ENSG00000134569

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378623 ENSG00000134569 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP4 protein_coding protein_coding 6.418241 6.456574 5.885957 0.7269323 0.5085159 -0.1332756 1.5117458 1.3787623 1.3647524 0.1699693 0.3253526 -0.01462784 0.2593500 0.2253000 0.2454667 0.02016667 9.894177e-01 4.492552e-06 FALSE TRUE
ENST00000529604 ENSG00000134569 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP4 protein_coding retained_intron 6.418241 6.456574 5.885957 0.7269323 0.5085159 -0.1332756 3.3515408 4.2914843 2.4245703 0.4782381 0.3495270 -0.82116742 0.5008208 0.6652667 0.4074667 -0.25780000 4.492552e-06 4.492552e-06 FALSE TRUE
MSTRG.5460.4 ENSG00000134569 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP4 protein_coding   6.418241 6.456574 5.885957 0.7269323 0.5085159 -0.1332756 0.9510627 0.6720143 0.8977778 0.3390116 0.1598880 0.41253721 0.1420458 0.0938000 0.1561333 0.06233333 6.985296e-01 4.492552e-06 FALSE TRUE
MSTRG.5460.5 ENSG00000134569 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP4 protein_coding   6.418241 6.456574 5.885957 0.7269323 0.5085159 -0.1332756 0.4430061 0.1143133 1.0782307 0.1143133 0.5422196 3.12993206 0.0716875 0.0156000 0.1688667 0.15326667 4.343323e-01 4.492552e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134569 E001 1.2910239 0.0101920037 1.898490e-01 3.135741e-01 11 46856717 46856734 18 - 0.453 0.229 -1.408
ENSG00000134569 E002 1.9897157 0.0073745021 6.721249e-01 7.782134e-01 11 46856735 46856815 81 - 0.497 0.436 -0.308
ENSG00000134569 E003 2.2110591 0.0066362475 3.279711e-01 4.714341e-01 11 46856816 46856869 54 - 0.403 0.576 0.855
ENSG00000134569 E004 257.1173088 0.0015761938 7.125786e-36 1.844206e-33 11 46856870 46858477 1608 - 2.198 2.544 1.155
ENSG00000134569 E005 80.6096177 0.0006687543 2.026997e-04 9.754333e-04 11 46858478 46858966 489 - 1.813 1.977 0.553
ENSG00000134569 E006 18.9629759 0.0157211752 1.969516e-01 3.224130e-01 11 46858967 46858980 14 - 1.212 1.355 0.502
ENSG00000134569 E007 66.8720340 0.0004141601 5.694113e-01 6.959655e-01 11 46858981 46859315 335 - 1.805 1.844 0.134
ENSG00000134569 E008 39.4928428 0.0006771182 3.942658e-01 5.381240e-01 11 46862606 46862747 142 - 1.573 1.636 0.212
ENSG00000134569 E009 1.2210915 0.0112034477 6.255322e-01 7.416262e-01 11 46862748 46862933 186 - 0.283 0.378 0.593
ENSG00000134569 E010 31.3343231 0.0178944711 7.927684e-01 8.675046e-01 11 46864448 46864535 88 - 1.492 1.531 0.134
ENSG00000134569 E011 25.2689537 0.0466220962 5.397056e-01 6.709470e-01 11 46865119 46865186 68 - 1.369 1.464 0.328
ENSG00000134569 E012 35.5191362 0.0092986961 4.282093e-01 5.709990e-01 11 46867979 46868114 136 - 1.521 1.596 0.259
ENSG00000134569 E013 30.6624270 0.0007101320 5.612803e-01 6.891465e-01 11 46868600 46868713 114 - 1.469 1.521 0.177
ENSG00000134569 E014 37.9838349 0.0061788455 6.632447e-01 7.713493e-01 11 46868988 46869132 145 - 1.591 1.579 -0.041
ENSG00000134569 E015 33.5655597 0.0006264441 5.163732e-02 1.120694e-01 11 46871525 46871633 109 - 1.584 1.483 -0.345
ENSG00000134569 E016 37.4957061 0.0006795170 9.430415e-01 9.682668e-01 11 46873100 46873234 135 - 1.580 1.592 0.038
ENSG00000134569 E017 41.7726926 0.0005322087 5.318932e-01 6.642949e-01 11 46873375 46873593 219 - 1.636 1.618 -0.061
ENSG00000134569 E018 1.1770843 0.0110231379 6.267502e-01 7.426473e-01 11 46873594 46873754 161 - 0.283 0.377 0.592
ENSG00000134569 E019 44.5288332 0.0005314574 5.605451e-01 6.885343e-01 11 46874800 46875103 304 - 1.627 1.672 0.156
ENSG00000134569 E020 30.4132083 0.0006818251 7.724250e-01 8.531129e-01 11 46875456 46875681 226 - 1.474 1.507 0.114
ENSG00000134569 E021 26.3029662 0.0007762860 6.353822e-01 7.497104e-01 11 46875804 46875966 163 - 1.441 1.425 -0.057
ENSG00000134569 E022 26.6425263 0.0054930964 2.251597e-02 5.675412e-02 11 46876466 46876637 172 - 1.516 1.364 -0.527
ENSG00000134569 E023 16.7736317 0.0227524626 2.106522e-02 5.373145e-02 11 46876744 46876830 87 - 1.357 1.126 -0.813
ENSG00000134569 E024 22.3501350 0.0008525464 1.149252e-02 3.233276e-02 11 46877199 46877339 141 - 1.446 1.278 -0.583
ENSG00000134569 E025 22.5359749 0.0010191577 1.105840e-01 2.063898e-01 11 46878907 46879038 132 - 1.417 1.316 -0.348
ENSG00000134569 E026 27.7710008 0.0008273316 4.753632e-03 1.524308e-02 11 46879126 46879315 190 - 1.540 1.371 -0.583
ENSG00000134569 E027 29.1595022 0.0079329324 1.989250e-02 5.125779e-02 11 46881702 46881903 202 - 1.552 1.391 -0.552
ENSG00000134569 E028 15.7176412 0.0012052071 5.749056e-02 1.223232e-01 11 46883871 46883923 53 - 1.287 1.140 -0.521
ENSG00000134569 E029 18.0292018 0.0010519861 4.663262e-02 1.031780e-01 11 46883924 46883976 53 - 1.345 1.201 -0.506
ENSG00000134569 E030 20.0399322 0.0016633190 1.984145e-01 3.242278e-01 11 46886091 46886172 82 - 1.363 1.279 -0.293
ENSG00000134569 E031 28.0987094 0.0132234118 3.621045e-02 8.398479e-02 11 46886325 46886502 178 - 1.537 1.373 -0.564
ENSG00000134569 E032 11.1553014 0.0015280323 2.762725e-01 4.157123e-01 11 46886503 46886533 31 - 1.122 1.029 -0.338
ENSG00000134569 E033 17.4211364 0.0011262605 1.376712e-01 2.448383e-01 11 46889411 46889533 123 - 1.307 1.201 -0.374
ENSG00000134569 E034 0.1472490 0.0431160222 5.276194e-01   11 46889534 46889687 154 - 0.116 0.000 -9.044
ENSG00000134569 E035 19.2525256 0.0010850610 8.712305e-05 4.615419e-04 11 46889944 46890120 177 - 1.427 1.129 -1.045
ENSG00000134569 E036 23.0173069 0.0015771822 8.187866e-05 4.368745e-04 11 46890277 46890494 218 - 1.496 1.220 -0.960
ENSG00000134569 E037 17.0875499 0.0020100598 2.698325e-01 4.083881e-01 11 46892973 46893129 157 - 1.287 1.211 -0.269
ENSG00000134569 E038 21.6208554 0.0009166855 1.137910e-01 2.110466e-01 11 46894589 46894819 231 - 1.396 1.294 -0.353
ENSG00000134569 E039 19.2052143 0.0009904279 8.383177e-02 1.655508e-01 11 46895166 46895291 126 - 1.357 1.237 -0.418
ENSG00000134569 E040 17.3643602 0.0052528236 2.271680e-02 5.716450e-02 11 46895884 46896018 135 - 1.345 1.162 -0.644
ENSG00000134569 E041 15.0211358 0.0107580326 1.041024e-01 1.967525e-01 11 46896210 46896335 126 - 1.273 1.129 -0.510
ENSG00000134569 E042 14.8909299 0.0014787398 4.036727e-03 1.324533e-02 11 46896869 46896994 126 - 1.307 1.069 -0.847
ENSG00000134569 E043 14.7045197 0.0012852612 3.471444e-03 1.164300e-02 11 46898558 46898677 120 - 1.301 1.056 -0.871
ENSG00000134569 E044 15.2645985 0.0011729702 1.102490e-03 4.311530e-03 11 46898904 46899032 129 - 1.326 1.056 -0.961
ENSG00000134569 E045 13.2987040 0.0012771027 3.684551e-04 1.652249e-03 11 46899387 46899503 117 - 1.287 0.969 -1.145
ENSG00000134569 E046 14.0609709 0.0013579889 5.631842e-04 2.396262e-03 11 46899863 46899976 114 - 1.301 1.000 -1.077
ENSG00000134569 E047 12.7879310 0.0030867561 7.672219e-04 3.140552e-03 11 46900262 46900378 117 - 1.266 0.953 -1.132
ENSG00000134569 E048 8.2056828 0.0021541569 3.873265e-02 8.868751e-02 11 46902783 46902929 147 - 1.057 0.838 -0.823
ENSG00000134569 E049 0.5244761 0.2102263197 6.809186e-01 7.847405e-01 11 46907382 46907510 129 - 0.208 0.131 -0.807
ENSG00000134569 E050 1.9886861 0.0069115506 6.865496e-02 1.411354e-01 11 46918328 46918642 315 - 0.609 0.309 -1.561