ENSG00000134508

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256925 ENSG00000134508 HEK293_OSMI2_2hA HEK293_TMG_2hB CABLES1 protein_coding protein_coding 23.02947 32.77009 18.79036 1.856827 0.4967431 -0.8020597 4.8363529 5.034090 6.280413 0.7928186 0.2186818 0.3185607 0.21451667 0.15260000 0.3348333 0.18223333 1.075083e-05 5.366449e-07 FALSE TRUE
ENST00000400473 ENSG00000134508 HEK293_OSMI2_2hA HEK293_TMG_2hB CABLES1 protein_coding protein_coding 23.02947 32.77009 18.79036 1.856827 0.4967431 -0.8020597 7.4252484 6.077324 8.002125 1.7056135 0.3602552 0.3963767 0.34404167 0.18413333 0.4254667 0.24133333 1.793592e-02 5.366449e-07 FALSE TRUE
ENST00000420687 ENSG00000134508 HEK293_OSMI2_2hA HEK293_TMG_2hB CABLES1 protein_coding protein_coding 23.02947 32.77009 18.79036 1.856827 0.4967431 -0.8020597 8.4659999 17.637913 3.809032 1.2877312 0.1911527 -2.2082188 0.34192083 0.54240000 0.2028000 -0.33960000 5.366449e-07 5.366449e-07 FALSE TRUE
ENST00000582882 ENSG00000134508 HEK293_OSMI2_2hA HEK293_TMG_2hB CABLES1 protein_coding protein_coding 23.02947 32.77009 18.79036 1.856827 0.4967431 -0.8020597 0.5008454 1.845011 0.000000 0.6883424 0.0000000 -7.5352837 0.01971667 0.05546667 0.0000000 -0.05546667 1.651435e-06 5.366449e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134508 E001 0.5546650 0.0212260442 1.000000e+00 1.000000e+00 18 23134564 23134651 88 + 0.158 0.171 0.142
ENSG00000134508 E002 0.3332198 0.0301282614 6.216050e-01   18 23134652 23134670 19 + 0.158 0.094 -0.860
ENSG00000134508 E003 1.8435239 0.0386013767 4.483118e-01 5.896003e-01 18 23135452 23135484 33 + 0.504 0.390 -0.595
ENSG00000134508 E004 10.7818482 0.0042043530 5.639602e-05 3.136098e-04 18 23135485 23135545 61 + 1.258 0.877 -1.389
ENSG00000134508 E005 99.7542263 0.0109313970 1.723861e-09 2.444830e-08 18 23135546 23136423 878 + 2.168 1.837 -1.114
ENSG00000134508 E006 57.0473214 0.0019425404 6.611378e-03 2.021638e-02 18 23136424 23136458 35 + 1.798 1.691 -0.361
ENSG00000134508 E007 67.1181559 0.0003968808 6.993509e-02 1.432649e-01 18 23136459 23136492 34 + 1.830 1.783 -0.160
ENSG00000134508 E008 73.5220542 0.0003368331 2.300850e-02 5.776810e-02 18 23136493 23136523 31 + 1.883 1.821 -0.210
ENSG00000134508 E009 74.2260711 0.0003395436 2.188277e-02 5.543243e-02 18 23136524 23136548 25 + 1.888 1.826 -0.211
ENSG00000134508 E010 86.5595697 0.0016789851 7.485603e-02 1.512973e-01 18 23136549 23136607 59 + 1.941 1.900 -0.141
ENSG00000134508 E011 0.0000000       18 23149709 23149975 267 +      
ENSG00000134508 E012 0.0000000       18 23155825 23155952 128 +      
ENSG00000134508 E013 92.0787597 0.0003075288 1.067596e-02 3.039569e-02 18 23188838 23188909 72 + 1.979 1.916 -0.212
ENSG00000134508 E014 0.3268771 0.0299959416 6.220623e-01   18 23188910 23189357 448 + 0.158 0.094 -0.860
ENSG00000134508 E015 0.8512514 0.0136968632 5.057032e-01 6.414341e-01 18 23190305 23190530 226 + 0.158 0.293 1.139
ENSG00000134508 E016 134.5796012 0.0014829818 1.305915e-03 4.996499e-03 18 23194448 23194540 93 + 2.152 2.070 -0.274
ENSG00000134508 E017 0.2924217 0.0271809338 7.359751e-02   18 23196849 23197053 205 + 0.273 0.000 -11.250
ENSG00000134508 E018 137.7045053 0.0002814595 2.354271e-03 8.321539e-03 18 23213977 23214054 78 + 2.149 2.087 -0.206
ENSG00000134508 E019 1.8672684 0.0114194540 2.601531e-01 3.976376e-01 18 23214055 23214231 177 + 0.273 0.501 1.309
ENSG00000134508 E020 178.3567889 0.0021861171 1.385696e-01 2.461166e-01 18 23234608 23234704 97 + 2.231 2.213 -0.061
ENSG00000134508 E021 209.4007516 0.0010595695 2.708650e-01 4.095205e-01 18 23235895 23236051 157 + 2.288 2.289 0.006
ENSG00000134508 E022 207.2114932 0.0026448387 3.766745e-02 8.670911e-02 18 23237142 23237245 104 + 2.311 2.273 -0.127
ENSG00000134508 E023 210.0306400 0.0004321236 1.597229e-04 7.906723e-04 18 23252960 23253066 107 + 2.335 2.270 -0.217
ENSG00000134508 E024 318.5886566 0.0001802045 6.114121e-01 7.305179e-01 18 23253729 23253936 208 + 2.455 2.479 0.080
ENSG00000134508 E025 9.5613226 0.0018346617 2.163816e-02 5.492560e-02 18 23255585 23255912 328 + 0.765 1.074 1.171
ENSG00000134508 E026 663.1081610 0.0001406898 1.798580e-02 4.710197e-02 18 23257227 23257894 668 + 2.742 2.811 0.230
ENSG00000134508 E027 1276.2556494 0.0038835429 7.069179e-08 7.388066e-07 18 23257895 23260470 2576 + 2.957 3.118 0.538