ENSG00000134775

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257209 ENSG00000134775 HEK293_OSMI2_2hA HEK293_TMG_2hB FHOD3 protein_coding protein_coding 6.256004 8.07393 5.849083 0.1132023 0.0294521 -0.4643821 2.21918015 1.6855181 3.1734812 0.20001572 0.4223917 0.9088790 0.35830417 0.20916667 0.54186667 0.33270000 8.325206e-04 4.177138e-23 FALSE TRUE
ENST00000359247 ENSG00000134775 HEK293_OSMI2_2hA HEK293_TMG_2hB FHOD3 protein_coding protein_coding 6.256004 8.07393 5.849083 0.1132023 0.0294521 -0.4643821 1.22019527 1.6150449 1.4628406 0.09714552 0.4463759 -0.1418782 0.20768750 0.20040000 0.25073333 0.05033333 8.999471e-01 4.177138e-23 FALSE TRUE
ENST00000585579 ENSG00000134775 HEK293_OSMI2_2hA HEK293_TMG_2hB FHOD3 protein_coding protein_coding 6.256004 8.07393 5.849083 0.1132023 0.0294521 -0.4643821 0.26556538 0.6474494 0.0000000 0.23943182 0.0000000 -6.0388079 0.03745000 0.07946667 0.00000000 -0.07946667 7.498795e-05 4.177138e-23 FALSE TRUE
ENST00000592128 ENSG00000134775 HEK293_OSMI2_2hA HEK293_TMG_2hB FHOD3 protein_coding protein_coding 6.256004 8.07393 5.849083 0.1132023 0.0294521 -0.4643821 1.37129703 3.4231065 0.0000000 0.36628752 0.0000000 -8.4233708 0.19713750 0.42396667 0.00000000 -0.42396667 4.177138e-23 4.177138e-23 FALSE TRUE
ENST00000592930 ENSG00000134775 HEK293_OSMI2_2hA HEK293_TMG_2hB FHOD3 protein_coding protein_coding 6.256004 8.07393 5.849083 0.1132023 0.0294521 -0.4643821 0.34720392 0.2075831 0.0000000 0.20758315 0.0000000 -4.4434949 0.05537083 0.02500000 0.00000000 -0.02500000 7.980567e-01 4.177138e-23 FALSE TRUE
MSTRG.15710.1 ENSG00000134775 HEK293_OSMI2_2hA HEK293_TMG_2hB FHOD3 protein_coding   6.256004 8.07393 5.849083 0.1132023 0.0294521 -0.4643821 0.33564195 0.4338701 0.6069665 0.27520884 0.3179701 0.4750547 0.05844583 0.05443333 0.10426667 0.04983333 8.879741e-01 4.177138e-23 FALSE TRUE
MSTRG.15710.2 ENSG00000134775 HEK293_OSMI2_2hA HEK293_TMG_2hB FHOD3 protein_coding   6.256004 8.07393 5.849083 0.1132023 0.0294521 -0.4643821 0.07874142 0.0000000 0.4527796 0.00000000 0.4527796 5.5322533 0.01252917 0.00000000 0.07686667 0.07686667 7.979334e-01 4.177138e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134775 E001 0.8448967 0.2699763449 7.595273e-01 8.438811e-01 18 36297701 36297709 9 + 0.300 0.217 -0.618
ENSG00000134775 E002 1.2888338 0.0303841629 1.348861e-01 2.409360e-01 18 36297710 36297712 3 + 0.476 0.214 -1.644
ENSG00000134775 E003 1.2888338 0.0303841629 1.348861e-01 2.409360e-01 18 36297713 36297713 1 + 0.476 0.214 -1.644
ENSG00000134775 E004 1.2888338 0.0303841629 1.348861e-01 2.409360e-01 18 36297714 36297716 3 + 0.476 0.214 -1.644
ENSG00000134775 E005 4.2479207 0.0311468077 3.673723e-02 8.496629e-02 18 36297717 36297750 34 + 0.865 0.550 -1.311
ENSG00000134775 E006 7.2737788 0.0191021794 1.666710e-03 6.175500e-03 18 36297751 36297794 44 + 1.090 0.684 -1.561
ENSG00000134775 E007 9.6341752 0.0113990043 3.128065e-02 7.444568e-02 18 36297795 36297834 40 + 1.135 0.904 -0.850
ENSG00000134775 E008 7.6275051 0.0292986687 3.013395e-01 4.431325e-01 18 36297835 36297835 1 + 0.999 0.868 -0.492
ENSG00000134775 E009 24.0082066 0.0048757738 7.472205e-02 1.510910e-01 18 36297836 36298000 165 + 1.451 1.331 -0.416
ENSG00000134775 E010 30.0409948 0.0006815496 2.054857e-02 5.264684e-02 18 36355539 36355645 107 + 1.551 1.423 -0.441
ENSG00000134775 E011 28.8145557 0.0006989482 5.808975e-02 1.233570e-01 18 36372680 36372744 65 + 1.526 1.423 -0.356
ENSG00000134775 E012 36.6926850 0.0038972778 6.921883e-03 2.101996e-02 18 36501932 36501999 68 + 1.652 1.499 -0.522
ENSG00000134775 E013 43.2969894 0.0005435082 2.601001e-05 1.570824e-04 18 36512438 36512543 106 + 1.742 1.537 -0.697
ENSG00000134775 E014 0.0000000       18 36544551 36544687 137 +      
ENSG00000134775 E015 38.0023773 0.0005894346 1.687476e-02 4.465674e-02 18 36576451 36576545 95 + 1.646 1.529 -0.398
ENSG00000134775 E016 0.2903454 0.3543606790 2.607131e-01   18 36594786 36594786 1 + 0.221 0.000 -11.699
ENSG00000134775 E017 43.2078519 0.0005486763 7.933270e-04 3.235805e-03 18 36594787 36594898 112 + 1.723 1.564 -0.541
ENSG00000134775 E018 39.6753916 0.0026124532 1.391096e-02 3.802442e-02 18 36602674 36602768 95 + 1.677 1.552 -0.428
ENSG00000134775 E019 42.2969450 0.0005579912 7.417079e-02 1.502112e-01 18 36611952 36612095 144 + 1.677 1.600 -0.262
ENSG00000134775 E020 46.2585980 0.0019318360 4.667456e-08 5.065221e-07 18 36625511 36625749 239 + 1.805 1.525 -0.953
ENSG00000134775 E021 0.3686942 0.0304706668 9.539859e-01 9.751781e-01 18 36649316 36649405 90 + 0.125 0.120 -0.060
ENSG00000134775 E022 0.9138088 0.2861802583 9.917291e-01 9.989159e-01 18 36652570 36652929 360 + 0.300 0.286 -0.091
ENSG00000134775 E023 0.2214452 0.0401741999 5.219584e-01   18 36653342 36653416 75 + 0.000 0.120 10.307
ENSG00000134775 E024 21.2899446 0.0008744828 1.659199e-04 8.175889e-04 18 36658075 36658130 56 + 1.466 1.203 -0.917
ENSG00000134775 E025 24.1811347 0.0010189384 4.721902e-04 2.053746e-03 18 36658131 36658188 58 + 1.504 1.275 -0.794
ENSG00000134775 E026 42.6608438 0.0006047026 4.310770e-02 9.675064e-02 18 36681436 36681570 135 + 1.686 1.597 -0.304
ENSG00000134775 E027 19.0739056 0.0017508908 2.820684e-01 4.220267e-01 18 36687128 36687178 51 + 1.335 1.268 -0.235
ENSG00000134775 E028 0.1515154 0.0429313976 4.541336e-01   18 36692976 36693208 233 + 0.125 0.000 -10.704
ENSG00000134775 E029 54.6308030 0.0069964721 5.744982e-01 7.003035e-01 18 36693209 36693423 215 + 1.750 1.735 -0.050
ENSG00000134775 E030 79.2254497 0.0003953158 1.440766e-03 5.442104e-03 18 36709095 36709391 297 + 1.957 1.850 -0.359
ENSG00000134775 E031 1.7099689 0.0092512805 2.179792e-02 5.525369e-02 18 36709392 36711469 2078 + 0.601 0.214 -2.233
ENSG00000134775 E032 114.7786431 0.0002616902 4.746541e-04 2.063042e-03 18 36717832 36718511 680 + 2.110 2.015 -0.317
ENSG00000134775 E033 24.8787519 0.0010078028 4.961287e-01 6.328618e-01 18 36718512 36718556 45 + 1.430 1.401 -0.101
ENSG00000134775 E034 45.9445324 0.0007044853 9.972691e-01 1.000000e+00 18 36718557 36718715 159 + 1.662 1.679 0.059
ENSG00000134775 E035 28.3991037 0.0007066335 8.608577e-01 9.142520e-01 18 36730646 36730703 58 + 1.461 1.467 0.020
ENSG00000134775 E036 35.8342207 0.0216164621 5.350399e-01 6.669894e-01 18 36730704 36730804 101 + 1.522 1.602 0.273
ENSG00000134775 E037 57.4946731 0.0076957477 2.279886e-02 5.732456e-02 18 36740656 36740838 183 + 1.671 1.832 0.543
ENSG00000134775 E038 57.0451440 0.0033519164 3.377928e-03 1.137304e-02 18 36742737 36742856 120 + 1.659 1.834 0.593
ENSG00000134775 E039 77.9273833 0.0004961718 8.170867e-03 2.421616e-02 18 36744032 36744193 162 + 1.823 1.947 0.417
ENSG00000134775 E040 90.3959771 0.0004489322 7.553821e-04 3.098956e-03 18 36746945 36747135 191 + 1.868 2.013 0.485
ENSG00000134775 E041 81.9193131 0.0004789448 9.886424e-06 6.579384e-05 18 36755119 36755311 193 + 1.794 1.988 0.653
ENSG00000134775 E042 0.0000000       18 36759118 36759141 24 +      
ENSG00000134775 E043 59.4543435 0.0049518743 1.331486e-06 1.076732e-05 18 36760608 36760782 175 + 1.586 1.882 1.000
ENSG00000134775 E044 72.3841400 0.0006274636 5.476810e-08 5.853022e-07 18 36769265 36769426 162 + 1.701 1.954 0.852
ENSG00000134775 E045 158.3741052 0.0077163552 1.662545e-07 1.619020e-06 18 36779448 36780220 773 + 2.027 2.300 0.914