ENSG00000134490

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000383233 ENSG00000134490 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM241 protein_coding protein_coding 11.84983 14.05366 9.668501 1.01582 0.7074439 -0.5391161 3.5060815 5.4712645 1.5165034 0.62545361 0.3227775 -1.8442779 0.28495417 0.38716667 0.16330000 -0.22386667 0.01523116 9.38301e-06 FALSE TRUE
ENST00000473688 ENSG00000134490 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM241 protein_coding nonsense_mediated_decay 11.84983 14.05366 9.668501 1.01582 0.7074439 -0.5391161 3.2351778 4.2378426 3.0821518 0.06203366 0.1411467 -0.4581191 0.27320417 0.30436667 0.32050000 0.01613333 0.87676111 9.38301e-06 TRUE FALSE
ENST00000477053 ENSG00000134490 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM241 protein_coding nonsense_mediated_decay 11.84983 14.05366 9.668501 1.01582 0.7074439 -0.5391161 1.0485306 1.2441871 0.3792006 0.15170655 0.2343226 -1.6881666 0.08767917 0.08976667 0.03610000 -0.05366667 0.41935009 9.38301e-06 TRUE FALSE
ENST00000497608 ENSG00000134490 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM241 protein_coding nonsense_mediated_decay 11.84983 14.05366 9.668501 1.01582 0.7074439 -0.5391161 0.9101073 1.1565528 0.4609724 0.08868758 0.2306961 -1.3085370 0.07789167 0.08320000 0.04850000 -0.03470000 0.64855521 9.38301e-06 FALSE FALSE
ENST00000542162 ENSG00000134490 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM241 protein_coding protein_coding 11.84983 14.05366 9.668501 1.01582 0.7074439 -0.5391161 0.3796945 0.2519742 0.8684681 0.25197423 0.2837990 1.7455651 0.03420833 0.01566667 0.08716667 0.07150000 0.11932582 9.38301e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134490 E001 0.6203429 0.0318850544 5.267312e-01 6.599232e-01 18 23197144 23197754 611 - 0.277 0.169 -0.911
ENSG00000134490 E002 0.0000000       18 23197755 23197792 38 -      
ENSG00000134490 E003 0.6621601 0.0165103646 5.233287e-01 6.570334e-01 18 23197793 23198090 298 - 0.277 0.169 -0.909
ENSG00000134490 E004 1.8467476 0.0984302574 5.375977e-02 1.158331e-01 18 23204387 23204656 270 - 0.660 0.288 -1.922
ENSG00000134490 E005 0.4513240 0.2551549550 3.180031e-01 4.609249e-01 18 23214602 23214744 143 - 0.278 0.091 -1.935
ENSG00000134490 E006 0.4815130 0.0203920049 1.000000e+00 1.000000e+00 18 23219131 23219255 125 - 0.160 0.169 0.089
ENSG00000134490 E007 0.1451727 0.0427331508 2.590089e-01   18 23226975 23227008 34 - 0.160 0.000 -10.516
ENSG00000134490 E008 5.9439608 0.0075950477 7.333126e-01 8.245426e-01 18 23295804 23295869 66 - 0.771 0.826 0.216
ENSG00000134490 E009 5.2358188 0.0031827637 8.857317e-01 9.309249e-01 18 23295870 23295907 38 - 0.771 0.760 -0.047
ENSG00000134490 E010 3.6731147 0.0052744428 8.162178e-01 8.837160e-01 18 23295908 23295936 29 - 0.615 0.659 0.190
ENSG00000134490 E011 4.0951671 0.0059620510 8.515855e-01 9.079751e-01 18 23296013 23296016 4 - 0.700 0.681 -0.081
ENSG00000134490 E012 93.3490710 0.0146269253 1.401777e-05 9.001199e-05 18 23296017 23296303 287 - 1.692 2.018 1.100
ENSG00000134490 E013 185.6981374 0.0006539106 3.843476e-22 3.103730e-20 18 23296304 23296743 440 - 1.996 2.311 1.052
ENSG00000134490 E014 224.9312527 0.0002709111 5.385008e-07 4.733325e-06 18 23296744 23297516 773 - 2.218 2.355 0.458
ENSG00000134490 E015 39.6269445 0.0157205961 9.327579e-01 9.616249e-01 18 23297517 23297597 81 - 1.575 1.582 0.025
ENSG00000134490 E016 60.8409418 0.0018355896 1.194122e-01 2.191082e-01 18 23297598 23297747 150 - 1.805 1.739 -0.225
ENSG00000134490 E017 38.2985020 0.0005543856 5.199805e-02 1.127193e-01 18 23297748 23297778 31 - 1.628 1.525 -0.350
ENSG00000134490 E018 54.1063215 0.0004713301 2.814297e-02 6.829608e-02 18 23297779 23297874 96 - 1.771 1.673 -0.332
ENSG00000134490 E019 26.7374166 0.0009524161 1.842264e-01 3.065349e-01 18 23297875 23297876 2 - 1.470 1.389 -0.281
ENSG00000134490 E020 39.2104032 0.0005982967 7.197388e-03 2.173812e-02 18 23297877 23297893 17 - 1.667 1.525 -0.484
ENSG00000134490 E021 65.9762471 0.0003803201 1.921383e-04 9.302331e-04 18 23297894 23298007 114 - 1.893 1.740 -0.518
ENSG00000134490 E022 47.9459204 0.0004972366 2.071081e-02 5.297796e-02 18 23298008 23298067 60 - 1.729 1.619 -0.374
ENSG00000134490 E023 56.1498063 0.0004551958 3.001707e-02 7.199286e-02 18 23309680 23309744 65 - 1.787 1.692 -0.321
ENSG00000134490 E024 0.0000000       18 23331030 23331254 225 -      
ENSG00000134490 E025 0.1482932 0.0417346111 9.154152e-01   18 23331255 23331574 320 - 0.000 0.092 8.586
ENSG00000134490 E026 53.6364031 0.0005171071 1.723436e-01 2.912525e-01 18 23352196 23352254 59 - 1.740 1.682 -0.198
ENSG00000134490 E027 39.5181614 0.0005912597 6.634128e-01 7.714928e-01 18 23352255 23352284 30 - 1.580 1.564 -0.055
ENSG00000134490 E028 33.8854550 0.0006719396 3.852867e-01 5.294796e-01 18 23352285 23352289 5 - 1.457 1.523 0.225
ENSG00000134490 E029 43.4165396 0.0005285072 4.175860e-02 9.429019e-02 18 23356594 23356629 36 - 1.520 1.648 0.437
ENSG00000134490 E030 45.7773895 0.0005505045 2.221631e-01 3.529936e-01 18 23356630 23356663 34 - 1.575 1.653 0.265
ENSG00000134490 E031 26.1681416 0.0007723166 5.642028e-01 6.915358e-01 18 23365634 23365634 1 - 1.359 1.410 0.177
ENSG00000134490 E032 36.0504186 0.0007159731 6.376326e-01 7.514765e-01 18 23365635 23365668 34 - 1.502 1.541 0.133
ENSG00000134490 E033 38.1068709 0.0005746349 8.949658e-01 9.368758e-01 18 23368715 23368750 36 - 1.554 1.555 0.006
ENSG00000134490 E034 32.0335078 0.0007359293 3.730353e-01 5.174705e-01 18 23370216 23370261 46 - 1.514 1.466 -0.164
ENSG00000134490 E035 0.4804688 0.0213769200 2.582021e-01 3.954196e-01 18 23370262 23370281 20 - 0.277 0.093 -1.909
ENSG00000134490 E036 18.4257505 0.0011491608 7.932739e-01 8.678135e-01 18 23371422 23371447 26 - 1.232 1.263 0.111
ENSG00000134490 E037 18.6774457 0.0010862728 6.382631e-01 7.519295e-01 18 23371448 23371470 23 - 1.220 1.269 0.172
ENSG00000134490 E038 56.1726333 0.0052071621 8.477898e-01 9.054807e-01 18 23373712 23373763 52 - 1.722 1.720 -0.007
ENSG00000134490 E039 13.1084177 0.0264396558 5.402270e-02 1.163031e-01 18 23376827 23376941 115 - 1.264 1.039 -0.806
ENSG00000134490 E040 42.4952812 0.0042585932 5.217955e-01 6.556647e-01 18 23377646 23377671 26 - 1.564 1.613 0.168
ENSG00000134490 E041 66.3217042 0.0004269673 2.316896e-01 3.644712e-01 18 23384990 23385067 78 - 1.820 1.776 -0.150
ENSG00000134490 E042 53.8127469 0.0007056986 3.261128e-03 1.103549e-02 18 23399566 23399647 82 - 1.796 1.661 -0.456
ENSG00000134490 E043 58.4386084 0.0003877077 1.144576e-04 5.883022e-04 18 23421367 23421444 78 - 1.849 1.679 -0.572
ENSG00000134490 E044 48.6605962 0.0005147365 1.402123e-06 1.127501e-05 18 23430631 23430677 47 - 1.808 1.575 -0.792
ENSG00000134490 E045 58.2281448 0.0004399751 2.644688e-08 3.010987e-07 18 23437781 23437961 181 - 1.890 1.643 -0.835