-01 4.521880e-01 18 36805992 36806096 105 - 0.357 0.097 -2.353
ENSG00000134779 E030 0.5212538 0.0205864049 9.395933e-01 9.660774e-01 18 36807538 36807846 309 - 0.154 0.175 0.216
ENSG00000134779 E031 1148.3036038 0.0004846754 2.142338e-06 1.655286e-05 18 36807847 36807934 88 - 3.072 3.014 -0.193
ENSG00000134779 E032 0.6621601 0.0166168663 5.740965e-01 6.999579e-01 18 36817595 36817771 177 - 0.268 0.175 -0.784
ENSG00000134779 E033 0.7727888 0.0509478691 8.524207e-01 9.085559e-01 18 36818513 36818893 381 - 0.268 0.241 -0.207
ENSG00000134779 E034 788.1627802 0.0005485746 1.025555e-08 1.261776e-07 18 36818894 36818937 44 - 2.926 2.840 -0.284
ENSG00000134779 E035 648.6277687 0.0005401956 9.748977e-06 6.499330e-05 18 36818938 36818973 36 - 2.830 2.762 -0.227
ENSG00000134779 E036 4.5252953 0.0037261545 4.919448e-02 1.077241e-01 18 36818974 36818992 19 - 0.496 0.810 1.352
ENSG00000134779 E037 1.3933327 0.1504666586 5.437628e-01 6.743216e-01 18 36820968 36821129 162 - 0.432 0.304 -0.751
ENSG00000134779 E038 15.7200391 0.0125580136 4.413196e-04 1.933147e-03 18 36823803 36823871 69 - 1.389 1.050 -1.200
ENSG00000134779 E039 750.5194722 0.0032790797 9.944664e-02 1.896370e-01 18 36828683 36829216 534 - 2.875 2.834 -0.138