ENSG00000134602

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394334 ENSG00000134602 HEK293_OSMI2_2hA HEK293_TMG_2hB STK26 protein_coding protein_coding 18.69417 7.773642 32.97838 0.9818791 0.7029112 2.08344 15.528365 3.567801 29.134803 0.5798892 0.8859190 3.0260938 0.7543792 0.4931667 0.88320000 0.3900333 9.727153e-03 4.850453e-10 FALSE TRUE
ENST00000394335 ENSG00000134602 HEK293_OSMI2_2hA HEK293_TMG_2hB STK26 protein_coding protein_coding 18.69417 7.773642 32.97838 0.9818791 0.7029112 2.08344 1.340338 2.280570 1.547547 1.2458573 0.1409894 -0.5564311 0.1285667 0.2613333 0.04683333 -0.2145000 6.638761e-01 4.850453e-10 FALSE TRUE
ENST00000496850 ENSG00000134602 HEK293_OSMI2_2hA HEK293_TMG_2hB STK26 protein_coding protein_coding 18.69417 7.773642 32.97838 0.9818791 0.7029112 2.08344 1.265136 1.745344 1.371872 0.2991656 0.2242355 -0.3451301 0.0878750 0.2225667 0.04193333 -0.1806333 4.850453e-10 4.850453e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134602 E001 14.649628 0.0012297488 1.176492e-01 2.165867e-01 X 132023302 132023304 3 + 1.096 1.018 -0.283
ENSG00000134602 E002 73.535351 0.0092428442 2.065494e-02 5.286003e-02 X 132023305 132023407 103 + 1.760 1.699 -0.208
ENSG00000134602 E003 97.842814 0.0019805559 1.304795e-04 6.609169e-04 X 132023508 132023607 100 + 1.887 1.795 -0.312
ENSG00000134602 E004 76.483897 0.0060411274 4.471374e-03 1.446160e-02 X 132023608 132023659 52 + 1.781 1.697 -0.283
ENSG00000134602 E005 163.190354 0.0003393899 2.542147e-15 9.119526e-14 X 132054631 132054861 231 + 2.123 1.917 -0.691
ENSG00000134602 E006 1.882222 0.0075828869 2.172660e-01 3.470940e-01 X 132055456 132055521 66 + 0.318 0.617 1.542
ENSG00000134602 E007 101.668140 0.0049775020 1.533269e-06 1.223097e-05 X 132063433 132063489 57 + 1.917 1.730 -0.631
ENSG00000134602 E008 130.765500 0.0007217941 2.317142e-06 1.777661e-05 X 132068215 132068323 109 + 2.014 1.921 -0.312
ENSG00000134602 E009 178.475435 0.0002082793 5.501493e-05 3.067400e-04 X 132068412 132068569 158 + 2.137 2.111 -0.089
ENSG00000134602 E010 185.462484 0.0003798561 1.787785e-05 1.121269e-04 X 132069478 132069663 186 + 2.157 2.121 -0.119
ENSG00000134602 E011 198.111451 0.0002565797 1.474755e-03 5.555317e-03 X 132071069 132071217 149 + 2.176 2.186 0.033
ENSG00000134602 E012 158.540676 0.0002492308 1.214383e-02 3.387688e-02 X 132072268 132072346 79 + 2.077 2.100 0.075
ENSG00000134602 E013 87.902837 0.0003583071 3.216665e-01 4.649246e-01 X 132072347 132072361 15 + 1.818 1.883 0.220
ENSG00000134602 E014 123.600023 0.0002752623 5.408446e-01 6.719220e-01 X 132072813 132072875 63 + 1.959 2.048 0.297
ENSG00000134602 E015 88.969827 0.0003313399 4.395099e-02 9.829212e-02 X 132072957 132072965 9 + 1.831 1.846 0.050
ENSG00000134602 E016 177.307105 0.0002276879 7.884678e-01 8.645826e-01 X 132072966 132073093 128 + 2.111 2.216 0.349
ENSG00000134602 E017 867.323666 0.0122629676 3.960169e-09 5.257110e-08 X 132074135 132075943 1809 + 2.738 3.072 1.112