ENSG00000134759

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358232 ENSG00000134759 HEK293_OSMI2_2hA HEK293_TMG_2hB ELP2 protein_coding protein_coding 93.62505 41.56392 130.3453 5.18724 3.344931 1.648698 9.472391 6.122029 12.40215 0.5350675 0.7014189 1.0173167 0.1213333 0.1501333 0.09496667 -0.055166667 8.891207e-03 1.34374e-06 FALSE TRUE
ENST00000535093 ENSG00000134759 HEK293_OSMI2_2hA HEK293_TMG_2hB ELP2 protein_coding processed_transcript 93.62505 41.56392 130.3453 5.18724 3.344931 1.648698 19.742079 8.604836 26.46667 0.7327298 0.5068933 1.6198262 0.2087875 0.2101333 0.20353333 -0.006600000 9.397390e-01 1.34374e-06 FALSE FALSE
ENST00000540135 ENSG00000134759 HEK293_OSMI2_2hA HEK293_TMG_2hB ELP2 protein_coding processed_transcript 93.62505 41.56392 130.3453 5.18724 3.344931 1.648698 13.334105 1.047092 18.25510 1.0470915 1.3633222 4.1109171 0.1107500 0.0229000 0.14003333 0.117133333 7.664217e-02 1.34374e-06 FALSE TRUE
ENST00000542050 ENSG00000134759 HEK293_OSMI2_2hA HEK293_TMG_2hB ELP2 protein_coding processed_transcript 93.62505 41.56392 130.3453 5.18724 3.344931 1.648698 11.880353 5.621326 16.70872 1.0264329 0.6319991 1.5699182 0.1306083 0.1333667 0.12830000 -0.005066667 8.960949e-01 1.34374e-06 FALSE TRUE
ENST00000543439 ENSG00000134759 HEK293_OSMI2_2hA HEK293_TMG_2hB ELP2 protein_coding processed_transcript 93.62505 41.56392 130.3453 5.18724 3.344931 1.648698 16.277787 4.702797 25.82980 1.6725480 2.4538067 2.4549398 0.1498958 0.1090667 0.19760000 0.088533333 1.522037e-01 1.34374e-06 FALSE FALSE
ENST00000543861 ENSG00000134759 HEK293_OSMI2_2hA HEK293_TMG_2hB ELP2 protein_coding processed_transcript 93.62505 41.56392 130.3453 5.18724 3.344931 1.648698 11.166188 9.691616 13.39703 1.1608375 1.9447269 0.4666923 0.1364625 0.2335333 0.10236667 -0.131166667 1.343740e-06 1.34374e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134759 E001 0.3268771 0.0308170059 6.089421e-01   18 36129444 36129497 54 + 0.089 0.165 1.020
ENSG00000134759 E002 6.5075471 0.0036618050 1.170583e-01 2.157484e-01 18 36129554 36129879 326 + 0.920 0.714 -0.810
ENSG00000134759 E003 3.6018696 0.0610563127 3.328698e-01 4.765429e-01 18 36129880 36129890 11 + 0.709 0.521 -0.828
ENSG00000134759 E004 3.1600088 0.0628306400 5.276338e-01 6.606608e-01 18 36129891 36129893 3 + 0.647 0.521 -0.566
ENSG00000134759 E005 3.1600088 0.0628306400 5.276338e-01 6.606608e-01 18 36129894 36129894 1 + 0.647 0.521 -0.566
ENSG00000134759 E006 3.3072578 0.0351610886 4.002766e-01 5.439633e-01 18 36129895 36129897 3 + 0.669 0.521 -0.659
ENSG00000134759 E007 3.3072578 0.0351610886 4.002766e-01 5.439633e-01 18 36129898 36129898 1 + 0.669 0.521 -0.659
ENSG00000134759 E008 3.4524305 0.0213414333 3.107612e-01 4.531922e-01 18 36129899 36129900 2 + 0.689 0.521 -0.746
ENSG00000134759 E009 3.4524305 0.0213414333 3.107612e-01 4.531922e-01 18 36129901 36129901 1 + 0.689 0.521 -0.746
ENSG00000134759 E010 2.9978842 0.0050772537 5.110578e-01 6.461623e-01 18 36129902 36129902 1 + 0.623 0.521 -0.466
ENSG00000134759 E011 11.0538429 0.0032520498 1.380198e-02 3.777712e-02 18 36129903 36129916 14 + 1.147 0.875 -1.005
ENSG00000134759 E012 12.7606913 0.0028234135 3.226652e-03 1.093465e-02 18 36129917 36129917 1 + 1.213 0.901 -1.139
ENSG00000134759 E013 18.3112670 0.0010055011 3.525161e-04 1.590188e-03 18 36129918 36129919 2 + 1.365 1.049 -1.121
ENSG00000134759 E014 28.2856933 0.0128453317 5.051523e-05 2.843801e-04 18 36129920 36129923 4 + 1.561 1.174 -1.346
ENSG00000134759 E015 28.9091568 0.0119493555 1.425383e-04 7.144921e-04 18 36129924 36129924 1 + 1.564 1.212 -1.220
ENSG00000134759 E016 184.1256024 0.0035712650 1.014128e-06 8.401048e-06 18 36129925 36130071 147 + 2.319 2.117 -0.673
ENSG00000134759 E017 194.2385221 0.0002368142 6.786355e-09 8.635509e-08 18 36133238 36133316 79 + 2.331 2.176 -0.518
ENSG00000134759 E018 180.9236087 0.0002399393 2.489660e-06 1.897946e-05 18 36136307 36136377 71 + 2.293 2.165 -0.427
ENSG00000134759 E019 0.0000000       18 36136378 36136632 255 +      
ENSG00000134759 E020 0.0000000       18 36137174 36137183 10 +      
ENSG00000134759 E021 0.0000000       18 36137184 36137235 52 +      
ENSG00000134759 E022 0.0000000       18 36138095 36138269 175 +      
ENSG00000134759 E023 95.3191933 0.0003110333 2.597516e-02 6.389637e-02 18 36138270 36138294 25 + 2.004 1.926 -0.262
ENSG00000134759 E024 206.1500017 0.0001911855 2.831517e-02 6.863529e-02 18 36138295 36138426 132 + 2.325 2.275 -0.168
ENSG00000134759 E025 1.0435424 0.1978836565 7.060686e-02 1.443507e-01 18 36138427 36138641 215 + 0.416 0.000 -11.375
ENSG00000134759 E026 118.1639523 0.0002443106 1.719869e-01 2.907897e-01 18 36138795 36138806 12 + 2.080 2.041 -0.133
ENSG00000134759 E027 175.0823921 0.0024549594 7.930160e-04 3.234675e-03 18 36138807 36138872 66 + 2.276 2.153 -0.411
ENSG00000134759 E028 5.2906333 0.0030796171 1.040716e-01 1.967101e-01 18 36139419 36139613 195 + 0.856 0.628 -0.928
ENSG00000134759 E029 0.4439371 0.0215653726 2.619270e-01 3.996463e-01 18 36139662 36139760 99 + 0.227 0.000 -11.304
ENSG00000134759 E030 204.7650561 0.0019033816 1.899397e-06 1.485204e-05 18 36141137 36141201 65 + 2.355 2.196 -0.531
ENSG00000134759 E031 1.9219759 0.0084319847 9.997142e-01 1.000000e+00 18 36141373 36141422 50 + 0.452 0.455 0.019
ENSG00000134759 E032 228.1595497 0.0019210298 5.558418e-05 3.095768e-04 18 36142281 36142347 67 + 2.392 2.263 -0.432
ENSG00000134759 E033 1.8446462 0.0076924590 1.978795e-01 3.235686e-01 18 36142348 36142349 2 + 0.517 0.285 -1.303
ENSG00000134759 E034 298.5424038 0.0019469476 4.222241e-03 1.376393e-02 18 36142826 36142966 141 + 2.494 2.412 -0.275
ENSG00000134759 E035 238.6027126 0.0002073324 1.115092e-02 3.152857e-02 18 36144939 36145034 96 + 2.390 2.335 -0.184
ENSG00000134759 E036 1.3995762 0.0091332227 9.965261e-01 1.000000e+00 18 36145035 36145358 324 + 0.375 0.378 0.018
ENSG00000134759 E037 255.3179957 0.0004821113 1.780657e-02 4.672043e-02 18 36145948 36146048 101 + 2.416 2.361 -0.182
ENSG00000134759 E038 316.6076845 0.0001655072 2.639342e-02 6.473277e-02 18 36146250 36146381 132 + 2.505 2.464 -0.136
ENSG00000134759 E039 306.4722859 0.0003281791 2.082372e-03 7.479364e-03 18 36154850 36154930 81 + 2.499 2.436 -0.211
ENSG00000134759 E040 286.5410871 0.0001656518 1.098077e-02 3.111529e-02 18 36154931 36154999 69 + 2.466 2.417 -0.165
ENSG00000134759 E041 385.2624283 0.0001246540 5.979345e-04 2.525988e-03 18 36156466 36156654 189 + 2.597 2.538 -0.196
ENSG00000134759 E042 0.0000000       18 36158503 36158614 112 +      
ENSG00000134759 E043 222.3687419 0.0017729460 1.944072e-01 3.192963e-01 18 36158835 36158904 70 + 2.321 2.370 0.163
ENSG00000134759 E044 153.3557473 0.0096820159 9.685817e-01 9.843407e-01 18 36159735 36159757 23 + 2.172 2.191 0.063
ENSG00000134759 E045 247.8091222 0.0006802581 1.427859e-02 3.885989e-02 18 36159758 36159830 73 + 2.360 2.430 0.235
ENSG00000134759 E046 3.0967579 0.0049595475 8.857847e-01 9.309645e-01 18 36159957 36159957 1 + 0.599 0.627 0.125
ENSG00000134759 E047 242.8348159 0.0009604092 1.959991e-03 7.100653e-03 18 36159958 36160015 58 + 2.341 2.429 0.295
ENSG00000134759 E048 240.2509729 0.0013666366 2.156652e-05 1.326745e-04 18 36160932 36161004 73 + 2.321 2.447 0.423
ENSG00000134759 E049 251.8640590 0.0005458004 1.740460e-09 2.467077e-08 18 36164475 36164531 57 + 2.329 2.484 0.517
ENSG00000134759 E050 394.2411628 0.0001274459 7.791047e-12 1.652105e-10 18 36164532 36164667 136 + 2.533 2.665 0.440
ENSG00000134759 E051 33.8624705 0.0038789538 1.007411e-06 8.349936e-06 18 36164668 36165225 558 + 1.632 1.269 -1.250
ENSG00000134759 E052 12.2313180 0.0014037606 1.441597e-01 2.536653e-01 18 36166889 36166965 77 + 1.154 1.011 -0.517
ENSG00000134759 E053 12.0053763 0.0180342783 5.210589e-01 6.549606e-01 18 36166966 36167047 82 + 1.125 1.050 -0.274
ENSG00000134759 E054 12.6257829 0.0382858560 2.774032e-01 4.169665e-01 18 36167048 36167100 53 + 1.168 1.015 -0.552
ENSG00000134759 E055 291.8231532 0.0010111943 4.283411e-08 4.684675e-07 18 36167101 36167152 52 + 2.396 2.543 0.488
ENSG00000134759 E056 167.9028967 0.0010178272 5.366387e-05 3.000549e-04 18 36167153 36167155 3 + 2.163 2.295 0.442
ENSG00000134759 E057 292.5944351 0.0010485750 1.332920e-05 8.602792e-05 18 36167156 36167222 67 + 2.409 2.527 0.393
ENSG00000134759 E058 8.1946827 0.0137394953 2.052053e-01 3.326703e-01 18 36169936 36170062 127 + 0.895 1.063 0.624
ENSG00000134759 E059 372.3109898 0.0017585583 1.172720e-06 9.598979e-06 18 36170063 36170196 134 + 2.505 2.643 0.459
ENSG00000134759 E060 7.9933169 0.0074164067 4.475264e-02 9.975354e-02 18 36170879 36171046 168 + 0.827 1.067 0.902
ENSG00000134759 E061 361.9344385 0.0046944396 4.862468e-03 1.554833e-02 18 36171047 36171160 114 + 2.503 2.613 0.368
ENSG00000134759 E062 997.6797847 0.0004479375 2.107067e-01 3.393818e-01 18 36174485 36180557 6073 + 2.979 3.002 0.074