ENSG00000134452

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000362091 ENSG00000134452 HEK293_OSMI2_2hA HEK293_TMG_2hB FBH1 protein_coding protein_coding 45.82133 55.56059 36.19964 6.055361 1.184742 -0.6179477 23.605642 21.756907 24.393176 1.255314 0.5185950 0.1649325 0.53379583 0.3993667 0.67523333 0.27586667 8.883879e-05 5.847538e-25 FALSE TRUE
ENST00000485290 ENSG00000134452 HEK293_OSMI2_2hA HEK293_TMG_2hB FBH1 protein_coding processed_transcript 45.82133 55.56059 36.19964 6.055361 1.184742 -0.6179477 2.982067 8.120743 0.000000 2.067069 0.0000000 -9.6672434 0.05392083 0.1412333 0.00000000 -0.14123333 5.847538e-25 5.847538e-25 FALSE FALSE
MSTRG.3493.3 ENSG00000134452 HEK293_OSMI2_2hA HEK293_TMG_2hB FBH1 protein_coding   45.82133 55.56059 36.19964 6.055361 1.184742 -0.6179477 3.113762 6.000141 1.638952 1.181651 0.9053337 -1.8658494 0.06401250 0.1094000 0.04376667 -0.06563333 5.731523e-01 5.847538e-25   FALSE
MSTRG.3493.6 ENSG00000134452 HEK293_OSMI2_2hA HEK293_TMG_2hB FBH1 protein_coding   45.82133 55.56059 36.19964 6.055361 1.184742 -0.6179477 3.653662 9.592291 0.000000 3.423152 0.0000000 -9.9072348 0.06985000 0.1673667 0.00000000 -0.16736667 4.591433e-17 5.847538e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134452 E001 3.748459 0.0622768548 5.030187e-01 6.390002e-01 10 5890203 5890242 40 + 0.731 0.622 -0.459
ENSG00000134452 E002 4.259117 0.1088043619 5.521052e-01 6.814478e-01 10 5890243 5890244 2 + 0.762 0.674 -0.361
ENSG00000134452 E003 5.590939 0.1160161437 3.630663e-01 5.074913e-01 10 5890245 5890247 3 + 0.891 0.744 -0.575
ENSG00000134452 E004 49.741992 0.0618077715 1.607122e-01 2.760481e-01 10 5890248 5890279 32 + 1.792 1.613 -0.609
ENSG00000134452 E005 81.174249 0.0334177678 3.026931e-01 4.445984e-01 10 5890280 5890346 67 + 1.959 1.855 -0.351
ENSG00000134452 E006 10.904971 0.0015731057 1.268002e-01 2.296974e-01 10 5891019 5891116 98 + 1.151 1.002 -0.541
ENSG00000134452 E007 37.527503 0.0030539818 7.006674e-07 6.016105e-06 10 5893977 5894247 271 + 1.321 1.664 1.180
ENSG00000134452 E008 5.846139 0.0027957148 7.153712e-03 2.162275e-02 10 5894386 5894511 126 + 1.007 0.674 -1.301
ENSG00000134452 E009 7.287066 0.0258135260 7.524635e-03 2.257641e-02 10 5895056 5895187 132 + 1.099 0.742 -1.355
ENSG00000134452 E010 153.291570 0.0068429743 1.528111e-05 9.735036e-05 10 5903020 5903165 146 + 2.297 2.080 -0.726
ENSG00000134452 E011 85.927308 0.0003649645 5.042479e-10 7.886424e-09 10 5903166 5903175 10 + 2.060 1.825 -0.790
ENSG00000134452 E012 5.322578 0.0084257839 3.321167e-01 4.757472e-01 10 5905218 5905287 70 + 0.868 0.741 -0.499
ENSG00000134452 E013 457.649051 0.0039150692 2.258342e-05 1.382927e-04 10 5906037 5906505 469 + 2.732 2.586 -0.489
ENSG00000134452 E014 296.584592 0.0032640585 9.773353e-05 5.114307e-04 10 5906506 5906632 127 + 2.539 2.402 -0.456
ENSG00000134452 E015 276.086084 0.0004560569 5.652613e-09 7.307702e-08 10 5908925 5909055 131 + 2.509 2.375 -0.445
ENSG00000134452 E016 234.135175 0.0009821724 8.649377e-06 5.830274e-05 10 5909159 5909294 136 + 2.430 2.309 -0.404
ENSG00000134452 E017 3.230402 0.0057778030 1.821201e-01 3.038682e-01 10 5909295 5909478 184 + 0.731 0.531 -0.873
ENSG00000134452 E018 289.220687 0.0007964148 5.630552e-04 2.395848e-03 10 5910938 5911128 191 + 2.501 2.418 -0.275
ENSG00000134452 E019 138.222765 0.0010042217 1.273201e-02 3.528182e-02 10 5913747 5913783 37 + 2.183 2.103 -0.266
ENSG00000134452 E020 185.625337 0.0004560678 4.754588e-04 2.066255e-03 10 5913784 5913839 56 + 2.318 2.225 -0.310
ENSG00000134452 E021 237.071307 0.0003224933 2.687129e-02 6.572781e-02 10 5914178 5914269 92 + 2.397 2.347 -0.169
ENSG00000134452 E022 334.888812 0.0011491848 5.154471e-02 1.118979e-01 10 5915403 5915571 169 + 2.542 2.494 -0.159
ENSG00000134452 E023 19.573410 0.0755742115 4.595250e-02 1.019458e-01 10 5915572 5915944 373 + 1.462 1.175 -1.002
ENSG00000134452 E024 435.432122 0.0001711764 4.513434e-02 1.004405e-01 10 5916234 5916456 223 + 2.647 2.614 -0.111
ENSG00000134452 E025 4.325441 0.0045905371 2.158449e-04 1.031928e-03 10 5917062 5917419 358 + 0.972 0.456 -2.169
ENSG00000134452 E026 278.271265 0.0001694798 2.046380e-01 3.319524e-01 10 5917420 5917507 88 + 2.449 2.424 -0.083
ENSG00000134452 E027 248.829433 0.0002284589 1.436677e-02 3.906058e-02 10 5917590 5917676 87 + 2.419 2.365 -0.181
ENSG00000134452 E028 306.734426 0.0001850644 6.538722e-01 7.642258e-01 10 5918342 5918478 137 + 2.480 2.473 -0.023
ENSG00000134452 E029 261.394725 0.0001830232 5.888711e-01 7.120168e-01 10 5921258 5921345 88 + 2.411 2.401 -0.033
ENSG00000134452 E030 166.383511 0.0007860187 8.736186e-01 9.227652e-01 10 5921346 5921353 8 + 2.210 2.206 -0.014
ENSG00000134452 E031 164.877825 0.0018962360 7.680634e-01 8.501416e-01 10 5921354 5921357 4 + 2.210 2.198 -0.042
ENSG00000134452 E032 365.842690 0.0001887320 5.936341e-01 7.160096e-01 10 5921448 5921569 122 + 2.555 2.546 -0.028
ENSG00000134452 E033 2.623674 0.0453533836 4.800011e-01 6.183342e-01 10 5923571 5923620 50 + 0.622 0.495 -0.584
ENSG00000134452 E034 314.077671 0.0002046866 8.225959e-02 1.630756e-01 10 5923621 5923696 76 + 2.459 2.497 0.129
ENSG00000134452 E035 6.327066 0.0026829171 7.050922e-01 8.035275e-01 10 5923697 5924310 614 + 0.818 0.868 0.194
ENSG00000134452 E036 451.630057 0.0001338959 9.795351e-11 1.730418e-09 10 5924311 5924508 198 + 2.564 2.681 0.390
ENSG00000134452 E037 7.745658 0.0021211856 4.064453e-01 5.500932e-01 10 5924751 5924801 51 + 0.990 0.898 -0.344
ENSG00000134452 E038 2.438750 0.0964583332 6.102890e-02 1.283668e-01 10 5925264 5925366 103 + 0.731 0.364 -1.740
ENSG00000134452 E039 212.024434 0.0002322592 1.413424e-18 7.637447e-17 10 5925367 5925410 44 + 2.149 2.388 0.801
ENSG00000134452 E040 255.815350 0.0018693924 8.108918e-13 2.021320e-11 10 5925411 5925492 82 + 2.235 2.465 0.765
ENSG00000134452 E041 284.891846 0.0039098323 1.258535e-05 8.172820e-05 10 5927435 5927541 107 + 2.328 2.492 0.550
ENSG00000134452 E042 1.329644 0.0099038709 8.922454e-01 9.351613e-01 10 5928336 5928673 338 + 0.342 0.367 0.153
ENSG00000134452 E043 1.511338 0.0089518269 5.715601e-02 1.217331e-01 10 5929375 5929866 492 + 0.578 0.254 -1.807
ENSG00000134452 E044 292.841151 0.0024949956 6.169809e-09 7.919050e-08 10 5936456 5936587 132 + 2.322 2.512 0.636
ENSG00000134452 E045 6.336429 0.0029360051 4.135449e-01 5.570136e-01 10 5936633 5936730 98 + 0.791 0.898 0.415
ENSG00000134452 E046 291.171216 0.0025095914 1.375017e-10 2.371351e-09 10 5937110 5937205 96 + 2.303 2.516 0.709
ENSG00000134452 E047 368.412034 0.0037409519 4.394954e-12 9.690535e-11 10 5937206 5937594 389 + 2.376 2.626 0.834