ENSG00000134453

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379888 ENSG00000134453 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM17 protein_coding protein_coding 86.72344 65.2886 108.6687 3.020379 2.953243 0.7349447 29.611149 27.791073 39.664501 1.1733884 1.497151 0.5130715 0.34562500 0.42586667 0.3660333 -0.05983333 2.352581e-01 1.205646e-08 FALSE  
ENST00000418631 ENSG00000134453 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM17 protein_coding protein_coding 86.72344 65.2886 108.6687 3.020379 2.953243 0.7349447 8.288171 2.646366 11.383284 0.2236806 1.194478 2.1006580 0.09060417 0.04053333 0.1053667 0.06483333 6.452278e-05 1.205646e-08 FALSE  
ENST00000432931 ENSG00000134453 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM17 protein_coding protein_coding 86.72344 65.2886 108.6687 3.020379 2.953243 0.7349447 5.597245 2.183065 8.015077 1.4643976 4.757255 1.8715665 0.05975417 0.03493333 0.0717000 0.03676667 9.111071e-01 1.205646e-08 FALSE  
ENST00000437845 ENSG00000134453 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM17 protein_coding protein_coding 86.72344 65.2886 108.6687 3.020379 2.953243 0.7349447 13.949482 12.910529 15.623084 1.3240068 1.306086 0.2749373 0.16385833 0.19886667 0.1438667 -0.05500000 2.726928e-01 1.205646e-08 FALSE  
ENST00000447032 ENSG00000134453 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM17 protein_coding protein_coding 86.72344 65.2886 108.6687 3.020379 2.953243 0.7349447 22.003312 17.407744 24.402777 2.9173346 1.647096 0.4870787 0.25730417 0.26366667 0.2241667 -0.03950000 6.563084e-01 1.205646e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134453 E001 38.792061 0.0345010336 3.891821e-08 4.289834e-07 10 6089034 6089053 20 + 1.803 1.167 -2.192
ENSG00000134453 E002 72.612880 0.0461772663 2.815333e-04 1.304720e-03 10 6089054 6089070 17 + 2.023 1.602 -1.423
ENSG00000134453 E003 231.664076 0.0152021131 2.883204e-03 9.919988e-03 10 6089071 6089193 123 + 2.454 2.251 -0.680
ENSG00000134453 E004 6.302334 0.0516778263 1.447613e-02 3.930603e-02 10 6089346 6089971 626 + 1.013 0.596 -1.661
ENSG00000134453 E005 6.516317 0.0039811486 1.905387e-02 4.945301e-02 10 6096910 6097047 138 + 1.001 0.699 -1.175
ENSG00000134453 E006 474.512442 0.0048213255 1.854420e-04 9.010995e-04 10 6097048 6097188 141 + 2.744 2.596 -0.493
ENSG00000134453 E007 523.638670 0.0007284110 9.753404e-06 6.501915e-05 10 6101271 6101387 117 + 2.764 2.669 -0.316
ENSG00000134453 E008 264.866916 0.0006973890 7.995196e-02 1.594889e-01 10 6104931 6104945 15 + 2.450 2.399 -0.169
ENSG00000134453 E009 292.458777 0.0002004675 2.936221e-03 1.007586e-02 10 6104946 6104970 25 + 2.501 2.431 -0.234
ENSG00000134453 E010 585.529503 0.0001442583 1.994183e-03 7.208395e-03 10 6104971 6105097 127 + 2.794 2.741 -0.178
ENSG00000134453 E011 270.746904 0.0004447705 2.782475e-01 4.179007e-01 10 6106141 6106143 3 + 2.450 2.418 -0.107
ENSG00000134453 E012 587.075726 0.0001432377 5.518867e-01 6.812940e-01 10 6106144 6106238 95 + 2.769 2.772 0.009
ENSG00000134453 E013 5.675123 0.0050817445 4.192295e-04 1.848178e-03 10 6106239 6106377 139 + 1.001 0.503 -2.050
ENSG00000134453 E014 12.774188 0.0096167889 1.113420e-08 1.360777e-07 10 6108488 6108685 198 + 1.348 0.667 -2.545
ENSG00000134453 E015 468.789917 0.0011907944 3.864413e-05 2.235424e-04 10 6108686 6108742 57 + 2.627 2.716 0.294
ENSG00000134453 E016 796.470038 0.0011055138 1.562839e-02 4.190732e-02 10 6109986 6110127 142 + 2.882 2.924 0.137
ENSG00000134453 E017 811.951544 0.0001367109 1.519946e-02 4.093793e-02 10 6112210 6112361 152 + 2.899 2.925 0.085
ENSG00000134453 E018 28.822754 0.0031368241 9.255746e-11 1.642752e-09 10 6112362 6112461 100 + 1.650 1.160 -1.700
ENSG00000134453 E019 23.380178 0.0063139511 4.386808e-04 1.923367e-03 10 6112588 6112629 42 + 1.503 1.203 -1.044
ENSG00000134453 E020 35.708931 0.0011499018 6.713726e-08 7.051589e-07 10 6112702 6112900 199 + 1.701 1.358 -1.174
ENSG00000134453 E021 36.043195 0.0006141756 4.111876e-09 5.438684e-08 10 6112901 6113068 168 + 1.711 1.344 -1.257
ENSG00000134453 E022 30.243875 0.0006671645 5.567745e-05 3.100324e-04 10 6113363 6113507 145 + 1.606 1.337 -0.924
ENSG00000134453 E023 544.967929 0.0001214555 8.969127e-03 2.620201e-02 10 6113508 6113581 74 + 2.722 2.756 0.114
ENSG00000134453 E024 10.338970 0.0020936666 7.643066e-01 8.474170e-01 10 6113907 6114048 142 + 1.071 1.034 -0.134
ENSG00000134453 E025 781.358112 0.0001185035 2.228864e-10 3.701039e-09 10 6114049 6114146 98 + 2.856 2.932 0.254
ENSG00000134453 E026 443.077765 0.0003122020 9.638473e-09 1.192671e-07 10 6114147 6114147 1 + 2.597 2.695 0.328
ENSG00000134453 E027 13.514890 0.0012719741 1.749324e-02 4.602901e-02 10 6114148 6115238 1091 + 1.260 1.034 -0.808
ENSG00000134453 E028 760.206614 0.0009089631 3.285717e-07 3.015109e-06 10 6115239 6115311 73 + 2.838 2.925 0.291
ENSG00000134453 E029 17.114435 0.0311460019 9.541034e-01 9.752456e-01 10 6115312 6115452 141 + 1.261 1.262 0.003
ENSG00000134453 E030 1391.636809 0.0015046650 5.148573e-01 6.495832e-01 10 6115453 6117457 2005 + 3.142 3.147 0.018