ENSG00000134748

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257181 ENSG00000134748 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF38A protein_coding protein_coding 33.56053 24.23398 44.87621 1.373977 0.8534394 0.8886458 16.191670 12.741998 22.7939406 0.5021639 0.6285863 0.8385598 0.48591250 0.5275667 0.50793333 -0.01963333 8.325652e-01 4.786578e-07 FALSE  
ENST00000474048 ENSG00000134748 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF38A protein_coding processed_transcript 33.56053 24.23398 44.87621 1.373977 0.8534394 0.8886458 1.781624 1.831650 0.8973775 0.2117084 0.1400321 -1.0212243 0.05913333 0.0751000 0.02013333 -0.05496667 4.786578e-07 4.786578e-07 FALSE  
ENST00000487160 ENSG00000134748 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF38A protein_coding processed_transcript 33.56053 24.23398 44.87621 1.373977 0.8534394 0.8886458 10.651872 6.431649 13.7290707 0.5159843 1.0011588 1.0927824 0.31083750 0.2649333 0.30546667 0.04053333 4.683341e-01 4.786578e-07 FALSE  
MSTRG.1202.1 ENSG00000134748 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF38A protein_coding   33.56053 24.23398 44.87621 1.373977 0.8534394 0.8886458 4.402869 2.915064 6.6608731 0.3546004 0.3712582 1.1894074 0.12887083 0.1196667 0.14886667 0.02920000 4.468539e-01 4.786578e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134748 E001 36.638746 8.507687e-04 3.417598e-05 2.004128e-04 1 52404578 52404583 6 + 1.680 1.433 -0.846
ENSG00000134748 E002 57.832424 5.015399e-04 8.069280e-03 2.395595e-02 1 52404584 52404601 18 + 1.827 1.703 -0.419
ENSG00000134748 E003 173.029202 2.104757e-04 9.043906e-05 4.771075e-04 1 52404602 52404619 18 + 2.288 2.180 -0.360
ENSG00000134748 E004 222.149084 2.036555e-04 2.020390e-03 7.288664e-03 1 52404620 52404627 8 + 2.383 2.308 -0.250
ENSG00000134748 E005 666.211962 7.551942e-04 6.584030e-01 7.675537e-01 1 52404628 52404879 252 + 2.830 2.820 -0.032
ENSG00000134748 E006 2.678936 5.257710e-02 1.697487e-03 6.275175e-03 1 52405260 52405313 54 + 0.754 0.141 -3.606
ENSG00000134748 E007 308.208592 1.999956e-04 2.281356e-01 3.602115e-01 1 52405680 52405713 34 + 2.480 2.506 0.085
ENSG00000134748 E008 431.769109 2.555268e-04 6.556110e-03 2.007135e-02 1 52405714 52405839 126 + 2.659 2.609 -0.163
ENSG00000134748 E009 462.559941 3.645539e-04 6.612013e-02 1.369110e-01 1 52408569 52408690 122 + 2.681 2.647 -0.114
ENSG00000134748 E010 9.455892 2.136546e-03 6.518361e-07 5.634623e-06 1 52408691 52409074 384 + 1.209 0.610 -2.305
ENSG00000134748 E011 424.444155 1.103165e-03 3.026742e-01 4.445741e-01 1 52411115 52411200 86 + 2.640 2.615 -0.086
ENSG00000134748 E012 572.539739 1.951611e-04 8.495467e-05 4.514813e-04 1 52412514 52412624 111 + 2.730 2.790 0.202
ENSG00000134748 E013 523.247984 1.811675e-04 3.410653e-07 3.119932e-06 1 52413879 52413991 113 + 2.680 2.762 0.273
ENSG00000134748 E014 271.897040 1.711225e-04 3.286474e-05 1.936225e-04 1 52414621 52414647 27 + 2.393 2.484 0.303
ENSG00000134748 E015 10.414668 1.665731e-03 2.513579e-01 3.875906e-01 1 52414741 52414761 21 + 1.109 0.992 -0.426
ENSG00000134748 E016 275.588096 7.561042e-04 5.618731e-05 3.126143e-04 1 52414762 52414782 21 + 2.395 2.495 0.332
ENSG00000134748 E017 438.662470 3.875885e-04 1.778220e-08 2.092802e-07 1 52414783 52414859 77 + 2.593 2.699 0.351
ENSG00000134748 E018 356.731731 4.717017e-04 2.273873e-07 2.157128e-06 1 52415338 52415386 49 + 2.503 2.611 0.360
ENSG00000134748 E019 1822.213047 7.707632e-05 8.105241e-15 2.702893e-13 1 52416648 52420836 4189 + 3.289 3.228 -0.203